ketoconazole has been researched along with Diabetes Mellitus, Adult-Onset in 12 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Piragliatin is a CYP3A substrate; its inactive metabolite M4, formed through cytosolic reductase, is reversibly metabolized back to piragliatin through CYP3A." | 2.82 | Exploratory effects of a strong CYP3A inhibitor (ketoconazole), a strong CYP3A inducer (rifampicin), and concomitant ethanol on piragliatin pharmacokinetics and pharmacodynamics in type 2 diabetic patients. ( Boldrin, M; Georgy, A; Liang, Z; Zhai, S; Zhi, J, 2016) |
| " Tolerability was assessed based on adverse events reported by subjects and the results of physical examinations and standard hematology, chemistry, and urinalysis tests performed on days 8 and 15." | 2.73 | Safety profile and metabolic effects of 14 days of treatment with DIO-902: results of a phase IIa multicenter, randomized, double-blind, placebo-controlled, parallel-group trial in patients with type 2 diabetes mellitus. ( Ahmann, AJ; Arauz-Pacheco, CJ; Rendell, M; Schwartz, SL; Thomas, A; Welles, BR, 2008) |
| "Onychomycosis is an infection of the nail unit by a fungus." | 1.43 | Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns. ( Atashili, J; Eba, M; Fuh, AN; Kwenti, ET; Mouliom, RN; Nchanji, GT; Njunda, AL, 2016) |
| "isolates for ketoconazole from type 1 diabetes patients was significantly higher than that of its matched control." | 1.37 | Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus. ( Back-Brito, GN; Balducci, I; Bremenkamp, RM; Brighenti, FL; Caris, AR; Jorge, AO; Koga-Ito, CY; Mota, AJ, 2011) |
| "Without treatment, Cushing's disease has significant morbidity and mortality." | 1.37 | Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing's disease resistant to surgery. ( Kocabay, G; Mert, M, 2011) |
| "Unfortunately the patient died of respiratory failure due to metastasis." | 1.37 | [Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma]. ( Montes-Mollón, MÁ; Paz Moreno-Arrones, J, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 8 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delivanis, DA | 1 |
| Athimulam, S | 1 |
| Bancos, I | 1 |
| Zhi, J | 1 |
| Zhai, S | 1 |
| Georgy, A | 1 |
| Liang, Z | 1 |
| Boldrin, M | 1 |
| Paun, DL | 1 |
| Vija, L | 1 |
| Stan, E | 1 |
| Banica, A | 1 |
| Bobeica, E | 1 |
| Terzea, D | 1 |
| Poiana, C | 1 |
| Badiu, C | 1 |
| Paun, S | 1 |
| Eba, M | 1 |
| Njunda, AL | 1 |
| Mouliom, RN | 1 |
| Kwenti, ET | 1 |
| Fuh, AN | 1 |
| Nchanji, GT | 1 |
| Atashili, J | 1 |
| Schwartz, SL | 1 |
| Rendell, M | 1 |
| Ahmann, AJ | 1 |
| Thomas, A | 1 |
| Arauz-Pacheco, CJ | 1 |
| Welles, BR | 1 |
| Arakaki, R | 1 |
| Welles, B | 1 |
| Bremenkamp, RM | 1 |
| Caris, AR | 1 |
| Jorge, AO | 1 |
| Back-Brito, GN | 1 |
| Mota, AJ | 1 |
| Balducci, I | 1 |
| Brighenti, FL | 1 |
| Koga-Ito, CY | 1 |
| Mert, M | 1 |
| Kocabay, G | 1 |
| Paz Moreno-Arrones, J | 1 |
| Montes-Mollón, MÁ | 1 |
| Manian, FA | 1 |
| Brischetto, MJ | 1 |
| Guiserix, J | 1 |
| Ramdane, M | 1 |
| Finielz, P | 1 |
| Michault, A | 1 |
| Rajaonarivelo, P | 1 |
| Young, C | 1 |
| Burrows, R | 1 |
| Katz, J | 1 |
| Beynon, H | 1 |
1 review available for ketoconazole and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Ketoconazole enantiomer for the treatment of diabetes mellitus.
Topics: Adrenal Glands; Clinical Trials, Phase II as Topic; Diabetes Mellitus, Type 2; Humans; Hydrocortison | 2010 |
2 trials available for ketoconazole and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Exploratory effects of a strong CYP3A inhibitor (ketoconazole), a strong CYP3A inducer (rifampicin), and concomitant ethanol on piragliatin pharmacokinetics and pharmacodynamics in type 2 diabetic patients.
Topics: Adult; Aged; Benzeneacetamides; Blood Glucose; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; | 2016 |
Safety profile and metabolic effects of 14 days of treatment with DIO-902: results of a phase IIa multicenter, randomized, double-blind, placebo-controlled, parallel-group trial in patients with type 2 diabetes mellitus.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Aged; Antifungal Agents; Blood Glucose; Diabetes Mel | 2008 |
9 other studies available for ketoconazole and Diabetes Mellitus, Adult-Onset
| Article | Year |
|---|---|
Modern Management of Mild Autonomous Cortisol Secretion.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr | 2019 |
Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Cushing | 2015 |
Onychomycosis in diabetic patients in Fako Division of Cameroon: prevalence, causative agents, associated factors and antifungal sensitivity patterns.
Topics: Adult; Aged; Aged, 80 and over; Amphotericin B; Antifungal Agents; Cameroon; Cross-Sectional Studies | 2016 |
Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Candida; Candidiasis, Oral; Case-Control Studies; Child; | 2011 |
Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing's disease resistant to surgery.
Topics: 14-alpha Demethylase Inhibitors; Aged; Diabetes Mellitus, Type 2; Female; Humans; Ketoconazole; Pitu | 2011 |
[Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma].
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Antineoplastic Combined Chemotherapy | 2011 |
Pulmonary infection due to Exophiala jeanselmei: successful treatment with ketoconazole.
Topics: Aged; Diabetes Mellitus, Type 2; Exophiala; Humans; Ketoconazole; Lung Diseases, Fungal; Male; Pneum | 1993 |
Trichoderma harzianum peritonitis in peritoneal dialysis.
Topics: Aged; Aged, 80 and over; Antifungal Agents; Bacterial Infections; Diabetes Mellitus, Type 2; Diabeti | 1996 |
Hypercalcaemia in sarcoidosis.
Topics: Adult; Diabetes Mellitus, Type 2; Diagnosis, Differential; Female; Humans; Hypercalcemia; Hyperparat | 1999 |