ketoconazole has been researched along with Acute Confusional Senile Dementia in 2 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD)." | 9.01 | Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies. ( Goss, S; Jin, Z; Locke, C; Lon, HK; Mendonca, N; Othman, AA; Rendenbach-Mueller, B, 2019) |
| "Alicapistat is an orally active selective inhibitor of calpain 1 and 2 whose overactivation has been linked to Alzheimer disease (AD)." | 5.01 | Pharmacokinetics, Safety, Tolerability, and Pharmacodynamics of Alicapistat, a Selective Inhibitor of Human Calpains 1 and 2 for the Treatment of Alzheimer Disease: An Overview of Phase 1 Studies. ( Goss, S; Jin, Z; Locke, C; Lon, HK; Mendonca, N; Othman, AA; Rendenbach-Mueller, B, 2019) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| McEneny-King, A | 1 |
| Edginton, AN | 1 |
| Rao, PP | 1 |
| Lon, HK | 1 |
| Mendonca, N | 1 |
| Goss, S | 1 |
| Othman, AA | 1 |
| Locke, C | 1 |
| Jin, Z | 1 |
| Rendenbach-Mueller, B | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| A Study to Evaluate the Safety, Tolerability and the Effects on Cerebrospinal Fluid Spectrin Breakdown Product-145 Levels of Multiple Doses of ABT-957 in Subjects With Mild Alzheimer's Disease and Mild Cognitive Impairment Due to Alzheimer's Disease[NCT02573740] | Phase 1 | 8 participants (Actual) | Interventional | 2015-12-31 | Terminated (stopped due to Insufficient target engagement of ABT-957 (preclinical data)) | ||
| A Multiple-Dose Study to Evaluate the Safety, Tolerability and Pharmacokinetics of ABT-957 in Subjects With Mild-to-Moderate Alzheimer's Disease on Stable Doses of Acetylcholinesterase Inhibitors[NCT02220738] | Phase 1 | 19 participants (Actual) | Interventional | 2014-09-30 | Terminated (stopped due to Slow subject enrollment) | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketoconazole and Acute Confusional Senile Dementia
1 other study available for ketoconazole and Acute Confusional Senile Dementia
| Article | Year |
|---|---|
Investigating the binding interactions of the anti-Alzheimer's drug donepezil with CYP3A4 and P-glycoprotein.
Topics: Alzheimer Disease; ATP Binding Cassette Transporter, Subfamily B, Member 1; Cytochrome P-450 CYP3A; | 2015 |