ketoconazole has been researched along with Cancer of Ovary in 8 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole has shown activity in advanced GCT in clinical and in vitro studies." | 3.30 | Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03. ( Bover, I; Cueva, J; de Castro, IP; Garcia-Casado, Z; Garcia-Donas, J; Garcia-Martinez, E; Garrigos, L; Grande, E; Guerra, E; Hurtado, A; Lainez, N; Lopez-Guerrero, JA; Navarro, P; Palacio, I; Prieto, M; Redondo, A; Rodriguez, V; Rodriguez-Moreno, JF; Rubio, MJ; Santaballa, A; Taus, A; Vidal, L, 2023) |
| "Epithelial ovarian cancer remains the most devastating gynecologic cancer with drug resistance and rapid recurrence." | 1.43 | Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells. ( Hiramatsu, Y; Masuyama, H; Nakamura, K; Nobumoto, E, 2016) |
| "The erythromycin breath test is a valuable tool for measuring instantaneous CYP3A activity in vivo." | 1.30 | Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole. ( Blake, DS; Collins, JM; Jamis-Dow, CA; Klecker, RW; Pearl, ML; Watkins, PB, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (25.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 5 (62.50) | 24.3611 |
| 2020's | 1 (12.50) | 2.80 |
| Authors | Studies |
|---|---|
| Garcia-Donas, J | 2 |
| Hurtado, A | 2 |
| Garrigos, L | 1 |
| Santaballa, A | 1 |
| Redondo, A | 1 |
| Vidal, L | 1 |
| Lainez, N | 1 |
| Guerra, E | 1 |
| Rodriguez, V | 1 |
| Cueva, J | 1 |
| Bover, I | 1 |
| Palacio, I | 1 |
| Rubio, MJ | 1 |
| Prieto, M | 1 |
| Lopez-Guerrero, JA | 2 |
| Rodriguez-Moreno, JF | 1 |
| Garcia-Casado, Z | 2 |
| Garcia-Martinez, E | 1 |
| Taus, A | 1 |
| de Castro, IP | 1 |
| Navarro, P | 1 |
| Grande, E | 2 |
| Liu, XJ | 1 |
| Lu, H | 1 |
| Sun, JX | 1 |
| Wang, SR | 1 |
| Mo, YS | 1 |
| Yang, XS | 1 |
| Shi, BK | 1 |
| Masuyama, H | 1 |
| Nakamura, K | 1 |
| Nobumoto, E | 1 |
| Hiramatsu, Y | 1 |
| Sedhom, R | 1 |
| Hu, S | 1 |
| Ohri, A | 1 |
| Infantino, D | 1 |
| Lubitz, S | 1 |
| La Rosa, S | 1 |
| Marando, A | 1 |
| Ghezzi, F | 1 |
| Colombo, P | 1 |
| Finzi, G | 1 |
| Capella, C | 1 |
| Albareda, J | 1 |
| Alemany, I | 1 |
| Camara, JC | 1 |
| Hernando, S | 1 |
| Donovan, JT | 1 |
| Otis, CN | 1 |
| Powell, JL | 1 |
| Cathcart, HK | 1 |
| Jamis-Dow, CA | 1 |
| Pearl, ML | 1 |
| Watkins, PB | 1 |
| Blake, DS | 1 |
| Klecker, RW | 1 |
| Collins, JM | 1 |
1 trial available for ketoconazole and Cancer of Ovary
| Article | Year |
|---|---|
Open-label phase II clinical trial of ketoconazole as CYP17 inhibitor in metastatic or advanced non-resectable granulosa cell ovarian tumors: the GREKO (GRanulosa Et KetOconazole) trial, GETHI 2011-03.
Topics: Enzyme Inhibitors; Female; Forkhead Transcription Factors; Granulosa Cells; Humans; Ketoconazole; Ov | 2023 |
7 other studies available for ketoconazole and Cancer of Ovary
| Article | Year |
|---|---|
Metabolic behavior prediction of pazopanib by cytochrome P450 (CYP) 3A4 by molecular docking.
Topics: Amino Acids; Antineoplastic Agents; Cytochrome P-450 CYP3A; Cytochrome P-450 Enzyme Inhibitors; Drug | 2016 |
Inhibition of pregnane X receptor pathway contributes to the cell growth inhibition and apoptosis of anticancer agents in ovarian cancer cells.
Topics: Antineoplastic Agents; ATP Binding Cassette Transporter, Subfamily B; Carcinoma, Ovarian Epithelial; | 2016 |
Symptomatic Cushing's syndrome and hyperandrogenemia in a steroid cell ovarian neoplasm: a case report.
Topics: Aged; Antineoplastic Agents, Hormonal; Cushing Syndrome; Disease Progression; Fatal Outcome; Female; | 2016 |
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case.
Topics: ACTH Syndrome, Ectopic; Adult; Carcinoma, Neuroendocrine; Cushing Syndrome; Fatal Outcome; Female; H | 2011 |
Cytochrome P17 inhibition with ketoconazole as treatment for advanced granulosa cell ovarian tumor.
Topics: 14-alpha Demethylase Inhibitors; Adult; Antineoplastic Combined Chemotherapy Protocols; Base Sequenc | 2013 |
Cushing's syndrome secondary to malignant lipoid cell tumor of the ovary.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Cushing Syndrome; Female; Humans; H | 1993 |
Predicting drug interactions in vivo from experiments in vitro. Human studies with paclitaxel and ketoconazole.
Topics: Antifungal Agents; Antineoplastic Agents, Phytogenic; Aryl Hydrocarbon Hydroxylases; Breath Tests; C | 1997 |