ketoconazole has been researched along with Hypophosphatemia in 1 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Hypophosphatemia: A condition of an abnormally low level of PHOSPHATES in the blood.
| Excerpt | Relevance | Reference |
|---|---|---|
| " No substantial change in T (max) or half-life was observed." | 2.76 | Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor. ( Chen, LC; de Jonge, M; Hamberg, P; Hengelage, T; Li, W; Porro, MG; Sharma, S; van der Biessen, D; Verweij, J; Woo, MM; Zhao, L, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Hamberg, P | 1 |
| Woo, MM | 1 |
| Chen, LC | 1 |
| Verweij, J | 1 |
| Porro, MG | 1 |
| Zhao, L | 1 |
| Li, W | 1 |
| van der Biessen, D | 1 |
| Sharma, S | 1 |
| Hengelage, T | 1 |
| de Jonge, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IB, Study to Investigate the Effect of Ketoconazole, a CYP3A4 Inhibitor, on Oral LBH589 and to Assess the Efficacy and Safety of Oral LBH589 in Patients With Advanced Solid Tumors.[NCT00503451] | Phase 1 | 14 participants (Actual) | Interventional | 2007-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 trial available for ketoconazole and Hypophosphatemia
| Article | Year |
|---|---|
Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor.
Topics: Adult; Aged; Antifungal Agents; Area Under Curve; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inh | 2011 |