ketoconazole has been researched along with Granulocytic Leukemia, Chronic in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Additionally, voriconazole could significantly increase Cmax of dasatinib by approximately 4." | 1.56 | Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS. ( Cheng, G; Huang, L; Li, T; Luo, X; Xue, X; Zhang, Y, 2020) |
| "Bosutinib is an orally available Src/Abl tyrosine kinase inhibitor indicated for the treatment of patients with Philadelphia chromosome-positive chronic myelogenous leukemia." | 1.46 | Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions. ( Abbas, R; Hsyu, PH; Loi, CM; Ono, C; Yamazaki, S, 2017) |
| "The hallmark of chronic myeloid leukemia (CML) is the presence of the bcr-abl oncogene, which is associated with transforming ability and an intrinsic resistance to induction of apoptosis by genotoxic agents." | 1.30 | Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells. ( Akard, L; Boswell, HS; Carlo-Stella, C; Dugan, M; Garau, D; Regazzi, E; Rizzo, MT; Rizzoli, V, 1999) |
| "The rhabdomyolysis was preceded by a grand mal seizure probably caused by a combination of cyclosporin A and corticosteroids given for the prevention and treatment of acute graft-versus-host disease." | 1.28 | Fatal rhabdomyolysis as a complication of bone marrow transplantation. ( Järventie, G; Ruutu, T; Volin, L, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prado-Carrillo, O | 1 |
| Arenas-Ramírez, A | 1 |
| Llaguno-Munive, M | 1 |
| Jurado, R | 1 |
| Pérez-Rojas, J | 1 |
| Cervera-Ceballos, E | 1 |
| Garcia-Lopez, P | 1 |
| Luo, X | 1 |
| Xue, X | 1 |
| Li, T | 1 |
| Zhang, Y | 1 |
| Huang, L | 1 |
| Cheng, G | 1 |
| Ono, C | 1 |
| Hsyu, PH | 1 |
| Abbas, R | 1 |
| Loi, CM | 1 |
| Yamazaki, S | 1 |
| Rizzo, MT | 1 |
| Regazzi, E | 1 |
| Garau, D | 1 |
| Akard, L | 1 |
| Dugan, M | 1 |
| Boswell, HS | 1 |
| Rizzoli, V | 1 |
| Carlo-Stella, C | 1 |
| Volin, L | 1 |
| Järventie, G | 1 |
| Ruutu, T | 1 |
5 other studies available for ketoconazole and Granulocytic Leukemia, Chronic
| Article | Year |
|---|---|
Ketoconazole Reverses Imatinib Resistance in Human Chronic Myelogenous Leukemia K562 Cells.
Topics: Antineoplastic Agents; Apoptosis; ATP Binding Cassette Transporter, Subfamily B; Doxorubicin; Drug R | 2022 |
Differential Impacts of Azole Antifungal Drugs on the Pharmacokinetic Profiles of Dasatinib in Rats by LC-MS-MS.
Topics: Administration, Oral; Animals; Antifungal Agents; Area Under Curve; Chromatography, High Pressure Li | 2020 |
Application of Physiologically Based Pharmacokinetic Modeling to the Understanding of Bosutinib Pharmacokinetics: Prediction of Drug-Drug and Drug-Disease Interactions.
Topics: Administration, Oral; Aniline Compounds; Area Under Curve; Computer Simulation; Cytochrome P-450 CYP | 2017 |
Induction of apoptosis by arachidonic acid in chronic myeloid leukemia cells.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Adult; Animals; Antioxidants; Apoptosis; Arachidonic Acid; Bone Mar | 1999 |
Fatal rhabdomyolysis as a complication of bone marrow transplantation.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Bone Marrow Transplantation; Cyclosporins; Graft vs H | 1990 |