ketoconazole has been researched along with Arrhythmias, Cardiac in 14 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Arrhythmias, Cardiac: Any disturbances of the normal rhythmic beating of the heart or MYOCARDIAL CONTRACTION. Cardiac arrhythmias can be classified by the abnormalities in HEART RATE, disorders of electrical impulse generation, or impulse conduction.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially fatal ventricular arrhythmias." | 3.69 | Possible interactions with terfenadine or astemizole. ( Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD, 1994) |
| "To assess the steady-state pharmacokinetic and QT(c) effects of domperidone and ketoconazole, given alone and together." | 2.77 | Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study. ( Baisley, KJ; Boyce, MJ; Warrington, SJ, 2012) |
| "The risk of serious ventricular arrhythmias with terfenadine using epidemiologic data is the same or less than that associated with traditional first-generation antihistamines." | 2.67 | Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. ( Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J, 1993) |
| " In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug-drug interactions, including those involving active metabolites." | 1.48 | Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models. ( Kulig, M; Lisowski, B; Polak, S; Wiśniowska, B, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Wiśniowska, B | 2 |
| Lisowski, B | 2 |
| Kulig, M | 1 |
| Polak, S | 2 |
| Badyra, B | 1 |
| Kudolo, J | 1 |
| Mearín, F | 1 |
| Plazas, MJ | 1 |
| Mas, M | 1 |
| Heras, J | 1 |
| Boyce, MJ | 1 |
| Baisley, KJ | 1 |
| Warrington, SJ | 1 |
| Hamlin, RL | 1 |
| Kijtawornrat, A | 1 |
| Keene, BW | 1 |
| Hamlin, DM | 1 |
| Dumaine, R | 1 |
| Antzelevitch, C | 1 |
| Zechnich, AD | 1 |
| Hedges, JR | 1 |
| Eiselt-Proteau, D | 1 |
| Haxby, D | 1 |
| Honig, PK | 1 |
| Cantilena, LR | 1 |
| Morganroth, J | 1 |
| Brown, AM | 1 |
| Critz, S | 1 |
| Crumb, WJ | 1 |
| Kunze, DL | 1 |
| Lacerda, AE | 1 |
| Lopez, H | 1 |
| Sabbah, A | 1 |
| Gras, J | 1 |
| Llenas, J | 1 |
| Palacios, JM | 1 |
| Roberts, DJ | 1 |
| Chan-Tompkins, NH | 1 |
| Babinchak, TJ | 1 |
2 trials available for ketoconazole and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study.
Topics: 14-alpha Demethylase Inhibitors; Adolescent; Adult; Analysis of Variance; Area Under Curve; Arrhythm | 2012 |
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.
Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; H | 1993 |
12 other studies available for ketoconazole and Arrhythmias, Cardiac
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
Topics: Arrhythmias, Cardiac; Drug Combinations; Drug Interactions; Electrophysiology; ERG1 Potassium Channe | 2018 |
How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Dextromethorphan; Dose-Response Relationshi | 2015 |
[Cardiac safety of cinitapride].
Topics: Arrhythmias, Cardiac; Aryl Hydrocarbon Hydroxylases; Benzamides; Cisapride; Cytochrome P-450 CYP2C8; | 2010 |
QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cisapride; Consciousness; Electro | 2003 |
Disopyramide: although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome?
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Disopyramide; Drug Interaction | 2006 |
Possible interactions with terfenadine or astemizole.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescripti | 1994 |
Ketoconazole and fluconazole drug interactions.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketocon | 1994 |
[Teldane update. Interview with Dr. Alfred Sabbah, chief of the immuno-allergology laboratory of the C.H.U. d'Angers. Interview by Dr. Pierre Ceddaha].
Topics: Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Contraindications; Cytochrome P-450 Enzyme Inh | 1993 |
The role of ketoconazole in the QTc interval prolonging effects of H1-antihistamines in a guinea-pig model of arrhythmogenicity.
Topics: Animals; Antifungal Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship | 1996 |
Cardiac arrhythmias associated with coadministration of azole compounds and cisapride.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Cisapride; Drug Interactions; Humans; Ketoconazole; Piperid | 1997 |
Special drug communication teleconference. August 7, 1992.
Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Dr | 1992 |