ketoconazole has been researched along with Cystic Fibrosis in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 5.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| " Three patients had underlying cystic fibrosis, and three had severe asthma; four of the six required continuous high-dose systemic prednisone (mean, 43 mg/day; confidence interval [CI], 23 to 63 mg/day) at the start of therapy." | 3.68 | Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. ( Denning, DW; Lewiston, NJ; Stevens, DA; Van Wye, JE, 1991) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 1.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kersting, U | 1 |
| Kersting, D | 1 |
| Spring, KR | 1 |
| Mannes, GP | 1 |
| van der Heide, S | 1 |
| van Aalderen, WM | 1 |
| Gerritsen, J | 1 |
| Hiller, EJ | 1 |
| Denning, DW | 1 |
| Van Wye, JE | 1 |
| Lewiston, NJ | 1 |
| Stevens, DA | 1 |
| Edwards, JH | 1 |
| Alfaham, M | 1 |
| Fifield, R | 1 |
| Philpot, C | 1 |
| Clement, MJ | 1 |
| Goodchild, MC | 1 |
5 other studies available for ketoconazole and Cystic Fibrosis
| Article | Year |
|---|---|
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi | 1993 |
Itraconazole and allergic bronchopulmonary aspergillosis in twin brothers with cystic fibrosis.
Topics: Adolescent; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Cystic Fibrosis; Diseases i | 1993 |
Aspergillosis.
Topics: Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Child; Cystic Fibrosis; Humans; Itracon | 1992 |
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole.
Topics: Adolescent; Adult; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Asthma; Cystic Fibro | 1991 |
Sequential serological responses to Aspergillus fumigatus in patients with cystic fibrosis. Use of antigen 'stretching' to delineate IgG and IgE activity.
Topics: Adolescent; Adult; Antibodies, Fungal; Antigens, Fungal; Aspergillosis; Aspergillus fumigatus; Child | 1990 |