ketoconazole has been researched along with Cardiac Diseases in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 7.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| " Recent clinical evidence shows that some of the early prototypes in this class, namely terfenadine and astemizole, have the potential for producing torsade de pointes, a rare form of ventricular arrhythmia that is life-threatening." | 3.69 | Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes. ( del Prado, M; Egan, RW; Hey, JA; Kreutner, W, 1996) |
| "A phase II clinical trial was performed to assess the antitumor activity and toxicity of ketoconazole in combination with doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH) in patients with androgen-independent prostate cancer (AI PCa)." | 2.67 | Phase II study of ketoconazole combined with weekly doxorubicin in patients with androgen-independent prostate cancer. ( Amato, R; Bui, C; Ellerhorst, J; Kilbourn, R; Logothetis, CJ; Sella, A; Zukiwski, AA, 1994) |
| "The risk of serious ventricular arrhythmias with terfenadine using epidemiologic data is the same or less than that associated with traditional first-generation antihistamines." | 2.67 | Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. ( Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (100.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sella, A | 1 |
| Kilbourn, R | 1 |
| Amato, R | 1 |
| Bui, C | 1 |
| Zukiwski, AA | 1 |
| Ellerhorst, J | 1 |
| Logothetis, CJ | 1 |
| Morganroth, J | 1 |
| Brown, AM | 1 |
| Critz, S | 1 |
| Crumb, WJ | 1 |
| Kunze, DL | 1 |
| Lacerda, AE | 1 |
| Lopez, H | 1 |
| Hey, JA | 1 |
| del Prado, M | 1 |
| Kreutner, W | 1 |
| Egan, RW | 1 |
2 trials available for ketoconazole and Cardiac Diseases
| Article | Year |
|---|---|
Phase II study of ketoconazole combined with weekly doxorubicin in patients with androgen-independent prostate cancer.
Topics: Administration, Oral; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Doxor | 1994 |
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.
Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; H | 1993 |
1 other study available for ketoconazole and Cardiac Diseases
| Article | Year |
|---|---|
Cardiotoxic and drug interaction profile of the second generation antihistamines ebastine and terfenadine in an experimental animal model of torsade de pointes.
Topics: Animals; Butyrophenones; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme System; Drug Interactions; | 1996 |