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ketoconazole and Cystic Fibrosis

ketoconazole has been researched along with Cystic Fibrosis in 5 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Cystic Fibrosis: An autosomal recessive genetic disease of the EXOCRINE GLANDS. It is caused by mutations in the gene encoding the CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR expressed in several organs including the LUNG, the PANCREAS, the BILIARY SYSTEM, and the SWEAT GLANDS. Cystic fibrosis is characterized by epithelial secretory dysfunction associated with ductal obstruction resulting in AIRWAY OBSTRUCTION; chronic RESPIRATORY INFECTIONS; PANCREATIC INSUFFICIENCY; maldigestion; salt depletion; and HEAT PROSTRATION.

Research Excerpts

ExcerptRelevanceReference
"Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells."5.29Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993)
" Three patients had underlying cystic fibrosis, and three had severe asthma; four of the six required continuous high-dose systemic prednisone (mean, 43 mg/day; confidence interval [CI], 23 to 63 mg/day) at the start of therapy."3.68Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. ( Denning, DW; Lewiston, NJ; Stevens, DA; Van Wye, JE, 1991)
"Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells."1.29Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Kersting, U1
Kersting, D1
Spring, KR1
Mannes, GP1
van der Heide, S1
van Aalderen, WM1
Gerritsen, J1
Hiller, EJ1
Denning, DW1
Van Wye, JE1
Lewiston, NJ1
Stevens, DA1
Edwards, JH1
Alfaham, M1
Fifield, R1
Philpot, C1
Clement, MJ1
Goodchild, MC1

Other Studies

5 other studies available for ketoconazole and Cystic Fibrosis

ArticleYear
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
    Proceedings of the National Academy of Sciences of the United States of America, 1993, May-01, Volume: 90, Issue:9

    Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi

1993
Itraconazole and allergic bronchopulmonary aspergillosis in twin brothers with cystic fibrosis.
    Lancet (London, England), 1993, Feb-20, Volume: 341, Issue:8843

    Topics: Adolescent; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Cystic Fibrosis; Diseases i

1993
Aspergillosis.
    Journal of the Royal Society of Medicine, 1992, Volume: 85 Suppl 19

    Topics: Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Child; Cystic Fibrosis; Humans; Itracon

1992
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole.
    Chest, 1991, Volume: 100, Issue:3

    Topics: Adolescent; Adult; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Asthma; Cystic Fibro

1991
Sequential serological responses to Aspergillus fumigatus in patients with cystic fibrosis. Use of antigen 'stretching' to delineate IgG and IgE activity.
    Clinical and experimental immunology, 1990, Volume: 81, Issue:1

    Topics: Adolescent; Adult; Antibodies, Fungal; Antigens, Fungal; Aspergillosis; Aspergillus fumigatus; Child

1990