ketoconazole has been researched along with Arrhythmia in 14 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Concurrent use of terfenadine or astemizole with erythromycin or ketoconazole can prolong the QT interval and produce potentially fatal ventricular arrhythmias." | 3.69 | Possible interactions with terfenadine or astemizole. ( Eiselt-Proteau, D; Haxby, D; Hedges, JR; Zechnich, AD, 1994) |
| "To assess the steady-state pharmacokinetic and QT(c) effects of domperidone and ketoconazole, given alone and together." | 2.77 | Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study. ( Baisley, KJ; Boyce, MJ; Warrington, SJ, 2012) |
| "The risk of serious ventricular arrhythmias with terfenadine using epidemiologic data is the same or less than that associated with traditional first-generation antihistamines." | 2.67 | Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event. ( Brown, AM; Critz, S; Crumb, WJ; Kunze, DL; Lacerda, AE; Lopez, H; Morganroth, J, 1993) |
| " In vitro assessment of the proarrhythmic potential of drugs is limited to one compound and thus neglects the potential of drug-drug interactions, including those involving active metabolites." | 1.48 | Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models. ( Kulig, M; Lisowski, B; Polak, S; Wiśniowska, B, 2018) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 4 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Jia, L | 1 |
| Sun, H | 1 |
| Wiśniowska, B | 2 |
| Lisowski, B | 2 |
| Kulig, M | 1 |
| Polak, S | 2 |
| Badyra, B | 1 |
| Kudolo, J | 1 |
| Mearín, F | 1 |
| Plazas, MJ | 1 |
| Mas, M | 1 |
| Heras, J | 1 |
| Boyce, MJ | 1 |
| Baisley, KJ | 1 |
| Warrington, SJ | 1 |
| Hamlin, RL | 1 |
| Kijtawornrat, A | 1 |
| Keene, BW | 1 |
| Hamlin, DM | 1 |
| Dumaine, R | 1 |
| Antzelevitch, C | 1 |
| Zechnich, AD | 1 |
| Hedges, JR | 1 |
| Eiselt-Proteau, D | 1 |
| Haxby, D | 1 |
| Honig, PK | 1 |
| Cantilena, LR | 1 |
| Morganroth, J | 1 |
| Brown, AM | 1 |
| Critz, S | 1 |
| Crumb, WJ | 1 |
| Kunze, DL | 1 |
| Lacerda, AE | 1 |
| Lopez, H | 1 |
| Sabbah, A | 1 |
| Gras, J | 1 |
| Llenas, J | 1 |
| Palacios, JM | 1 |
| Roberts, DJ | 1 |
| Chan-Tompkins, NH | 1 |
| Babinchak, TJ | 1 |
2 trials available for ketoconazole and Arrhythmia
| Article | Year |
|---|---|
Pharmacokinetic interaction between domperidone and ketoconazole leads to QT prolongation in healthy volunteers: a randomized, placebo-controlled, double-blind, crossover study.
Topics: 14-alpha Demethylase Inhibitors; Adolescent; Adult; Analysis of Variance; Area Under Curve; Arrhythm | 2012 |
Variability of the QTc interval: impact on defining drug effect and low-frequency cardiac event.
Topics: Adult; Animals; Arrhythmias, Cardiac; Double-Blind Method; Drug Interactions; Electrocardiography; H | 1993 |
12 other studies available for ketoconazole and Arrhythmia
| Article | Year |
|---|---|
Support vector machines classification of hERG liabilities based on atom types.
Topics: Animals; Arrhythmias, Cardiac; CHO Cells; Computer Simulation; Cricetinae; Cricetulus; Discriminant | 2008 |
Drug interaction at hERG channel: In vitro assessment of the electrophysiological consequences of drug combinations and comparison against theoretical models.
Topics: Arrhythmias, Cardiac; Drug Combinations; Drug Interactions; Electrophysiology; ERG1 Potassium Channe | 2018 |
How in vitro influences in silico utilized for the prediction of in vivo - pilot study of the drug-induced pro-arrhythmic potency prediction.
Topics: Animals; Arrhythmias, Cardiac; Calcium Channel Blockers; Dextromethorphan; Dose-Response Relationshi | 2015 |
[Cardiac safety of cinitapride].
Topics: Arrhythmias, Cardiac; Aryl Hydrocarbon Hydroxylases; Benzamides; Cisapride; Cytochrome P-450 CYP2C8; | 2010 |
QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles.
Topics: Anesthesia; Animals; Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Cisapride; Consciousness; Electro | 2003 |
Disopyramide: although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome?
Topics: Anti-Arrhythmia Agents; Arrhythmias, Cardiac; Death, Sudden, Cardiac; Disopyramide; Drug Interaction | 2006 |
Possible interactions with terfenadine or astemizole.
Topics: Adolescent; Adult; Aged; Arrhythmias, Cardiac; Astemizole; Child; Drug Interactions; Drug Prescripti | 1994 |
Ketoconazole and fluconazole drug interactions.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Astemizole; Drug Interactions; Fluconazole; Humans; Ketocon | 1994 |
[Teldane update. Interview with Dr. Alfred Sabbah, chief of the immuno-allergology laboratory of the C.H.U. d'Angers. Interview by Dr. Pierre Ceddaha].
Topics: Adult; Arrhythmias, Cardiac; Child; Child, Preschool; Contraindications; Cytochrome P-450 Enzyme Inh | 1993 |
The role of ketoconazole in the QTc interval prolonging effects of H1-antihistamines in a guinea-pig model of arrhythmogenicity.
Topics: Animals; Antifungal Agents; Arrhythmias, Cardiac; Disease Models, Animal; Dose-Response Relationship | 1996 |
Cardiac arrhythmias associated with coadministration of azole compounds and cisapride.
Topics: Antifungal Agents; Arrhythmias, Cardiac; Cisapride; Drug Interactions; Humans; Ketoconazole; Piperid | 1997 |
Special drug communication teleconference. August 7, 1992.
Topics: Anti-Bacterial Agents; Arrhythmias, Cardiac; Astemizole; Contraindications; Drug Incompatibility; Dr | 1992 |