ketoconazole has been researched along with Colorectal Neoplasms in 5 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Colorectal Neoplasms: Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Irinotecan (CPT-11) is a prodrug of SN-38 and has been registered for the treatment of advanced colorectal cancer." | 5.10 | Modulation of irinotecan metabolism by ketoconazole. ( de Bruijn, P; Kehrer, DF; Mathijssen, RH; Sparreboom, A; Verweij, J, 2002) |
| "Ketoconazole is an oral-antifungal agent that has been used worldwide in the treatment of some hormone-dependent human cancer." | 1.31 | Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines. ( Chaing, CC; Chen, RJ; Ho, YS; Hsieh, JY; Lee, WS; Liang, YC; Lin, CH; Lin, JK; Wang, YJ, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (40.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Kehrer, DF | 1 |
| Mathijssen, RH | 1 |
| Verweij, J | 1 |
| de Bruijn, P | 1 |
| Sparreboom, A | 1 |
| Martínez, C | 1 |
| García-Martín, E | 1 |
| Pizarro, RM | 1 |
| García-Gamito, FJ | 1 |
| Agúndez, JA | 1 |
| Vermuyten, K | 1 |
| Laurijssens, L | 1 |
| Vanden Bossche, H | 1 |
| Ho, YS | 2 |
| Tsai, PW | 1 |
| Yu, CF | 1 |
| Liu, HL | 1 |
| Chen, RJ | 2 |
| Lin, JK | 2 |
| Lee, WS | 1 |
| Liang, YC | 1 |
| Wang, YJ | 1 |
| Lin, CH | 1 |
| Hsieh, JY | 1 |
| Chaing, CC | 1 |
1 trial available for ketoconazole and Colorectal Neoplasms
| Article | Year |
|---|---|
Modulation of irinotecan metabolism by ketoconazole.
Topics: Adult; Aged; Antifungal Agents; Antineoplastic Agents, Phytogenic; Camptothecin; Chromatography, Hig | 2002 |
4 other studies available for ketoconazole and Colorectal Neoplasms
| Article | Year |
|---|---|
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy.
Topics: Aged; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Colon; Colorectal Neoplasms; | 2002 |
Azole antifungals: weak inhibitors of inducible nitric oxide synthase in mouse and human cells.
Topics: Adenocarcinoma; Adult; Animals; Antifungal Agents; Azoles; Candida albicans; Colorectal Neoplasms; E | 1997 |
Ketoconazole-induced apoptosis through P53-dependent pathway in human colorectal and hepatocellular carcinoma cell lines.
Topics: Adenocarcinoma; Animals; Apoptosis; bcl-2-Associated X Protein; Blotting, Western; Carcinoma, Hepato | 1998 |
Ketoconazole induces G0/G1 arrest in human colorectal and hepatocellular carcinoma cell lines.
Topics: Animals; Antifungal Agents; Blotting, Western; Carrier Proteins; Cell Cycle; Cell Cycle Proteins; Ce | 2000 |