ketoconazole has been researched along with Glioma in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Glioma: Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells." | 3.69 | Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994) |
| "C6 glioma cells accumulate the organic osmolyte inositol in response to chronic hypertonic stress." | 3.68 | Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. ( Jackson, PS; Strange, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McManus, M | 1 |
| Serhan, C | 1 |
| Jackson, P | 1 |
| Strange, K | 2 |
| Jackson, PS | 1 |
2 other studies available for ketoconazole and Glioma
| Article | Year |
|---|---|
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid | 1994 |
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
Topics: Animals; Biological Transport; Cell Line; Chloride Channels; Chlorides; Fatty Acids, Nonesterified; | 1993 |