ketoconazole has been researched along with Atrial Fibrillation in 3 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Atrial Fibrillation: Abnormal cardiac rhythm that is characterized by rapid, uncoordinated firing of electrical impulses in the upper chambers of the heart (HEART ATRIA). In such case, blood cannot be effectively pumped into the lower chambers of the heart (HEART VENTRICLES). It is caused by abnormal impulse generation.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Rivaroxaban is indicated for stroke prevention in nonvalvular atrial fibrillation (AF)." | 3.91 | Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban. ( Chan, ECY; Cheong, EJY; Chua, DXY; Teo, DWX, 2019) |
| " To evaluate drug-drug interactions, the impact of ketoconazole, a known strong inhibitor of cytochrome P450 3A4 and P-glycoprotein, was studied." | 2.90 | Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs. ( Burhenne, J; Foerster, KI; Haefeli, WE; Lehmann, ML; Mikus, G; Schaumaeker, M, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cheong, EJY | 1 |
| Teo, DWX | 1 |
| Chua, DXY | 1 |
| Chan, ECY | 1 |
| Mikus, G | 1 |
| Foerster, KI | 1 |
| Schaumaeker, M | 1 |
| Lehmann, ML | 1 |
| Burhenne, J | 1 |
| Haefeli, WE | 1 |
1 trial available for ketoconazole and Atrial Fibrillation
| Article | Year |
|---|---|
Microdosed Cocktail of Three Oral Factor Xa Inhibitors to Evaluate Drug-Drug Interactions with Potential Perpetrator Drugs.
Topics: Administration, Oral; Adolescent; Adult; Atrial Fibrillation; Case-Control Studies; Chromatography, | 2019 |
2 other studies available for ketoconazole and Atrial Fibrillation
| Article | Year |
|---|---|
Systematic Development and Verification of a Physiologically Based Pharmacokinetic Model of Rivaroxaban.
Topics: ATP Binding Cassette Transporter, Subfamily B, Member 1; Atrial Fibrillation; Computer Simulation; D | 2019 |
Dofetilide for atrial fibrillation.
Topics: Anti-Arrhythmia Agents; Anti-Infective Agents; Anti-Infective Agents, Urinary; Anti-Ulcer Agents; An | 2000 |