ketoconazole and Cushing Syndrome studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Cushing Syndrome: A condition caused by prolonged exposure to excess levels of cortisol (HYDROCORTISONE) or other GLUCOCORTICOIDS from endogenous or exogenous sources. It is characterized by upper body OBESITY; OSTEOPOROSIS; HYPERTENSION; DIABETES MELLITUS; HIRSUTISM; AMENORRHEA; and excess body fluid. Endogenous Cushing syndrome or spontaneous hypercortisolism is divided into two groups, those due to an excess of ADRENOCORTICOTROPIN and those that are ACTH-independent.

Research Excerpts

Excerpt	Relevance	Reference
"Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome."	9.30	Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. ( Auchus, RJ; Biller, BMK; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Greenman, Y; Pivonello, R; Salvatori, R; Witek, P, 2019)
"The effectiveness of ketoconazole for the therapy of Cushing's syndrome, both of adrenal and pituitary origin, was retrospectively evaluated."	9.06	[Evaluation of the treatment of Cushing's syndrome using ketoconazole]. ( Conget, JI; Esmatjes, E; Ferrer, J; Halperin, I; Martínez-Osaba, MJ; Vendrell, J; Vilardell, E, 1989)
"The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)."	9.06	Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989)
"The effects of Ketoconazole (600 mg/day) were evaluated in 10 patients with Cushing's syndrome during a mean period of 4."	8.77	[Short term effects of ketoconazole in Cushing's syndrome]. ( Bertagna, X; Billaud, L; Cerdas, S; Guilhaume, B; Laudat, MH; Luton, JP, 1989)
"The efficacy of levoketoconazole in treating hypercortisolism was demonstrated in an open-label phase 3 study (SONICS) of adults with endogenous Cushing's syndrome (CS) and baseline mean urinary free cortisol (mUFC) ≥ 1."	8.02	Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing's syndrome. ( Bex, M; Biller, BMK; Borresen, SW; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Pecori Giraldi, F; Pivonello, R; Puglisi, S; Salvatori, R; Witek, P, 2021)
"Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing's syndrome."	8.02	Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment. ( Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM, 2021)
"Cabergoline has been shown to have some effect in the treatment of moderate Cushing's disease, but its effectiveness in Cushing's syndrome of ectopic or occult origin remains to be investigated."	7.91	Cabergoline in severe ectopic or occult Cushing's syndrome. ( Borson-Chazot, F; Ilie, MD; Raverot, G; Raverot, V; Tronc, F; Vasiljevic, A, 2019)
"Metyrapone and ketoconazole, frequently used steroidogenesis inhibitors for treatment of Cushing syndrome, can be associated with side effects and limited efficacy."	7.91	Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study. ( Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM, 2019)
"Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS)."	7.88	Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France. ( Bertherat, J; Castinetti, F; Chabre, O; Chadarevian, R; Senoussi, S; Vantyghem, MC; Young, J, 2018)
" An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment."	7.78	Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012)
"Our objective was to assess the efficacy and safety of combination therapy with mitotane, metyrapone, and ketoconazole in severe ACTH-dependent Cushing's syndrome."	7.77	Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. ( Baudin, E; Blanchard, A; Brailly-Tabard, S; Chanson, P; Droumaguet, C; Gautier, JF; Jublanc, C; Kamenický, P; Leboulleux, S; Salenave, S; Schlumberger, M; Young, J, 2011)
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."	7.77	Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"A patient is reported who developed fatal liver failure on ketoconazole treatment for Cushing's syndrome."	7.71	Fatal liver failure due to ketoconazole treatment of a girl with Cushing's syndrome. ( Bonnici, F; Delport, S; Zöllner, E, 2001)
"To determine the usefulness of ketoconazole for the control of arterial hypertension (AH) in Cushing syndrome (CS) as temporary treatment."	7.70	[Ketoconazole in the control of arterial hypertension in Cushing's syndrome]. ( Alvarez Barreiro, JA; Calvo Romero, JM; Díaz Pérez de Madrid, J; Morales Pérez, F, 1999)
"To evaluate the safety and efficacy of ketoconazole treatment in the management of patients with paraneoplastic Cushing's syndrome (CS) secondary to ectopic adrenocorticotropin (ACTH) production by malignant neoplasms (ECS)."	7.69	Ketoconazole in the management of paraneoplastic Cushing's syndrome secondary to ectopic adrenocorticotropin production. ( Crump, M; Khamsi, F; Laskey, J; Shepherd, FA; Winquist, EW, 1995)
" We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy."	7.68	Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990)
"Ketoconazole treatment of Cushing's syndrome has been reported in single cases and a few small groups of 5-8 patients."	7.68	Ketoconazole treatment in Cushing's syndrome: experience in 34 patients. ( Boscaro, M; Mantero, F; Paoletta, A; Sonino, N; Ziliotto, D, 1991)
"Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension."	7.67	Arterial hypertension as a complication of prolonged ketoconazole treatment. ( Astorga, R; García-Luna, PP; Gomez-Pan, A; Leal-Cerro, A; Miranda, ML; Pereira, JL; Villar, J, 1989)
"The therapeutic value of ketoconazole for long term treatment of patients with Cushing's syndrome was studied."	7.67	Use of ketoconazole in the treatment of Cushing's syndrome. ( Berselli, ME; Loli, P; Tagliaferri, M, 1986)
"Alendronate is an aminobisphosphonate that is able to increase bone mass mainly by inhibiting bone resorption."	6.69	Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease. ( Colao, A; Di Somma, C; Faggiano, A; Klain, M; Lombardi, G; Merola, B; Pivonello, R; Salvatore, M; Tripodi, FS, 1998)
"Cushing's syndrome is a rare disorder."	6.40	Corticotropin-dependent Cushing's syndrome in older people: presentation of five cases and therapeutical use of ketoconazole. ( Abs, RE; Berwaerts, JJ; Verhaegen, AA; Verhaert, GC; Verhelst, JA, 1998)
"The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again."	5.46	A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017)
"Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome."	5.30	Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. ( Auchus, RJ; Biller, BMK; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Greenman, Y; Pivonello, R; Salvatori, R; Witek, P, 2019)
"Ketoconazole is an orally active imidazole derivative that is an effective therapeutic drug in the treatment of mycotic infection."	5.29	The effect of ketoconazole in pre-operative treatment in Cushing's syndrome: three cases report. ( Li, KL; Tung, SC; Wang, PW, 1996)
"Mild Cushing's syndrome was diagnosed in a 35 year old woman."	5.27	Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986)
"The aim of this study was to evaluate HPA intervention with low-dose ethanol, morphine, or ketoconazole on the neuroendocrine-immune axis and development of postoperative pneumonia in long-term alcoholic patients."	5.12	Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics. ( Achterberg, E; Althoff, H; Bohm, B; Eggers, V; Hegenscheid, K; Kaisers, U; Klein, M; Lau, A; Marks, C; Miller, P; Paschen, C; Pfeiffer, S; Sander, M; Schoenfeld, H; Schroeder, T; Spies, C; Szabo, G; Volk, HD; von Dossow, V; Wernecke, KD; Ziemer, S, 2006)
"The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)."	5.06	Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989)
"The effectiveness of ketoconazole for the therapy of Cushing's syndrome, both of adrenal and pituitary origin, was retrospectively evaluated."	5.06	[Evaluation of the treatment of Cushing's syndrome using ketoconazole]. ( Conget, JI; Esmatjes, E; Ferrer, J; Halperin, I; Martínez-Osaba, MJ; Vendrell, J; Vilardell, E, 1989)
"Inhibitors of steroid synthesis such as o,p'-DDD, aminoglutethimide, metyrapone, trilostane and ketoconazole are usually used for treatment of Cushing's syndrome in order to reduce the steroid production in the patients showing several complications, including severe hypertension and diabetes mellitus, and also an incomplete remission after the surgical treatment."	4.79	[Clinical usefulness of pharmacological treatment of Cushing's syndrome]. ( Nishikawa, T; Saito, J, 1994)
"Ketoconazole has been successfully used in short-term treatment of Cushing's syndrome."	4.78	[Value of ketoconazole in the treatment of Cushing disease]. ( Denet, S; Hartemann, P; Kaminski, P; Leclère, J; Pascal, V; Weryha, G, 1993)
"The effects of Ketoconazole (600 mg/day) were evaluated in 10 patients with Cushing's syndrome during a mean period of 4."	4.77	[Short term effects of ketoconazole in Cushing's syndrome]. ( Bertagna, X; Billaud, L; Cerdas, S; Guilhaume, B; Laudat, MH; Luton, JP, 1989)
"The efficacy of levoketoconazole in treating hypercortisolism was demonstrated in an open-label phase 3 study (SONICS) of adults with endogenous Cushing's syndrome (CS) and baseline mean urinary free cortisol (mUFC) ≥ 1."	4.02	Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing's syndrome. ( Bex, M; Biller, BMK; Borresen, SW; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Pecori Giraldi, F; Pivonello, R; Puglisi, S; Salvatori, R; Witek, P, 2021)
"Racemic ketoconazole (RK) is a steroidogenesis inhibitor used for treatment of Cushing's syndrome."	4.02	Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment. ( Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM, 2021)
"Metyrapone and ketoconazole, frequently used steroidogenesis inhibitors for treatment of Cushing syndrome, can be associated with side effects and limited efficacy."	3.91	Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study. ( Creemers, SG; de Jong, FH; de Rijke, YB; Feelders, RA; Franssen, GJH; Hofland, LJ; van Koetsveld, PM, 2019)
"Cabergoline has been shown to have some effect in the treatment of moderate Cushing's disease, but its effectiveness in Cushing's syndrome of ectopic or occult origin remains to be investigated."	3.91	Cabergoline in severe ectopic or occult Cushing's syndrome. ( Borson-Chazot, F; Ilie, MD; Raverot, G; Raverot, V; Tronc, F; Vasiljevic, A, 2019)
"Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS)."	3.88	Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France. ( Bertherat, J; Castinetti, F; Chabre, O; Chadarevian, R; Senoussi, S; Vantyghem, MC; Young, J, 2018)
"Steroidogenesis inhibitors, such as ketoconazole (KTZ) and metyrapone (MTP), are used to lower hypercortisolism in patients with Cushing's syndrome (CS)."	3.85	A polymorphism in the CYP17A1 gene influences the therapeutic response to steroidogenesis inhibitors in Cushing's syndrome. ( Aulinas, A; Glad, CA; Johannsson, G; Ragnarsson, O; Valassi, E; Webb, SM, 2017)
"To evaluate the outcome of preoperative therapy with ketoconazole (KTZ) and/or metyrapone (MTP) in previously untreated patients with Cushing's syndrome (CS)."	3.78	A reappraisal of the medical therapy with steroidogenesis inhibitors in Cushing's syndrome. ( Crespo, I; Gich, I; Rodríguez, J; Valassi, E; Webb, SM, 2012)
" An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment."	3.78	Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012)
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."	3.77	Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"Our objective was to assess the efficacy and safety of combination therapy with mitotane, metyrapone, and ketoconazole in severe ACTH-dependent Cushing's syndrome."	3.77	Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. ( Baudin, E; Blanchard, A; Brailly-Tabard, S; Chanson, P; Droumaguet, C; Gautier, JF; Jublanc, C; Kamenický, P; Leboulleux, S; Salenave, S; Schlumberger, M; Young, J, 2011)
"a) blood pressure levels normalized in most patients after remission of CS; b) ketoconazole was effective for the Control of HBP and seems to be a good indicator of post-surgical outcome, and c) higher age at presentation, longer duration of hypertension and higher systolic blood pressure figures before treatment negatively influence normalization of blood pressure after resolution of Cushing's syndrome."	3.74	Effect of hypercortisolism control on high blood pressure in Cushing's syndrome. ( Albiger, NM; Bruno, OD; Díaz, AG; Gómez, RM; Moncet, D; Pitoia, FA, 2007)
"To evaluate the efficacy of fluconazole as an alternative treatment for controlling hypercortisolism in Cushing's syndrome and to determine its effect on glucocorticoid production in vitro."	3.73	Long term control of hypercortisolism with fluconazole: case report and in vitro studies. ( Luger, A; Maier, C; Nowotny, P; Riedl, M; Schima, W; Zettinig, G, 2006)
"A patient is reported who developed fatal liver failure on ketoconazole treatment for Cushing's syndrome."	3.71	Fatal liver failure due to ketoconazole treatment of a girl with Cushing's syndrome. ( Bonnici, F; Delport, S; Zöllner, E, 2001)
"To determine the usefulness of ketoconazole for the control of arterial hypertension (AH) in Cushing syndrome (CS) as temporary treatment."	3.70	[Ketoconazole in the control of arterial hypertension in Cushing's syndrome]. ( Alvarez Barreiro, JA; Calvo Romero, JM; Díaz Pérez de Madrid, J; Morales Pérez, F, 1999)
"To evaluate the safety and efficacy of ketoconazole treatment in the management of patients with paraneoplastic Cushing's syndrome (CS) secondary to ectopic adrenocorticotropin (ACTH) production by malignant neoplasms (ECS)."	3.69	Ketoconazole in the management of paraneoplastic Cushing's syndrome secondary to ectopic adrenocorticotropin production. ( Crump, M; Khamsi, F; Laskey, J; Shepherd, FA; Winquist, EW, 1995)
"Ketoconazole treatment of Cushing's syndrome has been reported in single cases and a few small groups of 5-8 patients."	3.68	Ketoconazole treatment in Cushing's syndrome: experience in 34 patients. ( Boscaro, M; Mantero, F; Paoletta, A; Sonino, N; Ziliotto, D, 1991)
" We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy."	3.68	Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990)
"The direct effects of etomidate, ketoconazole, miconazole and metyrapone were investigated on the secretion of cortisol and its precursors by dispersed cells from the adrenal cortex of a normal individual and four patients with Cushing's syndrome."	3.67	Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells. ( Bons, EG; Bruining, HA; de Jong, FH; Lamberts, SW, 1987)
"The therapeutic value of ketoconazole for long term treatment of patients with Cushing's syndrome was studied."	3.67	Use of ketoconazole in the treatment of Cushing's syndrome. ( Berselli, ME; Loli, P; Tagliaferri, M, 1986)
"We investigated basal and ACTH stimulated levels of cortisol, corticosterone, 17 alpha-hydroxyprogesterone, 11-deoxycortisol and 11-deoxycorticosterone as well as plasma levels of ACTH before and during the oral administration of ketoconazole in five patients with Cushing's syndrome (3 with bilateral adrenal hyperplasia, 1 with adrenal adenoma and 1 with adrenal carcinoma) and in three controls."	3.67	Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11 beta-hydroxylase. ( Dörr, G; Engelhardt, D; Jaspers, C; Knorr, D, 1985)
"Ketoconazole has been used as a palliative treatment of Cushing's syndrome, due to its ability to lower cortisol production."	3.67	ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies. ( Boscaro, M; Mantero, F; Menegus, AM; Rampazzo, A; Sonino, N, 1987)
"Two of 14 patients with Cushing's syndrome treated on a long-term basis with ketoconazole developed sustained hypertension."	3.67	Arterial hypertension as a complication of prolonged ketoconazole treatment. ( Astorga, R; García-Luna, PP; Gomez-Pan, A; Leal-Cerro, A; Miranda, ML; Pereira, JL; Villar, J, 1989)
"Ketoconazole has been used as a second-line drug despite limited data on its safety and efficacy for this purpose."	3.01	Ketoconazole as second-line treatment for Cushing's disease after transsphenoidal surgery: systematic review and meta-analysis. ( Czepielewski, MA; Garcia, SP; Hirakata, VN; Mattos, ACV; Rodrigues, TDC; Viecceli, C, 2023)
"The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial."	2.75	Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). ( Correa-Silva, SR; Lengyel, AM; Molica, P; Nascif, SO; Sá, LB; Vieira, JG, 2010)
"Severe hypercortisolism is characterized as a life-threatening endocrine condition in patients with Cushing syndrome, usually related to the concomitant onset of one or more comorbidities, requiring rapid normalization of cortisol concentrations and aggressive treatment of associated complications."	2.72	Medical therapy in severe hypercortisolism. ( Boguszewski, CL; Marques, JVO, 2021)
"However, hypercortisolism may persist or recur postoperatively; in other cases, the underlying tumor may not be resectable or its location may not be known."	2.72	Adrenally Directed Medical Therapies for Cushing Syndrome. ( Tritos, NA, 2021)
"Osilodrostat has been shown to be highly effective at maintaining normal urinary free cortisol in patients with CD."	2.72	Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide. ( Fleseriu, M; Han, AJ; Varlamov, EV, 2021)
"Alendronate is an aminobisphosphonate that is able to increase bone mass mainly by inhibiting bone resorption."	2.69	Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease. ( Colao, A; Di Somma, C; Faggiano, A; Klain, M; Lombardi, G; Merola, B; Pivonello, R; Salvatore, M; Tripodi, FS, 1998)
"Medical therapy to control hypercortisolism in adrenal Cushing's syndrome is currently not the first-line therapy."	2.66	What is the role of medical therapy in adrenal-dependent Cushing's syndrome? ( Braun, LT; Reincke, M, 2020)
"Cushing's syndrome is associated with serious morbidity and increased mortality."	2.46	Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. ( de Herder, WW; Feelders, RA; Hofland, LJ, 2010)
"Active Cushing's syndrome is associated with insulin resistance induced by the high and prolonged circulating level of glucocorticoids."	2.46	Management of diabetes mellitus in Cushing's syndrome. ( Munir, A; Newell-Price, J, 2010)
"Cushing's syndrome is a complex endocrine condition with potential serious complications if untreated or inadequately treated."	2.45	Drugs in the medical treatment of Cushing's syndrome. ( Schteingart, DE, 2009)
"However, hypercortisolism is diagnosed by systematic evaluation in 2 to 5% of patients with poorly controlled type 2 diabetes and adrenal incidentalomas."	2.44	[Management of hypercortisolism]. ( Bertagna, X; Fierrard, H; Raffin-Sanson, ML; Rosales, C, 2008)
"Thus, we should treat Cushing's syndrome as soon as possible, since many complications, including cardiovascular diseases and infections, will soon occur when the definite diagnosis is delayed."	2.44	[Medical treatment for Cushing's syndrome]. ( Nishikawa, T; Omura, M; Saito, J, 2008)
"Cushing's syndrome is a rare disorder."	2.40	Corticotropin-dependent Cushing's syndrome in older people: presentation of five cases and therapeutical use of ketoconazole. ( Abs, RE; Berwaerts, JJ; Verhaegen, AA; Verhaert, GC; Verhelst, JA, 1998)
"Pregnancy is a rare occurrence in women with Cushing's syndrome."	2.38	Cushing's syndrome and pregnancy. ( Aron, DC; Schnall, AM; Sheeler, LR, 1990)
"Cushing syndrome is a rare endocrine disorder."	1.91	An exceptionally rare case of Cushing's syndrome caused by ectopic ACTH syndrome due to olfactory neuroblastoma in childhood. ( Gülten, G; Özhan, B; Yalçın, N; Yıldırım Çakar, D, 2023)
"The first-line treatment for Cushing's disease is transsphenoidal surgery, after which the rates of remission are 60 to 80%, with long-term recurrence of 20 to 30%, even in those with real initial remission."	1.72	Evaluation of ketoconazole as a treatment for Cushing's disease in a retrospective cohort. ( Costa, MCB; Czepielewski, MA; de Melo, RB; Mattos, ACV; Rodrigues, TDC; Viecceli, C, 2022)
"Cushing's syndrome is known to present with a characteristic set of clinical manifestations and complications, well described in literature."	1.51	Arterial thrombosis as primary presentation of endogenous Cushing's syndrome. ( Alexander, V; Carey, RA; Dasgupta, R; Koshy, M, 2019)
"Infantile Cushing's syndrome is potentially found as part of McCune-Albright syndrome (MAS) which is caused by postzygotic somatic mutations of the GNAS gene."	1.51	A Novel GNAS Mutation Causing Isolated Infantile Cushing's Syndrome. ( Dejkhamron, P; Ittiwut, C; Natesirinilkul, R; Shotelersuk, V; Sunkonkit, K; Suphapeetiporn, K; TangNgam, H, 2019)
"Surgery is the definitive treatment of Cushing's syndrome (CS) but medications may also be used as a first-line therapy."	1.48	Preoperative medical treatment in Cushing's syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN. ( Bolanowski, M; Brue, T; Chabre, O; Chanson, P; Droste, M; Fajardo, C; Feelders, RA; Franz, H; Kastelan, D; Komerdus, I; Krsek, M; Maiter, D; Netea-Maier, R; Pfeifer, M; Reincke, M; Santos, A; Strasburger, CJ; Tabarin, A; Tóth, M; Trainer, PJ; Tsagarakis, S; Valassi, E; Wass, JAH; Webb, SM; Yaneva, M, 2018)
"The ketoconazole was shift to metyrapone but afterwards ketoconazole was added again."	1.46	A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. ( Michalak, R; Zieleniewski, W, 2017)
"The hypercortisolism is a rare endocrine disease characterized by an autonomous steroid secretion or excessive adrenal stimulation by ACTH."	1.43	[Indications and future perspectives in the pharmacological treatment of hypercortisolism]. ( Stigliano, A; Toscano, V, 2016)
"Unfortunately the patient died of respiratory failure due to metastasis."	1.37	[Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma]. ( Montes-Mollón, MÁ; Paz Moreno-Arrones, J, 2011)
"Treatment with ketoconazole normalized urinary free cortisol (UFC) from 433."	1.32	Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk. ( Bruno, OD; Díaz, AG; Gómez, RM; Pignatta, AB, 2004)
"Since Cushing's disease due to large pituitary tumors is rare, we evaluated biochemical characteristics at entry and the results of first surgical approach and of adjuvant therapeutic strategies during a long-term follow-up period."	1.32	Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas. ( Almoto, B; Ambrosi, B; Cannavò, S; Corsello, S; Dall'Asta, C; De Menis, E; Lovicu, RM; Trimarchi, F, 2003)
"Medical treatment of hypercortisolism improves muscle strength and resolves the respiratory insufficiency."	1.31	Severe respiratory failure secondary to Cushing's myopathy. ( Alvarez, J; Blanco, C; Flores, J; Marazuela, M, 2001)
"Ketoconazole is an imidazole derivative used to treat systemic and superficial mycoses by inhibiting sterol synthesis in fungi."	1.31	Long-term effects of ketoconazole in the treatment of residual or recurrent Cushing's disease. ( Chou, SC; Lin, JD, 2000)
"Cushing's syndrome is infrequently associated with adenocarcinomas of the lung."	1.30	[Paraneoplastic hypercorticism associated with a bronchial adenocarcinoma]. ( Chaouat, A; Kessler, R; Schott, R; Tavernier, M; Weitzenblum, E, 1999)
"Ketoconazole treatment had success in to normalize the 24-hour UFC in all patients, except for the case of adrenal carcinoma."	1.30	[Cushing's syndrome: clinical study of fifteen cases]. ( Alvarez Barreiro, JA; Calvo Romero, JM; Diaz Pérez de Madrid, J; Morales Pérez, F, 1998)
"Ketoconazole is an orally active imidazole derivative that is an effective therapeutic drug in the treatment of mycotic infection."	1.29	The effect of ketoconazole in pre-operative treatment in Cushing's syndrome: three cases report. ( Li, KL; Tung, SC; Wang, PW, 1996)
" Adrenolytic treatment with ketoconazole (400 mg daily) caused symptoms of adrenal insufficiency, but a reduced dosage of 200 mg daily lowered the cortisol level to between 5 and 11 micrograms/dl and normalized the blood pressure and clinical signs of Cushing's syndrome disappeared."	1.29	[Bilateral massive macronodular adrenal gland hyperplasia. A rare cause of Cushing's syndrome]. ( Allolio, B; Diehl, KL; Reincke, M; Strohm, M; Theiss, M, 1994)
"Treatment with ketoconazole led to a remarkable response both clinically and biochemically."	1.29	Corticotropin-dependent Cushing's syndrome in a patient with chronic renal failure--a rare association. ( Bhansali, A; Chugh, KS; Dash, RJ; Gupta, KL; Jain, S; Sakhuja, V, 1993)
"Six to 10 months after hypercorticism was cured with ketoconazole and bilateral adrenalectomy, a thymic mass 2 to 5 cm in length was detected by computerized tomography or magnetic resonance imaging in all 3 patients."	1.29	[Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases]. ( Caillé, JM; Catargi, B; Drouillard, J; Greselle, JF; Laurent, F; Martigne, C; Roger, P; Tabarin, A, 1993)
"A patient with invasive basophilic pituitary adenoma is described, in whom the hypercortisolaemia and clinical features persisted despite two attempts to reduce the tumour mass by transfrontal pituitary surgery and external beam radiotherapy."	1.28	Persistent Cushing's disease in a patient with invasive pituitary adenoma. ( Dash, RJ; Kak, VK; Khandekar, S, 1990)
"Ketoconazole was administered po in order to block adrenal steroidogenesis, the drug caused a remarkable fall of cortisol serum concentrations, but was unable to modify significantly the immunological pattern of the patient."	1.28	Hormonal and immunological pattern in a patient with acquired immunodeficiency syndrome related complex and Cushing's syndrome. ( De Mercato, R; Ghiggi, MR; Giuliani, M; Lombardi, G; Panza, N; Rezza, G; Rossi, R; Suligoi, B; Tommaselli, AP, 1992)
"Ketoconazole is an antimycotic agent and a potent inhibitor of gonadal and adrenal steroidogenesis."	1.27	Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment. ( Boscaro, M; Mantero, F; Rampazzo, A; Sonino, N, 1987)
"Ketoconazole treatment markedly improved the clinical setting and caused a highly significant (p less than 0."	1.27	Ketoconazole treatment in Cushing's disease. Effect on the circadian profile of plasma ACTH and cortisol. ( Angeli, A; Paccotti, P; Panarelli, M; Piovesan, A; Terzolo, M; Torta, M, 1988)
"Mild Cushing's syndrome was diagnosed in a 35 year old woman."	1.27	Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986)

Research

Studies (166)

Authors

Clinical Trials (3)

Trial Overview

Trial Outcomes

Normalization in Urinary Free Cortisol in Patients With Endogenous Cushing's Syndrome.

Timeframe	Studies, this research(%)	All Research%
pre-1990	31 (18.67)	18.7374
1990's	53 (31.93)	18.2507
2000's	27 (16.27)	29.6817
2010's	38 (22.89)	24.3611
2020's	17 (10.24)	2.80

Authors	Studies
Vega-Beyhart, A	1
Laguna-Moreno, J	1
Díaz-Catalán, D	1
Boswell, L	1
Mora, M	1
Halperin, I	2
Casals, G	1
Hanzu, FA	1
Pivonello, R	6
Simeoli, C	1
Di Paola, N	1
Colao, A	2
Viecceli, C	2
Mattos, ACV	2
Costa, MCB	1
de Melo, RB	1
Rodrigues, TDC	2
Czepielewski, MA	2
Özhan, B	1
Yıldırım Çakar, D	1
Gülten, G	1
Yalçın, N	1
Hirakata, VN	1
Garcia, SP	1
Fleseriu, M	5
Elenkova, A	3
Salvatori, R	3
Auchus, RJ	2
Feelders, RA	7
Geer, EB	3
Greenman, Y	3
Witek, P	3
Cohen, F	3
Biller, BMK	3
Braun, LT	1
Reincke, M	5
Newell-Price, J	3
Nieman, LK	3
Tabarin, A	7
Tritos, NA	2
Bex, M	1
Borresen, SW	1
Puglisi, S	1
Pecori Giraldi, F	1
Creemers, SG	2
de Jong, FH	3
Franssen, GJH	2
de Rijke, YB	2
van Koetsveld, PM	2
Hofland, LJ	3
Marques, JVO	1
Boguszewski, CL	1
Tatsi, C	1
Maria, AG	1
Malloy, C	1
Lin, L	1
London, E	1
Settas, N	1
Flippo, C	1
Keil, M	1
Hannah-Shmouni, F	1
Hoffman, DA	1
Stratakis, CA	1
Castinetti, F	2
Varlamov, EV	1
Han, AJ	1
Perotti, P	1
Saiegh, L	1
Arnaldi, G	1
Karniadakis, I	1
Garoufalia, Z	1
Kouskos, E	1
Mantas, D	1
Zacharieva, S	1
Valassi, E	3
Aulinas, A	1
Glad, CA	1
Johannsson, G	1
Ragnarsson, O	1
Webb, SM	3
Seow, CJ	1
Young, WF	1
Biagetti, B	1
Simó-Servat, O	1
Ortiz-Z, A	1
Iglesias, C	1
Mesa, J	1
Franz, H	1
Brue, T	1
Netea-Maier, R	1
Tsagarakis, S	1
Yaneva, M	1
Droste, M	1
Komerdus, I	1
Maiter, D	1
Kastelan, D	1
Chanson, P	3
Pfeifer, M	1
Strasburger, CJ	1
Tóth, M	1
Chabre, O	2
Krsek, M	1
Fajardo, C	1
Bolanowski, M	1
Santos, A	1
Trainer, PJ	2
Wass, JAH	1
Young, J	3
Bertherat, J	1
Vantyghem, MC	1
Senoussi, S	1
Chadarevian, R	1
Ollivier, M	1
Haissaguerre, M	1
Ferriere, A	1
Alexander, V	1
Koshy, M	1
Dasgupta, R	1
Carey, RA	1
Ilie, MD	1
Raverot, V	1
Tronc, F	1
Vasiljevic, A	1
Borson-Chazot, F	1
Raverot, G	1
Dejkhamron, P	1
Ittiwut, C	1
TangNgam, H	1
Sunkonkit, K	1
Natesirinilkul, R	1
Suphapeetiporn, K	1
Shotelersuk, V	1
Davi', MV	1
Salgarello, M	1
Francia, G	1
Corcuff, JB	2
Masquefa-Giraud, P	1
Baudin, E	2
Daniel, E	1
Newell-Price, JD	1
Paun, DL	1
Vija, L	1
Stan, E	1
Banica, A	1
Bobeica, E	1
Terzea, D	1
Poiana, C	1
Badiu, C	1
Paun, S	1
Alexandraki, KI	1
Grossman, AB	2
Stigliano, A	2
Toscano, V	2
Sedhom, R	1
Hu, S	1
Ohri, A	1
Infantino, D	1
Lubitz, S	1
Cerquetti, L	1
Zieleniewski, W	1
Michalak, R	1
Izzedine, H	1
Besse, B	1
Lazareth, A	1
Bourry, EF	1
Soria, JC	1
Dabbagh, A	1
Sa'adat, N	1
Heidari, Z	1
Correa-Silva, SR	2
Nascif, SO	2
Molica, P	2
Sá, LB	1
Vieira, JG	1
Lengyel, AM	2
Vong, CH	1
Forest, M	1
Nicolino, M	1
Schteingart, DE	1
Munir, A	1
de Herder, WW	1
Boronat, M	1
Marrero, D	1
López-Plasencia, Y	1
Barber, M	1
Schamann, Y	1
Nóvoa, FJ	1
La Rosa, S	1
Marando, A	1
Ghezzi, F	1
Colombo, P	1
Finzi, G	1
Capella, C	1
Matarazzo, P	1
Tuli, G	1
Tessaris, D	1
Verna, F	1
Rabbone, I	1
Lezo, A	1
Brunati, A	1
Salizzoni, M	1
Carbonaro, G	1
Terzolo, M	2
Reimondo, G	1
Papotti, M	1
Lala, R	1
Kamenický, P	1
Droumaguet, C	1
Salenave, S	1
Blanchard, A	1
Jublanc, C	1
Gautier, JF	1
Brailly-Tabard, S	1
Leboulleux, S	1
Schlumberger, M	1
Paz Moreno-Arrones, J	1
Montes-Mollón, MÁ	1
da Mota, F	1
Murray, C	1
Ezzat, S	1
Brito, JP	1
Singh, E	1
Basu, A	1
Gabalec, F	1
Zavrelová, A	1
Havel, E	1
Cerman, J	1
Radocha, J	1
Svilias, I	1
Cáp, J	1
Biller, BM	1
Crespo, I	1
Gich, I	1
Rodríguez, J	1
Ahmed, A	1
Furqan, S	1
Islam, N	1
Dutta, D	1
Jain, R	1
Maisnam, I	1
Mishra, PK	1
Ghosh, S	1
Mukhopadhyay, S	1
Chowdhury, S	1
Barna, M	1
Wilson, K	1
Chiaruttini, R	1
Muchowski, K	1
Lim, WH	1
Torpy, DJ	1
Jeffries, WS	1
Stiefel, P	1
García-Morillo, JS	1
Jimenez, L	1
Pamies, E	1
Miranda, ML	2
Carneado, J	1
Villar, J	2
Leal-Cerro, A	3
Cannavò, S	1
Almoto, B	1
Dall'Asta, C	1
Corsello, S	1
Lovicu, RM	1
De Menis, E	1
Trimarchi, F	1
Ambrosi, B	1
Pignatta, AB	1
Díaz, AG	2
Gómez, RM	2
Bruno, OD	3
Greening, JE	1
Brain, CE	1
Perry, LA	1
Mushtaq, I	1
Sales Marques, J	1
Savage, MO	1
Ilias, I	1
Riedl, M	1
Maier, C	1
Zettinig, G	1
Nowotny, P	1
Schima, W	1
Luger, A	1
Spies, C	1
Eggers, V	1
Szabo, G	1
Lau, A	1
von Dossow, V	1
Schoenfeld, H	1
Althoff, H	1
Hegenscheid, K	1
Bohm, B	1
Schroeder, T	1
Pfeiffer, S	1
Ziemer, S	1
Paschen, C	1
Klein, M	1
Marks, C	1
Miller, P	1
Sander, M	1
Wernecke, KD	1
Achterberg, E	1
Kaisers, U	1
Volk, HD	1
Moncet, D	2
Morando, DJ	1
Pitoia, F	1
Katz, SB	1
Rossi, MA	1
Ramé, A	1
Oosterhuis, JK	1
van den Berg, G	1
Monteban-Kooistra, WE	1
Ligtenberg, JJ	1
Tulleken, JE	1
Meertens, JH	1
Zijlstra, JG	1
Albiger, NM	1
Pitoia, FA	1
Silva, MR	1
Nishikawa, T	2
Saito, J	2
Omura, M	1
Dang, CN	1
Trainer, P	1
Rosales, C	1
Fierrard, H	1
Bertagna, X	3
Raffin-Sanson, ML	1
Mosnier-Pudar, H	1
Thomopoulos, P	1
Fournier, C	1
Guiban, D	1
Luton, JP	2
Miller, JW	1
Crapo, L	1
Solomon, CG	1
Dluhy, RG	1
Winquist, EW	1
Laskey, J	2
Crump, M	1
Khamsi, F	2
Shepherd, FA	3
Peterson, ME	2
Kintzer, PP	1
Nichols, R	2
Myers, NC	1
Bruyette, DS	1
Engelhardt, D	5
Weber, MM	2
Catargi, B	1
Laurent, F	1
Greselle, JF	1
Martigne, C	1
Caillé, JM	1
Drouillard, J	1
Roger, P	3
Jain, S	1
Sakhuja, V	1
Bhansali, A	3
Gupta, KL	1
Dash, RJ	4
Chugh, KS	1
Fallo, F	2
Paoletta, A	2
Tona, F	1
Boscaro, M	6
Sonino, N	8
Strohm, M	1
Theiss, M	1
Diehl, KL	1
Allolio, B	1
Pascal, V	1
Denet, S	1
Weryha, G	1
Kaminski, P	1
Leclère, J	1
Hartemann, P	2
Donovan, JT	1
Otis, CN	1
Powell, JL	1
Cathcart, HK	1
Roca, B	1
Arenas, M	1
Li, KL	1
Tung, SC	1
Wang, PW	1
Singh, CP	1
Kumar, A	1
Agarwal, AK	1
Gupta, H	1
Gupta, A	1
Parthiban, A	1
Sundaram, DS	1
Reddy, DJ	1
Girinath, MR	1
Prabhakaran, R	1
Chidambaranathan, N	1
Calvo Romero, JM	2
Morales Pérez, F	2
Alvarez Barreiro, JA	2
Diaz Pérez de Madrid, J	2
Di Somma, C	1
Klain, M	1
Faggiano, A	1
Tripodi, FS	1
Merola, B	1
Salvatore, M	1
Lombardi, G	2
Herzog, AG	1
Sotrel, A	1
Ronthal, M	1
Berwaerts, JJ	1
Verhelst, JA	1
Verhaert, GC	1
Verhaegen, AA	1
Abs, RE	1
Höfle, G	1
Gasser, RW	1
Lhotta, K	1
Janetschek, G	1
Kreczy, A	1
Finkenstedt, G	1
Berwaerts, J	1
Verhelst, J	1
Mahler, C	1
Abs, R	1
Schott, R	1
Chaouat, A	1
Tavernier, M	1
Kessler, R	1
Weitzenblum, E	1
Carral San Laureano, F	1
Lechuga Campoy, JL	1
Merino López, J	1
Caro Contreras, J	1
Aguilar Diosdado, M	1
Chou, SC	1
Lin, JD	1
Rickman, T	1
Garmany, R	1
Doherty, T	1
Benson, D	1
Okusa, MD	1
Zöllner, E	1
Delport, S	1
Bonnici, F	1
Blanco, C	1
Marazuela, M	1
Flores, J	1
Alvarez, J	1
Luisetto, G	1
Zangari, M	1
Camozzi, V	1
Rossi, R	1
Tommaselli, AP	1
Panza, N	1
Ghiggi, MR	1
Rezza, G	1
Giuliani, M	1
Suligoi, B	1
De Mercato, R	1
Evans, WK	2
Goss, PE	1
Johansen, E	1
Kong, HL	1
Lee, KO	1
Cheah, JS	1
Pérez Gracia, A	1
Ramírez, L	1
Herrero, V	1
Espinosa, J	1
Manusharova, R	1
Mortimer, RH	1
Cannell, GR	1
Thew, CM	1
Galligan, JP	1
Steen, RE	1
Kapelrud, H	1
Haug, E	1
Frey, H	1
Kornely, E	1
Schlaghecke, R	1
Horster, FA	1
Mantero, F	4
Ziliotto, D	1
Sastre, J	1
López Guzmán, A	1
Díez, JJ	1
Salvador, J	1
Angeli, A	3
Masera, RG	1
Gatti, G	1
Khanderia, U	1
Guerin, V	1
Barbaud, A	1
Duquenne, M	1
Contet-Audonneau, N	1
Amiot, F	1

Trial	Phase	Enrollment	Study Type	Start Date	Status
An Open Label Study to Assess the Safety and Efficacy of COR-003 (Levoketoconazole) in the Treatment of Endogenous Cushing's Syndrome[NCT01838551]	Phase 3	94 participants (Actual)	Interventional	2014-08-31	Completed
Metabolic, Pressor and Neuropsychological Effects of Metyrapone Treatment in Patients With Hypercortisolism[NCT05255900]		20 participants (Anticipated)	Observational	2022-04-28	Recruiting
An Open-label Study of the Efficacy and Safety of CORLUX (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome[NCT00569582]	Phase 3	50 participants (Actual)	Interventional	2007-12-31	Completed
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

"The response to COR-003 is defined as mean UFC concentration ≤ULN following 6 months of maintenance phase therapy without a prior dose increase during that phase. The proportion of responders at the End of Maintenance Phase visit, following 6 months of treatment in the Maintenance Phase, for all dose groups combined was estimated using a generalized linear model with repeated measurements based on a binomial distribution with a logit link function and with region (US vs. non-US), concurrent CS medical conditions (diabetes [Yes/No], hypertension [Yes/No]), age (rounded median split based on the ITT population), sex, disease duration (years), prior CS medication (Yes/No), prior radiation therapy (Yes/No) as Baseline covariates and visit as an independent factor.~The least squares mean (LSMEAN) estimate of the UFC response after 6 months of treatment in the Maintenance Phase alongside its 95% Wald CI is presented." (NCT01838551)
Timeframe: 6 months of maintenance phase therapy without a prior dose increase during that phase

Decrease in Diastolic Blood Pressure.

Intervention	proportion of subjects meeting endpoint (Least Squares Mean)
Levoketoconazole All Doses	.30

Responder is defined as subject with a decrease greater than or equal to 5mm Hg in diastolic blood pressure from baseline to week 24 or last visit. (NCT00569582)
Timeframe: Baseline to Week 24

Improvement in Diabetes and/or Glucose Intolerance.

Intervention	participants (Number)
Mifepristone	8

Responder is defined as subject with a decrease greater than or equal to 25% in area under the curve for glucose on 2-hour oral glucose test from baseline to week 24 or last visit, for Cushing's patients with type-2 diabetes mellitus/impaired glucose tolerance. (NCT00569582)
Timeframe: Baseline to Week 24

Article	Year
Cushing's disease: adrenal steroidogenesis inhibitors. Pituitary, 2022, Volume: 25, Issue:5 Topics: Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hypokalemia; Ketoconazole; Male; Mety	2022
Ketoconazole as second-line treatment for Cushing's disease after transsphenoidal surgery: systematic review and meta-analysis. Frontiers in endocrinology, 2023, Volume: 14 Topics: Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Pituitary ACTH Hypersecretion; Prospective S	2023
What is the role of medical therapy in adrenal-dependent Cushing's syndrome? Best practice & research. Clinical endocrinology & metabolism, 2020, Volume: 34, Issue:3 Topics: Adrenal Gland Diseases; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane; Pituitary ACTH	2020
Adrenally Directed Medical Therapies for Cushing Syndrome. The Journal of clinical endocrinology and metabolism, 2021, 01-01, Volume: 106, Issue:1 Topics: Adrenal Glands; Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane;	2021
Medical therapy in severe hypercortisolism. Best practice & research. Clinical endocrinology & metabolism, 2021, Volume: 35, Issue:2 Topics: Cabergoline; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Mitotane	2021
Updates in adrenal steroidogenesis inhibitors for Cushing's syndrome - A practical guide. Best practice & research. Clinical endocrinology & metabolism, 2021, Volume: 35, Issue:1 Topics: Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzyme Inhibitors; Etomidate; Humans; Hydrocortisone; Im	2021
Levoketoconazole: a novel treatment for endogenous Cushing's syndrome. Expert review of endocrinology & metabolism, 2021, Volume: 16, Issue:4 Topics: Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Quality of Life	2021
Therapy of endocrine disease: steroidogenesis enzyme inhibitors in Cushing's syndrome. European journal of endocrinology, 2015, Volume: 172, Issue:6 Topics: Cushing Syndrome; Etomidate; Humans; Imidazoles; Ketoconazole; Metyrapone; Mitotane; Pyridines; Ster	2015
Therapeutic Strategies for the Treatment of Severe Cushing's Syndrome. Drugs, 2016, Volume: 76, Issue:4 Topics: Animals; Cushing Syndrome; Etomidate; Humans; Hydrocortisone; Ketoconazole; Metyrapone	2016
Drugs in the medical treatment of Cushing's syndrome. Expert opinion on emerging drugs, 2009, Volume: 14, Issue:4 Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Antiparkinson Agents; Cabergoline; Cushing Sy	2009
Management of diabetes mellitus in Cushing's syndrome. Neuroendocrinology, 2010, Volume: 92 Suppl 1 Topics: Cushing Syndrome; Diabetes Mellitus; Enzyme Inhibitors; Humans; Hypoglycemic Agents; Insulin Resista	2010
Management of dyslipidemia in Cushing's syndrome. Neuroendocrinology, 2010, Volume: 92 Suppl 1 Topics: Cushing Syndrome; Dyslipidemias; Enzyme Inhibitors; Humans; Ketoconazole; Mitotane	2010
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. Neuroendocrinology, 2010, Volume: 92 Suppl 1 Topics: Cushing Syndrome; Enzyme Inhibitors; Etomidate; Humans; Ketoconazole; Metyrapone; Mitotane	2010
Advances in medical therapies for Cushing's syndrome. Discovery medicine, 2012, Volume: 13, Issue:69 Topics: Animals; Bexarotene; Cushing Syndrome; Etomidate; Humans; Ketoconazole; Lapatinib; Metyrapone; Mifep	2012
The medical management of Cushing's syndrome during pregnancy. European journal of obstetrics, gynecology, and reproductive biology, 2013, Volume: 168, Issue:1 Topics: Adrenalectomy; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Metyrapone; Pre-Eclam	2013
Corticosteroids and pregnancy. Seminars in reproductive medicine, 2002, Volume: 20, Issue:4 Topics: Addison Disease; Adrenal Cortex Hormones; Animals; Cushing Syndrome; Female; Hydrocortisone; Hypotha	2002
Evaluation and treatment of Cushing's syndrome. The American journal of medicine, 2005, Volume: 118, Issue:12 Topics: Adrenalectomy; Adrenocorticotropic Hormone; Adult; Antifungal Agents; Child; Cushing Syndrome; Diagn	2005
[Medical treatment for Cushing's syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 2008, Volume: 66, Issue:1 Topics: Aminoglutethimide; Aromatase Inhibitors; Cushing Syndrome; Humans; Ketoconazole; Metyrapone; Steroid	2008
[Management of hypercortisolism]. La Revue de medecine interne, 2008, Volume: 29, Issue:4 Topics: Antineoplastic Agents, Hormonal; Cushing Syndrome; Decision Trees; Enzyme Inhibitors; Humans; Hypoph	2008
The medical treatment of Cushing's syndrome. Endocrine reviews, 1993, Volume: 14, Issue:4 Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrom	1993
Medical treatment of pituitary-dependent hyperadrenocorticism in dogs. Seminars in veterinary medicine and surgery (small animal), 1994, Volume: 9, Issue:3 Topics: Animals; Bromocriptine; Cushing Syndrome; Cyproheptadine; Dog Diseases; Dogs; Drug Administration Sc	1994
Concurrent illness and complications associated with canine hyperadrenocorticism. Seminars in veterinary medicine and surgery (small animal), 1994, Volume: 9, Issue:3 Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D	1994
Feline adrenocortical diseases: Part I--Hyperadrenocorticism. Seminars in veterinary medicine and surgery (small animal), 1994, Volume: 9, Issue:3 Topics: Adrenocorticotropic Hormone; Animals; Cat Diseases; Cats; Cushing Syndrome; Dexamethasone; Diagnosis	1994
Steroid biosynthesis inhibitors in Cushing's syndrome. The Clinical investigator, 1994, Volume: 72, Issue:7 Topics: Adrenal Cortex Hormones; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate; Humans	1994
Therapy of Cushing's syndrome with steroid biosynthesis inhibitors. The Journal of steroid biochemistry and molecular biology, 1994, Volume: 49, Issue:4-6 Topics: 3-Hydroxysteroid Dehydrogenases; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Etomidate	1994
[Clinical usefulness of pharmacological treatment of Cushing's syndrome]. Nihon rinsho. Japanese journal of clinical medicine, 1994, Volume: 52, Issue:3 Topics: Administration, Oral; Aminoglutethimide; Cushing Syndrome; Dihydrotestosterone; Humans; Ketoconazole	1994
[Value of ketoconazole in the treatment of Cushing disease]. La Revue de medecine interne, 1993, Volume: 14, Issue:1 Topics: Adult; Aged; Cushing Syndrome; Drug Resistance; Female; Humans; Ketoconazole; Time Factors	1993
Corticotropin-dependent Cushing's syndrome in older people: presentation of five cases and therapeutical use of ketoconazole. Journal of the American Geriatrics Society, 1998, Volume: 46, Issue:7 Topics: Adrenocorticotropic Hormone; Aged; Aged, 80 and over; Cushing Syndrome; Drug Therapy, Combination; F	1998
Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 1999, Volume: 13, Issue:3 Topics: Adult; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergolines; Female; Humans; Ketoconazole; Pr	1999
Medical treatment of canine pituitary-dependent hyperadrenocorticism (Cushing's disease). The Veterinary clinics of North America. Small animal practice, 2001, Volume: 31, Issue:5 Topics: Animals; Antifungal Agents; Cushing Syndrome; Dog Diseases; Dogs; Dose-Response Relationship, Drug;	2001
[Mycoses and adrenocortical function. New pathogenetic aspects of adrenal hypofunction]. Recenti progressi in medicina, 1991, Volume: 82, Issue:12 Topics: Acquired Immunodeficiency Syndrome; Adrenal Cortex Hormones; Adrenal Glands; Adrenal Insufficiency;	1991
Cushing's disease and cutaneous alternariosis. Archives of internal medicine, 1991, Volume: 151, Issue:9 Topics: Aged; Alternaria; Cushing Syndrome; Dermatomycoses; Female; Humans; Immune Tolerance; Ketoconazole;	1991
Problems associated with medical therapy of canine hyperadrenocorticism. Problems in veterinary medicine, 1990, Volume: 2, Issue:4 Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Cushing Syndrome; Diabetes Mellitus	1990
Cushing's syndrome and pregnancy. American journal of obstetrics and gynecology, 1990, Volume: 162, Issue:1 Topics: Adrenalectomy; Carbohydrate Metabolism; Cushing Syndrome; Female; Fetal Diseases; Humans; Hydrocorti	1990
[Short term effects of ketoconazole in Cushing's syndrome]. Annales d'endocrinologie, 1989, Volume: 50, Issue:6 Topics: Adult; Androgens; Cushing Syndrome; Desoxycorticosterone; Dose-Response Relationship, Drug; Drug Adm	1989
[The antimycotic ketoconazole. Indications in prostate disease, hirsutism, precocious puberty and Cushing syndrome?]. Medizinische Monatsschrift fur Pharmazeuten, 1988, Volume: 11, Issue:5 Topics: Cushing Syndrome; Hirsutism; Humans; Ketoconazole; Male; Prostatic Diseases; Puberty, Precocious	1988
Influence of naturally occurring and synthetic glucocorticoids on corticosteroid-binding globulin-steroid interaction in human peripheral plasma. Annals of the New York Academy of Sciences, 1988, Volume: 538 Topics: Circadian Rhythm; Cushing Syndrome; Glucocorticoids; Humans; Ketoconazole; Radioimmunoassay; Steroid	1988
The endocrine effects of ketoconazole. Journal of endocrinological investigation, 1986, Volume: 9, Issue:4 Topics: Animals; Breast Neoplasms; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Humans; K	1986

Article	Year
Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. The lancet. Diabetes & endocrinology, 2019, Volume: 7, Issue:11 Topics: Adolescent; Adrenal Insufficiency; Adult; Aged; Alanine Transaminase; Chemical and Drug Induced Live	2019
Levoketoconazole in the Treatment of Patients With Cushing's Syndrome and Diabetes Mellitus: Results From the SONICS Phase 3 Study. Frontiers in endocrinology, 2021, Volume: 12 Topics: Adult; Aged; Blood Glucose; Cushing Syndrome; Diabetes Complications; Enzyme Inhibitors; Female; Hum	2021
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). Clinical endocrinology, 2010, Volume: 72, Issue:1 Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Ghrelin; Hormone Antagonists;	2010
Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics. American journal of respiratory and critical care medicine, 2006, Aug-15, Volume: 174, Issue:4 Topics: Aged; Alcoholism; Antifungal Agents; APACHE; Comorbidity; Cushing Syndrome; Digestive System Neoplas	2006
Ketoconazole therapy: an efficacious alternative to achieve eucortisolism in patients with Cushing's syndrome. Medicina, 2007, Volume: 67, Issue:1 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Analysis of Variance; Cushing Syndrome; Dose-Respons	2007
Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease. Clinical endocrinology, 1998, Volume: 48, Issue:5 Topics: Acute Disease; Adult; Alendronate; Antifungal Agents; Biomarkers; Bone Density; Collagen; Collagen T	1998
Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. Klinische Wochenschrift, 1989, Feb-15, Volume: 67, Issue:4 Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Cushi	1989
[Evaluation of the treatment of Cushing's syndrome using ketoconazole]. Medicina clinica, 1989, Nov-04, Volume: 93, Issue:14 Topics: Adolescent; Adult; Clinical Trials as Topic; Cushing Syndrome; Drug Administration Schedule; Drug Ev	1989

Article	Year
Ketoconazole- and Metyrapone-Induced Reductions on Urinary Steroid Metabolites Alter the Urinary Free Cortisol Immunoassay Reliability in Cushing Syndrome. Frontiers in endocrinology, 2022, Volume: 13 Topics: Cushing Syndrome; Humans; Hydrocortisone; Immunoassay; Ketoconazole; Metyrapone; Reproducibility of	2022
Evaluation of ketoconazole as a treatment for Cushing's disease in a retrospective cohort. Frontiers in endocrinology, 2022, Volume: 13 Topics: Cabergoline; Cushing Syndrome; Humans; Hydrocortisone; Hypokalemia; Ketoconazole; Pituitary ACTH Hyp	2022
An exceptionally rare case of Cushing's syndrome caused by ectopic ACTH syndrome due to olfactory neuroblastoma in childhood. Journal of pediatric endocrinology & metabolism : JPEM, 2023, May-25, Volume: 36, Issue:5 Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Child; Child, Preschool; Cushing Syndrome; Esth	2023
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome. European journal of endocrinology, 2020, Volume: 183, Issue:1 Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Coronavirus Infections;	2020
Levoketoconazole improves clinical signs and symptoms and patient-reported outcomes in patients with Cushing's syndrome. Pituitary, 2021, Volume: 24, Issue:1 Topics: Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Male; Middle Aged; Patient Re	2021
Levoketoconazole, the 2S,4R Enantiomer of Ketoconazole, a New Steroidogenesis Inhibitor for Cushing's Syndrome Treatment. The Journal of clinical endocrinology and metabolism, 2021, 03-25, Volume: 106, Issue:4 Topics: Animals; Cell Line, Tumor; Cells, Cultured; Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole;	2021
Cushing Syndrome in a Pediatric Patient With a KCNJ5 Variant and Successful Treatment With Low-dose Ketoconazole. The Journal of clinical endocrinology and metabolism, 2021, 05-13, Volume: 106, Issue:6 Topics: Cells, Cultured; Child; Cushing Syndrome; Dose-Response Relationship, Drug; Female; G Protein-Couple	2021
Approach to the Patient Treated with Steroidogenesis Inhibitors. The Journal of clinical endocrinology and metabolism, 2021, 06-16, Volume: 106, Issue:7 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Enzyme Inhibitors; Female; Humans; Imidazoles;	2021
Pancreatic adenocarcinoma presenting with Cushing's syndrome. Lancet (London, England), 2021, 07-03, Volume: 398, Issue:10294 Topics: 14-alpha Demethylase Inhibitors; Adrenocorticotropic Hormone; Aged; Cushing Syndrome; Diagnosis, Dif	2021
A polymorphism in the CYP17A1 gene influences the therapeutic response to steroidogenesis inhibitors in Cushing's syndrome. Clinical endocrinology, 2017, Volume: 87, Issue:5 Topics: Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Male; Metyrapone; Middle Aged; Pharmacogeneti	2017
An Overlooked Cause of Hypokalemia. The American journal of medicine, 2017, Volume: 130, Issue:10 Topics: 14-alpha Demethylase Inhibitors; Adenoma; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergoline	2017
Ectopic Cushing's syndrome: Paradoxical effect of somatostatin analogs. Endocrinologia, diabetes y nutricion, 2017, Volume: 64, Issue:5 Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Medulla; Adrenalectomy; Adrenocorticotropic	2017
Preoperative medical treatment in Cushing's syndrome: frequency of use and its impact on postoperative assessment: data from ERCUSYN. European journal of endocrinology, 2018, Volume: 178, Issue:4 Topics: Adrenal Glands; Adult; Aged; Cushing Syndrome; Databases, Factual; Europe; Female; Humans; Ketoconaz	2018
Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France. European journal of endocrinology, 2018, Volume: 178, Issue:5 Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Child; Cohort St	2018
Should we avoid using ketoconazole in patients with severe Cushing’s syndrome and increased levels of liver enzymes? European journal of endocrinology, 2018, Oct-12, Volume: 179, Issue:5 Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Enzyme Inhibitors; Female; Humans; Ketoconazole;	2018
Arterial thrombosis as primary presentation of endogenous Cushing's syndrome. BMJ case reports, 2019, Feb-06, Volume: 12, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Anticoagulants; Aortic Diseases; Celiac Artery; Computed Tomogra	2019
Cabergoline in severe ectopic or occult Cushing's syndrome. European journal of endocrinology, 2019, Jul-01, Volume: 181, Issue:1 Topics: ACTH Syndrome, Ectopic; Adult; Aged; Cabergoline; Carcinoid Tumor; Cushing Syndrome; Dopamine Agonis	2019
Osilodrostat Is a Potential Novel Steroidogenesis Inhibitor for the Treatment of Cushing Syndrome: An In Vitro Study. The Journal of clinical endocrinology and metabolism, 2019, 08-01, Volume: 104, Issue:8 Topics: Aldosterone; Cell Culture Techniques; Cortodoxone; Cushing Syndrome; Cytochrome P-450 CYP11B2; Enzym	2019
A Novel GNAS Mutation Causing Isolated Infantile Cushing's Syndrome. Hormone research in paediatrics, 2019, Volume: 92, Issue:3 Topics: Chromogranins; Cushing Syndrome; Exome Sequencing; Female; Fibrous Dysplasia, Polyostotic; GTP-Bindi	2019
Positive (68)Ga-DOTATOC-PET/CT after cortisol level control during ketoconazole treatment in a patient with liver metastases from a pancreatic neuroendocrine tumor and ectopic Cushing syndrome. Endocrine, 2015, Volume: 49, Issue:2 Topics: Cushing Syndrome; Gallium Radioisotopes; Humans; Hydrocortisone; Ketoconazole; Liver Neoplasms; Male	2015
Rapid control of severe neoplastic hypercortisolism with metyrapone and ketoconazole. European journal of endocrinology, 2015, Volume: 172, Issue:4 Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenocortical Carcinoma; Adult; Aged; Cushing Synd	2015
Cushing syndrome secondary to ectopic adrenocorticotropic hormone secretion from a Meckel diverticulum neuroendocrine tumor: case report. BMC endocrine disorders, 2015, Nov-26, Volume: 15 Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Cushing	2015
[Indications and future perspectives in the pharmacological treatment of hypercortisolism]. Recenti progressi in medicina, 2016, Volume: 107, Issue:3 Topics: Adenoma; Cushing Syndrome; Humans; Hydrocortisone; Italy; Ketoconazole; Metyrapone; Pituitary Neopla	2016
Symptomatic Cushing's syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report. Journal of medical case reports, 2016, Oct-12, Volume: 10, Issue:1 Topics: Aged; Antineoplastic Agents, Hormonal; Cushing Syndrome; Disease Progression; Fatal Outcome; Female;	2016
[Pharmacological treatment in adrenal Cushing's syndrome.] Recenti progressi in medicina, 2016, Volume: 107, Issue:11 Topics: Cushing Syndrome; Humans; Ketoconazole; Metyrapone	2016
A successful case of pregnancy in a woman with ACTH-independent Cushing's syndrome treated with ketoconazole and metyrapone. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2017, Volume: 33, Issue:5 Topics: Adult; Cushing Syndrome; Drug Therapy, Combination; Female; Humans; Ketoconazole; Metyrapone; Pregna	2017
Hypokalemia, metabolic alkalosis, and hypertension in a lung cancer patient. Kidney international, 2009, Volume: 76, Issue:1 Topics: Aged; Alkalosis; Cushing Syndrome; France; Humans; Hypertension; Hypokalemia; Ketoconazole; Lung Neo	2009
Etomidate infusion in the critical care setting for suppressing the acute phase of Cushing's syndrome. Anesthesia and analgesia, 2009, Volume: 108, Issue:1 Topics: Acute Disease; Administration, Oral; Adolescent; Adrenalectomy; Critical Care; Cushing Syndrome; Enz	2009
Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome. The Journal of pediatrics, 2009, Volume: 154, Issue:3 Topics: Adrenergic Agents; Adrenocorticotropic Hormone; Aminoglutethimide; Antifungal Agents; Chemical and D	2009
Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9 Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adult; Cushing Syndrome; Female;	2011
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. Endocrine pathology, 2011, Volume: 22, Issue:2 Topics: ACTH Syndrome, Ectopic; Adult; Carcinoma, Neuroendocrine; Cushing Syndrome; Fatal Outcome; Female; H	2011
Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child. Journal of pediatric endocrinology & metabolism : JPEM, 2011, Volume: 24, Issue:3-4 Topics: Adrenocorticotropic Hormone; Carcinoma, Acinar Cell; Child, Preschool; Combined Modality Therapy; Cu	2011
Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:9 Topics: Adolescent; Adult; Aged; Antimetabolites; Antineoplastic Agents; Cushing Syndrome; Drug Therapy, Com	2011
[Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma]. Archivos de la Sociedad Espanola de Oftalmologia, 2011, Volume: 86, Issue:6 Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Antineoplastic Combined Chemotherapy	2011
Overt immune dysfunction after Cushing's syndrome remission: a consecutive case series and review of the literature. The Journal of clinical endocrinology and metabolism, 2011, Volume: 96, Issue:10 Topics: Adrenalectomy; Adult; Anti-Infective Agents, Local; Antifungal Agents; Asthma; Autoimmune Diseases;	2011
Iatrogenic heart block during treatment of a patient with Cushing's syndrome: report of a case. Endocrine, 2012, Volume: 41, Issue:2 Topics: Aged, 80 and over; Alkalosis; Antihypertensive Agents; Cushing Syndrome; Cytochrome P-450 CYP3A; Cyt	2012
Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome--a description of two cases. Acta medica (Hradec Kralove), 2011, Volume: 54, Issue:3 Topics: Adult; Cushing Syndrome; Etomidate; Female; Humans; Hydrocortisone; Ketoconazole; Male; Middle Aged;	2011
A reappraisal of the medical therapy with steroidogenesis inhibitors in Cushing's syndrome. Clinical endocrinology, 2012, Volume: 77, Issue:5 Topics: Adolescent; Adult; Aged; Antimetabolites; Child; Cushing Syndrome; Female; Humans; Ketoconazole; Mal	2012
Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. BMJ case reports, 2012, Jul-03, Volume: 2012 Topics: 14-alpha Demethylase Inhibitors; Adenoma; Adult; Antineoplastic Agents; Cabergoline; Cushing Syndrom	2012
Isolated Cushing's syndrome in early infancy due to left adrenal adenoma: an unusual aetiology. Journal of clinical research in pediatric endocrinology, 2012, Volume: 4, Issue:3 Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Ad	2012
Diagnostic puzzler: hypertension in teen. The Journal of family practice, 2012, Volume: 61, Issue:9 Topics: Adenoma; Adolescent; Adrenal Glands; Antifungal Agents; Cushing Syndrome; Diagnosis, Differential; D	2012
Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-tetrahydrocortisone ratios in nonectopic Cushing's syndrome. Endocrine, 2002, Volume: 18, Issue:3 Topics: Adult; Cortisone; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Male; Middle Aged;	2002
Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas. European journal of endocrinology, 2003, Volume: 149, Issue:3 Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Cushing Syndrome; Dexamethasone; Female; Glucocor	2003
Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk. Pituitary, 2004, Volume: 7, Issue:1 Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Pituitary Neoplasms;	2004
Efficient short-term control of hypercortisolaemia by low-dose etomidate in severe paediatric Cushing's disease. Hormone research, 2005, Volume: 64, Issue:3 Topics: Adrenalectomy; Child; Contraindications; Cushing Syndrome; Etomidate; Humans; Hydrocortisone; Ketoco	2005
Long term control of hypercortisolism with fluconazole: case report and in vitro studies. European journal of endocrinology, 2006, Volume: 154, Issue:4 Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aged, 80 and over; Antifungal Agents; Cell Line, Tu	2006
[Cushing syndrome]. Revue de l'infirmiere, 2007, Issue:129 Topics: Adrenalectomy; Causality; Cushing Syndrome; Humans; Hydrocortisone; Ketoconazole; Magnetic Resonance	2007
Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome. The Netherlands journal of medicine, 2007, Volume: 65, Issue:6 Topics: Cushing Syndrome; Disease Progression; Fatal Outcome; Female; Humans; Ketoconazole; Middle Aged; Mif	2007
Effect of hypercortisolism control on high blood pressure in Cushing's syndrome. Medicina, 2007, Volume: 67, Issue:5 Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Antihypertensive Agents; Blood Pre	2007
Effect of one month ketoconazole treatment on GH, cortisol and ACTH release after ghrelin, GHRP-6 and GHRH administration in patients with Cushing's disease. Arquivos brasileiros de endocrinologia e metabologia, 2007, Volume: 51, Issue:7 Topics: Adrenocorticotropic Hormone; Adult; Case-Control Studies; Cushing Syndrome; Female; Ghrelin; Growth	2007
Pharmacological management of Cushing's syndrome: an update. Arquivos brasileiros de endocrinologia e metabologia, 2007, Volume: 51, Issue:8 Topics: Cushing Syndrome; Dopamine Antagonists; Hormone Antagonists; Humans; Hypothalamo-Hypophyseal System;	2007
Long-distance and long-term follow-up of a patient with intermittent Cushing's disease by salivary cortisol measurements. European journal of endocrinology, 1995, Volume: 133, Issue:3 Topics: Africa, Northern; Cushing Syndrome; Female; Humans; Hydrocarbons, Chlorinated; Hydrocortisone; Ketoc	1995
Paraneoplastic endocrine syndromes. Current therapy in endocrinology and metabolism, 1994, Volume: 5 Topics: Acromegaly; Adrenocorticotropic Hormone; Aminoglutethimide; Bromocriptine; Calcitonin; Cushing Syndr	1994
Ketoconazole in the management of paraneoplastic Cushing's syndrome secondary to ectopic adrenocorticotropin production. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1995, Volume: 13, Issue:1 Topics: ACTH Syndrome, Ectopic; Adult; Aged; Aged, 80 and over; Carcinoid Tumor; Carcinoma, Small Cell; Caus	1995
[Paraneoplastic Cushing's syndrome. Pseudotumors of the thymus occurring after correction of hypercorticism. 3 cases]. Presse medicale (Paris, France : 1983), 1993, Dec-04, Volume: 22, Issue:38 Topics: Adrenalectomy; Adrenocortical Hyperfunction; Adult; Carcinoid Tumor; Cushing Syndrome; Drug Therapy,	1993
Corticotropin-dependent Cushing's syndrome in a patient with chronic renal failure--a rare association. Renal failure, 1993, Volume: 15, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dexamethasone; Glomerulonephritis, Membranous;	1993
Response of hypertension to conventional antihypertensive treatment and/or steroidogenesis inhibitors in Cushing's syndrome. Journal of internal medicine, 1993, Volume: 234, Issue:6 Topics: Adult; Antihypertensive Agents; Blood Pressure; Cushing Syndrome; Female; Humans; Hydrocortisone; Hy	1993
[Bilateral massive macronodular adrenal gland hyperplasia. A rare cause of Cushing's syndrome]. Deutsche medizinische Wochenschrift (1946), 1994, Feb-11, Volume: 119, Issue:6 Topics: Adrenal Gland Diseases; Adrenal Glands; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotr	1994
Cushing's syndrome secondary to malignant lipoid cell tumor of the ovary. Gynecologic oncology, 1993, Volume: 50, Issue:2 Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cushing Syndrome; Female; Humans; H	1993
[Ketoconazole and dexamethasone suppression tests]. Anales de medicina interna (Madrid, Spain : 1984), 1993, Volume: 10, Issue:3 Topics: Aged; Aged, 80 and over; Candidiasis; Cushing Syndrome; Dexamethasone; Drug Interactions; Humans; Hy	1993
The effect of ketoconazole in pre-operative treatment in Cushing's syndrome: three cases report. Changgeng yi xue za zhi, 1996, Volume: 19, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Dose-Response Relationship, Drug; Female; Huma	1996
Cushing's syndrome induced by occult ectopic acth secretion. The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:5 Topics: ACTH Syndrome, Ectopic; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Neopl	1995
Octreotide and ketoconazole for persistent ectopic ACTH Cushing's disease due to mediastinal carcinoid. The Journal of the Association of Physicians of India, 1995, Volume: 43, Issue:2 Topics: Adrenocorticotropic Hormone; Adult; Antineoplastic Agents, Hormonal; Carcinoid Tumor; Chemotherapy,	1995
[Cushing's syndrome: clinical study of fifteen cases]. Anales de medicina interna (Madrid, Spain : 1984), 1998, Volume: 15, Issue:5 Topics: Adult; Aged; Cushing Syndrome; Dexamethasone; Female; Humans; Hydrocortisone; Ketoconazole; Male; Me	1998
Reversible proximal myopathy in epilepsy related Cushing's syndrome. Journal of neurology, neurosurgery, and psychiatry, 1998, Volume: 65, Issue:1 Topics: Adult; Cushing Syndrome; Diagnosis, Differential; Electromyography; Epilepsies, Partial; Epilepsy, C	1998
Adrenocortical carcinoma evolving after diagnosis of preclinical Cushing's syndrome in an adrenal incidentaloma. A case report. Hormone research, 1998, Volume: 50, Issue:4 Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Androgens; Antineoplastic Combined Chemotherapy Prot	1998
[Ketoconazole in the control of arterial hypertension in Cushing's syndrome]. Revista clinica espanola, 1999, Volume: 199, Issue:1 Topics: Adult; Antihypertensive Agents; Cushing Syndrome; Drug Evaluation; Female; Humans; Hydrocortisone; H	1999
[Paraneoplastic hypercorticism associated with a bronchial adenocarcinoma]. Revue des maladies respiratoires, 1999, Volume: 16, Issue:3 Topics: Adenocarcinoma; Aged; Antifungal Agents; Cushing Syndrome; Humans; Ketoconazole; Lung Neoplasms; Mal	1999
[Therapeutic efficacy of ketoconazole in Cushing syndrome]. Anales espanoles de pediatria, 2000, Volume: 52, Issue:4 Topics: Child; Cushing Syndrome; Female; Humans; Ketoconazole	2000
Long-term effects of ketoconazole in the treatment of residual or recurrent Cushing's disease. Endocrine journal, 2000, Volume: 47, Issue:4 Topics: Adult; Cushing Syndrome; Female; Follow-Up Studies; Humans; Hydrocortisone; Ketoconazole; Middle Age	2000
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. American journal of kidney diseases : the official journal of the National Kidney Foundation, 2001, Volume: 37, Issue:4 Topics: ACTH Syndrome, Ectopic; Adenocarcinoma; Adrenocorticotropic Hormone; Aged; Alkalosis; Comorbidity; C	2001
Fatal liver failure due to ketoconazole treatment of a girl with Cushing's syndrome. Journal of pediatric endocrinology & metabolism : JPEM, 2001, Volume: 14, Issue:3 Topics: Adolescent; Cushing Syndrome; Fatal Outcome; Female; Humans; Ketoconazole; Liver Failure; Liver Func	2001
Severe respiratory failure secondary to Cushing's myopathy. Journal of endocrinological investigation, 2001, Volume: 24, Issue:8 Topics: Cushing Syndrome; Electromyography; Female; Humans; Hydrocortisone; Ketoconazole; Middle Aged; Muscu	2001
Recovery of bone mineral density after surgical cure, but not by ketoconazole treatment, in Cushing's syndrome. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2001, Volume: 12, Issue:11 Topics: Absorptiometry, Photon; Adenoma; Adrenal Gland Neoplasms; Adult; Bone Density; Cushing Syndrome; Dex	2001
Hormonal and immunological pattern in a patient with acquired immunodeficiency syndrome related complex and Cushing's syndrome. Journal of endocrinological investigation, 1992, Volume: 15, Issue:11 Topics: Adrenal Cortex Hormones; Adrenal Gland Neoplasms; Adult; AIDS-Related Complex; Cushing Syndrome; Hum	1992
Cushing's syndrome associated with ectopic corticotropin production and small-cell lung cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 1992, Volume: 10, Issue:1 Topics: ACTH Syndrome, Ectopic; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Smal	1992
Medical treatment of Cushing's syndrome with aminoglutethimide and ketoconazole. Singapore medical journal, 1992, Volume: 33, Issue:5 Topics: Adenoma; Adrenal Gland Neoplasms; Aminoglutethimide; Cushing Syndrome; Humans; Hydrocortisone; Ketoc	1992
[Treatment with ketoconazole of Cushing's syndrome due to ectopic secretion of ACTH]. Revista clinica espanola, 1992, Volume: 191, Issue:9 Topics: ACTH Syndrome, Ectopic; Bronchial Neoplasms; Carcinoid Tumor; Cushing Syndrome; Humans; Ketoconazole	1992
[Remission of Itsenko-Cushing disease after treatment with nizoral]. Rossiiskii meditsinskii zhurnal : organ Ministerstva zdravookhraneniia RSFSR, 1992, Issue:3 Topics: Adult; Cushing Syndrome; Female; Follow-Up Studies; Humans; Ketoconazole; Time Factors	1992
Ketoconazole and plasma and urine steroid levels in Cushing's disease. Clinical and experimental pharmacology & physiology, 1991, Volume: 18, Issue:8 Topics: Administration, Oral; Adrenal Cortex Hormones; Adrenocorticotropic Hormone; Adult; Cushing Syndrome;	1991
In vivo and in vitro inhibition by ketoconazole of ACTH secretion from a human thymic carcinoid tumour. Acta endocrinologica, 1991, Volume: 125, Issue:3 Topics: Adrenocorticotropic Hormone; Adult; Carcinoid Tumor; Circadian Rhythm; Corticotropin-Releasing Hormo	1991
Palliative therapy of an ectopic Cushing's syndrome due to a metastatic carcinoid tumor. Klinische Wochenschrift, 1991, Feb-26, Volume: 69, Issue:4 Topics: ACTH Syndrome, Ectopic; Adult; Carcinoid Tumor; Combined Modality Therapy; Cushing Syndrome; Dose-Re	1991
Ketoconazole treatment in Cushing's syndrome: experience in 34 patients. Clinical endocrinology, 1991, Volume: 35, Issue:4 Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Drug Administrati	1991
[Therapeutic attitude in Cushing's disease associated with empty sella turcica]. Medicina clinica, 1991, Nov-30, Volume: 97, Issue:19 Topics: Adrenalectomy; Aged; Cushing Syndrome; Empty Sella Syndrome; Female; Glucocorticoids; Humans; Ketoco	1991
Use of ketoconazole in the treatment of Cushing's syndrome. Clinical pharmacy, 1991, Volume: 10, Issue:1 Topics: Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; Cushing Syndrome; Humans; Ketoconazole; R	1991
Regulation of glucocorticoid receptors in human mononuclear cells: effects of glucocorticoid treatment, Cushing's disease and ketoconazole. The Journal of steroid biochemistry and molecular biology, 1991, Volume: 39, Issue:2 Topics: Adolescent; Adult; Cushing Syndrome; Female; Glucocorticoids; Humans; Hydrocortisone; Ketoconazole;	1991
Use of ketoconazole in the treatment of Cushing's disease and ectopic ACTH syndrome. Clinical endocrinology, 1991, Volume: 34, Issue:1 Topics: ACTH Syndrome, Ectopic; Adult; Cushing Syndrome; Diagnosis, Differential; Female; Humans; Hydrocorti	1991
Favourable response of a virilizing adrenocortical carcinoma to preoperative treatment with ketoconazole and postoperative chemotherapy. Acta endocrinologica, 1991, Volume: 124, Issue:4 Topics: Adrenal Cortex Neoplasms; Adult; Aldehyde-Lyases; Androgens; Antineoplastic Combined Chemotherapy Pr	1991
[Cushing's syndrome secondary to adrenal gland carcinoma controlled with ketoconazole]. Anales de medicina interna (Madrid, Spain : 1984), 1990, Volume: 7, Issue:2 Topics: Adrenal Gland Neoplasms; Aged; Carcinoma; Cushing Syndrome; Female; Humans; Ketoconazole	1990
[Efficacy and long-term tolerance of ketoconazole in the treatment of Cushing's disease]. Annales d'endocrinologie, 1990, Volume: 51, Issue:1 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Drug Administration Schedule; Drug Tolerance;	1990
Ketoconazole in the treatment of Cushing's disease. The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:7 Topics: 17-alpha-Hydroxyprogesterone; Adolescent; Adult; Androstenedione; Cushing Syndrome; Female; Humans;	1990
Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. Postgraduate medical journal, 1990, Volume: 66, Issue:773 Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy;	1990
Persistent Cushing's disease in a patient with invasive pituitary adenoma. The Journal of the Association of Physicians of India, 1990, Volume: 38, Issue:6 Topics: Adenocarcinoma; Adult; Combined Modality Therapy; Cushing Syndrome; Female; Humans; Hydrocortisone;	1990
Circulating cortisol & related steroids following ketoconazole challenge in Cushing's disease. The Indian journal of medical research, 1990, Volume: 92 Topics: 17-alpha-Hydroxyprogesterone; Aldehyde-Lyases; Androstenedione; Cushing Syndrome; Cytochrome P-450 E	1990
Ketoconazole treatment of Cushing's syndrome in pregnancy. American journal of obstetrics and gynecology, 1990, Volume: 163, Issue:3 Topics: Adenoma; Adrenal Gland Neoplasms; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; Pregnan	1990
[Cushing syndrome caused by macronodular adrenal hyperplasia, independent of ACTH: report of a case]. Revista medica de Chile, 1989, Volume: 117, Issue:12 Topics: Adrenal Glands; Adrenocorticotropic Hormone; Cushing Syndrome; Female; Humans; Hyperplasia; Ketocona	1989
[Value of ketoconazole in the treatment of Cushing's syndrome. Apropos of a case of adrenal polyadematosis]. Annales de medecine interne, 1989, Volume: 140, Issue:6 Topics: Adenoma; Adrenal Gland Neoplasms; Cushing Syndrome; Humans; Ketoconazole; Male; Middle Aged	1989
Arterial hypertension as a complication of prolonged ketoconazole treatment. Journal of hypertension. Supplement : official journal of the International Society of Hypertension, 1989, Volume: 7, Issue:6 Topics: Adolescent; Adult; Chronic Disease; Cushing Syndrome; Female; Humans; Hypertension; Ketoconazole; Ma	1989
[Control of adrenal adenocarcinoma and Cushing's syndrome with ketoconazole]. Medicina clinica, 1989, Jan-14, Volume: 92, Issue:1 Topics: Adenocarcinoma; Adrenal Gland Neoplasms; Adult; Cushing Syndrome; Humans; Ketoconazole; Male	1989
Inhibition of human adrenal androgen secretion by ketoconazole. Klinische Wochenschrift, 1989, Jul-17, Volume: 67, Issue:14 Topics: ACTH Syndrome, Ectopic; Adrenal Gland Neoplasms; Adrenal Glands; Androgens; Cushing Syndrome; Female	1989
Response of pituitary-adrenal axis to corticotrophin releasing hormone in patients with Cushing's disease before and after ketoconazole treatment. Clinical endocrinology, 1987, Volume: 27, Issue:4 Topics: Adrenocorticotropic Hormone; Adult; Aldosterone; Corticotropin-Releasing Hormone; Cushing Syndrome;	1987
Effect of ketoconazole on CRH-induced ACTH and cortisol release in patients with Cushing's disease. Hormone and metabolic research. Supplement series, 1987, Volume: 16 Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Corticotropin-Releasing Hormone; Cushing Syndrome; F	1987
ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies. Hormone and metabolic research. Supplement series, 1987, Volume: 16 Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Animals; Corticotropin-Releasing Hormone; Cushing Syndr	1987
Ketoconazole treatment in Cushing's disease. Effect on the circadian profile of plasma ACTH and cortisol. Journal of endocrinological investigation, 1988, Volume: 11, Issue:10 Topics: Adrenocorticotropic Hormone; Adult; Circadian Rhythm; Cushing Syndrome; Female; Humans; Hydrocortiso	1988
Ketoconazole therapy in Cushing's disease. Lancet (London, England), 1985, Apr-06, Volume: 1, Issue:8432 Topics: Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole	1985
Acute hypoadrenalism and hepatotoxicity after treatment with ketoconazole. Lancet (London, England), 1987, Mar-07, Volume: 1, Issue:8532 Topics: Acute Disease; Adrenal Insufficiency; Adult; Chemical and Drug Induced Liver Injury; Cushing Syndrom	1987
[Ketoconazole therapy of Cushing's syndrome caused by adrenal polyadenomatosis]. Presse medicale (Paris, France : 1983), 1988, Feb-20, Volume: 17, Issue:6 Topics: Adenoma; Adrenal Cortex Neoplasms; Cushing Syndrome; Humans; Ketoconazole; Male; Middle Aged	1988
Ketoconazole. Use in the treatment of ectopic adrenocorticotropic hormone production and Cushing's syndrome in small-cell lung cancer. Archives of internal medicine, 1985, Volume: 145, Issue:5 Topics: 17-Ketosteroids; Adrenocorticotropic Hormone; Carcinoma, Small Cell; Cushing Syndrome; Humans; Hydro	1985
Ketoconazole blocks cortisol secretion in man by inhibition of adrenal 11 beta-hydroxylase. Klinische Wochenschrift, 1985, Jul-01, Volume: 63, Issue:13 Topics: 17-alpha-Hydroxyprogesterone; Adrenal Glands; Adrenocorticotropic Hormone; Corticosterone; Cortodoxo	1985
Use of ketoconazole in the treatment of Cushing's syndrome. The Journal of clinical endocrinology and metabolism, 1986, Volume: 63, Issue:6 Topics: 17-Hydroxycorticosteroids; 17-Ketosteroids; Adolescent; Adrenocorticotropic Hormone; Adult; Cushing	1986
Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells. The Journal of pharmacology and experimental therapeutics, 1987, Volume: 240, Issue:1 Topics: 17-alpha-Hydroxyprogesterone; Adrenal Cortex; Adrenocorticotropic Hormone; Cortodoxone; Cushing Synd	1987
Current trends in the endocrine use of ketoconazole. Journal of endocrinological investigation, 1988, Volume: 11, Issue:10 Topics: Chemical Phenomena; Chemistry; Cushing Syndrome; Endocrine System Diseases; Female; Hirsutism; Human	1988
Ketoconazole as an inhibitor of steroid production. The New England journal of medicine, 1988, Mar-17, Volume: 318, Issue:11 Topics: Cushing Syndrome; Female; Humans; Hyperaldosteronism; Ketoconazole	1988
Total suppression of cortisol excretion by ketoconazole in the therapy of the ectopic adrenocorticotropic hormone syndrome. The American journal of medicine, 1988, Volume: 84, Issue:6 Topics: Carcinoid Tumor; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Middle Aged; Parane	1988
Clinical experience with ketoconazole as a therapy for patients with Cushing's syndrome. Clinical endocrinology, 1987, Volume: 27, Issue:5 Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Female; Humans; Hydrocortison	1987
Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. Acta endocrinologica, 1986, Volume: 113, Issue:3 Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Captopril; Cushing Syndrome	1986
[Ketoconazole: a new treatment of Cushing syndrome]. Medicina clinica, 1986, Jun-14, Volume: 87, Issue:3 Topics: Adult; Cushing Syndrome; Female; Humans; Ketoconazole	1986
Pseudallescheria boydii arthritis and osteomyelitis in a patient with Cushing's disease. Southern medical journal, 1987, Volume: 80, Issue:1 Topics: Adrenalectomy; Arthritis, Infectious; Combined Modality Therapy; Cushing Syndrome; Humans; Ketoconaz	1987
Adrenal rest tumor of the liver causing Cushing's syndrome: treatment with ketoconazole preceding an apparent surgical cure. The Journal of clinical endocrinology and metabolism, 1985, Volume: 60, Issue:1 Topics: 11-Hydroxycorticosteroids; 17-Hydroxycorticosteroids; Adrenal Rest Tumor; Adult; Cushing Syndrome; F	1985
Prolonged treatment of Cushing's disease by ketoconazole. The Journal of clinical endocrinology and metabolism, 1985, Volume: 61, Issue:4 Topics: Administration, Oral; Adolescent; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconaz	1985

ketoconazole and Cushing Syndrome