ketoconazole has been researched along with Leishmaniasis, Cutaneous in 30 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Leishmaniasis, Cutaneous: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral ketoconazole is much easier and safer therapy than intramuscular SSG in combination with intralesional SSG in the treatment of localized cutaneous leishmaniasis." | 2.75 | Intralesional sodium stibogluconate alone or its combination with either intramuscular sodium stibogluconate or oral ketoconazole in the treatment of localized cutaneous leishmaniasis: a comparative study. ( Anwar, AE; El-Sayed, M, 2010) |
| " This dosage was reduced to 200 mg/day for patients below 12 years of age." | 2.68 | A randomized clinical trial of topical paromomycin versus oral ketoconazole for treating cutaneous leishmaniasis in Turkey. ( Baydar, I; Ozgoztasi, O, 1997) |
| "Cutaneous leishmaniasis is endemic in much of the Middle East." | 2.38 | Cutaneous leishmaniasis acquired during military service in the Middle East. ( Frankenburg, S; Klaus, SN; Norton, SA, 1992) |
| "Cutaneous leishmaniasis was diagnosed in an Indiana resident, an 80-year-old man who had visited Afghanistan 7 months earlier." | 1.39 | A case of cutaneous leishmaniasis found in Indiana. ( Fathi, A; Fathi, R, 2013) |
| "Miltefosine treatment cured two patients with L." | 1.37 | A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. ( Fedorko, DP; Mahanty, S; Nash, TE; Ramanathan, R; Talaat, KR, 2011) |
| "Ketoconazole was shown to be effective against imported cutaneous leishmaniasis." | 1.30 | Imported cutaneous leishmaniasis in Thailand. ( Punpoowong, B; Riganti, M; Viravan, C; Viriyavejakul, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (53.33) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Salazar-Villamizar, ME | 1 |
| Escobar, P | 1 |
| Hafedh, AA | 1 |
| Dar, MJ | 1 |
| Khalid, S | 1 |
| Varikuti, S | 1 |
| Satoskar, AR | 1 |
| Khan, GM | 1 |
| Tsai, PH | 1 |
| Chen, YT | 1 |
| Liau, JY | 1 |
| Huang, MH | 1 |
| Hsu, HM | 1 |
| Yeong, EK | 1 |
| Hung, CC | 1 |
| Galvão, EL | 1 |
| Rabello, A | 1 |
| Cota, GF | 1 |
| Sakano, H | 1 |
| Mhoyan, A | 1 |
| Cueva, RA | 1 |
| Nazari-Vanani, R | 1 |
| Vais, RD | 1 |
| Sharifi, F | 1 |
| Sattarahmady, N | 1 |
| Karimian, K | 1 |
| Motazedian, MH | 1 |
| Heli, H | 1 |
| Fathi, R | 1 |
| Fathi, A | 1 |
| El-Sayed, M | 1 |
| Anwar, AE | 1 |
| Ramanathan, R | 1 |
| Talaat, KR | 1 |
| Fedorko, DP | 1 |
| Mahanty, S | 1 |
| Nash, TE | 1 |
| Salmanpour, R | 1 |
| Handjani, F | 1 |
| Nouhpisheh, MK | 1 |
| Momeni, AZ | 1 |
| Aminjavaheri, M | 1 |
| Omidghaemi, MR | 1 |
| Elamin, EM | 1 |
| Guerbouj, S | 1 |
| Musa, AM | 1 |
| Guizani, I | 1 |
| Khalil, EA | 1 |
| Mukhtar, MM | 1 |
| Elkadaro, AM | 1 |
| Mohamed, HS | 1 |
| Ibrahim, ME | 1 |
| Abdel Hamid, MM | 1 |
| El Azhari, M | 1 |
| El Hassan, AM | 1 |
| Scarisbrick, JJ | 1 |
| Chiodini, PL | 1 |
| Watson, J | 1 |
| Moody, A | 1 |
| Armstrong, M | 1 |
| Lockwood, D | 1 |
| Bryceson, A | 1 |
| Vega-López, F | 1 |
| Alsaleh, QA | 1 |
| Dvorak, R | 1 |
| Nanda, A | 1 |
| Buffet, P | 1 |
| Caumes, E | 1 |
| Gentilini, M | 1 |
| Singh, S | 2 |
| Singh, R | 2 |
| Sundar, S | 2 |
| Ramesh, V | 2 |
| Mukherjee, A | 1 |
| Ysmail-Dahlouk, M | 1 |
| Amar Khodja, A | 1 |
| Ysmail-Dahlouk, S | 1 |
| Ait Belkacem, F | 1 |
| Baum, KF | 1 |
| Berens, RL | 1 |
| Soto-Mancipe, J | 1 |
| Grogl, M | 1 |
| Berman, JD | 2 |
| Finkelstein, E | 1 |
| Amichai, B | 1 |
| Halevy, S | 1 |
| Ozgoztasi, O | 1 |
| Baydar, I | 1 |
| Viriyavejakul, P | 1 |
| Viravan, C | 1 |
| Riganti, M | 1 |
| Punpoowong, B | 1 |
| Navin, TR | 1 |
| Arana, BA | 1 |
| Arana, FE | 1 |
| Chajón, JF | 1 |
| Saxena, U | 1 |
| Misra, RS | 1 |
| Abahusein, A | 1 |
| Larbi, EB | 1 |
| al-Khawajah, A | 1 |
| al-Gindan, Y | 1 |
| Jain, S | 1 |
| al-Fouzan, AS | 1 |
| al Saleh, QA | 1 |
| Najem, NM | 1 |
| Rostom, AI | 1 |
| Norton, SA | 1 |
| Frankenburg, S | 1 |
| Klaus, SN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3 Open-label Study of Efficacy and Safety of Miltefosine or Thermotherapy vs Glucantime for Cutaneous Leishmaniasis in Colombia.[NCT00471705] | Phase 3 | 437 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Complete Clinical response: Initial cure plus the absence of recurrences or mucosal lesions for 6 months after the end of treatment.~Note: nitial cure: Complete re-epithelialization of all ulcers and complete disappearance of the induration up to 3 months after the end of treatment." (NCT00471705)
Timeframe: Until 6 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 85 |
| Glucantime® | 103 |
| Thermotherapy | 86 |
At least 50% increase in lesion size at the end of treatment, absence of clinical response at 6 weeks, or any sign of lesion activity 3 months after the end of treatment (NCT00471705)
Timeframe: Until 3 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 34 |
| Glucantime® | 14 |
| Thermotherapy | 42 |
Reactivation of the lesion at the original site after cure or mucosal compromise during follow-up. (NCT00471705)
Timeframe: Until 6 months post-treatment
| Intervention | Participants (Number) |
|---|---|
| Miltefosine | 3 |
| Glucantime® | 4 |
| Thermotherapy | 6 |
4 reviews available for ketoconazole and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
Efficacy of azole therapy for tegumentary leishmaniasis: A systematic review and meta-analysis.
Topics: Administration, Cutaneous; Administration, Mucosal; Antifungal Agents; Azoles; Databases, Factual; H | 2017 |
[Treatment of localized cutaneous leishmaniasis].
Topics: Amphotericin B; Antimony Sodium Gluconate; Antiprotozoal Agents; Humans; Itraconazole; Ketoconazole; | 1994 |
Post-kala-azar dermal leishmaniasis.
Topics: Allopurinol; Amphotericin B; Antimony Sodium Gluconate; Humans; Incidence; Ketoconazole; Leishmanias | 1995 |
Cutaneous leishmaniasis acquired during military service in the Middle East.
Topics: Adult; Disease Reservoirs; Fiji; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Male; Middle East; | 1992 |
9 trials available for ketoconazole and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
Intralesional sodium stibogluconate alone or its combination with either intramuscular sodium stibogluconate or oral ketoconazole in the treatment of localized cutaneous leishmaniasis: a comparative study.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Antimony Sodium Gluconate; Antiprotozoal | 2010 |
Comparative study of the efficacy of oral ketoconazole with intra-lesional meglumine antimoniate (Glucantime) for the treatment of cutaneous leishmaniasis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Child; Child, Preschool; Female; Huma | 2001 |
Treatment of cutaneous leishmaniasis with ketoconazole cream.
Topics: Administration, Cutaneous; Adolescent; Adult; Antifungal Agents; Child; Double-Blind Method; Female; | 2003 |
Ketoconazole in the treatment of cutaneous leishmaniasis in Kuwait.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Sc | 1995 |
Failure of ketoconazole treatment in cutaneous leishmaniasis.
Topics: Administration, Oral; Adolescent; Adult; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneo | 1995 |
Evaluation of pentamidine for the treatment of cutaneous leishmaniasis in Colombia.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Colombia; Follow-Up Studies; Humans; Inj | 1993 |
A randomized clinical trial of topical paromomycin versus oral ketoconazole for treating cutaneous leishmaniasis in Turkey.
Topics: Administration, Oral; Administration, Topical; Amebicides; Animals; Child; Child, Preschool; Female; | 1997 |
Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala.
Topics: Administration, Oral; Adult; Animals; Antimony Sodium Gluconate; Follow-Up Studies; Guatemala; Human | 1992 |
Cutaneous leishmaniasis in Kuwait. Clinical experience with itraconazole.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Capsules; Child; Female; Humans; Itracon | 1991 |
17 other studies available for ketoconazole and Leishmaniasis, Cutaneous
| Article | Year |
|---|---|
In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains.
Topics: Analysis of Variance; Animals; Antiprotozoal Agents; Drug Resistance; Drug Therapy, Combination; Fem | 2022 |
In vivo comparative study of the efficacy of β-sitosterol, ketoconazole 2% and mupirocin for the treatment cutaneous leishmaniosis.
Topics: Animals; Ketoconazole; Leishmania tropica; Leishmaniasis, Cutaneous; Male; Mice; Mupirocin; Sitoster | 2022 |
Nano-elastic liposomes as multidrug carrier of sodium stibogluconate and ketoconazole: A potential new approach for the topical treatment of cutaneous Leishmaniasis.
Topics: Administration, Topical; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Drug Carriers; El | 2020 |
Molecular diagnosis and therapy for cutaneous leishmaniasis of a returned traveler from Mexico.
Topics: Adult; Amphotericin B; DNA, Protozoan; Humans; Ketoconazole; Leishmania mexicana; Leishmaniasis, Cut | 2021 |
Auricular Swelling After Mild Trauma.
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Biopsy; Diagnosis, Differential; Drug Ther | 2018 |
Investigation of anti-leishmanial efficacy of miltefosine and ketoconazole loaded on nanoniosomes.
Topics: Animals; Antiprotozoal Agents; Ketoconazole; Leishmania major; Leishmaniasis, Cutaneous; Nanostructu | 2018 |
A case of cutaneous leishmaniasis found in Indiana.
Topics: Afghanistan; Aged, 80 and over; Antiprotozoal Agents; Biopsy; Humans; Indiana; Ketoconazole; Leishma | 2013 |
A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis.
Topics: Adult; Aged; Amphotericin B; Antiprotozoal Agents; Child; Female; Humans; Ketoconazole; Leishmania; | 2011 |
Uncommon clinical presentations of cutaneous leishmaniasis in Sudan.
Topics: Adult; Animals; Antifungal Agents; Antimony; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cut | 2005 |
Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis.
Topics: Adolescent; Adult; Aged; Animals; Antifungal Agents; Antimony Sodium Gluconate; Antiprotozoal Agents | 2006 |
[Lupoid leishmaniasis].
Topics: Adolescent; Chronic Disease; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Infant; Ket | 1994 |
Successful treatment of cutaneous leishmaniasis with allopurinol after failure of treatment with ketoconazole.
Topics: Adult; Allopurinol; Animals; Belize; Drug Resistance; Forestry; Humans; Ketoconazole; Leishmania mex | 1994 |
Paranoid delusions caused by ketoconazole.
Topics: Aged; Antiparasitic Agents; Delusions; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Paran | 1996 |
Failure of ketoconazole in oriental sore in India.
Topics: Adolescent; Adult; Antifungal Agents; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneous; | 1995 |
Imported cutaneous leishmaniasis in Thailand.
Topics: Adult; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Retrospective | 1997 |
Efficacy of ketoconazole in post-kala-azar dermal leishmaniasis.
Topics: Adult; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male | 1992 |
Evaluation of topical ketoconazole in cutaneous leishmaniasis.
Topics: Administration, Oral; Administration, Topical; Adult; Child, Preschool; Female; Humans; Ketoconazole | 1992 |