ketoconazole has been researched along with Adrenal Hyperplasia, Congenital in 4 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Adrenal Hyperplasia, Congenital: A group of inherited disorders of the ADRENAL GLANDS, caused by enzyme defects in the synthesis of cortisol (HYDROCORTISONE) and/or ALDOSTERONE leading to accumulation of precursors for ANDROGENS. Depending on the hormone imbalance, congenital adrenal hyperplasia can be classified as salt-wasting, hypertensive, virilizing, or feminizing. Defects in STEROID 21-HYDROXYLASE; STEROID 11-BETA-HYDROXYLASE; STEROID 17-ALPHA-HYDROXYLASE; 3-beta-hydroxysteroid dehydrogenase (3-HYDROXYSTEROID DEHYDROGENASES); TESTOSTERONE 5-ALPHA-REDUCTASE; or steroidogenic acute regulatory protein; among others, underlie these disorders.
| Excerpt | Relevance | Reference |
|---|---|---|
| "These findings suggest that late onset CAH can contribute to anxiety disorders and that adrenal suppressive therapy or inhibition of steroidogenesis with ketoconazole may be efficacious as adjuvant therapy." | 3.70 | Late-onset congenital adrenal hyperplasia: a treatable cause of anxiety. ( Coleman, AE; Edelheit, PB; Herzog, AG; Jacobs, AR, 1999) |
| "Abiraterone has been described as a lyase selective inhibitor, yet its use still requires co-administration of prednisone to suppress such a rise of ACTH and fall in cortisol." | 2.53 | The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature. ( Abbott, DH; Bird, IM, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 1 (25.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 1 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Melau, C | 1 |
| Nielsen, JE | 1 |
| Perlman, S | 1 |
| Lundvall, L | 1 |
| Langhoff Thuesen, L | 1 |
| Juul Hare, K | 1 |
| Schou Hammerum, M | 1 |
| Frederiksen, H | 1 |
| Mitchell, RT | 1 |
| Juul, A | 1 |
| Jørgensen, A | 1 |
| Bird, IM | 1 |
| Abbott, DH | 1 |
| Jacobs, AR | 2 |
| Edelheit, PB | 2 |
| Coleman, AE | 1 |
| Herzog, AG | 2 |
1 review available for ketoconazole and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
The hunt for a selective 17,20 lyase inhibitor; learning lessons from nature.
Topics: Adrenal Hyperplasia, Congenital; Androstadienes; Androstenes; Antineoplastic Agents; Benzimidazoles; | 2016 |
3 other studies available for ketoconazole and Adrenal Hyperplasia, Congenital
| Article | Year |
|---|---|
Establishment of a Novel Human Fetal Adrenal Culture Model that Supports de Novo and Manipulated Steroidogenesis.
Topics: Adrenal Glands; Adrenal Hyperplasia, Congenital; Adrenocorticotropic Hormone; Androgens; Cell Surviv | 2021 |
Late-onset congenital adrenal hyperplasia: a treatable cause of anxiety.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Antifungal Agents; Anxiety Disorders; Dehydroepi | 1999 |
Low salivary cortisol levels and aggressive behavior.
Topics: Adolescent; Adrenal Hyperplasia, Congenital; Adult; Aggression; Dose-Response Relationship, Drug; Dr | 2001 |