ketoconazole has been researched along with Brain Disorders in 11 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties: they had either failed standard therapy (Amphotericin-B + 5-Fluorocytosine) or suffered intolerable side-effects to it." | 7.68 | Ketoconazole in the treatment of cryptococcosis of the central nervous system. ( Sander, JW; Silvado, CS; Trevisol-Bittencourt, PC; Wittig, EO, 1991) |
| "Fluconazole was 5-20-fold more active than ketoconazole against systemic aspergillosis and against systemic, intracranial and pulmonary cryptococcosis but was less active than amphotericin B." | 5.27 | Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice. ( Andrews, RJ; Marriott, MS; Richardson, K; Troke, PF, 1987) |
| "A 49-year-old man with disseminated histoplasmosis (pulmonary and central nervous system involvement) successfully treated with ketoconazole and fluconazole combination is reported." | 3.70 | [Disseminated histoplasmosis caused by Histoplasma capsulatum with cerebral involvement occurring 13 years after the primary infection]. ( Astoul, P; Bérard, H; Boutin, C; Cho, K; Cuguillière, A; Frenay, C, 1999) |
| "Two patients with cryptococcosis of the CNS were treated with ketoconazole (KTZ), an imidazole derivative with fungistatic properties: they had either failed standard therapy (Amphotericin-B + 5-Fluorocytosine) or suffered intolerable side-effects to it." | 3.68 | Ketoconazole in the treatment of cryptococcosis of the central nervous system. ( Sander, JW; Silvado, CS; Trevisol-Bittencourt, PC; Wittig, EO, 1991) |
| "Fluconazole was 5-20-fold more active than ketoconazole against systemic aspergillosis and against systemic, intracranial and pulmonary cryptococcosis but was less active than amphotericin B." | 1.27 | Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice. ( Andrews, RJ; Marriott, MS; Richardson, K; Troke, PF, 1987) |
| "Rhinocerebral mucormycosis is a devastating fungal disease with a high mortality rate." | 1.27 | Rhinocerebral mucormycosis with cerebral extension successfully treated with adjunctive hyperbaric oxygen therapy. ( Couch, L; Mader, JT; Theilen, F, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 7 (63.64) | 18.7374 |
| 1990's | 4 (36.36) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bérard, H | 1 |
| Astoul, P | 1 |
| Frenay, C | 1 |
| Cuguillière, A | 1 |
| Cho, K | 1 |
| Boutin, C | 1 |
| Kloss, S | 1 |
| Schuster, A | 1 |
| Schroten, H | 1 |
| Lamprecht, J | 1 |
| Wahn, V | 1 |
| Trevisol-Bittencourt, PC | 1 |
| Sander, JW | 1 |
| Silvado, CS | 1 |
| Wittig, EO | 1 |
| Jennings, FW | 1 |
| Hunziker, UA | 1 |
| Nadal, D | 1 |
| Jendis, JB | 1 |
| Tomasik, Z | 1 |
| Wetzel, JC | 1 |
| Schüpbach, J | 1 |
| Seger, RA | 1 |
| Hanash, KA | 1 |
| Pitrak, DL | 1 |
| Andersen, BR | 1 |
| Finquelievich, JL | 1 |
| Negroni, R | 1 |
| Bava, AJ | 1 |
| Iovannitti, C | 1 |
| Troke, PF | 1 |
| Andrews, RJ | 1 |
| Marriott, MS | 1 |
| Richardson, K | 1 |
| Couch, L | 1 |
| Theilen, F | 1 |
| Mader, JT | 1 |
| Kwong, YL | 1 |
| Yu, YL | 1 |
| Chan, FL | 1 |
| Lam, KS | 1 |
| Woo, E | 1 |
| Huang, CY | 1 |
11 other studies available for ketoconazole and Brain Disorders
| Article | Year |
|---|---|
[Disseminated histoplasmosis caused by Histoplasma capsulatum with cerebral involvement occurring 13 years after the primary infection].
Topics: Antifungal Agents; Brain; Brain Diseases; Central Nervous System Fungal Infections; Fluconazole; His | 1999 |
Control of proven pulmonary and suspected CNS aspergillus infection with itraconazole in a patient with chronic granulomatous disease.
Topics: Antifungal Agents; Aspergillosis; Brain Diseases; Child; Granulomatous Disease, Chronic; Humans; Itr | 1991 |
Ketoconazole in the treatment of cryptococcosis of the central nervous system.
Topics: Aged; Brain Diseases; Cryptococcosis; Humans; Ketoconazole; Male; Middle Aged | 1991 |
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination | 1991 |
Stable human immunodeficiency virus encephalopathy in two infants receiving early intravenous gammaglobulin plus antimicrobial prophylaxis.
Topics: Acquired Immunodeficiency Syndrome; Brain Diseases; Drug Combinations; Drug Therapy, Combination; HI | 1989 |
Neurologic complications of ketoconazole therapy for advanced prostatic cancer.
Topics: Adenocarcinoma; Aged; Brain Diseases; Humans; Ketoconazole; Male; Prostatic Neoplasms; Radiography | 1989 |
Cerebral blastomycoma after ketoconazole therapy for respiratory tract blastomycosis.
Topics: Administration, Oral; Adult; Biopsy, Needle; Blastomycosis; Brain; Brain Diseases; Female; Humans; K | 1989 |
Treatment of experimental sub-acute cryptococcosis in the Wistar rat.
Topics: Amphotericin B; Animals; Antifungal Agents; Brain Diseases; Cryptococcosis; Female; Granuloma, Giant | 1988 |
Efficacy of fluconazole (UK-49,858) against experimental aspergillosis and cryptococcosis in mice.
Topics: Amphotericin B; Animals; Antifungal Agents; Aspergillosis; Aspergillus flavus; Aspergillus fumigatus | 1987 |
Rhinocerebral mucormycosis with cerebral extension successfully treated with adjunctive hyperbaric oxygen therapy.
Topics: Adult; Amphotericin B; Brain Abscess; Brain Diseases; Combined Modality Therapy; Debridement; Female | 1988 |
High dose ketoconazole in the treatment of cerebral aspergilloma.
Topics: Adult; Amphotericin B; Aspergillosis; Brain Diseases; Drug Therapy, Combination; Female; Flucytosine | 1987 |