ketoconazole has been researched along with Acute Liver Injury, Drug-Induced in 132 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome." | 9.30 | Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. ( Auchus, RJ; Biller, BMK; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Greenman, Y; Pivonello, R; Salvatori, R; Witek, P, 2019) |
| "To evaluate the incidence, severity, and course of ketoconazole-associated hepatic injury, 211 patients with onychomycosis were randomized by a ratio of 2:1 to receive either ketoconazole (137 patients) or griseofulvin (74 patients)." | 9.08 | Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study. ( Chien, RN; Liaw, YF; Lin, PY; Yang, LJ, 1997) |
| "A multicenter double-blind study was conducted on the use of ketoconazole and griseofulvin for the treatment of dermatomycoses." | 9.05 | A multicenter double-blind evaluation of ketoconazole in the treatment of dermatomycoses. ( Daily, AD; Glogau, R; Jolly, HW; Krupp, I; Rex, IH; Stegman, SJ; Tromovitch, TA, 1983) |
| " The case of a patient with environmental illness and systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased." | 8.78 | Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis. ( Brusko, CS; Marten, JT, 1991) |
| "Orally administered ketoconazole may rarely induce liver injury and adrenal insufficiency." | 8.12 | Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency. ( Fukami, T; Hirosawa, K; Honda, S; Kisui, F; Konishi, K; Nagaoka, M; Nakajima, M; Nakano, M; Ogiso, T; Sakai, Y; Tashiro, K; Yamada, T, 2022) |
| "Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS)." | 7.88 | Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France. ( Bertherat, J; Castinetti, F; Chabre, O; Chadarevian, R; Senoussi, S; Vantyghem, MC; Young, J, 2018) |
| "We describe a previously healthy woman who developed liver cirrhosis as a sequela of acute hepatic injury that was induced by ketoconazole administration to treat onychomycosis." | 7.72 | Liver cirrhosis developed after ketoconazole-induced acute hepatic injury. ( Chang, R; Chang, YW; Dong, SH; Han, YS; Kim, BH; Kim, HJ; Kim, TH; Kim, YW; Lee, JI; Yang, DM, 2003) |
| " The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma." | 7.71 | Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases. ( Chang, FY; Huang, DF; Huang, YH; Huang, YS; Huo, TI; Lee, SD; Lin, CC; Wu, JC, 2001) |
| " violaceum tinea capitis was given systemic ketoconazole therapy." | 7.68 | Juvenile tinea capitis caused by Trichophyton violaceum. Hepatic reactions during ketoconazole treatment. ( Falk, ES; Gasior-Chrzan, B; Stenvold, SE, 1991) |
| "Out of 67 patients with Cushing's syndrome admitted during the last 6 years, 34 (28 females/six males; age range 14-67 years) received ketoconazole as a palliative treatment due to severe clinical conditions or management of the disease while awaiting results of definitive therapy." | 7.68 | Ketoconazole treatment in Cushing's syndrome: experience in 34 patients. ( Boscaro, M; Mantero, F; Paoletta, A; Sonino, N; Ziliotto, D, 1991) |
| "Our experience in the treatment of chronic mucocutaneous candidiasis with ketoconazole is reviewed." | 7.66 | Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: experience with twenty-one patients. ( Horsburgh, CR; Kirkpatrick, CH, 1983) |
| "Levoketoconazole is a ketoconazole stereoisomer in development for treatment of Cushing's syndrome and has not been assessed previously in a clinical trial in patients with Cushing's syndrome." | 5.30 | Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial. ( Auchus, RJ; Biller, BMK; Cohen, F; Elenkova, A; Feelders, RA; Fleseriu, M; Geer, EB; Greenman, Y; Pivonello, R; Salvatori, R; Witek, P, 2019) |
| "To evaluate the incidence, severity, and course of ketoconazole-associated hepatic injury, 211 patients with onychomycosis were randomized by a ratio of 2:1 to receive either ketoconazole (137 patients) or griseofulvin (74 patients)." | 5.08 | Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study. ( Chien, RN; Liaw, YF; Lin, PY; Yang, LJ, 1997) |
| "A multicenter double-blind study was conducted on the use of ketoconazole and griseofulvin for the treatment of dermatomycoses." | 5.05 | A multicenter double-blind evaluation of ketoconazole in the treatment of dermatomycoses. ( Daily, AD; Glogau, R; Jolly, HW; Krupp, I; Rex, IH; Stegman, SJ; Tromovitch, TA, 1983) |
| " The case of a patient with environmental illness and systemic candidiasis for six weeks with ketoconazole, liver enzyme concentrations increased." | 4.78 | Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis. ( Brusko, CS; Marten, JT, 1991) |
| "Orally administered ketoconazole may rarely induce liver injury and adrenal insufficiency." | 4.12 | Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency. ( Fukami, T; Hirosawa, K; Honda, S; Kisui, F; Konishi, K; Nagaoka, M; Nakajima, M; Nakano, M; Ogiso, T; Sakai, Y; Tashiro, K; Yamada, T, 2022) |
| "Ketoconazole (KTZ) is one of few available treatments for Cushing's syndrome (CS)." | 3.88 | Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France. ( Bertherat, J; Castinetti, F; Chabre, O; Chadarevian, R; Senoussi, S; Vantyghem, MC; Young, J, 2018) |
| "We describe a previously healthy woman who developed liver cirrhosis as a sequela of acute hepatic injury that was induced by ketoconazole administration to treat onychomycosis." | 3.72 | Liver cirrhosis developed after ketoconazole-induced acute hepatic injury. ( Chang, R; Chang, YW; Dong, SH; Han, YS; Kim, BH; Kim, HJ; Kim, TH; Kim, YW; Lee, JI; Yang, DM, 2003) |
| " The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma." | 3.71 | Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases. ( Chang, FY; Huang, DF; Huang, YH; Huang, YS; Huo, TI; Lee, SD; Lin, CC; Wu, JC, 2001) |
| "Out of 67 patients with Cushing's syndrome admitted during the last 6 years, 34 (28 females/six males; age range 14-67 years) received ketoconazole as a palliative treatment due to severe clinical conditions or management of the disease while awaiting results of definitive therapy." | 3.68 | Ketoconazole treatment in Cushing's syndrome: experience in 34 patients. ( Boscaro, M; Mantero, F; Paoletta, A; Sonino, N; Ziliotto, D, 1991) |
| " violaceum tinea capitis was given systemic ketoconazole therapy." | 3.68 | Juvenile tinea capitis caused by Trichophyton violaceum. Hepatic reactions during ketoconazole treatment. ( Falk, ES; Gasior-Chrzan, B; Stenvold, SE, 1991) |
| "Our experience in the treatment of chronic mucocutaneous candidiasis with ketoconazole is reviewed." | 3.66 | Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: experience with twenty-one patients. ( Horsburgh, CR; Kirkpatrick, CH, 1983) |
| " The extract was as effective as the positive control ketoconazole dosed at 60 mg/kg." | 2.77 | A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole. ( Duncan, N; Eloff, JN; Naidoo, V; Suleiman, MM, 2012) |
| "Ketoconazole is a potent CYP3A inhibitor in vivo, and frequently serves as an index CYP3A inhibitor in drug-drug interaction (DDI) studies with healthy volunteers." | 2.53 | Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers. ( Banankhah, PS; Garnick, KA; Greenblatt, DJ, 2016) |
| "This drug safety review summarizes reports of oral ketoconazole-related adverse events retrieved from a search of the PubMed database using the search strategy 'ketoconazole OR Nizoral AND hepat*', references from relevant publications, and data from the FDA Adverse Event Reporting System." | 2.52 | Drug safety assessment of oral formulations of ketoconazole. ( Daigle, D; Foley, KA; Gupta, AK, 2015) |
| " The dosage and duration specific subgroup analyses did not show any significant difference among groups, while the age specific subgroup analysis showed the incidence in children and people aged >60 years was 1." | 2.49 | Ketoconazole associated hepatotoxicity: a systematic review and meta- analysis. ( Nie, XL; Tao, QM; Yan, JY; Zhan, SY; Zhang, YD, 2013) |
| "Ketoconazole was first considered as a more or less safe drug." | 2.38 | Safety aspects of ketoconazole, the most commonly used systemic antifungal. ( Cauwenbergh, G, 1989) |
| "Ketoconazole (KTC) pretreatment reduced the generation of the GSH conjugate in mouse liver and cultured primary hepatocytes after TOL treatment." | 1.91 | In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A. ( Li, W; Liu, M; Peng, Y; Wang, A; Wang, Y; Zhao, G; Zhao, Q; Zheng, J, 2023) |
| " KTC and licorice similarly inhibited the production of toxic metabolites, changed metabolism in vivo, and produced many new II and a few phases I metabolites, while the contents of toxic metabolites increased in the DXMS group." | 1.91 | Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS. ( Fang, S; Hua, H; Liu, X; Pan, Y; Ren, K; Ren, S; Wang, D; Wang, R, 2023) |
| "Cholestasis is a DILI that results from impairment of bile acid transporters, such as the bile salt export pump (BSEP), leading to accumulation of bile acids." | 1.51 | Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver. ( Fujino, C; Ishida, Y; Kisoh, K; Kotake, Y; Ohta, S; Sanoh, S; Sugahara, G; Tamura, Y; Tateno, C; Yanagi, A; Yoshizane, Y, 2019) |
| "Ketoconazole is a first orally available anti-fungal drug which has been reported as a potent inhibitor of human cytochrome P-450." | 1.51 | Hepatoprotective effect of ketoconazole in chronic liver injury model. ( Ahmed, M; Akhtar, U; Ali, G; Shehzad, U; Tayyeb, A, 2019) |
| "Ketoconazole pretreatment adult male rats were intraperitoneally injected with carbon tetrachloride for 24 hr and various hepatic parameters were analyzed." | 1.51 | Ketoconazole pretreatment ameliorates carbon tetrachloride-induced acute liver injury in rats by suppressing inflammation and oxidative stress. ( Huang, K; Peng, C; Zhou, Y; Zhou, Z, 2019) |
| " However, tacrine was removed from the market due to its hepatotoxicity concerns as it undergoes metabolism to toxic quinonemethide species through the cytochrome P450 enzyme CYP1A2." | 1.46 | Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity. ( Edginton, AN; McEneny-King, A; Osman, W; Rao, PPN, 2017) |
| "Pretreatment with ketoconazole prevented the animals from developing EEA-induced liver injury, caused 7- and 13-fold increases in the plasma Cmax and AUC of EEA, and decreased urinary excretion of glutathione conjugates derived from EEA." | 1.43 | Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid. ( Gao, H; Jiang, C; Li, W; Lin, D; Peng, Y; Xu, Y; Zheng, J, 2016) |
| "Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease; however, its use is often discontinued due to numerous adverse effects, including hepatotoxicity." | 1.43 | The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity. ( Bryant, MS; Guo, L; Ning, B; Ren, Z; Wu, Q; Xuan, J, 2016) |
| " These data demonstrate that UA is bio-transformed to less toxic metabolites in rat primary hepatocytes, probably mainly by CYP1A and 3A, but not 2B/2C." | 1.40 | Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes. ( Greenhaw, J; Salminen, WF; Shi, Q, 2014) |
| " We proposed a systematic classification scheme using FDA-approved drug labeling to assess the DILI potential of drugs, which yielded a benchmark dataset with 287 drugs representing a wide range of therapeutic categories and daily dosage amounts." | 1.37 | FDA-approved drug labeling for the study of drug-induced liver injury. ( Chen, M; Fang, H; Liu, Z; Shi, Q; Tong, W; Vijay, V, 2011) |
| " An understanding of structure-activity relationships (SARs) of chemicals can make a significant contribution to the identification of potential toxic effects early in the drug development process and aid in avoiding such problems." | 1.36 | Developing structure-activity relationships for the prediction of hepatotoxicity. ( Fisk, L; Greene, N; Naven, RT; Note, RR; Patel, ML; Pelletier, DJ, 2010) |
| "Paracoccidioidomycosis is a chronic progressive infection." | 1.34 | Report of an imported cutaneous disseminated case of paracoccidioidomycosis. ( Domínguez, M; Fernández-Torres, B; López-Aracil, V; Mayayo, E; Mayayo, R, 2007) |
| " Unfortunately, its adverse effects, mainly hypersensitivity skin reactions and hepatotoxicity, have hampered the use of nevirapine." | 1.33 | RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity. ( Abraham, AM; Barr, S; Walubo, A, 2006) |
| " Thereafter, two groups of 15 male Sprague-Dawley rats each were treated with the toxic dose of paracetamol intraperitoneally to induce severe hepatotoxicity." | 1.32 | The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. ( Abraham, AM; Barr, S; Coetsee, C; Walubo, A, 2004) |
| "Ketoconazole was the antifungal associated with the highest relative risk, 228." | 1.30 | A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs. ( Castellsague, J; Duque, A; García Rodríguez, LA; Pérez-Gutthann, S; Stricker, BH, 1999) |
| "Ketoconazole is an imidazole derivative recently developed as an antifungal agent." | 1.27 | Severe hepatitis during ketoconazole therapy. ( Akaike, M; Aramaki, T; Iizuka, K; Katsuta, Y; Kusunoki, T; Ohta, M; Okumura, H; Satomura, K; Terada, H, 1983) |
| "Treatment with ketoconazole resulted in prompt improvement and ultimate healing." | 1.27 | Successful ketoconazole treatment of protothecosis with ketoconazole-associated hepatotoxicity. ( Burke, JG; Hampton, KD; Kerns, FT; Pegram, PS; Scharyj, M; Wasilauskas, BL, 1983) |
| "Ketoconazole has only recently been recognized as a cause of hepatic injury, with most reports coming from outside the United States." | 1.27 | Hepatic injury associated with ketoconazole therapy. Analysis of 33 cases. ( Benson, GD; Ishak, KG; Lewis, JH; Zimmerman, HJ, 1984) |
| "Ketoconazole was introduced in the United Kingdom in 1981." | 1.27 | Hepatic reactions associated with ketoconazole in the United Kingdom. ( Lake-Bakaar, G; Scheuer, PJ; Sherlock, S, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 54 (40.91) | 18.7374 |
| 1990's | 16 (12.12) | 18.2507 |
| 2000's | 11 (8.33) | 29.6817 |
| 2010's | 45 (34.09) | 24.3611 |
| 2020's | 6 (4.55) | 2.80 |
| Authors | Studies |
|---|---|
| Fourches, D | 1 |
| Barnes, JC | 1 |
| Day, NC | 1 |
| Bradley, P | 1 |
| Reed, JZ | 1 |
| Tropsha, A | 1 |
| Greene, N | 1 |
| Fisk, L | 1 |
| Naven, RT | 1 |
| Note, RR | 1 |
| Patel, ML | 1 |
| Pelletier, DJ | 1 |
| Morgan, RE | 2 |
| Trauner, M | 1 |
| van Staden, CJ | 2 |
| Lee, PH | 1 |
| Ramachandran, B | 1 |
| Eschenberg, M | 1 |
| Afshari, CA | 2 |
| Qualls, CW | 1 |
| Lightfoot-Dunn, R | 1 |
| Hamadeh, HK | 2 |
| Ekins, S | 1 |
| Williams, AJ | 1 |
| Xu, JJ | 1 |
| Chen, M | 2 |
| Vijay, V | 1 |
| Shi, Q | 3 |
| Liu, Z | 2 |
| Fang, H | 2 |
| Tong, W | 3 |
| Dawson, S | 1 |
| Stahl, S | 2 |
| Paul, N | 1 |
| Barber, J | 1 |
| Kenna, JG | 2 |
| Ding, D | 1 |
| Kelly, R | 1 |
| Sakatis, MZ | 1 |
| Reese, MJ | 1 |
| Harrell, AW | 1 |
| Taylor, MA | 1 |
| Baines, IA | 1 |
| Chen, L | 1 |
| Bloomer, JC | 1 |
| Yang, EY | 1 |
| Ellens, HM | 1 |
| Ambroso, JL | 1 |
| Lovatt, CA | 1 |
| Ayrton, AD | 1 |
| Clarke, SE | 1 |
| Warner, DJ | 1 |
| Chen, H | 1 |
| Cantin, LD | 1 |
| Walker, CL | 1 |
| Noeske, T | 1 |
| Chen, Y | 2 |
| Kalyanaraman, N | 1 |
| Kalanzi, J | 1 |
| Dunn, RT | 1 |
| Aleo, MD | 1 |
| Luo, Y | 1 |
| Swiss, R | 1 |
| Bonin, PD | 1 |
| Potter, DM | 1 |
| Will, Y | 1 |
| Suzuki, A | 1 |
| Thakkar, S | 1 |
| Yu, K | 1 |
| Hu, C | 1 |
| McEneny-King, A | 1 |
| Osman, W | 1 |
| Edginton, AN | 1 |
| Rao, PPN | 1 |
| Wei, H | 1 |
| Li, AP | 2 |
| Nagaoka, M | 1 |
| Fukami, T | 5 |
| Kisui, F | 1 |
| Yamada, T | 1 |
| Sakai, Y | 2 |
| Tashiro, K | 1 |
| Ogiso, T | 1 |
| Konishi, K | 2 |
| Honda, S | 1 |
| Hirosawa, K | 1 |
| Nakano, M | 1 |
| Nakajima, M | 5 |
| Ren, K | 2 |
| Wang, R | 2 |
| Fang, S | 2 |
| Ren, S | 2 |
| Hua, H | 2 |
| Wang, D | 2 |
| Pan, Y | 2 |
| Liu, X | 2 |
| Wang, A | 1 |
| Zhao, Q | 2 |
| Liu, M | 1 |
| Wang, Y | 1 |
| Zhao, G | 1 |
| Li, W | 3 |
| Peng, Y | 5 |
| Zheng, J | 5 |
| Fleseriu, M | 1 |
| Pivonello, R | 1 |
| Elenkova, A | 1 |
| Salvatori, R | 1 |
| Auchus, RJ | 1 |
| Feelders, RA | 1 |
| Geer, EB | 1 |
| Greenman, Y | 1 |
| Witek, P | 1 |
| Cohen, F | 1 |
| Biller, BMK | 1 |
| Fasbender, F | 1 |
| Obholzer, M | 1 |
| Metzler, S | 1 |
| Stöber, R | 1 |
| Hengstler, JG | 1 |
| Watzl, C | 1 |
| Xiao, X | 1 |
| Zhang, T | 1 |
| Huang, J | 1 |
| Li, F | 1 |
| Wang, K | 2 |
| Lin, D | 4 |
| Guo, X | 2 |
| Huang, W | 1 |
| Young, J | 1 |
| Bertherat, J | 1 |
| Vantyghem, MC | 1 |
| Chabre, O | 1 |
| Senoussi, S | 1 |
| Chadarevian, R | 1 |
| Castinetti, F | 1 |
| Shi, F | 1 |
| Pan, H | 1 |
| Cui, B | 1 |
| Li, Y | 1 |
| Huang, L | 1 |
| Lu, Y | 1 |
| Greenblatt, DJ | 3 |
| Mikus, G | 1 |
| Ali, I | 1 |
| Khalid, S | 1 |
| Stieger, B | 1 |
| Brouwer, KLR | 1 |
| Deguchi, S | 1 |
| Yamashita, T | 1 |
| Igai, K | 1 |
| Harada, K | 1 |
| Toba, Y | 1 |
| Hirata, K | 1 |
| Takayama, K | 1 |
| Mizuguchi, H | 1 |
| Yang, F | 1 |
| Takeuchi, T | 1 |
| Tsuneyama, K | 3 |
| Yokoi, T | 4 |
| Oda, S | 2 |
| Zhou, Y | 1 |
| Peng, C | 1 |
| Zhou, Z | 1 |
| Huang, K | 1 |
| Akhtar, U | 1 |
| Ahmed, M | 1 |
| Tayyeb, A | 1 |
| Shehzad, U | 1 |
| Ali, G | 1 |
| Sanoh, S | 1 |
| Tamura, Y | 1 |
| Fujino, C | 1 |
| Sugahara, G | 1 |
| Yoshizane, Y | 1 |
| Yanagi, A | 1 |
| Kisoh, K | 1 |
| Ishida, Y | 1 |
| Tateno, C | 1 |
| Ohta, S | 1 |
| Kotake, Y | 1 |
| Hadi, M | 2 |
| Westra, IM | 1 |
| Starokozhko, V | 2 |
| Dragovic, S | 1 |
| Merema, MT | 2 |
| Groothuis, GM | 2 |
| Greenhaw, J | 1 |
| Salminen, WF | 1 |
| Yan, JY | 1 |
| Nie, XL | 1 |
| Tao, QM | 1 |
| Zhan, SY | 1 |
| Zhang, YD | 1 |
| Greenblatt, HK | 1 |
| Gupta, AK | 1 |
| Daigle, D | 1 |
| Foley, KA | 1 |
| Gao, H | 3 |
| Xu, Y | 2 |
| Meng, D | 1 |
| Smith, CV | 1 |
| Iida, A | 2 |
| Sasaki, E | 1 |
| Yano, A | 1 |
| Takai, S | 1 |
| Utkarsh, D | 1 |
| Loretz, C | 1 |
| Banankhah, PS | 1 |
| Garnick, KA | 1 |
| Jiang, C | 1 |
| Wewering, F | 1 |
| Jouy, F | 1 |
| Wissenbach, DK | 1 |
| Gebauer, S | 1 |
| Blüher, M | 1 |
| Gebhardt, R | 1 |
| Pirow, R | 1 |
| von Bergen, M | 1 |
| Kalkhof, S | 1 |
| Luch, A | 1 |
| Zellmer, S | 1 |
| Wu, Q | 1 |
| Ning, B | 1 |
| Xuan, J | 1 |
| Ren, Z | 1 |
| Guo, L | 1 |
| Bryant, MS | 1 |
| Periasamy, S | 1 |
| Liu, CT | 1 |
| Chien, SP | 1 |
| Chen, YC | 1 |
| Liu, MY | 1 |
| Vong, CH | 1 |
| Forest, M | 1 |
| Nicolino, M | 1 |
| Ishihara, Y | 1 |
| Ishii, S | 1 |
| Yamamura, N | 1 |
| Onishi, Y | 1 |
| Shimamoto, N | 1 |
| Endo, S | 1 |
| Toyoda, Y | 1 |
| Suleiman, MM | 1 |
| Duncan, N | 1 |
| Eloff, JN | 1 |
| Naidoo, V | 1 |
| Rodriguez, RJ | 1 |
| Buckholz, CJ | 1 |
| Lin, G | 1 |
| Cui, YY | 1 |
| Liu, XQ | 1 |
| Kim, TH | 1 |
| Kim, BH | 1 |
| Kim, YW | 1 |
| Yang, DM | 1 |
| Han, YS | 1 |
| Dong, SH | 1 |
| Kim, HJ | 1 |
| Chang, YW | 1 |
| Lee, JI | 1 |
| Chang, R | 1 |
| Chien, RN | 2 |
| Sheen, IS | 1 |
| Liaw, YF | 2 |
| Walubo, A | 2 |
| Barr, S | 2 |
| Abraham, AM | 2 |
| Coetsee, C | 1 |
| Amin, A | 1 |
| Hamza, AA | 1 |
| Stein, CA | 1 |
| Goel, S | 1 |
| Ghavamian, R | 1 |
| Mayayo, E | 1 |
| López-Aracil, V | 1 |
| Fernández-Torres, B | 1 |
| Mayayo, R | 1 |
| Domínguez, M | 1 |
| Male, O | 1 |
| Delpre, G | 1 |
| Kadish, U | 1 |
| Kolts, BE | 1 |
| Langfitt, M | 1 |
| Pérez-Mateo, M | 1 |
| Sillero, C | 1 |
| Vázquez, N | 1 |
| Daneshmend, TK | 1 |
| Roberts, CJ | 1 |
| Horseburgh, CR | 1 |
| Kirkpatrick, CH | 2 |
| Teutsch, CB | 1 |
| Janssen, PA | 1 |
| Symoens, JE | 1 |
| Henning, H | 1 |
| Kasper, B | 1 |
| Lüders, CJ | 1 |
| Heiberg, JK | 1 |
| Svejgaard, E | 2 |
| Stern, RS | 1 |
| Strauss, JS | 1 |
| Ranek, L | 1 |
| Tkach, JR | 1 |
| Rinaldi, MG | 1 |
| Horsburgh, CR | 1 |
| Graybill, JR | 1 |
| Rollman, O | 1 |
| Lööf, L | 1 |
| Jolly, HW | 1 |
| Daily, AD | 1 |
| Rex, IH | 1 |
| Krupp, I | 1 |
| Tromovitch, TA | 1 |
| Stegman, SJ | 1 |
| Glogau, R | 1 |
| van Dijke, CP | 1 |
| Boëtius, G | 1 |
| Peeters, JP | 1 |
| Peters, JH | 1 |
| Kramer, NJ | 1 |
| Montnor, LP | 1 |
| Berghuis, PH | 2 |
| Okumura, H | 1 |
| Aramaki, T | 1 |
| Satomura, K | 1 |
| Iizuka, K | 1 |
| Ohta, M | 1 |
| Katsuta, Y | 1 |
| Akaike, M | 1 |
| Terada, H | 1 |
| Kusunoki, T | 1 |
| Meinhof, W | 1 |
| Boughton, K | 1 |
| Pegram, PS | 1 |
| Kerns, FT | 1 |
| Wasilauskas, BL | 1 |
| Hampton, KD | 1 |
| Scharyj, M | 1 |
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| Ishak, KG | 1 |
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| Lavrijsen, AP | 2 |
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| Stricker, BH | 5 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| An Open Label Study to Assess the Safety and Efficacy of COR-003 (Levoketoconazole) in the Treatment of Endogenous Cushing's Syndrome[NCT01838551] | Phase 3 | 94 participants (Actual) | Interventional | 2014-08-31 | Completed | ||
| Feedback Control of FSH Secretion in the Human Male[NCT00392457] | 175 participants (Anticipated) | Interventional | 1995-07-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
"The response to COR-003 is defined as mean UFC concentration ≤ULN following 6 months of maintenance phase therapy without a prior dose increase during that phase. The proportion of responders at the End of Maintenance Phase visit, following 6 months of treatment in the Maintenance Phase, for all dose groups combined was estimated using a generalized linear model with repeated measurements based on a binomial distribution with a logit link function and with region (US vs. non-US), concurrent CS medical conditions (diabetes [Yes/No], hypertension [Yes/No]), age (rounded median split based on the ITT population), sex, disease duration (years), prior CS medication (Yes/No), prior radiation therapy (Yes/No) as Baseline covariates and visit as an independent factor.~The least squares mean (LSMEAN) estimate of the UFC response after 6 months of treatment in the Maintenance Phase alongside its 95% Wald CI is presented." (NCT01838551)
Timeframe: 6 months of maintenance phase therapy without a prior dose increase during that phase
| Intervention | proportion of subjects meeting endpoint (Least Squares Mean) |
|---|---|
| Levoketoconazole All Doses | .30 |
10 reviews available for ketoconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
DILIrank: the largest reference drug list ranked by the risk for developing drug-induced liver injury in humans.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Drug Labeling; Humans; Pharmaceutical Pr | 2016 |
Ketoconazole associated hepatotoxicity: a systematic review and meta- analysis.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Off-Label Use | 2013 |
Liver injury associated with ketoconazole: review of the published evidence.
Topics: Animals; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A Inhibitor | 2014 |
Drug safety assessment of oral formulations of ketoconazole.
Topics: Administration, Oral; Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; | 2015 |
Ketoconazole-Associated Liver Injury in Drug-Drug Interaction Studies in Healthy Volunteers.
Topics: Alanine Transaminase; Antifungal Agents; Aspartate Aminotransferases; Chemical and Drug Induced Live | 2016 |
[Current aspects of ketoconazole therapy].
Topics: Adrenal Cortex; Anaphylaxis; Androgens; Chemical and Drug Induced Liver Injury; Cholesterol; Depress | 1984 |
Ketoconazole hepatotoxicity in a patient treated for environmental illness and systemic candidiasis.
Topics: Adult; Candidiasis; Chemical and Drug Induced Liver Injury; Environmental Exposure; Environmental Po | 1991 |
Ketoconazole-induced fulminant hepatitis necessitating liver transplantation.
Topics: Candidiasis; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver Transplanta | 1991 |
Griseofulvin and ketoconazole in the treatment of dermatophyte infections.
Topics: Arthrodermataceae; Chemical and Drug Induced Liver Injury; Dermatomycoses; Drug Interactions; Griseo | 1989 |
Safety aspects of ketoconazole, the most commonly used systemic antifungal.
Topics: Androgen Antagonists; Chemical and Drug Induced Liver Injury; Drug Hypersensitivity; Humans; Immune | 1989 |
5 trials available for ketoconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Efficacy and safety of levoketoconazole in the treatment of endogenous Cushing's syndrome (SONICS): a phase 3, multicentre, open-label, single-arm trial.
Topics: Adolescent; Adrenal Insufficiency; Adult; Aged; Alanine Transaminase; Chemical and Drug Induced Live | 2019 |
A controlled study to determine the efficacy of Loxostylis alata (Anacardiaceae) in the treatment of aspergillus in a chicken (Gallus domesticus) model in comparison to ketoconazole.
Topics: Anacardiaceae; Animals; Antifungal Agents; Aspergillosis; Chemical and Drug Induced Liver Injury; Ch | 2012 |
A multicenter double-blind evaluation of ketoconazole in the treatment of dermatomycoses.
Topics: Adolescent; Adult; Aged; Antifungal Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Chi | 1983 |
Hepatic injury during ketoconazole therapy in patients with onychomycosis: a controlled cohort study.
Topics: Adult; Aged; Alanine Transaminase; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cohort | 1997 |
Pityriasis versicolor with ketoconazole.
Topics: Administration, Oral; Adolescent; Adult; Chemical and Drug Induced Liver Injury; Clinical Trials as | 1989 |
117 other studies available for ketoconazole and Acute Liver Injury, Drug-Induced
| Article | Year |
|---|---|
Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Topics: Animals; Chemical and Drug Induced Liver Injury; Cluster Analysis; Databases, Factual; Humans; MEDLI | 2010 |
Developing structure-activity relationships for the prediction of hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Databases, Factual; Humans; Structure-Activity Relationship; | 2010 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2010 |
A predictive ligand-based Bayesian model for human drug-induced liver injury.
Topics: Bayes Theorem; Chemical and Drug Induced Liver Injury; Humans; Ligands | 2010 |
FDA-approved drug labeling for the study of drug-induced liver injury.
Topics: Animals; Benchmarking; Biomarkers, Pharmacological; Chemical and Drug Induced Liver Injury; Drug Des | 2011 |
In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps).
Topics: Animals; Anti-Infective Agents; Anti-Inflammatory Agents; Chemical and Drug Induced Liver Injury; Da | 2011 |
Preclinical strategy to reduce clinical hepatotoxicity using in vitro bioactivation data for >200 compounds.
Topics: Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme | 2012 |
Mitigating the inhibition of human bile salt export pump by drugs: opportunities provided by physicochemical property modulation, in silico modeling, and structural modification.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2012 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily | 2013 |
Human drug-induced liver injury severity is highly associated with dual inhibition of liver mitochondrial function and bile salt export pump.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters | 2014 |
Cytochrome P450 binding studies of novel tacrine derivatives: Predicting the risk of hepatotoxicity.
Topics: Benzoflavones; Binding Sites; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP1A2; Cytoc | 2017 |
Permeabilized Cryopreserved Human Hepatocytes as an Exogenous Metabolic System in a Novel Metabolism-Dependent Cytotoxicity Assay for the Evaluation of Metabolic Activation and Detoxification of Drugs Associated with Drug-Induced Liver Injuries: Results w
Topics: Acetaminophen; Activation, Metabolic; Amiodarone; Chemical and Drug Induced Liver Injury; Cyclophosp | 2022 |
Arylacetamide deacetylase knockout mice are sensitive to ketoconazole-induced hepatotoxicity and adrenal insufficiency.
Topics: Adrenal Insufficiency; Animals; Area Under Curve; Carboxylic Ester Hydrolases; Chemical and Drug Ind | 2022 |
Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS.
Topics: Alkaloids; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cy | 2023 |
Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS.
Topics: Alkaloids; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cy | 2023 |
Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS.
Topics: Alkaloids; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cy | 2023 |
Effect of CYP3A inducer/inhibitor and licorice on hepatotoxicity and in vivo metabolism of main alkaloids of Euodiae Fructus based on UPLC-Q-Exactive-MS.
Topics: Alkaloids; Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cy | 2023 |
In Vitro and In Vivo Metabolic Activation of Tolterodine Mediated by CYP3A.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Cytochrome P-450 C | 2023 |
Enhanced activation of human NK cells by drug-exposed hepatocytes.
Topics: Antibodies, Neutralizing; Aspirin; Chemical and Drug Induced Liver Injury; Coculture Techniques; Cyt | 2020 |
Effect of CYP3A4 on liver injury induced by triptolide.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chromatography, High Pressure Liquid; Cytochrome P- | 2020 |
Chemical Identity of Interaction of Protein with Reactive Metabolite of Diosbulbin B In Vitro and In Vivo.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cysteine; Dose-Response Rela | 2017 |
Hepatic safety of ketoconazole in Cushing's syndrome: results of a Compassionate Use Programme in France.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Chemical and Drug Induced Liver Injury; Child; Cohort St | 2018 |
Dictamnine-induced hepatotoxicity in mice: the role of metabolic activation of furan.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 CYP3A; Cyto | 2019 |
Ketoconazole and Liver Injury: A Five-Year Update.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; Healthy Volunteers; Hu | 2019 |
Effect of a Common Genetic Variant (p.V444A) in the Bile Salt Export Pump on the Inhibition of Bile Acid Transport by Cholestatic Medications.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Baculoviridae; Bile Acids and Sal | 2019 |
Modeling of Hepatic Drug Metabolism and Responses in CYP2C19 Poor Metabolizer Using Genetically Manipulated Human iPS cells.
Topics: Cell Differentiation; Cell Line; Cell Survival; Chemical and Drug Induced Liver Injury; Clopidogrel; | 2019 |
Experimental Evidence of Liver Injury by BSEP-Inhibiting Drugs With a Bile Salt Supplementation in Rats.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; Chemical and Drug Induced Liver I | 2019 |
Ketoconazole pretreatment ameliorates carbon tetrachloride-induced acute liver injury in rats by suppressing inflammation and oxidative stress.
Topics: Animals; Anti-Inflammatory Agents; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cyt | 2019 |
Hepatoprotective effect of ketoconazole in chronic liver injury model.
Topics: Actins; Animals; Carbon Tetrachloride; Cell Death; Chemical and Drug Induced Liver Injury; Disease M | 2019 |
Changes in Bile Acid Concentrations after Administration of Ketoconazole or Rifampicin to Chimeric Mice with Humanized Liver.
Topics: Alanine Transaminase; Alkaline Phosphatase; Animals; Aspartate Aminotransferases; Bile Acids and Sal | 2019 |
Human precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Clozapine; Female; Humans; In Vitro | 2013 |
Inhibition of cytochrome P450s enhances (+)-usnic acid cytotoxicity in primary cultured rat hepatocytes.
Topics: Animals; Benzoflavones; Benzofurans; Cells, Cultured; Chemical and Drug Induced Liver Injury; Cytoch | 2014 |
Nizoral (Ketoconazole): drug safety communication- potentially fatal liver injury, risk of drug interactions, and adrenal gland problems.
Topics: Adrenal Glands; Antifungal Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; Humans | 2013 |
Metabolic activation of furan moiety makes Diosbulbin B hepatotoxic.
Topics: Activation, Metabolic; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Fura | 2016 |
Carbamazepine-Induced Liver Injury Requires CYP3A-Mediated Metabolism and Glutathione Depletion in Rats.
Topics: Alanine Transaminase; Animals; Anti-Bacterial Agents; Antifungal Agents; Buthionine Sulfoximine; Car | 2015 |
Establishment of a mouse model for amiodarone-induced liver injury and analyses of its hepatotoxic mechanism.
Topics: Alanine Transaminase; Amiodarone; Animals; Chemical and Drug Induced Liver Injury; Dexamethasone; Ga | 2016 |
In vitro evaluation of hepatotoxic drugs in human hepatocytes from multiple donors: Identification of P450 activity as a potential risk factor for drug-induced liver injuries.
Topics: Acetaminophen; Adolescent; Adult; Aged; Analgesics, Non-Narcotic; Antifungal Agents; Cells, Cultured | 2016 |
Role of Metabolic Activation in 8-Epidiosbulbin E Acetate-Induced Liver Injury: Mechanism of Action of the Hepatotoxic Furanoid.
Topics: Activation, Metabolic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome P-450 Enzyme Syst | 2016 |
Characterization of chemical-induced sterile inflammation in vitro: application of the model compound ketoconazole in a human hepatic co-culture system.
Topics: Chemical and Drug Induced Liver Injury; Coculture Techniques; Hep G2 Cells; Humans; Interleukin-8; K | 2017 |
The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity.
Topics: Activation, Metabolic; Amiodarone; Anti-Arrhythmia Agents; Benzoflavones; Cell Survival; Chemical an | 2016 |
Human arylacetamide deacetylase hydrolyzes ketoconazole to trigger hepatocellular toxicity.
Topics: Activation, Metabolic; Antifungal Agents; Biocatalysis; Carboxylic Ester Hydrolases; Cell Line, Tumo | 2016 |
Daily sesame oil supplementation mitigates ketoconazole-induced oxidative stress-mediated apoptosis and hepatic injury.
Topics: Animals; Antifungal Agents; Antioxidants; Apoptosis; Biomarkers; Chemical and Drug Induced Liver Inj | 2016 |
Lysine- and cysteine-based protein adductions derived from toxic metabolites of 8-epidiosbulbin E acetate.
Topics: Activation, Metabolic; Animals; Buthionine Sulfoximine; Chemical and Drug Induced Liver Injury; Cyst | 2016 |
Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome.
Topics: Adrenergic Agents; Adrenocorticotropic Hormone; Aminoglutethimide; Antifungal Agents; Chemical and D | 2009 |
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats.
Topics: alpha-Tocopherol; Animals; Antioxidants; Chemical and Drug Induced Liver Injury; Cimetidine; Cytochr | 2011 |
Stimulation of human monocytic THP-1 cells by metabolic activation of hepatotoxic drugs.
Topics: Albendazole; Amiodarone; B7-2 Antigen; Biotransformation; Cell Line, Tumor; Chemical and Drug Induce | 2012 |
Mouse precision-cut liver slices as an ex vivo model to study idiosyncratic drug-induced liver injury.
Topics: Animals; Benzodiazepines; Biomarkers; Carbamazepine; Cell Survival; Chemical and Drug Induced Liver | 2012 |
Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding.
Topics: Alanine Transaminase; Animals; Antifungal Agents; Biotransformation; Chemical and Drug Induced Liver | 2003 |
Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat.
Topics: Animals; Aryl Hydrocarbon Hydroxylases; Chemical and Drug Induced Liver Injury; Chromatography, High | 2003 |
Liver cirrhosis developed after ketoconazole-induced acute hepatic injury.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Live | 2003 |
Unintentional rechallenge resulting in a causative relationship between ketoconazole and acute liver injury.
Topics: Acute Disease; Antifungal Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Hu | 2003 |
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 2004 |
Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Antifungal Agents; Antiviral Agents; Calcium; Chem | 2005 |
RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity.
Topics: Administration, Oral; Alanine Transaminase; Animals; Anti-HIV Agents; Aryl Hydrocarbon Hydroxylases; | 2006 |
Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy.
Topics: Aged, 80 and over; Antineoplastic Agents; Chemical and Drug Induced Liver Injury; Drug Interactions; | 2007 |
Report of an imported cutaneous disseminated case of paracoccidioidomycosis.
Topics: Adult; Antifungal Agents; Blastomycosis; Chemical and Drug Induced Liver Injury; Cholecystitis; Derm | 2007 |
Ketoconazole and the liver: further considerations.
Topics: Chemical and Drug Induced Liver Injury; Humans; Ketoconazole | 1984 |
Drugs and the liver.
Topics: Acetaminophen; Adult; Aspirin; Chemical and Drug Induced Liver Injury; Chemical and Drug Induced Liv | 1984 |
[Is ketoconazole hepatotoxic at high doses?].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole | 1984 |
Ketoconazole.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Ketoconazole; Kinetic | 1982 |
Ketoconazole and the liver.
Topics: Candidiasis; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Ketoconazole; Piperazines | 1982 |
Hepatic reactions during ketoconazole treatment.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Antifungal Agents; Aspartate Am | 1983 |
[Ketoconazole-induced hepatitis. Case report].
Topics: Alanine Transaminase; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; Female; g | 1983 |
Toxic hepatis during ketoconazole treatment.
Topics: Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Imidazoles; Ketocon | 1981 |
Hepatitis and ketoconazole therapy.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Child, Preschool; Female; Humans; Imidazo | 1981 |
Ketoconazole: assessing its risks.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Ketoconazole; Piperaz | 1982 |
Ketoconazole and the liver.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Imidazoles; Ketoconazole; Middle Aged; Piper | 1982 |
Hepatic dysfunction and ketoconazole therapy.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Ketoconazole; Liver F | 1982 |
Severe hepatitis associated with ketoconazole therapy for chronic mucocutaneous candidiasis.
Topics: Antifungal Agents; Candidiasis; Candidiasis, Chronic Mucocutaneous; Chemical and Drug Induced Liver | 1982 |
Hepatotoxic potential of ketoconazole under investigation.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Drug Labeling; Female; Humans; Imidazoles; Keto | 1982 |
Long-term therapy of chronic mucocutaneous candidiasis with ketoconazole: experience with twenty-one patients.
Topics: Adolescent; Adult; Antifungal Agents; Candidiasis; Candidiasis, Chronic Mucocutaneous; Chemical and | 1983 |
Potential and problems with ketoconazole.
Topics: Antifungal Agents; Candidiasis; Chemical and Drug Induced Liver Injury; Coccidioidomycosis; Endocrin | 1983 |
Hepatic toxicity of ketoconazole.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Imidazoles; Ketoconazole; | 1983 |
[Hepatitis during the administration of ketoconazole (Nizoral)].
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Dermatomycoses; Female; Humans; Im | 1983 |
[Toxic hepatitis caused by ketoconazole (Nizoral)].
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Imidazoles; Ketoco | 1983 |
[Toxic hepatitis during the administration of ketoconazole (Nizoral)].
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Dermatomycoses; Female; Humans; Im | 1983 |
Severe hepatitis during ketoconazole therapy.
Topics: Adult; Alanine Transaminase; Antifungal Agents; Aspartate Aminotransferases; Biopsy; Chemical and Dr | 1983 |
[Ketoconazole--a change in antimycotic therapy?].
Topics: Aged; Antifungal Agents; Candidiasis, Cutaneous; Chemical and Drug Induced Liver Injury; Dermatomyco | 1983 |
Ketoconazole and hepatic reactions.
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Imidazoles; Ketoconazole; | 1983 |
[Toxic hepatitis caused by ketoconazole].
Topics: Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Dermatomycoses; Female; Humans; Imi | 1983 |
Successful ketoconazole treatment of protothecosis with ketoconazole-associated hepatotoxicity.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Imidazoles; Infections; Ketoconazole; Middle | 1983 |
Hepatic injury associated with ketoconazole therapy. Analysis of 33 cases.
Topics: Adolescent; Adult; Aged; Alanine Transaminase; Alkaline Phosphatase; Aspartate Aminotransferases; Ch | 1984 |
Toxic hepatitis following ketoconazole treatment.
Topics: Candidiasis; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Middle Aged | 1984 |
[Hepatitis during treatment with ketoconazole].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole | 1984 |
Fatal hepatitis associated with ketoconazole therapy.
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Onychomycosis | 1984 |
Therapeutic rounds. Ketoconazole in the treatment of tinea corporis.
Topics: Adult; Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Male; Tinea | 1983 |
Acetaminophen-induced hepatotoxicity: protection by enzyme inhibition.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Animals; Chemical and Drug Induced Liver Injury; Cytochrome | 1995 |
Ketoconazole inhibits acetaminophen-induced hepatotoxicity in mice.
Topics: Acetaminophen; Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced | 1995 |
[Liver damage during administration of itraconazole (Trisporal)].
Topics: Aged; Antifungal Agents; Aspergillosis, Allergic Bronchopulmonary; Chemical and Drug Induced Liver I | 1993 |
[Liver damage during administration of itraconazole (Trisporal)].
Topics: Antifungal Agents; Chemical and Drug Induced Liver Injury; Humans; Itraconazole; Ketoconazole; Liver | 1993 |
Ketoconazole-induced hepatotoxicity.
Topics: Adult; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cohort Studies; Female; Humans; Hy | 1997 |
Ketoconazole-induced liver damage.
Topics: Adult; Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Fatal Outcome; Female; Human | 1998 |
[Acute hepatocytic necrosis during ketoconazole therapy for treatment of onychomycosis. National Foundation for Registry and Evaluation of Adverse Effects].
Topics: Adolescent; Adult; Adverse Drug Reaction Reporting Systems; Aged; Antifungal Agents; Chemical and Dr | 1998 |
A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs.
Topics: Acute Disease; Adult; Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cohort Studie | 1999 |
Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases.
Topics: Antifungal Agents; Carcinoma, Hepatocellular; Chemical and Drug Induced Liver Injury; Female; Hepati | 2001 |
Hepatic injury associated with itraconazole.
Topics: Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Female; Humans; Itraconazole; Ketoc | 1992 |
Ketoconazole and hepatitis.
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Middle Aged; Onychomycosis | 1992 |
Juvenile tinea capitis caused by Trichophyton violaceum. Hepatic reactions during ketoconazole treatment.
Topics: Chemical and Drug Induced Liver Injury; Child; Clotrimazole; Humans; Ketoconazole; Liver Diseases; M | 1991 |
Ketoconazole treatment in Cushing's syndrome: experience in 34 patients.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Drug Administrati | 1991 |
[Usefulness of ketoconazole combined with cyclosporin in renal transplantation].
Topics: Adolescent; Adult; Azathioprine; Biotransformation; Chemical and Drug Induced Liver Injury; Cyclospo | 1991 |
[Hepatotoxicity caused by ketoconazole].
Topics: Adolescent; Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Male | 1989 |
Acute hypoadrenalism and hepatotoxicity after treatment with ketoconazole.
Topics: Acute Disease; Adrenal Insufficiency; Adult; Chemical and Drug Induced Liver Injury; Cushing Syndrom | 1987 |
Ketoconazole-induced hepatitis: a case with a definite cause-effect relationship.
Topics: Acute Disease; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; | 1987 |
Comparison of benefit against risk of ketoconazole therapy.
Topics: Adult; Aged; Candidiasis; Chemical and Drug Induced Liver Injury; Clinical Enzyme Tests; Dermatomyco | 1986 |
Hepatic reactions associated with ketoconazole in the United Kingdom.
Topics: Adolescent; Adult; Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver | 1987 |
[Histopathologic observations on acute liver lesions in patients taking Nizoralt (ketokonazol)].
Topics: Adult; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver; Liver Cirrhosis; | 1988 |
[Hepatic lesions induced by drugs. Report of 26 cases].
Topics: Adult; Aged; Biopsy; Carbon Tetrachloride; Chemical and Drug Induced Liver Injury; Cholestasis, Intr | 1987 |
[Hepatic toxicity of ketoconazole].
Topics: Candidiasis, Cutaneous; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Middle | 1987 |
Clinical experience with ketoconazole as a therapy for patients with Cushing's syndrome.
Topics: Adult; Aged; Chemical and Drug Induced Liver Injury; Cushing Syndrome; Female; Humans; Hydrocortison | 1987 |
Ketoconazole-associated hepatic injury. A clinicopathological study of 55 cases.
Topics: Biopsy; Chemical and Drug Induced Liver Injury; Cholestasis; Female; Humans; Ketoconazole; Liver; Ma | 1986 |
Ketoconazole induced hepatitis.
Topics: Aged; Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Male | 1987 |
[Ketoconazole hepatoxicity. Apropos of a case].
Topics: Aged; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole | 1986 |
[Ketoconazole-induced acute liver necrosis].
Topics: Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; Liver; Middle Aged; Necrosis | 1986 |
Ketoconazole: a reappraisal.
Topics: Adult; Candidiasis; Chemical and Drug Induced Liver Injury; Dermatomycoses; Female; Humans; Ketocona | 1985 |
CSM update: adverse drug reactions and the liver.
Topics: Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Liver Cirrhosis | 1985 |
Ketoconazole-induced fulminant hepatitis.
Topics: Adult; Alanine Transaminase; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; M | 1985 |
Potential toxicity of ketoconazole.
Topics: Chemical and Drug Induced Liver Injury; Humans; Ketoconazole | 1985 |
[The yellow peril].
Topics: Chemical and Drug Induced Liver Injury; Humans; Ketoconazole; Mycoses | 1985 |
Trichosporon infection in a cat.
Topics: Amphotericin B; Animals; Cat Diseases; Cats; Chemical and Drug Induced Liver Injury; Humans; Ketocon | 1985 |