Page last updated: 2024-10-29

ketoconazole and Depressive Disorder, Major

ketoconazole has been researched along with Depressive Disorder, Major in 5 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Depressive Disorder, Major: Disorder in which five (or more) of the following symptoms have been present during the same 2-week period and represent a change from previous functioning; at least one of the symptoms is either (1) depressed mood or (2) loss of interest or pleasure. Symptoms include: depressed mood most of the day, nearly every daily; markedly diminished interest or pleasure in activities most of the day, nearly every day; significant weight loss when not dieting or weight gain; Insomnia or hypersomnia nearly every day; psychomotor agitation or retardation nearly every day; fatigue or loss of energy nearly every day; feelings of worthlessness or excessive or inappropriate guilt; diminished ability to think or concentrate, or indecisiveness, nearly every day; or recurrent thoughts of death, recurrent suicidal ideation without a specific plan, or a suicide attempt. (DSM-5)

Research Excerpts

ExcerptRelevanceReference
" Part 1 was an open-label pharmacokinetic assessment of a single 5-mg vilazodone dose with or without ketoconazole."2.79Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects. ( Boinpally, R; Gad, N; Gupta, S; Periclou, A, 2014)
"Ketoconazole was generally well tolerated with no occurrence of significant side effects or laboratory abnormalities."2.69Antiglucocorticoid treatment of depression: double-blind ketoconazole. ( Canick, J; Chan, T; Johnson, R; Manfredi, F; Raum, W; Reus, VI; Wolkowitz, OM, 1999)
"Major depressive disorder affects a substantial percentage of the U."2.45Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? ( Coleman, VH; Kling, MA; Schulkin, J, 2009)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's2 (40.00)18.2507
2000's1 (20.00)29.6817
2010's2 (40.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Boinpally, R1
Gad, N1
Gupta, S1
Periclou, A1
Kling, MA1
Coleman, VH1
Schulkin, J1
Paslakis, G1
Lecei, O1
Stalla, GK1
Landgraf, R1
Uhr, M1
Hamann, B1
Luppa, P1
Gilles, M1
Heuser, I1
Deuschle, M1
Wolkowitz, OM1
Reus, VI1
Chan, T1
Manfredi, F1
Raum, W1
Johnson, R1
Canick, J1
Bech, P1
Raabaek Olsen, L1
Jarløv, N1
Hammer, M1
Schütze, T1
Breum, L1

Reviews

1 review available for ketoconazole and Depressive Disorder, Major

ArticleYear
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus?
    Depression and anxiety, 2009, Volume: 26, Issue:7

    Topics: Adrenal Glands; Aminoglutethimide; Anti-Inflammatory Agents; Corticotropin-Releasing Hormone; Depres

2009

Trials

3 trials available for ketoconazole and Depressive Disorder, Major

ArticleYear
Influence of CYP3A4 induction/inhibition on the pharmacokinetics of vilazodone in healthy subjects.
    Clinical therapeutics, 2014, Nov-01, Volume: 36, Issue:11

    Topics: Adolescent; Adult; Carbamazepine; Cross-Over Studies; Cytochrome P-450 CYP3A Inducers; Cytochrome P-

2014
The effect of treatment with ketoconazole on central CRH systems of depressed patients.
    Human psychopharmacology, 2011, Volume: 26, Issue:1

    Topics: 14-alpha Demethylase Inhibitors; Aged; Aged, 80 and over; Arginine Vasopressin; Corticotropin-Releas

2011
Antiglucocorticoid treatment of depression: double-blind ketoconazole.
    Biological psychiatry, 1999, Apr-15, Volume: 45, Issue:8

    Topics: Adult; Depressive Disorder, Major; Double-Blind Method; Female; Glucocorticoids; Humans; Hydrocortis

1999

Other Studies

1 other study available for ketoconazole and Depressive Disorder, Major

ArticleYear
A case of sequential anti-stress medication in a patient with major depression resistant to amine-reuptake inhibitors.
    Acta psychiatrica Scandinavica, 1999, Volume: 100, Issue:1

    Topics: Amines; Antidepressive Agents; Anxiety Disorders; Dehydroepiandrosterone; Depressive Disorder, Major

1999