ketoconazole has been researched along with Epilepsy in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Epilepsy: A disorder characterized by recurrent episodes of paroxysmal brain dysfunction due to a sudden, disorderly, and excessive neuronal discharge. Epilepsy classification systems are generally based upon: (1) clinical features of the seizure episodes (e.g., motor seizure), (2) etiology (e.g., post-traumatic), (3) anatomic site of seizure origin (e.g., frontal lobe seizure), (4) tendency to spread to other structures in the brain, and (5) temporal patterns (e.g., nocturnal epilepsy). (From Adams et al., Principles of Neurology, 6th ed, p313)
| Excerpt | Relevance | Reference |
|---|---|---|
| " The efficacy evaluation of NPs/KCZ was evaluated in a kainic acid (KA)-induced mice model of epilepsy with carbamazepine (CBZ) treatment." | 8.12 | Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. ( Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J, 2022) |
| "The effect of ketoconazole (200 mg/d orally for 10 days) on the plasma concentrations of carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) was assessed in eight patients with epilepsy stabilized on CBZ therapy." | 7.69 | Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy. ( Arena, D; Fazio, A; Perucca, E; Pisani, F; Scordo, MG; Spina, E, 1997) |
| " The efficacy evaluation of NPs/KCZ was evaluated in a kainic acid (KA)-induced mice model of epilepsy with carbamazepine (CBZ) treatment." | 4.12 | Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy. ( Fu, J; Lv, K; Sun, W; Wang, J; Yin, X; Zhang, J, 2022) |
| "The effect of ketoconazole (200 mg/d orally for 10 days) on the plasma concentrations of carbamazepine (CBZ) and its active metabolite carbamazepine-10,11-epoxide (CBZ-E) was assessed in eight patients with epilepsy stabilized on CBZ therapy." | 3.69 | Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy. ( Arena, D; Fazio, A; Perucca, E; Pisani, F; Scordo, MG; Spina, E, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, J | 1 |
| Fu, J | 1 |
| Sun, W | 1 |
| Yin, X | 1 |
| Lv, K | 1 |
| Zhang, J | 1 |
| Spina, E | 1 |
| Arena, D | 1 |
| Scordo, MG | 1 |
| Fazio, A | 1 |
| Pisani, F | 1 |
| Perucca, E | 1 |
2 other studies available for ketoconazole and Epilepsy
| Article | Year |
|---|---|
Functionalized PEG-PLA nanoparticles for brain targeted delivery of ketoconazole contribute to pregnane X receptor overexpressing in drug-resistant epilepsy.
Topics: Animals; Brain; Carbamazepine; Drug Resistant Epilepsy; Epilepsy; Kainic Acid; Ketoconazole; Mice; M | 2022 |
Elevation of plasma carbamazepine concentrations by ketoconazole in patients with epilepsy.
Topics: Adult; Antifungal Agents; Carbamazepine; Drug Interactions; Drug Monitoring; Epilepsy; Female; Human | 1997 |