ketoconazole has been researched along with Adrenal Cortex Neoplasms in 24 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Adrenal Cortex Neoplasms: Tumors or cancers of the ADRENAL CORTEX.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)." | 9.06 | Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 7.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "Mild Cushing's syndrome was diagnosed in a 35 year old woman." | 5.27 | Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986) |
| "The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)." | 5.06 | Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 3.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "Cushing's syndrome is a complex endocrine condition with potential serious complications if untreated or inadequately treated." | 2.45 | Drugs in the medical treatment of Cushing's syndrome. ( Schteingart, DE, 2009) |
| "Unfortunately the patient died of respiratory failure due to metastasis." | 1.37 | [Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma]. ( Montes-Mollón, MÁ; Paz Moreno-Arrones, J, 2011) |
| "Aminoglutethimide was examined only for effects on CYP11A activity and was shown to inhibit pregnenolone formation (20 microM: 61 +/- 4% of control)." | 1.31 | Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. ( Johansson, MK; Lund, BO; Sanderson, JT, 2002) |
| " Twenty dogs with hyperadrenocorticism (11 with PDH, 9 with adrenocortical tumor) were treated with ketoconazole at a dosage of 15 mg/kg given every 12 hours for a half month to 12 months." | 1.28 | Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism. ( Bruyette, DS; Farver, TB; Feldman, EC; Nelson, RW, 1990) |
| "Mild Cushing's syndrome was diagnosed in a 35 year old woman." | 1.27 | Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (25.00) | 18.7374 |
| 1990's | 11 (45.83) | 18.2507 |
| 2000's | 4 (16.67) | 29.6817 |
| 2010's | 3 (12.50) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Delivanis, DA | 1 |
| Athimulam, S | 1 |
| Bancos, I | 1 |
| Schteingart, DE | 1 |
| Paz Moreno-Arrones, J | 1 |
| Montes-Mollón, MÁ | 1 |
| Dutta, D | 1 |
| Jain, R | 1 |
| Maisnam, I | 1 |
| Mishra, PK | 1 |
| Ghosh, S | 1 |
| Mukhopadhyay, S | 1 |
| Chowdhury, S | 1 |
| Carmona-Bayonas, A | 1 |
| Soler, IO | 1 |
| Gómez, FI | 1 |
| Billalabeitia, EG | 1 |
| Saura, HP | 1 |
| Tafalla, MS | 1 |
| Díaz, MP | 1 |
| Kowal, J | 1 |
| Miller, JW | 1 |
| Crapo, L | 1 |
| Rosenthal, KL | 1 |
| Quesenberry, KE | 1 |
| Peterson, ME | 2 |
| Archambeaud-Mouveroux, F | 1 |
| Miossec, P | 1 |
| Teissier, MP | 1 |
| Vieira, JC | 1 |
| Descottes, B | 1 |
| Höfle, G | 1 |
| Gasser, RW | 1 |
| Lhotta, K | 1 |
| Janetschek, G | 1 |
| Kreczy, A | 1 |
| Finkenstedt, G | 1 |
| Behrend, EN | 1 |
| Kemppainen, RJ | 1 |
| Clark, TP | 1 |
| Salman, MD | 1 |
| Neto, LS | 1 |
| Filho, AG | 1 |
| Bustorff-Silva, JM | 1 |
| Köler, H | 1 |
| Epelman, S | 1 |
| Marini, SH | 1 |
| Júnior, GG | 1 |
| Johansson, MK | 1 |
| Sanderson, JT | 1 |
| Lund, BO | 1 |
| Harinarayan, CV | 1 |
| Gupta, S | 1 |
| Ammini, AC | 1 |
| Karmarkar, MG | 1 |
| Gupta, R | 1 |
| Sharma, LK | 1 |
| Ahuja, MM | 1 |
| Kruimel, JW | 1 |
| Smals, AG | 1 |
| Beex, LV | 1 |
| Swinkels, LM | 1 |
| Pieters, GF | 1 |
| Kloppenborg, PW | 1 |
| Nichols, R | 1 |
| Saadi, HF | 1 |
| Bravo, EL | 1 |
| Aron, DC | 1 |
| Amado, JA | 1 |
| Pesquera, C | 1 |
| Gonzalez, EM | 1 |
| Otero, M | 1 |
| Freijanes, J | 1 |
| Alvarez, A | 1 |
| Feldman, EC | 1 |
| Bruyette, DS | 1 |
| Nelson, RW | 1 |
| Farver, TB | 1 |
| Engelhardt, D | 1 |
| Jacob, K | 1 |
| Doerr, HG | 1 |
| Sinnaeve, LJ | 1 |
| Becks, GP | 1 |
| Verhelst, JA | 1 |
| Druwé, P | 1 |
| van Erps, P | 1 |
| Denis, LJ | 1 |
| Mahler, C | 1 |
| Feve, B | 1 |
| Bauduceau, B | 1 |
| Lefebvre, H | 1 |
| Garcin, JM | 1 |
| Gautier, D | 1 |
| Oelkers, W | 1 |
| Bähr, V | 1 |
| Hensen, J | 1 |
| Pickartz, H | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open-label Study of the Efficacy and Safety of CORLUX (Mifepristone) in the Treatment of the Signs and Symptoms of Endogenous Cushing's Syndrome[NCT00569582] | Phase 3 | 50 participants (Actual) | Interventional | 2007-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Responder is defined as subject with a decrease greater than or equal to 5mm Hg in diastolic blood pressure from baseline to week 24 or last visit. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 8 |
Responder is defined as subject with a decrease greater than or equal to 25% in area under the curve for glucose on 2-hour oral glucose test from baseline to week 24 or last visit, for Cushing's patients with type-2 diabetes mellitus/impaired glucose tolerance. (NCT00569582)
Timeframe: Baseline to Week 24
| Intervention | participants (Number) |
|---|---|
| Mifepristone | 15 |
3 reviews available for ketoconazole and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Drugs in the medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Antiparkinson Agents; Cabergoline; Cushing Sy | 2009 |
The medical treatment of Cushing's syndrome.
Topics: Adrenal Cortex Neoplasms; Adrenal Glands; Aminoglutethimide; Animals; Bromocriptine; Cushing Syndrom | 1993 |
Problems associated with medical therapy of canine hyperadrenocorticism.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Cushing Syndrome; Diabetes Mellitus | 1990 |
1 trial available for ketoconazole and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Cushi | 1989 |
20 other studies available for ketoconazole and Adrenal Cortex Neoplasms
| Article | Year |
|---|---|
Modern Management of Mild Autonomous Cortisol Secretion.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenal Insufficiency; Adrenalectomy; Adr | 2019 |
[Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma].
Topics: Adenocarcinoma; Adrenal Cortex Neoplasms; Adrenalectomy; Aged; Antineoplastic Combined Chemotherapy | 2011 |
Isolated Cushing's syndrome in early infancy due to left adrenal adenoma: an unusual aetiology.
Topics: 14-alpha Demethylase Inhibitors; Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Ad | 2012 |
Tailored hormonal therapy in secretory adrenocortical cancer.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Carcinoma; Aged; Aldosterone; Alkalosis; Ang | 2007 |
The effect of ketoconazole on steroidogenesis in cultured mouse adrenal cortex tumor cells.
Topics: Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Animals; Antifungal Agents; Cells, Cultured; | 1983 |
Questions about assays used for estradiol 1-17 beta.
Topics: Adrenal Cortex Neoplasms; Animals; Estradiol; Female; Ferrets; Ketoconazole; Male; Radioimmunoassay; | 1994 |
[Malignant adrenocortical carcinoma and ketoconazole].
Topics: Adrenal Cortex Neoplasms; Adult; Female; Humans; Ketoconazole | 1993 |
Adrenocortical carcinoma evolving after diagnosis of preclinical Cushing's syndrome in an adrenal incidentaloma. A case report.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adult; Androgens; Antineoplastic Combined Chemotherapy Prot | 1998 |
Treatment of hyperadrenocorticism in dogs: a survey of internists and dermatologists.
Topics: Adrenal Cortex Neoplasms; Adrenalectomy; Adrenocortical Hyperfunction; Adrenocorticotropic Hormone; | 1999 |
Pre-operative control of arterial hypertension using ketoconazole in pediatric patients with adrenocortical tumors.
Topics: Adrenal Cortex Neoplasms; Child, Preschool; Humans; Hypertension; Infant; Ketoconazole; Male; Preope | 2000 |
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line.
Topics: Adrenal Cortex Neoplasms; Aminoglutethimide; Carcinoma; Chromatography, High Pressure Liquid; Colfor | 2002 |
Clinical utility of ketoconazole in cases of adrenocortical carcinoma.
Topics: Adolescent; Adrenal Cortex Neoplasms; Adult; Child; Female; Humans; Ketoconazole; Male | 1991 |
Favourable response of a virilizing adrenocortical carcinoma to preoperative treatment with ketoconazole and postoperative chemotherapy.
Topics: Adrenal Cortex Neoplasms; Adult; Aldehyde-Lyases; Androgens; Antineoplastic Combined Chemotherapy Pr | 1991 |
Feminizing adrenocortical tumor: steroid hormone response to ketoconazole.
Topics: 17-Ketosteroids; Adrenal Cortex Neoplasms; Aldosterone; Androgen-Insensitivity Syndrome; Corticoster | 1990 |
Successful treatment with ketoconazole of Cushing's syndrome in pregnancy.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; | 1990 |
Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism.
Topics: Adenoma; Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Carc | 1990 |
Preoperative ketoconazole therapy for adrenocortical carcinoma.
Topics: Adrenal Cortex Neoplasms; Carcinoma; Combined Modality Therapy; Drug Evaluation; Female; Humans; Ket | 1989 |
Use of ketoconazole in the treatment of a virilizing adrenocortical carcinoma.
Topics: Adrenal Cortex Hormones; Adrenal Cortex Neoplasms; Carcinoma; Female; Gonadal Steroid Hormones; Hirs | 1989 |
[Ketoconazole therapy of Cushing's syndrome caused by adrenal polyadenomatosis].
Topics: Adenoma; Adrenal Cortex Neoplasms; Cushing Syndrome; Humans; Ketoconazole; Male; Middle Aged | 1988 |
Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Captopril; Cushing Syndrome | 1986 |