ketoconazole has been researched along with Depressive Disorder in 12 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Depressive Disorder: An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The authors examined the efficacy of ketoconazole in 16 adults with treatment-refractory major depressive disorder." | 5.09 | Limited efficacy of ketoconazole in treatment-refractory major depression. ( Anand, A; Carpenter, L; Heninger, GR; Kirwin, P; Malison, RT; McDougle, CJ; Pelton, GH; Price, LH, 1999) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (8.33) | 18.7374 |
| 1990's | 10 (83.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Caixeta, M | 1 |
| Caixeta, L | 1 |
| Anand, A | 2 |
| Malison, R | 1 |
| McDougle, CJ | 3 |
| Price, LH | 3 |
| Thakore, JH | 1 |
| Dinan, TG | 1 |
| Ghadirian, AM | 3 |
| Engelsmann, F | 1 |
| Dhar, V | 3 |
| Filipini, D | 1 |
| Keller, R | 2 |
| Chouinard, G | 2 |
| Murphy, BE | 3 |
| Wolkowitz, OM | 1 |
| Reus, VI | 1 |
| Manfredi, F | 1 |
| Ingbar, J | 1 |
| Brizendine, L | 1 |
| Weingartner, H | 1 |
| Sovner, R | 1 |
| Fogelman, S | 1 |
| Cappiello, A | 1 |
| Malison, RT | 2 |
| Pelton, GH | 2 |
| Schöllnhammer, G | 1 |
| Heninger, GR | 2 |
| Kirwin, P | 1 |
| Carpenter, L | 1 |
| Rothschild, AJ | 1 |
| Schatzberg, AF | 1 |
| Ravaris, CL | 1 |
| Sateia, MJ | 1 |
| Beroza, KW | 1 |
| Noordsy, DL | 1 |
| Brinck-Johnsen, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Effects of the Addition of Metyrapone to Antidepressant Therapy in Depression With Dexamethasone Suppression Test Non-suppression.[NCT03491696] | Phase 4 | 14 participants (Anticipated) | Interventional | 2018-12-22 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
5 trials available for ketoconazole and Depressive Disorder
| Article | Year |
|---|---|
Antiglucocorticoid treatment of refractory depression with ketoconazole: a case report.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Hydrocort | 1995 |
Effects of antiglucocorticoid treatment on 5-HT1A function in depressed patients and healthy subjects.
Topics: Adrenocorticotropic Hormone; Adult; Body Temperature; Depressive Disorder; Double-Blind Method; Feed | 1997 |
Neuroendocrine responses to inhibitors of steroid biosynthesis in patients with major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Analysis of Variance; Androgen Antagonists; Antidepressive Agents; Dehydro | 1998 |
Limited efficacy of ketoconazole in treatment-refractory major depression.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Double-Blind Method; Drug Resistance; Female; Hum | 1999 |
Response to steroid suppression in major depression resistant to antidepressant therapy.
Topics: Adult; Aminoglutethimide; Antidepressive Agents; Dehydroepiandrosterone; Depressive Disorder; Dexame | 1991 |
7 other studies available for ketoconazole and Depressive Disorder
| Article | Year |
|---|---|
[Ketoconazole in the prevention of acute delirium episodes].
Topics: Acute Disease; Adult; Antipsychotic Agents; Delirium; Depressive Disorder; Female; Humans; Ketoconaz | 2004 |
Cortisol synthesis inhibition: a new treatment strategy for the clinical and endocrine manifestations of depression.
Topics: Adult; Depressive Disorder; Dose-Response Relationship, Drug; Female; Fenfluramine; Humans; Hydrocor | 1995 |
The psychotropic effects of inhibitors of steroid biosynthesis in depressed patients refractory to treatment.
Topics: Adrenal Cortex Hormones; Adult; Aminoglutethimide; Bipolar Disorder; Depressive Disorder; Dose-Respo | 1995 |
Ketoconazole administration in hypercortisolemic depression.
Topics: Adult; Aged; Depression, Chemical; Depressive Disorder; Female; Humans; Hydrocortisone; Ketoconazole | 1993 |
Ketoconazole therapy for atypical depression.
Topics: Adult; Antidepressive Agents; Depressive Disorder; Dose-Response Relationship, Drug; Female; Humans; | 1996 |
Theoretical basis for response to steroid suppression in major depression.
Topics: Aminoglutethimide; Depressive Disorder; Dopamine; Humans; Hydrocortisone; Ketoconazole; Metyrapone | 1992 |
Effect of ketoconazole on a hypophysectomized, hypercortisolemic, psychotically depressed woman.
Topics: Adult; Depressive Disorder; Dexamethasone; Female; Haloperidol; Humans; Hydrocortisone; Hypophysecto | 1988 |