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ketoconazole and Hirsutism

ketoconazole has been researched along with Hirsutism in 22 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Hirsutism: A condition observed in WOMEN and CHILDREN when there is excess coarse body hair of an adult male distribution pattern, such as facial and chest areas. It is the result of elevated ANDROGENS from the OVARIES, the ADRENAL GLANDS, or exogenous sources. The concept does not include HYPERTRICHOSIS, which is an androgen-independent excessive hair growth.

Research Excerpts

ExcerptRelevanceReference
"Ketoconazole was administered in a case of hirsutismus over a period of 4 months with high doses of 800 mg/day, and bilateral papilledema developed."7.68Ketoconazole induced papilledema. ( Akbatur, H; Bilgihan, K; Cakir, N; Hasanerisoğlu, B; Or, M, 1993)
"The effects of ketoconazole, a synthetic imidazole derivate, were evaluated in 42 women affected by acne (17 cases) and/or hirsutism (36 cases) treated with 400 mg/day for 3-6 months."7.68Ketoconazole therapy for women with acne and/or hirsutism. ( Capelli, M; Dal Prato, L; Fabbri, R; Flamigni, C; Magrini, O; Mantovani, B; Venturoli, S, 1990)
"Twelve women affected by functional postpuberal hirsutism were administered daily with 400 mg of ketoconazole."7.67Clinical and hormonal effects of ketoconazole on hirsutism in women. ( De Pedrini, P; Montemurro, G; Spanò, G; Tommaselli, A, 1988)
"Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor in basal conditions and after 90, 180, 270, and 360 days of treatment."6.69A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism. ( Bagnoli, A; Colombo, FM; Flamigni, C; Macrelli, S; Marescalchi, O; Paradisi, R; Ravaioli, B; Venturoli, S, 1999)
"To determine the efficacy of ketoconazole in the treatment of hirsutism, clinical and hormonal effects of this agent were evaluated with a randomized, placebo-controlled, double-blind cross-over study design."5.07Effects of ketoconazole in hirsute women. ( Akalin, S, 1991)
"Ketoconazole was administered in a case of hirsutismus over a period of 4 months with high doses of 800 mg/day, and bilateral papilledema developed."3.68Ketoconazole induced papilledema. ( Akbatur, H; Bilgihan, K; Cakir, N; Hasanerisoğlu, B; Or, M, 1993)
"The effects of ketoconazole, a synthetic imidazole derivate, were evaluated in 42 women affected by acne (17 cases) and/or hirsutism (36 cases) treated with 400 mg/day for 3-6 months."3.68Ketoconazole therapy for women with acne and/or hirsutism. ( Capelli, M; Dal Prato, L; Fabbri, R; Flamigni, C; Magrini, O; Mantovani, B; Venturoli, S, 1990)
"Hirsutism was evaluated by the Ferriman-Gallwey score, and hair diameter and hair growth rate were determined by a special image analysis processor in basal conditions and after 90, 180, 270, and 360 days of treatment."2.69A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism. ( Bagnoli, A; Colombo, FM; Flamigni, C; Macrelli, S; Marescalchi, O; Paradisi, R; Ravaioli, B; Venturoli, S, 1999)
"Polycystic ovary syndrome is the most common endocrinological problem associated with hirsutism."2.68Comparison of four different treatment regimes in hirsutism related to polycystic ovary syndrome. ( Gökmen, O; Gülekli, B; Işik, AZ; Senöz, S, 1996)
"BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome."1.46BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017)
"Ketoconazole is an orally active antimycotic agent and a potent inhibitor of gonadal and adrenal steroidogenesis."1.28Low-dose ketoconazole treatment in hirsute women. ( Biason, A; Boscaro, M; Mantero, F; Scaroni, C; Sonino, N, 1990)
"Ketoconazole treatment decreased testosterone, androstenedione and dehydroepiandrosterone sulfate, while 17-alfahydroxyprogesterone increased."1.28Evaluation of clinical and hormonal effects in hirsute women treated with ketoconazole. ( Conget, JI; Ferrer, J; González-Clemente, JM; Halperin, I; Martinez-Osaba, MJ; Vilardell, E, 1990)

Research

Studies (22)

TimeframeStudies, this research(%)All Research%
pre-19909 (40.91)18.7374
1990's11 (50.00)18.2507
2000's0 (0.00)29.6817
2010's2 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Geer, EB1
Shafiq, I1
Gordon, MB1
Bonert, V1
Ayala, A1
Swerdloff, RS1
Katznelson, L1
Lalazar, Y1
Manuylova, E1
Pulaski-Liebert, KJ1
Carmichael, JD1
Hannoush, Z1
Surampudi, V1
Broder, MS1
Cherepanov, D1
Eagan, M1
Lee, J1
Said, Q1
Neary, MP1
Biller, BMK1
Piraccini, BM1
Alessandrini, A1
Carpenter, PC1
Turk, DM1
Vidal-Puig, AJ1
Muñoz-Torres, M1
Jódar-Gimeno, E1
García-Calvente, CJ1
Lardelli, P1
Ruiz-Requena, ME1
Escobar-Jiménez, F1
Or, M1
Akbatur, H1
Hasanerisoğlu, B1
Bilgihan, K1
Cakir, N1
Gökmen, O2
Senöz, S2
Gülekli, B1
Işik, AZ2
Zeyneloğlu, HB1
Zorlu, CG1
Venturoli, S2
Marescalchi, O1
Colombo, FM1
Macrelli, S1
Ravaioli, B1
Bagnoli, A1
Paradisi, R1
Flamigni, C2
Manusharova, RA1
Akalin, S1
Sonino, N3
Scaroni, C1
Biason, A1
Boscaro, M1
Mantero, F1
Conget, JI1
Halperin, I1
Ferrer, J1
González-Clemente, JM1
Martinez-Osaba, MJ1
Vilardell, E1
Fabbri, R1
Dal Prato, L1
Mantovani, B1
Capelli, M1
Magrini, O1
Weber, MM1
Luppa, P1
Engelhardt, D1
Verhelst, JA1
Druwé, P1
van Erps, P1
Denis, LJ1
Mahler, C1
Carvalho, D1
Pignatelli, D1
Resende, C1
Martikainen, H1
Heikkinen, J1
Ruokonen, A1
Kauppila, A1
Presl, J1
De Pedrini, P1
Tommaselli, A1
Spanò, G1
Montemurro, G1

Reviews

3 reviews available for ketoconazole and Hirsutism

ArticleYear
Androgenetic alopecia.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2014, Volume: 149, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Alopecia; Androgen Antagonists; Biopsy; Comorbidity; Contraindications

2014
[The antimycotic ketoconazole. Indications in prostate disease, hirsutism, precocious puberty and Cushing syndrome?].
    Medizinische Monatsschrift fur Pharmazeuten, 1988, Volume: 11, Issue:5

    Topics: Cushing Syndrome; Hirsutism; Humans; Ketoconazole; Male; Prostatic Diseases; Puberty, Precocious

1988
The endocrine effects of ketoconazole.
    Journal of endocrinological investigation, 1986, Volume: 9, Issue:4

    Topics: Animals; Breast Neoplasms; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Humans; K

1986

Trials

5 trials available for ketoconazole and Hirsutism

ArticleYear
Ketoconazole therapy: hormonal and clinical effects in non-tumoral hyperandrogenism.
    European journal of endocrinology, 1994, Volume: 130, Issue:4

    Topics: Acne Vulgaris; Adolescent; Adult; Female; Follicle Stimulating Hormone; Gonadal Steroid Hormones; Hi

1994
Comparison of four different treatment regimes in hirsutism related to polycystic ovary syndrome.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1996, Volume: 10, Issue:4

    Topics: Adolescent; Adult; Androgen Antagonists; Cholesterol, HDL; Cholesterol, LDL; Cohort Studies; Contrac

1996
Low dose ketoconazole is an effective and a relatively safe alternative in the treatment of hirsutism.
    The Australian & New Zealand journal of obstetrics & gynaecology, 1996, Volume: 36, Issue:4

    Topics: Adult; Androgen Antagonists; Female; Hirsutism; Hormones; Humans; Ketoconazole; Luteinizing Hormone;

1996
A prospective randomized trial comparing low dose flutamide, finasteride, ketoconazole, and cyproterone acetate-estrogen regimens in the treatment of hirsutism.
    The Journal of clinical endocrinology and metabolism, 1999, Volume: 84, Issue:4

    Topics: Adult; Cyproterone Acetate; Ethinyl Estradiol; Female; Finasteride; Flutamide; Hirsutism; Hormones;

1999
Effects of ketoconazole in hirsute women.
    Acta endocrinologica, 1991, Volume: 124, Issue:1

    Topics: Adult; Dehydroepiandrosterone; Double-Blind Method; Estradiol; Female; Hirsutism; Humans; Hydrocorti

1991

Other Studies

14 other studies available for ketoconazole and Hirsutism

ArticleYear
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom

2017
Hirsutism.
    Current therapy in endocrinology and metabolism, 1994, Volume: 5

    Topics: Androgen Antagonists; Bromocriptine; Contraceptives, Oral, Combined; Dexamethasone; Female; Finaster

1994
Ketoconazole induced papilledema.
    Acta ophthalmologica, 1993, Volume: 71, Issue:2

    Topics: Adult; Female; Fluorescein Angiography; Fundus Oculi; Hirsutism; Humans; Ketoconazole; Papilledema

1993
[The effect of nizoral on the function of the hypothalamo-hypophyseal-ovarian system in virilism].
    Likars'ka sprava, 1992, Issue:8

    Topics: Adolescent; Adult; Drug Evaluation; Female; Hirsutism; Humans; Hypothalamo-Hypophyseal System; Ketoc

1992
Low-dose ketoconazole treatment in hirsute women.
    Journal of endocrinological investigation, 1990, Volume: 13, Issue:1

    Topics: Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Drug Evaluation; Estradiol; Female; Foll

1990
Evaluation of clinical and hormonal effects in hirsute women treated with ketoconazole.
    Journal of endocrinological investigation, 1990, Volume: 13, Issue:11

    Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androstenedione; Dehydroepiandrosterone; Dehydroepi

1990
Ketoconazole therapy for women with acne and/or hirsutism.
    The Journal of clinical endocrinology and metabolism, 1990, Volume: 71, Issue:2

    Topics: Acne Vulgaris; Adrenocorticotropic Hormone; Adult; Androgens; Estradiol; Estrone; Female; Follicle S

1990
Inhibition of human adrenal androgen secretion by ketoconazole.
    Klinische Wochenschrift, 1989, Jul-17, Volume: 67, Issue:14

    Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Cushing Syndrome; Female

1989
Use of ketoconazole in the treatment of a virilizing adrenocortical carcinoma.
    Acta endocrinologica, 1989, Volume: 121, Issue:2

    Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Female; Gonadal Steroid Hormones; Hirs

1989
Ketoconazole for hirsutism.
    Lancet (London, England), 1985, Sep-07, Volume: 2, Issue:8454

    Topics: Adult; Female; Hirsutism; Humans; Ketoconazole; Liver

1985
Hormonal and clinical effects of ketoconazole in hirsute women.
    The Journal of clinical endocrinology and metabolism, 1988, Volume: 66, Issue:5

    Topics: Adult; Androgens; Dehydroepiandrosterone; Female; Follicle Stimulating Hormone; Hirsutism; Humans; H

1988
[Ketoconazole in the treatment of hirsutism].
    Ceskoslovenska gynekologie, 1988, Volume: 53, Issue:9

    Topics: Female; Hirsutism; Humans; Ketoconazole

1988
Clinical and hormonal effects of ketoconazole on hirsutism in women.
    International journal of tissue reactions, 1988, Volume: 10, Issue:3

    Topics: Adolescent; Adult; Androgens; Female; Hirsutism; Humans; Ketoconazole

1988
Current trends in the endocrine use of ketoconazole.
    Journal of endocrinological investigation, 1988, Volume: 11, Issue:10

    Topics: Chemical Phenomena; Chemistry; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Human

1988