ketoconazole has been researched along with Leishmaniasis, American in 30 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Oral ketoconazole is much easier and safer therapy than intramuscular SSG in combination with intralesional SSG in the treatment of localized cutaneous leishmaniasis." | 2.75 | Intralesional sodium stibogluconate alone or its combination with either intramuscular sodium stibogluconate or oral ketoconazole in the treatment of localized cutaneous leishmaniasis: a comparative study. ( Anwar, AE; El-Sayed, M, 2010) |
| " This dosage was reduced to 200 mg/day for patients below 12 years of age." | 2.68 | A randomized clinical trial of topical paromomycin versus oral ketoconazole for treating cutaneous leishmaniasis in Turkey. ( Baydar, I; Ozgoztasi, O, 1997) |
| "Cutaneous leishmaniasis is endemic in much of the Middle East." | 2.38 | Cutaneous leishmaniasis acquired during military service in the Middle East. ( Frankenburg, S; Klaus, SN; Norton, SA, 1992) |
| "Cutaneous leishmaniasis was diagnosed in an Indiana resident, an 80-year-old man who had visited Afghanistan 7 months earlier." | 1.39 | A case of cutaneous leishmaniasis found in Indiana. ( Fathi, A; Fathi, R, 2013) |
| "Miltefosine treatment cured two patients with L." | 1.37 | A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. ( Fedorko, DP; Mahanty, S; Nash, TE; Ramanathan, R; Talaat, KR, 2011) |
| "Ketoconazole was shown to be effective against imported cutaneous leishmaniasis." | 1.30 | Imported cutaneous leishmaniasis in Thailand. ( Punpoowong, B; Riganti, M; Viravan, C; Viriyavejakul, P, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 16 (53.33) | 18.2507 |
| 2000's | 4 (13.33) | 29.6817 |
| 2010's | 6 (20.00) | 24.3611 |
| 2020's | 4 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Salazar-Villamizar, ME | 1 |
| Escobar, P | 1 |
| Hafedh, AA | 1 |
| Dar, MJ | 1 |
| Khalid, S | 1 |
| Varikuti, S | 1 |
| Satoskar, AR | 1 |
| Khan, GM | 1 |
| Tsai, PH | 1 |
| Chen, YT | 1 |
| Liau, JY | 1 |
| Huang, MH | 1 |
| Hsu, HM | 1 |
| Yeong, EK | 1 |
| Hung, CC | 1 |
| Galvão, EL | 1 |
| Rabello, A | 1 |
| Cota, GF | 1 |
| Sakano, H | 1 |
| Mhoyan, A | 1 |
| Cueva, RA | 1 |
| Nazari-Vanani, R | 1 |
| Vais, RD | 1 |
| Sharifi, F | 1 |
| Sattarahmady, N | 1 |
| Karimian, K | 1 |
| Motazedian, MH | 1 |
| Heli, H | 1 |
| Fathi, R | 1 |
| Fathi, A | 1 |
| El-Sayed, M | 1 |
| Anwar, AE | 1 |
| Ramanathan, R | 1 |
| Talaat, KR | 1 |
| Fedorko, DP | 1 |
| Mahanty, S | 1 |
| Nash, TE | 1 |
| Salmanpour, R | 1 |
| Handjani, F | 1 |
| Nouhpisheh, MK | 1 |
| Momeni, AZ | 1 |
| Aminjavaheri, M | 1 |
| Omidghaemi, MR | 1 |
| Elamin, EM | 1 |
| Guerbouj, S | 1 |
| Musa, AM | 1 |
| Guizani, I | 1 |
| Khalil, EA | 1 |
| Mukhtar, MM | 1 |
| Elkadaro, AM | 1 |
| Mohamed, HS | 1 |
| Ibrahim, ME | 1 |
| Abdel Hamid, MM | 1 |
| El Azhari, M | 1 |
| El Hassan, AM | 1 |
| Scarisbrick, JJ | 1 |
| Chiodini, PL | 1 |
| Watson, J | 1 |
| Moody, A | 1 |
| Armstrong, M | 1 |
| Lockwood, D | 1 |
| Bryceson, A | 1 |
| Vega-López, F | 1 |
| Alsaleh, QA | 1 |
| Dvorak, R | 1 |
| Nanda, A | 1 |
| Buffet, P | 1 |
| Caumes, E | 1 |
| Gentilini, M | 1 |
| Singh, S | 2 |
| Singh, R | 2 |
| Sundar, S | 2 |
| Ramesh, V | 2 |
| Mukherjee, A | 1 |
| Ysmail-Dahlouk, M | 1 |
| Amar Khodja, A | 1 |
| Ysmail-Dahlouk, S | 1 |
| Ait Belkacem, F | 1 |
| Baum, KF | 1 |
| Berens, RL | 1 |
| Soto-Mancipe, J | 1 |
| Grogl, M | 1 |
| Berman, JD | 2 |
| Finkelstein, E | 1 |
| Amichai, B | 1 |
| Halevy, S | 1 |
| Ozgoztasi, O | 1 |
| Baydar, I | 1 |
| Viriyavejakul, P | 1 |
| Viravan, C | 1 |
| Riganti, M | 1 |
| Punpoowong, B | 1 |
| Navin, TR | 1 |
| Arana, BA | 1 |
| Arana, FE | 1 |
| Chajón, JF | 1 |
| Saxena, U | 1 |
| Misra, RS | 1 |
| Abahusein, A | 1 |
| Larbi, EB | 1 |
| al-Khawajah, A | 1 |
| al-Gindan, Y | 1 |
| Jain, S | 1 |
| al-Fouzan, AS | 1 |
| al Saleh, QA | 1 |
| Najem, NM | 1 |
| Rostom, AI | 1 |
| Norton, SA | 1 |
| Frankenburg, S | 1 |
| Klaus, SN | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Phase 3 Open-label Study of Efficacy and Safety of Miltefosine or Thermotherapy vs Glucantime for Cutaneous Leishmaniasis in Colombia.[NCT00471705] | Phase 3 | 437 participants (Actual) | Interventional | 2006-06-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"Complete Clinical response: Initial cure plus the absence of recurrences or mucosal lesions for 6 months after the end of treatment.~Note: nitial cure: Complete re-epithelialization of all ulcers and complete disappearance of the induration up to 3 months after the end of treatment." (NCT00471705)
Timeframe: Until 6 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 85 |
| Glucantime® | 103 |
| Thermotherapy | 86 |
At least 50% increase in lesion size at the end of treatment, absence of clinical response at 6 weeks, or any sign of lesion activity 3 months after the end of treatment (NCT00471705)
Timeframe: Until 3 months posttreatment
| Intervention | participants (Number) |
|---|---|
| Miltefosine | 34 |
| Glucantime® | 14 |
| Thermotherapy | 42 |
Reactivation of the lesion at the original site after cure or mucosal compromise during follow-up. (NCT00471705)
Timeframe: Until 6 months post-treatment
| Intervention | Participants (Number) |
|---|---|
| Miltefosine | 3 |
| Glucantime® | 4 |
| Thermotherapy | 6 |
4 reviews available for ketoconazole and Leishmaniasis, American
| Article | Year |
|---|---|
Efficacy of azole therapy for tegumentary leishmaniasis: A systematic review and meta-analysis.
Topics: Administration, Cutaneous; Administration, Mucosal; Antifungal Agents; Azoles; Databases, Factual; H | 2017 |
[Treatment of localized cutaneous leishmaniasis].
Topics: Amphotericin B; Antimony Sodium Gluconate; Antiprotozoal Agents; Humans; Itraconazole; Ketoconazole; | 1994 |
Post-kala-azar dermal leishmaniasis.
Topics: Allopurinol; Amphotericin B; Antimony Sodium Gluconate; Humans; Incidence; Ketoconazole; Leishmanias | 1995 |
Cutaneous leishmaniasis acquired during military service in the Middle East.
Topics: Adult; Disease Reservoirs; Fiji; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Male; Middle East; | 1992 |
9 trials available for ketoconazole and Leishmaniasis, American
| Article | Year |
|---|---|
Intralesional sodium stibogluconate alone or its combination with either intramuscular sodium stibogluconate or oral ketoconazole in the treatment of localized cutaneous leishmaniasis: a comparative study.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Antimony Sodium Gluconate; Antiprotozoal | 2010 |
Comparative study of the efficacy of oral ketoconazole with intra-lesional meglumine antimoniate (Glucantime) for the treatment of cutaneous leishmaniasis.
Topics: Administration, Oral; Adolescent; Adult; Antiprotozoal Agents; Child; Child, Preschool; Female; Huma | 2001 |
Treatment of cutaneous leishmaniasis with ketoconazole cream.
Topics: Administration, Cutaneous; Adolescent; Adult; Antifungal Agents; Child; Double-Blind Method; Female; | 2003 |
Ketoconazole in the treatment of cutaneous leishmaniasis in Kuwait.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Dose-Response Relationship, Drug; Drug Administration Sc | 1995 |
Failure of ketoconazole treatment in cutaneous leishmaniasis.
Topics: Administration, Oral; Adolescent; Adult; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneo | 1995 |
Evaluation of pentamidine for the treatment of cutaneous leishmaniasis in Colombia.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Colombia; Follow-Up Studies; Humans; Inj | 1993 |
A randomized clinical trial of topical paromomycin versus oral ketoconazole for treating cutaneous leishmaniasis in Turkey.
Topics: Administration, Oral; Administration, Topical; Amebicides; Animals; Child; Child, Preschool; Female; | 1997 |
Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala.
Topics: Administration, Oral; Adult; Animals; Antimony Sodium Gluconate; Follow-Up Studies; Guatemala; Human | 1992 |
Cutaneous leishmaniasis in Kuwait. Clinical experience with itraconazole.
Topics: Administration, Oral; Adolescent; Adult; Antifungal Agents; Capsules; Child; Female; Humans; Itracon | 1991 |
17 other studies available for ketoconazole and Leishmaniasis, American
| Article | Year |
|---|---|
In vitro selection of ketoconazole-pentamidine-resistant Leishmania (Viannia) braziliensis strains.
Topics: Analysis of Variance; Animals; Antiprotozoal Agents; Drug Resistance; Drug Therapy, Combination; Fem | 2022 |
In vivo comparative study of the efficacy of β-sitosterol, ketoconazole 2% and mupirocin for the treatment cutaneous leishmaniosis.
Topics: Animals; Ketoconazole; Leishmania tropica; Leishmaniasis, Cutaneous; Male; Mice; Mupirocin; Sitoster | 2022 |
Nano-elastic liposomes as multidrug carrier of sodium stibogluconate and ketoconazole: A potential new approach for the topical treatment of cutaneous Leishmaniasis.
Topics: Administration, Topical; Animals; Antimony Sodium Gluconate; Antiprotozoal Agents; Drug Carriers; El | 2020 |
Molecular diagnosis and therapy for cutaneous leishmaniasis of a returned traveler from Mexico.
Topics: Adult; Amphotericin B; DNA, Protozoan; Humans; Ketoconazole; Leishmania mexicana; Leishmaniasis, Cut | 2021 |
Auricular Swelling After Mild Trauma.
Topics: Amphotericin B; Anti-Bacterial Agents; Antifungal Agents; Biopsy; Diagnosis, Differential; Drug Ther | 2018 |
Investigation of anti-leishmanial efficacy of miltefosine and ketoconazole loaded on nanoniosomes.
Topics: Animals; Antiprotozoal Agents; Ketoconazole; Leishmania major; Leishmaniasis, Cutaneous; Nanostructu | 2018 |
A case of cutaneous leishmaniasis found in Indiana.
Topics: Afghanistan; Aged, 80 and over; Antiprotozoal Agents; Biopsy; Humans; Indiana; Ketoconazole; Leishma | 2013 |
A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis.
Topics: Adult; Aged; Amphotericin B; Antiprotozoal Agents; Child; Female; Humans; Ketoconazole; Leishmania; | 2011 |
Uncommon clinical presentations of cutaneous leishmaniasis in Sudan.
Topics: Adult; Animals; Antifungal Agents; Antimony; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cut | 2005 |
Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis.
Topics: Adolescent; Adult; Aged; Animals; Antifungal Agents; Antimony Sodium Gluconate; Antiprotozoal Agents | 2006 |
[Lupoid leishmaniasis].
Topics: Adolescent; Chronic Disease; Diagnosis, Differential; Facial Dermatoses; Female; Humans; Infant; Ket | 1994 |
Successful treatment of cutaneous leishmaniasis with allopurinol after failure of treatment with ketoconazole.
Topics: Adult; Allopurinol; Animals; Belize; Drug Resistance; Forestry; Humans; Ketoconazole; Leishmania mex | 1994 |
Paranoid delusions caused by ketoconazole.
Topics: Aged; Antiparasitic Agents; Delusions; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Paran | 1996 |
Failure of ketoconazole in oriental sore in India.
Topics: Adolescent; Adult; Antifungal Agents; Child; Female; Humans; Ketoconazole; Leishmaniasis, Cutaneous; | 1995 |
Imported cutaneous leishmaniasis in Thailand.
Topics: Adult; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male; Retrospective | 1997 |
Efficacy of ketoconazole in post-kala-azar dermal leishmaniasis.
Topics: Adult; Humans; Ketoconazole; Leishmaniasis, Cutaneous; Leishmaniasis, Visceral; Male | 1992 |
Evaluation of topical ketoconazole in cutaneous leishmaniasis.
Topics: Administration, Oral; Administration, Topical; Adult; Child, Preschool; Female; Humans; Ketoconazole | 1992 |