ketoconazole has been researched along with Acute Respiratory Distress Syndrome in 17 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Three clinical studies have suggested that ketoconazole, a synthetic imidazole with anti-inflammatory activity, may prevent the development of acute respiratory distress syndrome (ARDS) in critically ill patients." | 9.09 | Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network. ( , 2000) |
| "To determine if ketoconazole, a thromboxane A2 synthetase inhibitor, given within the first 24 hrs after diagnosis and arrival in the intensive care unit (ICU) would decrease the frequency of adult respiratory distress syndrome in the septic patient population." | 9.07 | A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. ( Tomasa, G; Yu, M, 1993) |
| "A case is herein reported of pneumocystis carinii pneumonia in a 60-year-old female patient with ectopic production of ACTH at a position 2 cm superior to her right clavicle, revealed in an octreotide scan." | 5.31 | Pneumocystis carinii pneumonia associated with a rapid reduction of cortisol level in a patient with ectopic ACTH syndrome treated by octreotide and ketoconazole. ( Choi, WH; Choi, YY; Jeon, SC; Kim, DS; Kim, TW; Park, SK; Ryu, JS, 2000) |
| "Acute inflammatory lung injury (adult respiratory distress syndrome [ARDS]) causes significant morbidity and death in surgical patients." | 5.28 | Ketoconazole inhibits alveolar macrophage production of inflammatory mediators involved in acute lung injury (adult respiratory distress syndrome). ( Maier, RV; Williams, JG, 1992) |
| "Three clinical studies have suggested that ketoconazole, a synthetic imidazole with anti-inflammatory activity, may prevent the development of acute respiratory distress syndrome (ARDS) in critically ill patients." | 5.09 | Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network. ( , 2000) |
| "To determine if ketoconazole, a thromboxane A2 synthetase inhibitor, given within the first 24 hrs after diagnosis and arrival in the intensive care unit (ICU) would decrease the frequency of adult respiratory distress syndrome in the septic patient population." | 5.07 | A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome. ( Tomasa, G; Yu, M, 1993) |
| "The purpose of this study was to develop, implement, and evaluate a practice guideline using ketoconazole for the prevention of the adult respiratory distress syndrome (ARDS) in critically ill patients." | 3.70 | Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis. ( Cook, DJ; Fuller, HD; Peterson, JC; Sinuff, T, 1999) |
| "A case is herein reported of pneumocystis carinii pneumonia in a 60-year-old female patient with ectopic production of ACTH at a position 2 cm superior to her right clavicle, revealed in an octreotide scan." | 1.31 | Pneumocystis carinii pneumonia associated with a rapid reduction of cortisol level in a patient with ectopic ACTH syndrome treated by octreotide and ketoconazole. ( Choi, WH; Choi, YY; Jeon, SC; Kim, DS; Kim, TW; Park, SK; Ryu, JS, 2000) |
| "Acute inflammatory lung injury (adult respiratory distress syndrome [ARDS]) causes significant morbidity and death in surgical patients." | 1.28 | Ketoconazole inhibits alveolar macrophage production of inflammatory mediators involved in acute lung injury (adult respiratory distress syndrome). ( Maier, RV; Williams, JG, 1992) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.88) | 18.7374 |
| 1990's | 10 (58.82) | 18.2507 |
| 2000's | 6 (35.29) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Spragg, RG | 1 |
| Wiedemann, HP | 2 |
| Arroliga, AC | 1 |
| Komara, JJ | 2 |
| Beilman, G | 1 |
| Lee, K | 1 |
| Slotman, GJ | 2 |
| Yu, M | 1 |
| Tomasa, G | 1 |
| Stratta, RJ | 1 |
| Taylor, RJ | 1 |
| Weide, LG | 1 |
| Sindhi, R | 1 |
| Sudan, D | 1 |
| Castaldo, P | 1 |
| Cushing, KA | 1 |
| Frisbie, K | 1 |
| Radio, SJ | 1 |
| Krafft, P | 1 |
| Fridrich, P | 1 |
| Hammerle, AF | 1 |
| Steltzer, H | 1 |
| Perez-Trepichio, P | 1 |
| Sinuff, T | 1 |
| Cook, DJ | 1 |
| Peterson, JC | 1 |
| Fuller, HD | 1 |
| Jacka, MJ | 1 |
| Meade, MO | 1 |
| Kim, DS | 1 |
| Park, SK | 1 |
| Choi, WH | 1 |
| Kim, TW | 1 |
| Choi, YY | 1 |
| Jeon, SC | 1 |
| Ryu, JS | 1 |
| Schilling, MK | 1 |
| Eichenberger, M | 1 |
| Maurer, CA | 1 |
| Sigurdsson, G | 1 |
| Büchler, MW | 1 |
| Schoenfeld, DA | 1 |
| Williams, JG | 1 |
| Maier, RV | 1 |
| Burchard, KW | 1 |
| D'Arezzo, A | 1 |
| Gann, DS | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Acute Respiratory Distress Syndrome Clinical Network (ARDSNet)[NCT00000579] | Phase 3 | 0 participants | Interventional | 1994-09-30 | Completed | ||
| The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis[NCT04169828] | 176 participants (Anticipated) | Interventional | 2019-08-02 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketoconazole and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Acute lung injury in 2003.
Topics: Adrenal Cortex Hormones; High-Frequency Ventilation; Humans; Hypoxia; Ketoconazole; Positive-Pressur | 2003 |
Emerging systemic pharmacologic approaches in acute respiratory distress syndrome.
Topics: Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antioxidants; Atrial Natriuretic Factor; Humans; | 2003 |
Systemic pharmacologic therapy of ARDS.
Topics: Adrenal Cortex Hormones; Animals; Antioxidants; Cytokines; Humans; Ketoconazole; Respiratory Distres | 1998 |
5 trials available for ketoconazole and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
A double-blind, prospective, randomized trial of ketoconazole, a thromboxane synthetase inhibitor, in the prophylaxis of the adult respiratory distress syndrome.
Topics: Adult; Aged; Bacterial Infections; Chi-Square Distribution; Critical Care; Double-Blind Method; Fema | 1993 |
A prospective randomized trial of OKT3 vs ATGAM induction therapy in pancreas transplant recipients.
Topics: Adult; Antilymphocyte Serum; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Female; Follow-Up St | 1996 |
Ketoconazole for early treatment of acute lung injury and acute respiratory distress syndrome: a randomized controlled trial. The ARDS Network.
Topics: Antifungal Agents; Double-Blind Method; Female; Humans; Ketoconazole; Male; Middle Aged; Multiple Or | 2000 |
Ketoconazole and pulmonary failure after esophagectomy: a prospective clinical trial.
Topics: Aged; Antifungal Agents; Esophageal Neoplasms; Esophagectomy; Female; Humans; Ketoconazole; Male; Mi | 2001 |
Ketoconazole prevents acute respiratory failure in critically ill surgical patients.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Clinical Trials as Topic; Double-Blind Method; Female; H | 1988 |
9 other studies available for ketoconazole and Acute Respiratory Distress Syndrome
| Article | Year |
|---|---|
Ketoconazole for prophylaxis of the adult respiratory distress syndrome.
Topics: Humans; Ketoconazole; Middle Aged; Respiratory Distress Syndrome | 1995 |
Use of ketoconazole in the prophylaxis of adult respiratory distress syndrome.
Topics: Humans; Ketoconazole; Respiratory Distress Syndrome; Sepsis | 1994 |
Ketoconazole: maybe it isn't the magic potion, but....
Topics: Drug Interactions; Humans; Ketoconazole; Leukotriene Antagonists; Respiratory Distress Syndrome; Thr | 1993 |
Supportive pharmacotherapy for patients with acute respiratory distress syndrome.
Topics: Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Antioxidants; Glucocorticoids; Human | 1996 |
Development, implementation, and evaluation of a ketoconazole practice guideline for ARDS prophylaxis.
Topics: APACHE; Critical Care; Enzyme Inhibitors; Female; Humans; Intensive Care Units; Ketoconazole; Length | 1999 |
A successful multifocal strategy of guideline implementation.
Topics: Adult; Antifungal Agents; Humans; Ketoconazole; Respiratory Distress Syndrome | 1999 |
Pneumocystis carinii pneumonia associated with a rapid reduction of cortisol level in a patient with ectopic ACTH syndrome treated by octreotide and ketoconazole.
Topics: ACTH Syndrome, Ectopic; Adrenocorticotropic Hormone; Disseminated Intravascular Coagulation; Escheri | 2000 |
A simple algorithm for designing group sequential clinical trials.
Topics: Algorithms; Biometry; Clinical Trials as Topic; Humans; Ketoconazole; Medical Futility; Probability; | 2001 |
Ketoconazole inhibits alveolar macrophage production of inflammatory mediators involved in acute lung injury (adult respiratory distress syndrome).
Topics: Animals; Blood Coagulation Factors; Ketoconazole; Leukotriene B4; Macrophages, Alveolar; Rabbits; Re | 1992 |