Page last updated: 2024-10-29
ketoconazole and Female Genital Neoplasms
ketoconazole has been researched along with Female Genital Neoplasms in 1 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Research Excerpts
| Excerpt | Relevance | Reference |
|---|
| "Ixabepilone is a good CYP3A4 substrate in vitro; however, in humans, it is likely to be cleared by multiple mechanisms." | 2.73 | The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. ( André, F; Cohen, M; Cömezoglu, SN; Comprelli, A; Goel, S; Goldberg, G; Horwitz, SB; Humphreys, WG; Iacono, L; Jayabalan, D; Ly, VT; Mani, S; McDaid, H; Perrin, L; Xu, C; Zhang, D, 2008) |
Research
Studies (1)
| Timeframe | Studies, this research(%) | All Research% |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|
| Goel, S | 1 |
| Cohen, M | 1 |
| Cömezoglu, SN | 1 |
| Perrin, L | 1 |
| André, F | 1 |
| Jayabalan, D | 1 |
| Iacono, L | 1 |
| Comprelli, A | 1 |
| Ly, VT | 1 |
| Zhang, D | 1 |
| Xu, C | 1 |
| Humphreys, WG | 1 |
| McDaid, H | 1 |
| Goldberg, G | 1 |
| Horwitz, SB | 1 |
| Mani, S | 1 |
Clinical Trials (1)
Trial Overview
| Trial | Phase | Enrollment | Study Type | Start Date | Status |
|---|
| The Effect of Ketoconazole on the Pharmacokinetics and Pharmacodynamics of Ixabepilone In Patients With Advanced Cancer[NCT00096317] | Phase 1 | 29 participants (Actual) | Interventional | 2003-03-31 | Completed |
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] |
Trials
1 trial available for ketoconazole and Female Genital Neoplasms