ketoconazole has been researched along with Hyperplasia in 4 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Hyperplasia: An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole was reintroduced cautiously at a lower dose, with no ill-effect, and reasonable control of testotoxicosis." | 1.29 | Hazards of ketoconazole therapy in testotoxicosis. ( Babovic-Vuksanovic, D; Donaldson, MD; Gibson, NA; Wallace, AM, 1994) |
| " Adrenolytic treatment with ketoconazole (400 mg daily) caused symptoms of adrenal insufficiency, but a reduced dosage of 200 mg daily lowered the cortisol level to between 5 and 11 micrograms/dl and normalized the blood pressure and clinical signs of Cushing's syndrome disappeared." | 1.29 | [Bilateral massive macronodular adrenal gland hyperplasia. A rare cause of Cushing's syndrome]. ( Allolio, B; Diehl, KL; Reincke, M; Strohm, M; Theiss, M, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (50.00) | 18.7374 |
| 1990's | 2 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Babovic-Vuksanovic, D | 1 |
| Donaldson, MD | 1 |
| Gibson, NA | 1 |
| Wallace, AM | 1 |
| Strohm, M | 1 |
| Reincke, M | 1 |
| Theiss, M | 1 |
| Diehl, KL | 1 |
| Allolio, B | 1 |
| Arteaga, E | 1 |
| Mahana, D | 1 |
| González, R | 1 |
| Martínez, P | 1 |
| Geller, J | 1 |
| Albert, J | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| The Effect of Male Hormonal Contraceptive Regimens on Prostate Tissue In Normal Men[NCT00490555] | Phase 2/Phase 3 | 32 participants (Actual) | Interventional | 2009-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT00490555)
Timeframe: 10 weeks
| Intervention | ng/mL (Median) |
|---|---|
| 1) Placebo | 0.9 |
| 2) Testosterone Gel | 0.9 |
| 3) T Gel +Dutasteride | 1.8 |
| 4) T Gel+ DMPA | 0.7 |
(NCT00490555)
Timeframe: 10 weeks
| Intervention | ng/mL (Median) |
|---|---|
| 1) Placebo | 4.3 |
| 2) Testosterone Gel | 3.5 |
| 3) T Gel +Dutasteride | 3.8 |
| 4) T Gel+ DMPA | 3.2 |
(NCT00490555)
Timeframe: 10 weeks
| Intervention | ng/mL (Median) |
|---|---|
| 1) Placebo | 0.5 |
| 2) Testosterone Gel | 1.8 |
| 3) T Gel +Dutasteride | 0.5 |
| 4) T Gel+ DMPA | 0.6 |
PSA level week 10 end of treatment (NCT00490555)
Timeframe: 10 weeks
| Intervention | ng/mL (Median) |
|---|---|
| 1) Placebo | 0.8 |
| 2) Testosterone Gel | 0.9 |
| 3) T Gel +Dutasteride | 0.7 |
| 4) T Gel+ DMPA | 0.4 |
(NCT00490555)
Timeframe: 10 weeks
| Intervention | ng/mL (Median) |
|---|---|
| 1) Placebo | 4.0 |
| 2) Testosterone Gel | 4.4 |
| 3) T Gel +Dutasteride | 7.0 |
| 4) T Gel+ DMPA | 1.8 |
4 other studies available for ketoconazole and Hyperplasia
| Article | Year |
|---|---|
Hazards of ketoconazole therapy in testotoxicosis.
Topics: Child; Dose-Response Relationship, Drug; Drug Hypersensitivity; Humans; Hyperplasia; Ketoconazole; L | 1994 |
[Bilateral massive macronodular adrenal gland hyperplasia. A rare cause of Cushing's syndrome].
Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotr | 1994 |
[Cushing syndrome caused by macronodular adrenal hyperplasia, independent of ACTH: report of a case].
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hyperplasia; Ketocona | 1989 |
Effects of castration compared with total androgen blockade on tissue dihydrotestosterone (DHT) concentration in benign prostatic hyperplasia (BPH).
Topics: Androgen Antagonists; Castration; Combined Modality Therapy; Diethylstilbestrol; Dihydrotestosterone | 1987 |