ketoconazole has been researched along with Hepatocellular Carcinoma in 17 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma." | 7.71 | Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases. ( Chang, FY; Huang, DF; Huang, YH; Huang, YS; Huo, TI; Lee, SD; Lin, CC; Wu, JC, 2001) |
| "Lacking a treatment for nonresectable hepatocellular carcinoma (HCC), we have utilized the androgen antagonist properties of ketoconazole in treating eight patients, seven men and one woman, with HCC, which, in view of a higher prevalence of HCC in men, seems to be androgen dependent." | 7.67 | Failure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinoma. ( Gupta, S; Korula, J, 1988) |
| "Ketoconazole is a broad-spectrum antifungal agent, which has recently been characterized as a potential anticancer agent in several cancer types." | 5.51 | A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery. ( Chen, HN; Chen, Y; Huang, C; Wei, Y; Zhou, ZG, 2019) |
| " The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma." | 3.71 | Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases. ( Chang, FY; Huang, DF; Huang, YH; Huang, YS; Huo, TI; Lee, SD; Lin, CC; Wu, JC, 2001) |
| "Lacking a treatment for nonresectable hepatocellular carcinoma (HCC), we have utilized the androgen antagonist properties of ketoconazole in treating eight patients, seven men and one woman, with HCC, which, in view of a higher prevalence of HCC in men, seems to be androgen dependent." | 3.67 | Failure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinoma. ( Gupta, S; Korula, J, 1988) |
| "The effects of amphotericin B, ketoconazole, and adenine arabinoside on production of hepatitis B surface antigen (HBsAg) particles by the human hepatoma cell line PLC/PRF/5 were examined." | 3.67 | Inhibition of in vitro HBsAg production by amphotericin B and ketoconazole. ( Kessler, HA; Pottage, JC, 1985) |
| "Ketoconazole is a broad-spectrum antifungal agent, which has recently been characterized as a potential anticancer agent in several cancer types." | 1.51 | A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery. ( Chen, HN; Chen, Y; Huang, C; Wei, Y; Zhou, ZG, 2019) |
| "Ketoconazole (KTZ) has 2 chiral centers with the therapeutically active form being a racemic mixture of 2 cis-enantiomers, namely, (2R,4S)-(+)-KTZ and (2S,4R)-(-)-KTZ." | 1.43 | Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells. ( Anwar-Mohamed, A; Brocks, DR; El-Kadi, AO; El-Sherbeni, AA; Hamdy, DA; Korashy, HM, 2016) |
| "Sterol profiling assay in the human hepatoma HepG2 cells revealed that compounds target human lanosterol 14alpha-demethylase (CYP51)." | 1.35 | Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). ( Acimovic, J; Kocjan, D; Korosec, T; Rozman, D; Seliskar, M; Tacer, KF; Urleb, U, 2008) |
| " Because loss of PXR maintains blood levels of paclitaxel upon chronic dosing, ketoconazole analogues may also serve to preserve paclitaxel blood levels on chronic dosing of drugs." | 1.34 | Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. ( Baker, SD; Huang, H; Kalpana, G; Li, H; Mani, S; Redinbo, MR; Sinz, M; Staudinger, J; Teotico, DG; Wang, H, 2007) |
| "Ketoconazole (KT) is a worldwide used oral antifungal agent with a broad spectrum of activity against both superficial and systemic mycosis." | 1.31 | Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. ( Chen, CF; Chen, CH; Chen, LC; Ho, YS; Liang, YC; Lin, CH; Lin, JK; Lin, SY; Wang, YJ; Yu, CF, 2002) |
| "Polysome profiles from both hepatoma cells and fibroblasts suggest that the rate of elongation or termination on LDLr mRNA is relatively low in the presence of reconstituted complete serum, and that it increases in fibroblasts upon lipoprotein depletion, but not in the hepatoma cells." | 1.28 | Differences between the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasts reside primarily at the translational and post-translational levels. ( Brissette, L; Deeley, RG; Ramharack, R; Tam, SP, 1991) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (23.53) | 18.7374 |
| 1990's | 3 (17.65) | 18.2507 |
| 2000's | 7 (41.18) | 29.6817 |
| 2010's | 3 (17.65) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Korosec, T | 1 |
| Acimovic, J | 1 |
| Seliskar, M | 1 |
| Kocjan, D | 1 |
| Tacer, KF | 1 |
| Rozman, D | 1 |
| Urleb, U | 1 |
| Chen, Y | 2 |
| Chen, HN | 2 |
| Wang, K | 1 |
| Zhang, L | 1 |
| Huang, Z | 1 |
| Liu, J | 1 |
| Zhang, Z | 1 |
| Luo, M | 1 |
| Lei, Y | 1 |
| Peng, Y | 1 |
| Zhou, ZG | 2 |
| Wei, Y | 2 |
| Huang, C | 2 |
| Anwar-Mohamed, A | 1 |
| El-Sherbeni, AA | 1 |
| Hamdy, DA | 1 |
| Korashy, HM | 3 |
| Brocks, DR | 3 |
| El-Kadi, AO | 3 |
| Wang, YJ | 1 |
| Yu, CF | 2 |
| Chen, LC | 1 |
| Chen, CH | 1 |
| Lin, JK | 2 |
| Liang, YC | 1 |
| Lin, CH | 1 |
| Lin, SY | 1 |
| Chen, CF | 1 |
| Ho, YS | 2 |
| Trubetskoy, O | 1 |
| Marks, B | 1 |
| Zielinski, T | 1 |
| Yueh, MF | 1 |
| Raucy, J | 1 |
| Shayeganpour, A | 1 |
| Wang, H | 1 |
| Huang, H | 1 |
| Li, H | 1 |
| Teotico, DG | 1 |
| Sinz, M | 1 |
| Baker, SD | 1 |
| Staudinger, J | 1 |
| Kalpana, G | 1 |
| Redinbo, MR | 1 |
| Mani, S | 1 |
| Loose, DS | 1 |
| Stover, EP | 1 |
| Feldman, D | 1 |
| Parker, RA | 1 |
| Pearce, BC | 1 |
| Clark, RW | 1 |
| Gordon, DA | 1 |
| Wright, JJ | 1 |
| Tsai, PW | 1 |
| Liu, HL | 1 |
| Chen, RJ | 1 |
| Lin, CC | 1 |
| Wu, JC | 1 |
| Huang, DF | 1 |
| Huang, YS | 1 |
| Huang, YH | 1 |
| Huo, TI | 1 |
| Chang, FY | 1 |
| Lee, SD | 1 |
| Tam, SP | 1 |
| Brissette, L | 1 |
| Ramharack, R | 1 |
| Deeley, RG | 1 |
| Gupta, S | 1 |
| Korula, J | 1 |
| Pottage, JC | 1 |
| Kessler, HA | 1 |
| Kempen, HJ | 1 |
| van Son, K | 1 |
| Cohen, LH | 1 |
| Griffioen, M | 1 |
| Verboom, H | 1 |
| Havekes, L | 1 |
17 other studies available for ketoconazole and Hepatocellular Carcinoma
| Article | Year |
|---|---|
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51).
Topics: Anticholesteremic Agents; Binding Sites; Carcinoma, Hepatocellular; Cell Line, Tumor; Cholesterol; C | 2008 |
Ketoconazole exacerbates mitophagy to induce apoptosis by downregulating cyclooxygenase-2 in hepatocellular carcinoma.
Topics: Apoptosis; Carcinoma, Hepatocellular; Cell Line, Tumor; Cyclooxygenase 2; Cytochrome P-450 CYP3A Inh | 2019 |
A novel role for ketoconazole in hepatocellular carcinoma treatment: linking PTGS2 to mitophagy machinery.
Topics: Autophagy; Carcinoma, Hepatocellular; Cyclooxygenase 2; Humans; Ketoconazole; Liver Neoplasms; Mitop | 2019 |
Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells.
Topics: Animals; Antifungal Agents; Carcinoma, Hepatocellular; Cell Line, Tumor; Cytochrome P-450 CYP1A1; He | 2016 |
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity.
Topics: Animals; Apoptosis; Baculoviridae; Carcinoma, Hepatocellular; Cytochrome P-450 CYP3A; Cytochrome P-4 | 2002 |
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Chromans; Clotrimazole; Cytochrome P-450 CYP1A2; Cytoch | 2005 |
Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines.
Topics: Animals; Antifungal Agents; Basic Helix-Loop-Helix Transcription Factors; Carcinoma, Hepatocellular; | 2007 |
Activated pregnenolone X-receptor is a target for ketoconazole and its analogs.
Topics: Carcinoma, Hepatocellular; Cell Line, Tumor; Cell Survival; Genes, Reporter; Humans; Ketoconazole; L | 2007 |
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection.
Topics: Animals; Antifungal Agents; Carcinoma, Hepatocellular; Enzyme Activation; Enzyme Induction; Fluconaz | 2007 |
Ketoconazole binds to glucocorticoid receptors and exhibits glucocorticoid antagonist activity in cultured cells.
Topics: Animals; Antifungal Agents; Carcinoma, Hepatocellular; Cells, Cultured; Clotrimazole; Dexamethasone; | 1983 |
Tocotrienols regulate cholesterol production in mammalian cells by post-transcriptional suppression of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.
Topics: Acetates; Acetic Acid; Androstenes; Animals; Carbon Radioisotopes; Carcinoma, Hepatocellular; Cell L | 1993 |
Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinoma, Hepato | 1998 |
Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases.
Topics: Antifungal Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Female; Hepati | 2001 |
Differences between the regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase and low density lipoprotein receptor in human hepatoma cells and fibroblasts reside primarily at the translational and post-translational levels.
Topics: Carcinoma, Hepatocellular; Cell Division; Cells, Cultured; Cholesterol; Fibroblasts; Gene Expression | 1991 |
Failure of ketoconazole as anti-androgen therapy in nonresectable primary hepatocellular carcinoma.
Topics: Adult; Aged; alpha-Fetoproteins; Androgen Antagonists; Carcinoma, Hepatocellular; Female; Humans; Ke | 1988 |
Inhibition of in vitro HBsAg production by amphotericin B and ketoconazole.
Topics: Amphotericin B; Antigens, Neoplasm; Antiviral Agents; Carcinoma, Hepatocellular; Cell Line; Depressi | 1985 |
Effect of ketoconazole on cholesterol synthesis and on HMG-CoA reductase and LDL-receptor activities in Hep G2 cells.
Topics: Carcinoma, Hepatocellular; Cell Line; Cholesterol; Humans; Hydroxymethylglutaryl-CoA Reductase Inhib | 1987 |