ketoconazole has been researched along with Acute Disease in 37 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Acute Disease: Disease having a short and relatively severe course.
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole." | 9.05 | Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984) |
| "We have reported the first case of successful treatment of disseminated histoplasmosis in a renal allograft recipient using a short course (14 days) of amphotericin B in combination with prolonged therapy (161 days) with ketoconazole." | 7.67 | Combined ketoconazole and amphotericin B treatment of acute disseminated histoplasmosis in a renal allograft recipient. ( Goetz, MB; Jones, JM, 1985) |
| "Alendronate is an aminobisphosphonate that is able to increase bone mass mainly by inhibiting bone resorption." | 6.69 | Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease. ( Colao, A; Di Somma, C; Faggiano, A; Klain, M; Lombardi, G; Merola, B; Pivonello, R; Salvatore, M; Tripodi, FS, 1998) |
| "Acute generalized exanthematous pustulosis is a rare disorder characterized by an acute onset of generalized, nonfollicular, pustular eruption associated with fever." | 5.36 | Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. ( Kadurina, M; Miteva, L; Schwartz, RA, 2010) |
| "Acute pancreatitis is a rarely reported adverse effect." | 5.31 | Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate. ( Bakirtaç, A; Kara, C; Kuyucu, N; Teziç, T, 2001) |
| "In a comparative study of infection prophylaxis, patients with acute leukemia receiving remission induction therapy were assigned either no prophylaxis, sulfamethoxazole and trimethoprim, ketoconazole, or the combination of sulfamethoxazole and trimethoprim and ketoconazole." | 5.05 | Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two. ( Bodey, GP; Estey, E; Fainstein, V; Freireich, EJ; Keating, M; Maksymiuk, A; McCredie, KB; Smith, T, 1984) |
| "We describe a patient with type I diabetes mellitus and hypothyroidism who developed frank adrenocortical insufficiency while receiving a high-dose ketoconazole therapy for keratitis caused by Acanthamoeba species." | 3.67 | Adrenal crisis in the setting of high-dose ketoconazole therapy. ( Demerjian, Z; Godine, JE; Khosla, S; Wolfson, JS, 1989) |
| "We have reported the first case of successful treatment of disseminated histoplasmosis in a renal allograft recipient using a short course (14 days) of amphotericin B in combination with prolonged therapy (161 days) with ketoconazole." | 3.67 | Combined ketoconazole and amphotericin B treatment of acute disseminated histoplasmosis in a renal allograft recipient. ( Goetz, MB; Jones, JM, 1985) |
| "Alendronate is an aminobisphosphonate that is able to increase bone mass mainly by inhibiting bone resorption." | 2.69 | Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease. ( Colao, A; Di Somma, C; Faggiano, A; Klain, M; Lombardi, G; Merola, B; Pivonello, R; Salvatore, M; Tripodi, FS, 1998) |
| " The feasibility of one-day therapy was assessed in a clinical study in which three different dosage regimens were compared in a total of 552 patients with acute vulvovaginal candidosis: 200 mg twice daily for one day; 200 mg once daily for two days; and 200 mg once daily for three days." | 2.67 | Itraconazole: a single-day oral treatment for acute vulvovaginal candidosis. ( Wesel, S, 1990) |
| "Ketoconazole was administered in a 200 mg dose twice daily." | 2.66 | A randomized trial comparing ketoconazole and nystatin prophylactic therapy in neutropenic patients. ( Malcom, LG; Vogler, WR; Winton, EF, 1987) |
| "Acute generalized exanthematous pustulosis is a rare disorder characterized by an acute onset of generalized, nonfollicular, pustular eruption associated with fever." | 1.36 | Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. ( Kadurina, M; Miteva, L; Schwartz, RA, 2010) |
| "Acute pancreatitis is a rarely reported adverse effect." | 1.31 | Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate. ( Bakirtaç, A; Kara, C; Kuyucu, N; Teziç, T, 2001) |
| "Ketoconazole was used as an adjuvant to conventional 3-component immunosuppression in 56 patients with transplanted kidney." | 1.30 | [Combination of cyclosporin and ketoconazole in immunosuppression schemes in patients with transplanted kidney]. ( Ankova, EV; Shoĭkhet, IN; Treĭvish, VS, 1998) |
| "Ketoconazole was the antifungal associated with the highest relative risk, 228." | 1.30 | A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs. ( Castellsague, J; Duque, A; García Rodríguez, LA; Pérez-Gutthann, S; Stricker, BH, 1999) |
| "Ketoconazole treatment of mice resulted in no positive cultures." | 1.28 | Gamma interferon suppresses acute and chronic Trypanosoma cruzi infection in cyclosporin-treated mice. ( McCabe, R; Meagher, S; Mullins, B, 1991) |
| "The rhabdomyolysis was preceded by a grand mal seizure probably caused by a combination of cyclosporin A and corticosteroids given for the prevention and treatment of acute graft-versus-host disease." | 1.28 | Fatal rhabdomyolysis as a complication of bone marrow transplantation. ( Järventie, G; Ruutu, T; Volin, L, 1990) |
| "Acute histoplasmosis is an infrequently recognized pulmonary disease endemic in Puerto Rico." | 1.28 | Acute histoplasmosis: a modern appraisal. ( Ramírez Rivera, J, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 15 (40.54) | 18.7374 |
| 1990's | 15 (40.54) | 18.2507 |
| 2000's | 6 (16.22) | 29.6817 |
| 2010's | 1 (2.70) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amir, M | 1 |
| Kumar, H | 1 |
| Javed, SA | 1 |
| Dabbagh, A | 1 |
| Sa'adat, N | 1 |
| Heidari, Z | 1 |
| Miteva, L | 1 |
| Kadurina, M | 1 |
| Schwartz, RA | 1 |
| Chien, RN | 1 |
| Sheen, IS | 1 |
| Liaw, YF | 1 |
| Caixeta, M | 1 |
| Caixeta, L | 1 |
| Estey, E | 1 |
| Maksymiuk, A | 1 |
| Smith, T | 1 |
| Fainstein, V | 2 |
| Keating, M | 1 |
| McCredie, KB | 1 |
| Freireich, EJ | 1 |
| Bodey, GP | 2 |
| Maksymiuk, AW | 1 |
| Thongprasert, S | 1 |
| Hopfer, R | 1 |
| Luna, M | 1 |
| Pollock, AV | 1 |
| Evans, M | 1 |
| Harris, LF | 1 |
| Le Grand, MP | 1 |
| Serio, RA | 1 |
| Brincker, H | 1 |
| Srinath, L | 1 |
| Ahkee, S | 1 |
| Huang, A | 1 |
| Raff, MJ | 1 |
| Ramirez, JA | 1 |
| Nichols, R | 1 |
| Sobel, JD | 1 |
| Schmitt, C | 1 |
| Stein, G | 1 |
| Mummaw, N | 1 |
| Christensen, S | 1 |
| Meriwether, C | 1 |
| Graybill, JR | 1 |
| Treĭvish, VS | 1 |
| Shoĭkhet, IN | 1 |
| Ankova, EV | 1 |
| Di Somma, C | 1 |
| Colao, A | 1 |
| Pivonello, R | 1 |
| Klain, M | 1 |
| Faggiano, A | 1 |
| Tripodi, FS | 1 |
| Merola, B | 1 |
| Salvatore, M | 1 |
| Lombardi, G | 1 |
| García Rodríguez, LA | 1 |
| Duque, A | 1 |
| Castellsague, J | 1 |
| Pérez-Gutthann, S | 1 |
| Stricker, BH | 1 |
| Kuyucu, N | 1 |
| Kara, C | 1 |
| Bakirtaç, A | 1 |
| Teziç, T | 1 |
| Bruserud, O | 1 |
| Roongpisuthipong, A | 1 |
| Sentrakul, P | 1 |
| Bhiraleus, P | 1 |
| Dusitsin, N | 1 |
| Sukroongreung, S | 1 |
| Pupaibul, K | 1 |
| Persat, F | 1 |
| Marzullo, C | 1 |
| Guyotat, D | 1 |
| Rochet, MJ | 1 |
| Piens, MA | 1 |
| Pether, JV | 1 |
| Jones, W | 1 |
| Greatorex, FB | 1 |
| Bunting, W | 1 |
| McCabe, R | 1 |
| Meagher, S | 1 |
| Mullins, B | 1 |
| Wesel, S | 1 |
| Wolf, HH | 1 |
| Scharf, RE | 1 |
| Arning, M | 1 |
| Schneider, W | 1 |
| Naranjo, MS | 1 |
| Trujillo, M | 1 |
| Munera, MI | 1 |
| Restrepo, P | 1 |
| Gomez, I | 1 |
| Restrepo, A | 1 |
| Volin, L | 1 |
| Järventie, G | 1 |
| Ruutu, T | 1 |
| Faggian, G | 1 |
| Livi, U | 1 |
| Bortolotti, U | 1 |
| Mazzucco, A | 1 |
| Stellin, G | 1 |
| Chiominto, B | 1 |
| Vivani, MA | 1 |
| Gallucci, V | 1 |
| Khosla, S | 1 |
| Wolfson, JS | 1 |
| Demerjian, Z | 1 |
| Godine, JE | 1 |
| Ramírez Rivera, J | 1 |
| McCance, DR | 1 |
| Ritchie, CM | 1 |
| Sheridan, B | 1 |
| Atkinson, AB | 1 |
| van Parys, G | 1 |
| Evenepoel, C | 1 |
| van Damme, B | 1 |
| Desmet, VJ | 1 |
| Verhagen, C | 1 |
| Stalpers, LJ | 1 |
| de Pauw, BE | 1 |
| Haanen, C | 1 |
| Cade, JE | 1 |
| Lancaster, DM | 1 |
| Barsley, RE | 1 |
| Rodu, B | 1 |
| Carpenter, JT | 1 |
| Jones, MR | 1 |
| Vogler, WR | 1 |
| Malcom, LG | 1 |
| Winton, EF | 1 |
| Goetz, MB | 1 |
| Jones, JM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Phase IIa Randomized, Active-controlled, Double-blind, Dose-escalation Study in Patients With Vulvovaginal Candidiasis to Evaluate Dose Response Relationship of Clinical Efficacy, Safety and Tolerability of Topically Administered ProF-001[NCT03115073] | Phase 2/Phase 3 | 84 participants (Actual) | Interventional | 2017-04-04 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketoconazole and Acute Disease
| Article | Year |
|---|---|
Concurrent illness and complications associated with canine hyperadrenocorticism.
Topics: Acute Disease; Animals; Cushing Syndrome; Diabetes Complications; Diabetes Mellitus; Dog Diseases; D | 1994 |
Treatment of coccidioidomycosis.
Topics: Acute Disease; AIDS-Related Opportunistic Infections; Amphotericin B; Antifungal Agents; Chronic Dis | 1993 |
Ketoconazole therapy for acute pseudomembranous candidiasis: a case report.
Topics: Acute Disease; Candidiasis, Oral; Female; Humans; Ketoconazole; Middle Aged | 1988 |
5 trials available for ketoconazole and Acute Disease
| Article | Year |
|---|---|
Infection prophylaxis in acute leukemia. Comparative effectiveness of sulfamethoxazole and trimethoprim, ketoconazole, and a combination of the two.
Topics: Acute Disease; Adolescent; Adult; Aged; Bacterial Infections; Drug Combinations; Drug Therapy, Combi | 1984 |
Initial management of recurrent vulvovaginal candidiasis with oral ketoconazole and topical clotrimazole.
Topics: Acute Disease; Administration, Intravaginal; Administration, Oral; Adolescent; Adult; Candidiasis, V | 1994 |
Effectiveness of chronic treatment with alendronate in the osteoporosis of Cushing's disease.
Topics: Acute Disease; Adult; Alendronate; Antifungal Agents; Biomarkers; Bone Density; Collagen; Collagen T | 1998 |
Itraconazole: a single-day oral treatment for acute vulvovaginal candidosis.
Topics: Acute Disease; Administration, Oral; Antifungal Agents; Candidiasis, Vulvovaginal; Female; Humans; I | 1990 |
A randomized trial comparing ketoconazole and nystatin prophylactic therapy in neutropenic patients.
Topics: Acute Disease; Adolescent; Adult; Aged; Agranulocytosis; Candidiasis, Oral; Female; Humans; Immune T | 1987 |
29 other studies available for ketoconazole and Acute Disease
| Article | Year |
|---|---|
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid.
Topics: Acute Disease; Analgesics; Animals; Bacteria; Diphenylacetic Acids; Female; Fungi; Hepatocytes; Ibup | 2008 |
Etomidate infusion in the critical care setting for suppressing the acute phase of Cushing's syndrome.
Topics: Acute Disease; Administration, Oral; Adolescent; Adrenalectomy; Critical Care; Cushing Syndrome; Enz | 2009 |
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole.
Topics: Acute Disease; Antifungal Agents; Candidiasis, Oral; Child; Drug Eruptions; Exanthema; Female; Human | 2010 |
Unintentional rechallenge resulting in a causative relationship between ketoconazole and acute liver injury.
Topics: Acute Disease; Antifungal Agents; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Hu | 2003 |
[Ketoconazole in the prevention of acute delirium episodes].
Topics: Acute Disease; Adult; Antipsychotic Agents; Delirium; Depressive Disorder; Female; Humans; Ketoconaz | 2004 |
Systemic candidiasis in cancer patients.
Topics: Acute Disease; Amphotericin B; Bacterial Infections; Bacteriological Techniques; Candida; Candidiasi | 1984 |
Oral ketoconazole and amphotericin B for the prevention of yeast colonization in patients with acute leukaemia.
Topics: Acute Disease; Amphotericin B; Humans; Ketoconazole; Leukemia; Mycoses | 1984 |
Histoplasmosis in Huntsville, Alabama.
Topics: Acute Disease; Adolescent; Adult; Aged; Alabama; Amphotericin B; Bone Diseases; Chronic Disease; His | 1982 |
Prevention of mycosis in granulocytopenic patients with prophylactic ketoconazole treatment.
Topics: Acute Disease; Adult; Agranulocytosis; Antifungal Agents; Candidiasis, Cutaneous; Double-Blind Metho | 1983 |
Acute miliary blastomycosis in an AIDS patient.
Topics: Acquired Immunodeficiency Syndrome; Acute Disease; Administration, Oral; Adult; Blastomyces; Blastom | 1994 |
[Combination of cyclosporin and ketoconazole in immunosuppression schemes in patients with transplanted kidney].
Topics: Acute Disease; Antifungal Agents; Cyclosporine; Dose-Response Relationship, Drug; Drug Therapy, Comb | 1998 |
A cohort study on the risk of acute liver injury among users of ketoconazole and other antifungal drugs.
Topics: Acute Disease; Adult; Aged; Antifungal Agents; Chemical and Drug Induced Liver Injury; Cohort Studie | 1999 |
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.
Topics: Acute Disease; Allopurinol; Antiprotozoal Agents; Child, Preschool; Humans; Ketoconazole; Leishmania | 2001 |
Effects of azoles on human acute myelogenous leukemia blasts and T lymphocytes derived from acute leukemia patients with chemotherapy-induced cytopenia.
Topics: Acute Disease; Aged; Aged, 80 and over; Antifungal Agents; CD4-Positive T-Lymphocytes; CD8-Positive | 2001 |
Itraconazole in the treatment of acute vaginal candidosis.
Topics: Acute Disease; Adolescent; Adult; Antifungal Agents; Candidiasis, Vulvovaginal; Female; Humans; Itra | 1992 |
Plasma itraconazole concentrations in neutropenic patients after repeated high-dose treatment.
Topics: Acute Disease; Adult; Aged; Antineoplastic Agents; Bone Marrow Transplantation; Combined Modality Th | 1992 |
Acute pyogenic Pseudallescheria boydii foot infection sequentially treated with miconazole and itraconazole.
Topics: Acute Disease; Antifungal Agents; Foot Diseases; Humans; Itraconazole; Ketoconazole; Male; Miconazol | 1992 |
Gamma interferon suppresses acute and chronic Trypanosoma cruzi infection in cyclosporin-treated mice.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Cyclosporins; Interferon-gamma; Ketoconazol | 1991 |
Preliminary results of treatment with itraconazole in patients with systemic fungal infections.
Topics: Acute Disease; Adult; Agranulocytosis; Antifungal Agents; Antineoplastic Agents; Drug Evaluation; Dr | 1990 |
Treatment of paracoccidioidomycosis with itraconazole.
Topics: Acute Disease; Adolescent; Adult; Aged; Antifungal Agents; Child; Chronic Disease; Humans; Itraconaz | 1990 |
Fatal rhabdomyolysis as a complication of bone marrow transplantation.
Topics: Acute Disease; Adrenal Cortex Hormones; Adult; Bone Marrow Transplantation; Cyclosporins; Graft vs H | 1990 |
Itraconazole therapy for acute invasive pulmonary aspergillosis in heart transplantation.
Topics: Acute Disease; Adult; Aspergillosis; Cyclosporins; Heart Transplantation; Humans; Itraconazole; Keto | 1989 |
Adrenal crisis in the setting of high-dose ketoconazole therapy.
Topics: Acanthamoeba; Acute Disease; Adrenal Cortex Diseases; Amebiasis; Animals; Diabetes Mellitus, Type 1; | 1989 |
Acute histoplasmosis: a modern appraisal.
Topics: Acute Disease; Adult; Histoplasmosis; Humans; Ketoconazole; Lung Diseases, Fungal; Male; Puerto Rico | 1989 |
Acute hypoadrenalism and hepatotoxicity after treatment with ketoconazole.
Topics: Acute Disease; Adrenal Insufficiency; Adult; Chemical and Drug Induced Liver Injury; Cushing Syndrom | 1987 |
Ketoconazole-induced hepatitis: a case with a definite cause-effect relationship.
Topics: Acute Disease; Biopsy, Needle; Chemical and Drug Induced Liver Injury; Female; Humans; Ketoconazole; | 1987 |
Drug-induced skin reactions in patients with acute non-lymphocytic leukaemia.
Topics: Acute Disease; Adult; Allopurinol; Cephalosporins; Drug Combinations; Drug Eruptions; Female; Humans | 1987 |
The pathogenesis and clinical significance of cytologically detectable oral Candida in acute leukemia.
Topics: Acute Disease; Adolescent; Adult; Aged; Amphotericin B; Candida; Candidiasis, Oral; Female; Humans; | 1988 |
Combined ketoconazole and amphotericin B treatment of acute disseminated histoplasmosis in a renal allograft recipient.
Topics: Acute Disease; Adult; Amphotericin B; Drug Combinations; Follow-Up Studies; Histoplasmosis; Humans; | 1985 |