ketoconazole has been researched along with Depressive Disorder, Major in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)
Excerpt | Relevance | Reference |
---|---|---|
" Part 1 was an open-label pharmacokinetic assessment of a single 5-mg vilazodone dose with or without ketoconazole." | 2.79 | Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects. ( Boinpally, R; Gad, N; Gupta, S; Periclou, A, 2014) |
"Ketoconazole was generally well tolerated with no occurrence of significant side effects or laboratory abnormalities." | 2.69 | Antiglucocorticoid treatment of depression: double-blind ketoconazole. ( Canick, J; Chan, T; Johnson, R; Manfredi, F; Raum, W; Reus, VI; Wolkowitz, OM, 1999) |
"Major depressive disorder affects a substantial percentage of the U." | 2.45 | Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? ( Coleman, VH; Kling, MA; Schulkin, J, 2009) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 0 (0.00) | 18.7374 |
1990's | 2 (40.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 2 (40.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Boinpally, R | 1 |
Gad, N | 1 |
Gupta, S | 1 |
Periclou, A | 1 |
Kling, MA | 1 |
Coleman, VH | 1 |
Schulkin, J | 1 |
Paslakis, G | 1 |
Lecei, O | 1 |
Stalla, GK | 1 |
Landgraf, R | 1 |
Uhr, M | 1 |
Hamann, B | 1 |
Luppa, P | 1 |
Gilles, M | 1 |
Heuser, I | 1 |
Deuschle, M | 1 |
Wolkowitz, OM | 1 |
Reus, VI | 1 |
Chan, T | 1 |
Manfredi, F | 1 |
Raum, W | 1 |
Johnson, R | 1 |
Canick, J | 1 |
Bech, P | 1 |
Raabaek Olsen, L | 1 |
Jarløv, N | 1 |
Hammer, M | 1 |
Schütze, T | 1 |
Breum, L | 1 |
1 review available for ketoconazole and Depressive Disorder, Major
Article | Year |
---|---|
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depres | 2009 |
3 trials available for ketoconazole and Depressive Disorder, Major
Article | Year |
---|---|
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.
Topics: Adolescent; Adult; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; Cytochrome P- | 2014 |
The effect of treatment with ketoconazole on central CRH systems of depressed patients.
Topics: 14-alpha Demethylase Inhibitors; Aged; Aged, 80 and over; Arginine Vasopressin; Corticotropin-Releas | 2011 |
Antiglucocorticoid treatment of depression: double-blind ketoconazole.
Topics: Adult; Depressive Disorder, Major; Double-Blind Method; Female; Glucocorticoids; Humans; Hydrocortis | 1999 |
1 other study available for ketoconazole and Depressive Disorder, Major
Article | Year |
---|---|
A case of sequential anti-stress medication in a patient with major depression resistant to amine-reuptake inhibitors.
Topics: Amines; Antidepressive Agents; Anxiety Disorders; Dehydroepiandrosterone; Depressive Disorder, Major | 1999 |