ketoconazole has been researched along with Gynecomastia in 9 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Gynecomastia: Enlargement of the BREAST in the males, caused by an excess of ESTROGENS. Physiological gynecomastia is normally observed in NEWBORNS; ADOLESCENT; and AGING males.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole, an antifungal drug, causes gynecomastia in some patients." | 7.67 | Ketoconazole-induced increase in estradiol-testosterone ratio. Probable explanation for gynecomastia. ( Goldman, ES; Pont, A; Siiteri, PK; Stevens, DA; Sugar, AM, 1985) |
| "Three of forty men developed bilateral gynecomastia upon ketoconazole treatment." | 7.66 | Gynecomastia with ketoconazole. ( DeFelice, R; Galgiani, JN; Johnson, DG, 1981) |
| "Ketoconazole, an antifungal drug, causes gynecomastia in some patients." | 3.67 | Ketoconazole-induced increase in estradiol-testosterone ratio. Probable explanation for gynecomastia. ( Goldman, ES; Pont, A; Siiteri, PK; Stevens, DA; Sugar, AM, 1985) |
| "Three of forty men developed bilateral gynecomastia upon ketoconazole treatment." | 3.66 | Gynecomastia with ketoconazole. ( DeFelice, R; Galgiani, JN; Johnson, DG, 1981) |
| " The concentrations of ketoconazole that inhibited human chorionic gonadotropin stimulation of testicular androgen production and displaced sex steroids from sex hormone-binding globulin were in the range of blood levels found in patients on higher therapeutic dosage regimens." | 1.27 | Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins. ( Boyden, TW; Galgiani, JN; Grosso, DS; Johnson, DG; Pamenter, RW; Stevens, DA, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (77.78) | 18.7374 |
| 1990's | 1 (11.11) | 18.2507 |
| 2000's | 1 (11.11) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Pont, A | 3 |
| Graybill, JR | 1 |
| Craven, PC | 1 |
| Galgiani, JN | 3 |
| Dismukes, WE | 1 |
| Reitz, RE | 2 |
| Stevens, DA | 4 |
| Schürmeyer, T | 1 |
| Nieschlag, E | 1 |
| Moncada, B | 1 |
| Baranda, L | 1 |
| DeFelice, R | 1 |
| Johnson, DG | 2 |
| Williams, PL | 1 |
| Azhar, S | 1 |
| Bochra, C | 1 |
| Smith, ER | 1 |
| Grosso, DS | 1 |
| Boyden, TW | 1 |
| Pamenter, RW | 1 |
| Satoh, T | 1 |
| Fujita, KI | 1 |
| Munakata, H | 1 |
| Itoh, S | 2 |
| Nakamura, K | 1 |
| Kamataki, T | 1 |
| Yoshizawa, I | 1 |
| Goldman, ES | 1 |
| Sugar, AM | 1 |
| Siiteri, PK | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Feedback Control of FSH Secretion in the Human Male[NCT00392457] | 175 participants (Anticipated) | Interventional | 1995-07-31 | Completed | |||
| Mechanisms of Hormonal Control of Spermatogenesis in Man[NCT02147964] | Phase 2 | 0 participants (Actual) | Interventional | 2019-06-30 | Withdrawn (stopped due to No funding was obtained for this study.) | ||
| Mechanisms of Control of the Intratesticular Hormonal Milieu in Man[NCT01215292] | Phase 1/Phase 2 | 46 participants (Actual) | Interventional | 2011-01-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01215292)
Timeframe: 10 days
| Intervention | ng/mL (Median) |
|---|---|
| Acyline + Testosterone Gel (Tgel)+ Placebo | .87 |
| Acyline + Tgel + Ketoconazole 400mg | 0.5 |
| Acyline + Tgel + Ketoconazole 800mg | 0.12 |
| Acyline & TGel & Dutasteride 2.5mg | 1.7 |
| Acyline & TGel & Anastrazole 1mg | 3.6 |
(NCT01215292)
Timeframe: 10 days
| Intervention | ng/mL (Median) |
|---|---|
| Acyline + Testosterone Gel (Tgel)+ Placebo | 3.17 |
| Acyline & TGel & Ketoconazole 400 mg | 2.08 |
| Acyline & TGel & Ketoconazole 800 mg | 1.46 |
| Acyline & TGel & Dutasteride | 0.12 |
| Acyline & TGel & Anastrazole | 3.63 |
(NCT01215292)
Timeframe: 10 days
| Intervention | ng/mL (Median) |
|---|---|
| Acyline + Testosterone Gel + Placebo | 14 |
| Acyline + Tgel + Ketoconazole 400mg | 3.7 |
| Acyline + Tgel + Ketoconazole 800mg | 1.7 |
| Acyline & TGel & Dutasteride 2.5mg | 18.4 |
| Acyline & TGel & Anastrazole 1mg | 24.0 |
9 other studies available for ketoconazole and Gynecomastia
| Article | Year |
|---|---|
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
High-dose ketoconazole therapy and adrenal and testicular function in humans.
Topics: Adrenal Glands; Adrenocorticotropic Hormone; Adult; Erectile Dysfunction; Gynecomastia; Humans; Hydr | 1984 |
Ketoconazole-induced drop in serum and saliva testosterone.
Topics: Adult; Antifungal Agents; Depression, Chemical; Gynecomastia; Humans; Imidazoles; Ketoconazole; Male | 1982 |
Ketoconazole and gynecomastia.
Topics: Gynecomastia; Humans; Imidazoles; Ketoconazole; Male; Piperazines | 1982 |
Gynecomastia with ketoconazole.
Topics: Adult; Aged; Antifungal Agents; Gynecomastia; Humans; Imidazoles; Ketoconazole; Male; Middle Aged; P | 1981 |
Ketoconazole blocks testosterone synthesis.
Topics: Adult; Animals; Antifungal Agents; Coccidioidomycosis; Gynecomastia; Humans; Imidazoles; Ketoconazol | 1982 |
Ketoconazole inhibition of testicular secretion of testosterone and displacement of steroid hormones from serum transport proteins.
Topics: Animals; Antifungal Agents; Chorionic Gonadotropin; Dihydrotestosterone; Dogs; Gonadal Steroid Hormo | 1983 |
Systemic antifungal drugs.
Topics: Amphotericin B; Anorexia; Antifungal Agents; Aspergillosis; Blastomycosis; Candidiasis; Coccidioidom | 1997 |
Studies on the interactions between drugs and estrogen: analytical method for prediction system of gynecomastia induced by drugs on the inhibitory metabolism of estradiol using Escherichia coli coexpressing human CYP3A4 with human NADPH-cytochrome P450 re
Topics: Catechols; Cimetidine; Cyclosporine; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Cyt | 2000 |
Ketoconazole-induced increase in estradiol-testosterone ratio. Probable explanation for gynecomastia.
Topics: Estradiol; Gynecomastia; Humans; Ketoconazole; Kinetics; Male; Prostatic Neoplasms; Sex Hormone-Bind | 1985 |