ketoconazole has been researched along with Cystic Fibrosis of Pancreas in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 5.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| " Three patients had underlying cystic fibrosis, and three had severe asthma; four of the six required continuous high-dose systemic prednisone (mean, 43 mg/day; confidence interval [CI], 23 to 63 mg/day) at the start of therapy." | 3.68 | Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole. ( Denning, DW; Lewiston, NJ; Stevens, DA; Van Wye, JE, 1991) |
| "Ketoconazole treatment effectively reversed the cystic fibrosis defect in these cultured cells." | 1.29 | Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells. ( Kersting, D; Kersting, U; Spring, KR, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kersting, U | 1 |
| Kersting, D | 1 |
| Spring, KR | 1 |
| Mannes, GP | 1 |
| van der Heide, S | 1 |
| van Aalderen, WM | 1 |
| Gerritsen, J | 1 |
| Hiller, EJ | 1 |
| Denning, DW | 1 |
| Van Wye, JE | 1 |
| Lewiston, NJ | 1 |
| Stevens, DA | 1 |
| Edwards, JH | 1 |
| Alfaham, M | 1 |
| Fifield, R | 1 |
| Philpot, C | 1 |
| Clement, MJ | 1 |
| Goodchild, MC | 1 |
5 other studies available for ketoconazole and Cystic Fibrosis of Pancreas
| Article | Year |
|---|---|
Ketoconazole activates Cl- conductance and blocks Cl- and fluid absorption by cultured cystic fibrosis (CFPAC-1) cells.
Topics: Absorption; Cell Line; Cell Membrane; Chloride Channels; Chlorides; Colforsin; Cyclic AMP; Cystic Fi | 1993 |
Itraconazole and allergic bronchopulmonary aspergillosis in twin brothers with cystic fibrosis.
Topics: Adolescent; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Cystic Fibrosis; Diseases i | 1993 |
Aspergillosis.
Topics: Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Child; Cystic Fibrosis; Humans; Itracon | 1992 |
Adjunctive therapy of allergic bronchopulmonary aspergillosis with itraconazole.
Topics: Adolescent; Adult; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Asthma; Cystic Fibro | 1991 |
Sequential serological responses to Aspergillus fumigatus in patients with cystic fibrosis. Use of antigen 'stretching' to delineate IgG and IgE activity.
Topics: Adolescent; Adult; Antibodies, Fungal; Antigens, Fungal; Aspergillosis; Aspergillus fumigatus; Child | 1990 |