Page last updated: 2024-10-29

ketoconazole and Alopecia

ketoconazole has been researched along with Alopecia in 18 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Alopecia: Absence of hair from areas where it is normally present.

Research Excerpts

ExcerptRelevanceReference
"The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia."9.08Ketoconazole shampoo: effect of long-term use in androgenic alopecia. ( Cauwenbergh, G; De Doncker, P; Piérard, GE; Piérard-Franchimont, C, 1998)
"Ketoconazole has been clinically shown to be effective in the treatment of AGA."5.32Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men. ( Hugo Perez, BS, 2004)
"The aim of our study was to determine if ketoconazole (KCZ) which is active against the scalp microflora and shows some intrinsic anti-inflammatory activity might improve alopecia."5.08Ketoconazole shampoo: effect of long-term use in androgenic alopecia. ( Cauwenbergh, G; De Doncker, P; Piérard, GE; Piérard-Franchimont, C, 1998)
"Ciclosporin treatment, in combination with ketoconazole, can be effective for treatment of alopecia universalis in the dog."3.83Alopecia universalis in a dog with testicular neoplasia. ( Affolter, VK; Outerbridge, CA; White, SD, 2016)
"The scheme of hair loss treatment, by means of preparations affecting pathogenetical mechanisms of diffuse hair loss development is offered."2.73[Effectiveness of the treatment plan for androgenetic alopecia]. ( Tsiskarishvili, NV; Tsiskarishvili, TsI, 2007)
"Our understanding of the aetiology of androgenetic alopecia (AGA) has substantially increased in recent years."2.70Comparative efficacy of various treatment regimens for androgenetic alopecia in men. ( Khandpur, S; Reddy, BS; Suman, M, 2002)
"Female pattern hair loss, or female pattern androgenetic alopecia, is a nonscarring alopecia with a multi-factorial etiology that mostly affects postmenopausal women and is characterized by a reduction in hair density over the crown and frontal scalp."2.52Female pattern hair loss. ( Ioannides, D; Lazaridou, E, 2015)
"Female pattern hair loss (FPHL) is the most common cause of alopecia in women."2.49Hair: what is new in diagnosis and management? Female pattern hair loss update: diagnosis and treatment. ( Atanaskova Mesinkovska, N; Bergfeld, WF, 2013)
"Male and female pattern hair loss affects a large percentage of the population, and patients frequently present for treatment of this to their dermatologist."2.44Medical treatments for male and female pattern hair loss. ( Avram, MR; Rogers, NE, 2008)
"Pharmacologic management of pattern hair loss is an active area of research, and clinicians should be aware of new data and treatment modalities."2.42Pharmacologic management of pattern hair loss. ( Haber, RS, 2004)
"Tinea capitis is a fungal infection of the scalp and hair shaft that mainly affects prepubescent children."1.34Tinea capitis: no incision nor excision. ( Baudraz-Rosselet, F; de Buys Roessingh, AS; Dushi, G; Hohlfeld, J; Laffitte, E; von Laer Tschudin, L, 2007)
"Ketoconazole (KCZ) is an imidazole anti-fungal agent that is also effective in topical applications for treating seborrheic dermatitis and dandruff."1.33Topical application of ketoconazole stimulates hair growth in C3H/HeN mice. ( Jiang, J; Kojima, Y; Ogawa, H; Tsuboi, R, 2005)
"Ketoconazole has been clinically shown to be effective in the treatment of AGA."1.32Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men. ( Hugo Perez, BS, 2004)

Research

Studies (18)

TimeframeStudies, this research(%)All Research%
pre-19901 (5.56)18.7374
1990's2 (11.11)18.2507
2000's9 (50.00)29.6817
2010's5 (27.78)24.3611
2020's1 (5.56)2.80

Authors

AuthorsStudies
Fields, JR1
Vonu, PM1
Monir, RL1
Schoch, JJ1
Choi, FD1
Juhasz, MLW1
Atanaskova Mesinkovska, N2
Piraccini, BM1
Alessandrini, A1
Ioannides, D1
Lazaridou, E1
Outerbridge, CA1
White, SD1
Affolter, VK1
Rogers, NE1
Avram, MR1
Bergfeld, WF1
Prigent, F1
Khandpur, S1
Suman, M1
Reddy, BS1
Hugo Perez, BS1
Haber, RS1
Jiang, J1
Tsuboi, R1
Kojima, Y1
Ogawa, H1
Tsiskarishvili, NV1
Tsiskarishvili, TsI1
von Laer Tschudin, L1
Laffitte, E1
Baudraz-Rosselet, F1
Dushi, G1
Hohlfeld, J1
de Buys Roessingh, AS1
Polsen, JA1
Cohen, PR1
Sella, A1
Piérard-Franchimont, C1
De Doncker, P1
Cauwenbergh, G1
Piérard, GE1
Brodell, RT1
Vescera, G1
Boudghene-Stambouli, O1
Merad-Boudia, A1
Bouali, O1

Clinical Trials (1)

Trial Overview

TrialPhaseEnrollmentStudy TypeStart DateStatus
Evaluating PAI-1 Expression in the Hair Follicles of Patients With Non-scarring Hair Loss.[NCT02548689]10 participants (Actual)Observational2015-07-31Terminated (stopped due to Original lead investigator left Northwestern University)
[information is prepared from clinicaltrials.gov, extracted Sep-2024]

Reviews

7 reviews available for ketoconazole and Alopecia

ArticleYear
Topical ketoconazole for the treatment of androgenetic alopecia: A systematic review.
    Dermatologic therapy, 2020, Volume: 33, Issue:1

    Topics: Administration, Topical; Alopecia; Animals; Hair; Humans; Ketoconazole; Mice; Treatment Outcome

2020
Topical ketoconazole: a systematic review of current dermatological applications and future developments.
    The Journal of dermatological treatment, 2019, Volume: 30, Issue:8

    Topics: Administration, Topical; Alopecia; Antifungal Agents; Dermatitis, Seborrheic; Humans; Ketoconazole;

2019
Androgenetic alopecia.
    Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia, 2014, Volume: 149, Issue:1

    Topics: 5-alpha Reductase Inhibitors; Alopecia; Androgen Antagonists; Biopsy; Comorbidity; Contraindications

2014
Female pattern hair loss.
    Current problems in dermatology, 2015, Volume: 47

    Topics: 5-alpha Reductase Inhibitors; Administration, Cutaneous; Alopecia; Androgen Antagonists; Androgen Re

2015
Medical treatments for male and female pattern hair loss.
    Journal of the American Academy of Dermatology, 2008, Volume: 59, Issue:4

    Topics: Adult; Alopecia; Androgen Antagonists; Azasteroids; Drug Therapy, Combination; Dutasteride; Female;

2008
Hair: what is new in diagnosis and management? Female pattern hair loss update: diagnosis and treatment.
    Dermatologic clinics, 2013, Volume: 31, Issue:1

    Topics: 14-alpha Demethylase Inhibitors; Alopecia; Androgen Antagonists; Female; Hair; Humans; Ketoconazole;

2013
Pharmacologic management of pattern hair loss.
    Facial plastic surgery clinics of North America, 2004, Volume: 12, Issue:2

    Topics: Administration, Topical; Alopecia; Androgen Antagonists; Dose-Response Relationship, Drug; Drug Admi

2004

Trials

4 trials available for ketoconazole and Alopecia

ArticleYear
Comparative efficacy of various treatment regimens for androgenetic alopecia in men.
    The Journal of dermatology, 2002, Volume: 29, Issue:8

    Topics: 5-alpha Reductase Inhibitors; Administration, Oral; Administration, Topical; Adolescent; Adult; Alop

2002
[Effectiveness of the treatment plan for androgenetic alopecia].
    Georgian medical news, 2007, Issue:145

    Topics: Adolescent; Adult; Alopecia; Antifungal Agents; Chronic Disease; Enzyme Inhibitors; Female; Finaster

2007
Acquired cutaneous adherence in patients with androgen-independent prostate cancer receiving ketoconazole and doxorubicin: medication-induced sticky skin.
    Journal of the American Academy of Dermatology, 1995, Volume: 32, Issue:4

    Topics: Adhesiveness; Aged; Alopecia; Antineoplastic Combined Chemotherapy Protocols; Carcinoembryonic Antig

1995
Ketoconazole shampoo: effect of long-term use in androgenic alopecia.
    Dermatology (Basel, Switzerland), 1998, Volume: 196, Issue:4

    Topics: Adult; Alopecia; Analysis of Variance; Antifungal Agents; Drug Therapy, Combination; Hair; Hair Prep

1998

Other Studies

7 other studies available for ketoconazole and Alopecia

ArticleYear
Alopecia universalis in a dog with testicular neoplasia.
    Veterinary dermatology, 2016, Volume: 27, Issue:6

    Topics: 14-alpha Demethylase Inhibitors; Alopecia; Animals; Cyclosporine; Dermatologic Agents; Dog Diseases;

2016
[Tinea].
    Archives de pediatrie : organe officiel de la Societe francaise de pediatrie, 2002, Volume: 9, Issue:7

    Topics: Adolescent; Age Factors; Alopecia; Antifungal Agents; Child; Ciclopirox; Griseofulvin; Humans; Ketoc

2002
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men.
    Medical hypotheses, 2004, Volume: 62, Issue:1

    Topics: Administration, Oral; Administration, Topical; Alopecia; Antifungal Agents; Chemotherapy, Adjuvant;

2004
Topical application of ketoconazole stimulates hair growth in C3H/HeN mice.
    The Journal of dermatology, 2005, Volume: 32, Issue:4

    Topics: Administration, Cutaneous; Alopecia; Animals; Antifungal Agents; Disease Models, Animal; Drug Admini

2005
Tinea capitis: no incision nor excision.
    Journal of pediatric surgery, 2007, Volume: 42, Issue:8

    Topics: Administration, Oral; Administration, Topical; Alopecia; Antifungal Agents; Arthrodermataceae; Child

2007
Black-dot tinea capitis. Patchy hair loss is common in pediatric patients.
    Postgraduate medicine, 2002, Volume: 111, Issue:4

    Topics: Alopecia; Antifungal Agents; Child, Preschool; Griseofulvin; Humans; Ketoconazole; Male; Tinea Capit

2002
[Dermatophytosis caused by Trichophyton violaceum. Apropos of a new case].
    Annales de dermatologie et de venereologie, 1988, Volume: 115, Issue:9

    Topics: Adult; Alopecia; Humans; Ketoconazole; Lymphatic Diseases; Male; Tinea; Trichophyton

1988