ketoconazole has been researched along with Carcinoma in 15 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Carcinoma: A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole has been recently used in the treatment of advanced prostatic cancer and is believed to exert its effect by inhibition of androgen production." | 5.28 | Ketoconazole: a possible direct cytotoxic effect on prostate carcinoma cells. ( Eichenberger, T; Keating, A; Toor, P; Trachtenberg, J, 1989) |
| "Twenty-two patients who had progressive metastatic prostatic carcinoma (Stage D2) despite androgen-deprivation therapy (bilateral orchiectomy, 10 cases; bilateral orchiectomy followed by diethylstilbestrol, 7 cases; diethylstilbestrol, 3 cases; combined megestrol acetate and low-dose estrogen, 2 cases) were treated with ketoconazole." | 3.67 | Ketoconazole therapy for hormonally refractive metastatic prostate cancer. ( Babaian, RJ; Johnson, DE; Tenney, D; von Eschenbach, AC; Wishnow, KI, 1988) |
| "Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia." | 2.72 | Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021) |
| "Aminoglutethimide was examined only for effects on CYP11A activity and was shown to inhibit pregnenolone formation (20 microM: 61 +/- 4% of control)." | 1.31 | Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. ( Johansson, MK; Lund, BO; Sanderson, JT, 2002) |
| " Twenty dogs with hyperadrenocorticism (11 with PDH, 9 with adrenocortical tumor) were treated with ketoconazole at a dosage of 15 mg/kg given every 12 hours for a half month to 12 months." | 1.28 | Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism. ( Bruyette, DS; Farver, TB; Feldman, EC; Nelson, RW, 1990) |
| "Ketoconazole has been recently used in the treatment of advanced prostatic cancer and is believed to exert its effect by inhibition of androgen production." | 1.28 | Ketoconazole: a possible direct cytotoxic effect on prostate carcinoma cells. ( Eichenberger, T; Keating, A; Toor, P; Trachtenberg, J, 1989) |
| "Ketoconazole is an orally administered broad-spectrum antifungal agent that acts through the inhibition of the steroid synthetic pathways." | 1.27 | Ketoconazole: a novel and rapid treatment for advanced prostatic cancer. ( Halpern, N; Pont, A; Trachtenberg, J, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (46.67) | 18.7374 |
| 1990's | 4 (26.67) | 18.2507 |
| 2000's | 2 (13.33) | 29.6817 |
| 2010's | 1 (6.67) | 24.3611 |
| 2020's | 1 (6.67) | 2.80 |
| Authors | Studies |
|---|---|
| Yamamoto, M | 1 |
| Nakao, T | 1 |
| Ogawa, W | 1 |
| Fukuoka, H | 1 |
| Seneviratne, CJ | 1 |
| Fong, PH | 1 |
| Wong, SS | 1 |
| Lee, VH | 1 |
| Argirovic, Dj | 1 |
| Trachtenberg, J | 2 |
| Halpern, N | 1 |
| Pont, A | 2 |
| Johansson, MK | 1 |
| Sanderson, JT | 1 |
| Lund, BO | 1 |
| Percy, LA | 1 |
| Kruimel, JW | 1 |
| Smals, AG | 1 |
| Beex, LV | 1 |
| Swinkels, LM | 1 |
| Pieters, GF | 1 |
| Kloppenborg, PW | 1 |
| Gregori, J | 1 |
| Ruiz Rivas, JL | 1 |
| Pascual, R | 1 |
| Palacios, C | 1 |
| Feldman, EC | 1 |
| Bruyette, DS | 1 |
| Nelson, RW | 1 |
| Farver, TB | 1 |
| Sinnaeve, LJ | 1 |
| Becks, GP | 1 |
| Verhelst, JA | 1 |
| Druwé, P | 1 |
| van Erps, P | 1 |
| Denis, LJ | 1 |
| Mahler, C | 1 |
| Eichenberger, T | 1 |
| Toor, P | 1 |
| Keating, A | 1 |
| Oelschläger, H | 1 |
| Rothley, D | 1 |
| Dunzendorfer, U | 1 |
| Johnson, DE | 1 |
| Babaian, RJ | 1 |
| von Eschenbach, AC | 1 |
| Wishnow, KI | 1 |
| Tenney, D | 1 |
| Kraemer, FB | 1 |
2 reviews available for ketoconazole and Carcinoma
| Article | Year |
|---|---|
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists | 2021 |
Ketoconazole in advanced prostate cancer.
Topics: Carcinoma; Hormones; Humans; Ketoconazole; Male; Neoplasm Staging; Orchiectomy; Prostatic Neoplasms; | 1992 |
13 other studies available for ketoconazole and Carcinoma
| Article | Year |
|---|---|
Antifungal susceptibility and phenotypic characterization of oral isolates of a black fungus from a nasopharyngeal carcinoma patient under radiotherapy.
Topics: Amphotericin B; Antifungal Agents; Biofilms; Carcinoma; Caspofungin; Chemoradiotherapy; Chemotherapy | 2015 |
An evaluation of high-doses ketoconazole with hydrocortisone substitution in hormone-refractory prostate cancer.
Topics: Aged; Aged, 80 and over; Androgen Antagonists; Antineoplastic Agents; Bone Neoplasms; Carcinoma; Dis | 2005 |
Ketoconazole: a novel and rapid treatment for advanced prostatic cancer.
Topics: Aged; Carcinoma; Humans; Imidazoles; Ketoconazole; Male; Piperazines; Prostatic Neoplasms | 1983 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colfor | 2002 |
Favourable response of a virilizing adrenocortical carcinoma to preoperative treatment with ketoconazole and postoperative chemotherapy.
Topics: Adrenal Cortex Neoplasms; Adult; Aldehyde-Lyases; Androgens; Antineoplastic Combined Chemotherapy Pr | 1991 |
[Cushing's syndrome secondary to adrenal gland carcinoma controlled with ketoconazole].
Topics: Adrenal Gland Neoplasms; Aged; Carcinoma; Cushing Syndrome; Female; Humans; Ketoconazole | 1990 |
Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism.
Topics: Adenoma; Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Carc | 1990 |
Preoperative ketoconazole therapy for adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Carcinoma; Combined Modality Therapy; Drug Evaluation; Female; Humans; Ket | 1989 |
Use of ketoconazole in the treatment of a virilizing adrenocortical carcinoma.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Female; Gonadal Steroid Hormones; Hirs | 1989 |
Ketoconazole: a possible direct cytotoxic effect on prostate carcinoma cells.
Topics: Carcinoma; Cell Line; Colony-Forming Units Assay; Humans; Ketoconazole; Male; Prostatic Neoplasms; T | 1989 |
[Drug therapy of metastasizing prostate carcinoma with special reference to the bioavailability of fosfestrol after oral administration].
Topics: Administration, Oral; Aged; Androgen Antagonists; Antineoplastic Agents; Biological Availability; Bi | 1988 |
Ketoconazole therapy for hormonally refractive metastatic prostate cancer.
Topics: Aged; Aged, 80 and over; Androgens; Bone Neoplasms; Carcinoma; Combined Modality Therapy; Diethylsti | 1988 |
Inhibition of cholesterol synthesis by ketoconazole.
Topics: Aged; Carcinoma; Cholesterol; Humans; Ketoconazole; Male; Middle Aged; Prostatic Neoplasms | 1986 |