ketoconazole has been researched along with Diffuse Mixed Small and Large Cell Lymphoma in 7 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Review of these five cases and 31 additional relapsing cases from the literature indicates that fungal endocarditis or endarteritis without surgical treatment, underlying lymphoreticular neoplasm, and amphotericin B dosage of less than 2 g appear to be associated with relapse of PDH." | 5.26 | Conditions associated with relapse of amphotericin B-treated disseminated histoplasmosis. ( Alford, RH; Bradsher, RW; Hawkins, SS; Spickard, WA, 1982) |
| "Eleven patients had evaluable pharmacokinetic data and were therefore included in the statistical analyses." | 2.84 | Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-Hodgkin lymphoma. ( Agarwal, SK; Chien, D; Danilov, AV; Gutierrez, M; Hu, B; Lewis, LD; Puvvada, S; Salem, AH; Wong, SL, 2017) |
| "5]octan-6-yl] N-[(2R)-1-amino-3-methyl-1-oxobutan-2-yl]carbamate, demonstrates rapid inactivation of its molecular target, methionine aminopeptidase-2 (MetAP2), and good efficacy in several rodent models of cancer and inflammation with oral dosing despite low apparent oral bioavailability." | 2.78 | Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity. ( Arico-Muendel, CC; Belanger, B; Benjamin, D; Blanchette, HS; Caiazzo, TM; Centrella, PA; DeLorey, J; Doyle, EG; Gradhand, U; Griffin, ST; Hill, S; Labenski, MT; Morgan, BA; O'Donovan, G; Prasad, K; Skinner, S; Taghizadeh, N; Thompson, CD; Wakefield, J; Westlin, W; White, KF, 2013) |
| " The half-life of ketoconazole was 3." | 1.27 | Ketoconazole pharmacokinetics during chronic dosing in adults with haematological malignancy. ( Bredow, MT; Daneshmend, TK; Richardson, MD; Slade, RR; Stockley, RJ; Warnock, DW, 1986) |
| " Review of these five cases and 31 additional relapsing cases from the literature indicates that fungal endocarditis or endarteritis without surgical treatment, underlying lymphoreticular neoplasm, and amphotericin B dosage of less than 2 g appear to be associated with relapse of PDH." | 1.26 | Conditions associated with relapse of amphotericin B-treated disseminated histoplasmosis. ( Alford, RH; Bradsher, RW; Hawkins, SS; Spickard, WA, 1982) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (57.14) | 18.7374 |
| 1990's | 1 (14.29) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Arico-Muendel, CC | 1 |
| Belanger, B | 1 |
| Benjamin, D | 1 |
| Blanchette, HS | 1 |
| Caiazzo, TM | 1 |
| Centrella, PA | 1 |
| DeLorey, J | 1 |
| Doyle, EG | 1 |
| Gradhand, U | 1 |
| Griffin, ST | 1 |
| Hill, S | 1 |
| Labenski, MT | 1 |
| Morgan, BA | 1 |
| O'Donovan, G | 1 |
| Prasad, K | 1 |
| Skinner, S | 1 |
| Taghizadeh, N | 1 |
| Thompson, CD | 1 |
| Wakefield, J | 1 |
| Westlin, W | 1 |
| White, KF | 1 |
| Agarwal, SK | 1 |
| Salem, AH | 1 |
| Danilov, AV | 1 |
| Hu, B | 1 |
| Puvvada, S | 1 |
| Gutierrez, M | 1 |
| Chien, D | 1 |
| Lewis, LD | 1 |
| Wong, SL | 1 |
| Bradsher, RW | 1 |
| Alford, RH | 1 |
| Hawkins, SS | 1 |
| Spickard, WA | 1 |
| Bertini, M | 1 |
| Freilone, R | 1 |
| Vitolo, U | 1 |
| Botto, B | 1 |
| Ciotti, R | 1 |
| Cinieri, S | 1 |
| Di Nota, A | 1 |
| Di Vito, F | 1 |
| Levis, A | 1 |
| Orsucci, L | 1 |
| Pini, M | 1 |
| Rota-Scalabrini, D | 1 |
| Todeschini, G | 1 |
| Resegotti, L | 1 |
| Turhan, A | 1 |
| Connors, JM | 1 |
| Klimo, P | 1 |
| Stockley, RJ | 1 |
| Daneshmend, TK | 1 |
| Bredow, MT | 1 |
| Warnock, DW | 1 |
| Richardson, MD | 1 |
| Slade, RR | 1 |
| Schønheyder, H | 1 |
| Brincker, H | 1 |
| Olsen, H | 1 |
| Stenderup, A | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase 1 Study to Assess the Effect of Ketoconazole on the Pharmacokinetics of ABT-199[NCT01969669] | Phase 1 | 12 participants (Actual) | Interventional | 2013-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
4 trials available for ketoconazole and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
Topics: Aminopeptidases; Angiogenesis Inhibitors; Animals; Drug Administration Schedule; Epoxy Compounds; Hu | 2013 |
Effect of ketoconazole, a strong CYP3A inhibitor, on the pharmacokinetics of venetoclax, a BCL-2 inhibitor, in patients with non-Hodgkin lymphoma.
Topics: Administration, Oral; Adult; Aged; Aged, 80 and over; Antineoplastic Agents; Area Under Curve; Bridg | 2017 |
The treatment of elderly patients with aggressive non-Hodgkin's lymphomas: feasibility and efficacy of an intensive multidrug regimen.
Topics: Aged; Anti-Infective Agents; Antibiotic Prophylaxis; Antifungal Agents; Antineoplastic Combined Chem | 1996 |
Ketoconazole versus nystatin as prophylaxis against fungal infection for lymphoma patients receiving chemotherapy.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Clinical Trials as Topic; Cyclophos | 1987 |
3 other studies available for ketoconazole and Diffuse Mixed Small and Large Cell Lymphoma
| Article | Year |
|---|---|
Conditions associated with relapse of amphotericin B-treated disseminated histoplasmosis.
Topics: Aged; Amphotericin B; Antifungal Agents; Endocarditis; Histoplasmosis; Humans; Imidazoles; Ketoconaz | 1982 |
Ketoconazole pharmacokinetics during chronic dosing in adults with haematological malignancy.
Topics: Adult; Drug Administration Schedule; Female; Half-Life; Humans; Immune Tolerance; Ketoconazole; Kine | 1986 |
The serological response to Candida albicans in leukemic patients prophylactically treated with ketoconazole.
Topics: Adolescent; Adult; Aged; Antibodies, Fungal; Candida albicans; Candidiasis; Female; Humans; Immunogl | 1987 |