ketoconazole has been researched along with Glial Cell Tumors in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole, cinnamyl-3,4-dihydroxy-alpha-cyanocinnamate, and gossypol are reported inhibitors of the lipoxygenase (LO) and cytochrome P-450 enzyme systems and are potent blockers of swelling-activated efflux of organic osmolytes and volume-sensitive anion channels in C6 glioma cells." | 3.69 | Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion. ( Jackson, P; McManus, M; Serhan, C; Strange, K, 1994) |
| "C6 glioma cells accumulate the organic osmolyte inositol in response to chronic hypertonic stress." | 3.68 | Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux. ( Jackson, PS; Strange, K, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McManus, M | 1 |
| Serhan, C | 1 |
| Jackson, P | 1 |
| Strange, K | 2 |
| Jackson, PS | 1 |
2 other studies available for ketoconazole and Glial Cell Tumors
| Article | Year |
|---|---|
Ketoconazole blocks organic osmolyte efflux independently of its effect on arachidonic acid conversion.
Topics: Animals; Anions; Arachidonic Acid; Brain Neoplasms; Chromatography, High Pressure Liquid; Eicosanoid | 1994 |
Volume-sensitive anion channels mediate swelling-activated inositol and taurine efflux.
Topics: Animals; Biological Transport; Cell Line; Chloride Channels; Chlorides; Fatty Acids, Nonesterified; | 1993 |