ketoconazole has been researched along with Abnormalities, Drug-Induced in 6 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketoconazole has been shown to be teratogenic at high, toxic doses in pregnant rats." | 2.38 | Safety aspects of oral antifungal agents. ( Coussement, W; De Coster, R; Lampo, A; Marsboom, R; Van Cauteren, H; Vandenberghe, J; Vanparys, P, 1990) |
| "Ketoconazole is a major breakthrough although hepatic side-effects as well as interactions with mammalian steroids might rarely occur during prolonged treatment." | 2.38 | Toxicological profile and safety evaluation of antifungal azole derivatives. ( Coussement, W; De Coster, R; Lampo, A; Marsboom, R; Van Cauteren, H; Vandenberghe, J; Vanparys, P, 1989) |
| "Ketoconazole (KT) is a broad-spectrum antifungal agent whose pharmacological activity is based on the capability to interfere with steroid biosynthesis through an interaction with fungal cytochrome P-450 enzymes and thereby avoiding the formation of fungal walls." | 1.35 | Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses. ( Amaral, VC; Nunes, GP, 2009) |
| "Ketoconazole has been given a teratogenic classification of C by the US Food and Drug Administration, but human controlled epidemiological studies of the treatment's effects have not been reported." | 1.33 | Population-based case-control study of oral ketoconazole treatment for birth outcomes. ( Czeizel, AE; Kazy, Z; Puhó, E, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (16.67) | 18.7374 |
| 1990's | 1 (16.67) | 18.2507 |
| 2000's | 2 (33.33) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Amaral, VC | 1 |
| Nunes, GP | 1 |
| Dodo, T | 1 |
| Uchida, K | 2 |
| Hirose, T | 1 |
| Fukuta, T | 2 |
| Kojima, C | 1 |
| Shiraishi, I | 1 |
| Kato, E | 2 |
| Horiba, T | 1 |
| Mineshima, H | 2 |
| Okuda, Y | 1 |
| Maeda, M | 1 |
| Katsutani, N | 1 |
| Hirano, K | 1 |
| Aoki, T | 2 |
| Matsuno, Y | 1 |
| Mori, C | 1 |
| Kazy, Z | 1 |
| Puhó, E | 1 |
| Czeizel, AE | 1 |
| Van Cauteren, H | 2 |
| Lampo, A | 2 |
| Vandenberghe, J | 2 |
| Vanparys, P | 2 |
| Coussement, W | 2 |
| De Coster, R | 2 |
| Marsboom, R | 2 |
2 reviews available for ketoconazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Safety aspects of oral antifungal agents.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Animals; Antifungal Agents; Endocrine Glands; Hum | 1990 |
Toxicological profile and safety evaluation of antifungal azole derivatives.
Topics: Abnormalities, Drug-Induced; Animals; Antifungal Agents; Endocrine Glands; Fluconazole; Humans; Itra | 1989 |
4 other studies available for ketoconazole and Abnormalities, Drug-Induced
| Article | Year |
|---|---|
Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses.
Topics: Abnormalities, Drug-Induced; Animals; Bone and Bones; Dose-Response Relationship, Drug; Drinking; Dr | 2009 |
Increases in discontinuous rib cartilage and fused carpal bone in rat fetuses exposed to the teratogens, busulfan, acetazolamide, vitamin A, and ketoconazole.
Topics: Abnormalities, Drug-Induced; Acetazolamide; Animals; Busulfan; Carpal Bones; Cartilage; Diterpenes; | 2010 |
Malformation spectrum induced by ketoconazole after single administration to pregnant rats during the critical period - comparison with vitamin A-induced malformation spectrum.
Topics: Abnormalities, Drug-Induced; Animals; Dose-Response Relationship, Drug; Female; Fetal Diseases; Fetu | 2012 |
Population-based case-control study of oral ketoconazole treatment for birth outcomes.
Topics: Abnormalities, Drug-Induced; Administration, Oral; Adult; Antifungal Agents; Birth Weight; Case-Cont | 2005 |