ketoconazole has been researched along with Adenoma, Basal Cell in 32 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)." | 9.06 | Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989) |
| " An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment." | 7.78 | Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 7.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 7.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| "Mild Cushing's syndrome was diagnosed in a 35 year old woman." | 5.27 | Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986) |
| "The property of ketoconazole to inhibit adrenal biosynthesis of cortisol was used in a clinical study of 14 patients with Cushing's syndrome (pituitary-dependent Cushing's disease, n = 10; adrenocortical adenoma, n = 2; adrenocortical carcinoma, n = 1; ectopic ACTH syndrome, n = 1)." | 5.06 | Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome. ( Doerr, HG; Engelhardt, D; Jacob, K, 1989) |
| " An extremely ill patient with Cushing's syndrome caused by adrenocorticotropic hormone producing pituitary macro adenoma responded dramatically to ketoconazole and cabergoline treatment." | 3.78 | Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings. ( Ahmed, A; Furqan, S; Islam, N, 2012) |
| "To evaluate the efficacy of fluconazole as an alternative treatment for controlling hypercortisolism in Cushing's syndrome and to determine its effect on glucocorticoid production in vitro." | 3.73 | Long term control of hypercortisolism with fluconazole: case report and in vitro studies. ( Luger, A; Maier, C; Nowotny, P; Riedl, M; Schima, W; Zettinig, G, 2006) |
| " We report a patient with Cushing's syndrome due to adrenocortical adenoma who became pregnant and was successfully treated with ketoconazole during the last period of pregnancy." | 3.68 | Successful treatment with ketoconazole of Cushing's syndrome in pregnancy. ( Alvarez, A; Amado, JA; Freijanes, J; Gonzalez, EM; Otero, M; Pesquera, C, 1990) |
| "The direct effects of ketoconazole on the secretion of ACTH by human pituitary adenoma cells from 2 patient with Nelson's syndrome were studied in vitro." | 3.67 | In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome. ( Astorga, R; Bernal, G; Garcia, J; Garcia-Luna, PP; Jimenez Reina, L; Leal-Cerro, A, 1989) |
| "Ketoconazole has been used as a palliative treatment of Cushing's syndrome, due to its ability to lower cortisol production." | 3.67 | ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies. ( Boscaro, M; Mantero, F; Menegus, AM; Rampazzo, A; Sonino, N, 1987) |
| "Modes of inhibition and binding of ketoconazole, an orally antimycotic agent, to NADPH-cytochrome P-450 dependent enzymes were investigated using subcellular fractions of human and rat testes, human adrenocortical adenoma tissue and rat adrenals and livers." | 3.67 | Ketoconazole as a possible universal inhibitor of cytochrome P-450 dependent enzymes: its mode of inhibition. ( Higashi, Y; Inano, H; Omura, M; Oshima, H; Suzuki, K, 1987) |
| "The effect of clinical treatment of hypercortisolism with ketoconazole on ACTH secretion in CD is controversial." | 2.75 | Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). ( Correa-Silva, SR; Lengyel, AM; Molica, P; Nascif, SO; Sá, LB; Vieira, JG, 2010) |
| "Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia." | 2.72 | Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021) |
| "ketoconazole (n = 20) in dogs with Cushing's disease was assigned for a period of 180 d." | 2.72 | Retinoic acid as a novel medical therapy for Cushing's disease in dogs. ( Arzt, E; Castillo, V; Giacomini, D; Grossman, AB; Holsboer, F; Labeur, M; Páez-Pereda, M; Stalla, GK; Stalla, J; Theodoropoulou, M, 2006) |
| "Hypercortisolism induced by Cushing disease causes high morbidity and mortality." | 2.48 | New prospects for drug treatment in Cushing disease. ( Barahona Constanzo, MJ; del Pozo Picó, C, 2012) |
| "To our knowledge, histoplasmosis has not been previously reported in Cushing's disease, and has rarely been reported in patients with exogenous glucocorticoid use." | 2.44 | Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review. ( Jordan, RM; Kosseifi, SG; Nassour, DN; Peiris, AN; Sarubbi, FA; Shaikh, MA, 2007) |
| "The evaluation of β-arrestin mRNA in corticotroph adenomas from CD patients with variable disease activity showed a significant positive correlation between β-arrestin 1 mRNA and urinary cortisol levels." | 1.56 | β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids. ( Arvigo, M; Bruzzone, E; Dogan, F; Feelders, RA; Ferone, D; Gatto, F; Hofland, L; Lamberts, S; van der Pas, R; van Koetsveld, P, 2020) |
| "BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome." | 1.46 | BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017) |
| "The hypercortisolism is a rare endocrine disease characterized by an autonomous steroid secretion or excessive adrenal stimulation by ACTH." | 1.43 | [Indications and future perspectives in the pharmacological treatment of hypercortisolism]. ( Stigliano, A; Toscano, V, 2016) |
| "Since Cushing's disease due to large pituitary tumors is rare, we evaluated biochemical characteristics at entry and the results of first surgical approach and of adjuvant therapeutic strategies during a long-term follow-up period." | 1.32 | Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas. ( Almoto, B; Ambrosi, B; Cannavò, S; Corsello, S; Dall'Asta, C; De Menis, E; Lovicu, RM; Trimarchi, F, 2003) |
| "Treatment with ketoconazole normalized urinary free cortisol (UFC) from 433." | 1.32 | Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk. ( Bruno, OD; Díaz, AG; Gómez, RM; Pignatta, AB, 2004) |
| " Twenty dogs with hyperadrenocorticism (11 with PDH, 9 with adrenocortical tumor) were treated with ketoconazole at a dosage of 15 mg/kg given every 12 hours for a half month to 12 months." | 1.28 | Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism. ( Bruyette, DS; Farver, TB; Feldman, EC; Nelson, RW, 1990) |
| "Mild Cushing's syndrome was diagnosed in a 35 year old woman." | 1.27 | Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells. ( Bähr, V; Hensen, J; Oelkers, W; Pickartz, H, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (25.00) | 18.7374 |
| 1990's | 6 (18.75) | 18.2507 |
| 2000's | 6 (18.75) | 29.6817 |
| 2010's | 9 (28.13) | 24.3611 |
| 2020's | 3 (9.38) | 2.80 |
| Authors | Studies |
|---|---|
| Gatto, F | 1 |
| Feelders, RA | 1 |
| van der Pas, R | 1 |
| van Koetsveld, P | 1 |
| Bruzzone, E | 1 |
| Arvigo, M | 1 |
| Dogan, F | 1 |
| Lamberts, S | 1 |
| Ferone, D | 1 |
| Hofland, L | 1 |
| Newell-Price, J | 1 |
| Nieman, LK | 1 |
| Reincke, M | 1 |
| Tabarin, A | 2 |
| Yamamoto, M | 1 |
| Nakao, T | 1 |
| Ogawa, W | 1 |
| Fukuoka, H | 1 |
| Espinosa-de-Los-Monteros, AL | 1 |
| Sosa-Eroza, E | 1 |
| Espinosa, E | 1 |
| Mendoza, V | 1 |
| Arreola, R | 1 |
| Mercado, M | 1 |
| Geer, EB | 1 |
| Shafiq, I | 1 |
| Gordon, MB | 1 |
| Bonert, V | 1 |
| Ayala, A | 1 |
| Swerdloff, RS | 1 |
| Katznelson, L | 1 |
| Lalazar, Y | 1 |
| Manuylova, E | 1 |
| Pulaski-Liebert, KJ | 1 |
| Carmichael, JD | 1 |
| Hannoush, Z | 1 |
| Surampudi, V | 1 |
| Broder, MS | 2 |
| Cherepanov, D | 2 |
| Eagan, M | 1 |
| Lee, J | 1 |
| Said, Q | 1 |
| Neary, MP | 2 |
| Biller, BMK | 1 |
| Seow, CJ | 1 |
| Young, WF | 1 |
| Chang, E | 1 |
| Sun, GH | 1 |
| Ludlam, WH | 1 |
| Stigliano, A | 1 |
| Toscano, V | 1 |
| Correa-Silva, SR | 1 |
| Nascif, SO | 1 |
| Molica, P | 1 |
| Sá, LB | 1 |
| Vieira, JG | 1 |
| Lengyel, AM | 1 |
| Ahmed, A | 1 |
| Furqan, S | 1 |
| Islam, N | 1 |
| Barna, M | 1 |
| Wilson, K | 1 |
| Chiaruttini, R | 1 |
| Muchowski, K | 1 |
| Barahona Constanzo, MJ | 1 |
| del Pozo Picó, C | 1 |
| Cannavò, S | 1 |
| Almoto, B | 1 |
| Dall'Asta, C | 1 |
| Corsello, S | 1 |
| Lovicu, RM | 1 |
| De Menis, E | 1 |
| Trimarchi, F | 1 |
| Ambrosi, B | 1 |
| Pignatta, AB | 1 |
| Díaz, AG | 1 |
| Gómez, RM | 1 |
| Bruno, OD | 1 |
| Riedl, M | 1 |
| Maier, C | 1 |
| Zettinig, G | 1 |
| Nowotny, P | 1 |
| Schima, W | 1 |
| Luger, A | 1 |
| Castillo, V | 1 |
| Giacomini, D | 1 |
| Páez-Pereda, M | 1 |
| Stalla, J | 1 |
| Labeur, M | 1 |
| Theodoropoulou, M | 1 |
| Holsboer, F | 1 |
| Grossman, AB | 1 |
| Stalla, GK | 1 |
| Arzt, E | 1 |
| Kosseifi, SG | 1 |
| Nassour, DN | 1 |
| Shaikh, MA | 1 |
| Sarubbi, FA | 1 |
| Jordan, RM | 1 |
| Peiris, AN | 1 |
| Engelhardt, D | 2 |
| Mann, K | 1 |
| Hörmann, R | 1 |
| Braun, S | 1 |
| Karl, HJ | 1 |
| Kintzer, PP | 1 |
| Peterson, ME | 1 |
| Luisetto, G | 1 |
| Zangari, M | 1 |
| Camozzi, V | 1 |
| Boscaro, M | 2 |
| Sonino, N | 2 |
| Fallo, F | 1 |
| Kong, HL | 1 |
| Lee, KO | 1 |
| Cheah, JS | 1 |
| Gilles, C | 1 |
| Navarranne, A | 1 |
| Parneix, M | 1 |
| Roger, P | 1 |
| Amado, JA | 1 |
| Pesquera, C | 1 |
| Gonzalez, EM | 1 |
| Otero, M | 1 |
| Freijanes, J | 1 |
| Alvarez, A | 1 |
| Feldman, EC | 1 |
| Bruyette, DS | 1 |
| Nelson, RW | 1 |
| Farver, TB | 1 |
| Divers, MJ | 1 |
| Jacob, K | 1 |
| Doerr, HG | 1 |
| Jimenez Reina, L | 1 |
| Leal-Cerro, A | 1 |
| Garcia, J | 1 |
| Garcia-Luna, PP | 1 |
| Astorga, R | 1 |
| Bernal, G | 1 |
| Fève, B | 2 |
| Bauduceau, B | 2 |
| Lefebvre, H | 2 |
| Ritz, P | 1 |
| Garcin, JM | 2 |
| Gautier, D | 2 |
| Rampazzo, A | 1 |
| Menegus, AM | 1 |
| Mantero, F | 1 |
| Higashi, Y | 1 |
| Omura, M | 1 |
| Suzuki, K | 1 |
| Inano, H | 1 |
| Oshima, H | 1 |
| Oelkers, W | 1 |
| Bähr, V | 1 |
| Hensen, J | 1 |
| Pickartz, H | 1 |
4 reviews available for ketoconazole and Adenoma, Basal Cell
| Article | Year |
|---|---|
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists | 2021 |
New prospects for drug treatment in Cushing disease.
Topics: Adenoma; Adrenocorticotropic Hormone; Animals; Cabergoline; Clinical Trials as Topic; Clinical Trial | 2012 |
Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review.
Topics: Adenoma; Aminoglutethimide; Dexamethasone; Histoplasmosis; Humans; Itraconazole; Ketoconazole; Lung | 2007 |
Diagnosis and management of canine cortisol-secreting adrenal tumors.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Adrenocorticotropic Hormone; Animals; Antifungal A | 1997 |
3 trials available for ketoconazole and Adenoma, Basal Cell
| Article | Year |
|---|---|
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6).
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Ghrelin; Hormone Antagonists; | 2010 |
Retinoic acid as a novel medical therapy for Cushing's disease in dogs.
Topics: Adenoma; Adrenocorticotropic Hormone; alpha-MSH; Animals; Body Weight; Creatinine; Dog Diseases; Dog | 2006 |
Different therapeutic efficacy of ketoconazole in patients with Cushing's syndrome.
Topics: ACTH Syndrome, Ectopic; Adenoma; Adrenal Cortex Neoplasms; Adrenocorticotropic Hormone; Adult; Cushi | 1989 |
25 other studies available for ketoconazole and Adenoma, Basal Cell
| Article | Year |
|---|---|
β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adult; Aged; Animals; Anti-Inflammatory Agents; beta-Arre | 2020 |
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Coronavirus Infections; | 2020 |
LONG-TERM OUTCOME OF THE DIFFERENT TREATMENT ALTERNATIVES FOR RECURRENT AND PERSISTENT CUSHING DISEASE.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Antifungal Agents; Coho | 2017 |
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom | 2017 |
An Overlooked Cause of Hypokalemia.
Topics: 14-alpha Demethylase Inhibitors; Adenoma; Cabergoline; Cushing Syndrome; Dopamine Agonists; Ergoline | 2017 |
Treatment patterns in Cushing's disease patients in two large United States nationwide databases: application of a novel, graphical methodology.
Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Co | 2015 |
[Indications and future perspectives in the pharmacological treatment of hypercortisolism].
Topics: Adenoma; Cushing Syndrome; Humans; Hydrocortisone; Italy; Ketoconazole; Metyrapone; Pituitary Neopla | 2016 |
Disappearance of pituitary macro adenoma with combination of ketoconazole and cabergoline treatment: an unusual case of Cushing's syndrome with interesting findings.
Topics: 14-alpha Demethylase Inhibitors; Adenoma; Adult; Antineoplastic Agents; Cabergoline; Cushing Syndrom | 2012 |
Diagnostic puzzler: hypertension in teen.
Topics: Adenoma; Adolescent; Adrenal Glands; Antifungal Agents; Cushing Syndrome; Diagnosis, Differential; D | 2012 |
Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Aged; Cushing Syndrome; Dexamethasone; Female; Glucocor | 2003 |
Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk.
Topics: Adenoma; Adult; Cushing Syndrome; Female; Humans; Hydrocortisone; Ketoconazole; Pituitary Neoplasms; | 2004 |
Long term control of hypercortisolism with fluconazole: case report and in vitro studies.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenalectomy; Aged, 80 and over; Antifungal Agents; Cell Line, Tu | 2006 |
Ketoconazole inhibits cortisol secretion of an adrenal adenoma in vivo and in vitro.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Antifungal Agents; Humans; Hydrocorti | 1983 |
Recovery of bone mineral density after surgical cure, but not by ketoconazole treatment, in Cushing's syndrome.
Topics: Absorptiometry, Photon; Adenoma; Adrenal Gland Neoplasms; Adult; Bone Density; Cushing Syndrome; Dex | 2001 |
Medical treatment of Cushing's syndrome with aminoglutethimide and ketoconazole.
Topics: Adenoma; Adrenal Gland Neoplasms; Aminoglutethimide; Cushing Syndrome; Humans; Hydrocortisone; Ketoc | 1992 |
[Use of ketoconazole in a case of malignant secreting adrenocortical adenoma].
Topics: Adenoma; Adrenal Gland Neoplasms; Adult; Female; Humans; Ketoconazole | 1991 |
Successful treatment with ketoconazole of Cushing's syndrome in pregnancy.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adult; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; | 1990 |
Plasma cortisol response to ketoconazole administration in dogs with hyperadrenocorticism.
Topics: Adenoma; Administration, Oral; Adrenal Cortex Neoplasms; Adrenocortical Hyperfunction; Animals; Carc | 1990 |
Ketoconazole treatment of Cushing's syndrome in pregnancy.
Topics: Adenoma; Adrenal Gland Neoplasms; Cushing Syndrome; Female; Humans; Ketoconazole; Pregnancy; Pregnan | 1990 |
In vitro effects of ketoconazole on corticotrope cell morphology and ACTH secretion of two pituitary adenomas removed from patients with Nelson's syndrome.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Cells, Cultured; Female; Humans; Immunohistochemistry; | 1989 |
[Value of ketoconazole in the treatment of Cushing's syndrome. Apropos of a case of adrenal polyadematosis].
Topics: Adenoma; Adrenal Gland Neoplasms; Cushing Syndrome; Humans; Ketoconazole; Male; Middle Aged | 1989 |
ACTH response to corticotropin releasing hormone in Cushing's disease before and after ketoconazole: in vivo and in vitro studies.
Topics: Adenoma; Adrenocorticotropic Hormone; Adult; Animals; Corticotropin-Releasing Hormone; Cushing Syndr | 1987 |
[Ketoconazole therapy of Cushing's syndrome caused by adrenal polyadenomatosis].
Topics: Adenoma; Adrenal Cortex Neoplasms; Cushing Syndrome; Humans; Ketoconazole; Male; Middle Aged | 1988 |
Ketoconazole as a possible universal inhibitor of cytochrome P-450 dependent enzymes: its mode of inhibition.
Topics: Adenoma; Adrenal Gland Neoplasms; Adrenal Glands; Animals; Cytochrome P-450 Enzyme Inhibitors; Cytoc | 1987 |
Primary adrenocortical micronodular adenomatosis causing Cushing's syndrome. Effects of ketoconazole on steroid production and in vitro performance of adrenal cells.
Topics: Adenoma; Adrenal Cortex Neoplasms; Adrenal Glands; Adrenalectomy; Adult; Captopril; Cushing Syndrome | 1986 |