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ketoconazole and ACTH-Producing Pituitary Adenoma

ketoconazole has been researched along with ACTH-Producing Pituitary Adenoma in 11 studies

1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.

Research Excerpts

ExcerptRelevanceReference
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."7.77Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"Ketoconazole is the most widely used medical treatment for Cushing's syndrome, but, because of its potential to cause birth defects, it is not recommended during pregnancy."3.77Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation. ( Barber, M; Boronat, M; López-Plasencia, Y; Marrero, D; Nóvoa, FJ; Schamann, Y, 2011)
"Cushing's disease is a syndromic pathological condition caused by adrenocorticotropic hormone (ACTH)-secreting pituitary adenomas (ACTHomas) mediated by hypercortisolemia."2.72Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach. ( Fukuoka, H; Nakao, T; Ogawa, W; Yamamoto, M, 2021)
"Cushing disease is most frequently caused by pituitary adenomas that secrete adrenocorticotrophic hormone."2.44Management of recurrent and refractory Cushing disease. ( Aghi, MK, 2008)
"The evaluation of β-arrestin mRNA in corticotroph adenomas from CD patients with variable disease activity showed a significant positive correlation between β-arrestin 1 mRNA and urinary cortisol levels."1.56β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids. ( Arvigo, M; Bruzzone, E; Dogan, F; Feelders, RA; Ferone, D; Gatto, F; Hofland, L; Lamberts, S; van der Pas, R; van Koetsveld, P, 2020)
"BLA = bilateral adrenalectomy CD = Cushing disease CS = Cushing syndrome eCRF = electronic case report form MRI = magnetic resonance imaging PCOS = polycystic ovary syndrome."1.46BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY. ( Ayala, A; Biller, BMK; Bonert, V; Broder, MS; Carmichael, JD; Cherepanov, D; Eagan, M; Geer, EB; Gordon, MB; Hannoush, Z; Katznelson, L; Lalazar, Y; Lee, J; Manuylova, E; Neary, MP; Pulaski-Liebert, KJ; Said, Q; Shafiq, I; Surampudi, V; Swerdloff, RS, 2017)
"Treatment of Cushing's disease poses interesting dilemmas in clinical practice."1.42Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha. ( Aguirre, M; Alramadan, M; Huguet, I; Lamas, C; Quiroga, I; Silva, J; Vicente, A, 2015)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (18.18)29.6817
2010's5 (45.45)24.3611
2020's4 (36.36)2.80

Authors

AuthorsStudies
Gatto, F1
Feelders, RA1
van der Pas, R1
van Koetsveld, P1
Bruzzone, E1
Arvigo, M1
Dogan, F1
Lamberts, S1
Ferone, D1
Hofland, L1
Newell-Price, J1
Nieman, LK1
Reincke, M1
Tabarin, A1
Kudsieh, B1
Casado López de la Franca, E1
Díez Gómez, MA1
Ruiz Moreno, JM1
Yamamoto, M1
Nakao, T1
Ogawa, W1
Fukuoka, H1
Espinosa-de-Los-Monteros, AL1
Sosa-Eroza, E1
Espinosa, E1
Mendoza, V1
Arreola, R1
Mercado, M1
Geer, EB1
Shafiq, I1
Gordon, MB1
Bonert, V1
Ayala, A1
Swerdloff, RS1
Katznelson, L1
Lalazar, Y1
Manuylova, E1
Pulaski-Liebert, KJ1
Carmichael, JD1
Hannoush, Z1
Surampudi, V1
Broder, MS2
Cherepanov, D2
Eagan, M1
Lee, J1
Said, Q1
Neary, MP2
Biller, BMK1
Chang, E1
Sun, GH1
Ludlam, WH1
Huguet, I1
Aguirre, M1
Vicente, A1
Alramadan, M1
Quiroga, I1
Silva, J1
Lamas, C1
Aghi, MK1
Boronat, M1
Marrero, D1
López-Plasencia, Y1
Barber, M1
Schamann, Y1
Nóvoa, FJ1
Polli, N1
Pecori Giraldi, F1
Cavagnini, F1

Reviews

3 reviews available for ketoconazole and ACTH-Producing Pituitary Adenoma

ArticleYear
Aggressive Cushing's Disease: Molecular Pathology and Its Therapeutic Approach.
    Frontiers in endocrinology, 2021, Volume: 12

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenocorticotropic Hormone; Carcinoma; Dopamine Agonists

2021
Management of recurrent and refractory Cushing disease.
    Nature clinical practice. Endocrinology & metabolism, 2008, Volume: 4, Issue:10

    Topics: ACTH-Secreting Pituitary Adenoma; Adrenalectomy; Humans; Hypophysectomy; Ketoconazole; Models, Biolo

2008
Cushing's disease and pregnancy.
    Pituitary, 2004, Volume: 7, Issue:4

    Topics: ACTH-Secreting Pituitary Adenoma; Adrenocorticotropic Hormone; Female; Humans; Hydrocortisone; Hypot

2004

Other Studies

8 other studies available for ketoconazole and ACTH-Producing Pituitary Adenoma

ArticleYear
β-arrestin expression in corticotroph tumor cells is modulated by glucocorticoids.
    The Journal of endocrinology, 2020, Volume: 245, Issue:1

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adult; Aged; Animals; Anti-Inflammatory Agents; beta-Arre

2020
ENDOCRINOLOGY IN THE TIME OF COVID-19: Management of Cushing's syndrome.
    European journal of endocrinology, 2020, Volume: 183, Issue:1

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Coronavirus Infections;

2020
Open angle glaucoma secondary to endogenous cortisone due to pituitary microadenoma in a young patient, a case report.
    Archivos de la Sociedad Espanola de Oftalmologia, 2020, Volume: 95, Issue:7

    Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Cortisone; Diagnostic Techniques

2020
LONG-TERM OUTCOME OF THE DIFFERENT TREATMENT ALTERNATIVES FOR RECURRENT AND PERSISTENT CUSHING DISEASE.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:7

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectomy; Adult; Antifungal Agents; Coho

2017
BIOCHEMICAL CONTROL DURING LONG-TERM FOLLOW-UP OF 230 ADULT PATIENTS WITH CUSHING DISEASE: A MULTICENTER RETROSPECTIVE STUDY.
    Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists, 2017, Volume: 23, Issue:8

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adenoma; Adolescent; Adrenalectom

2017
Treatment patterns in Cushing's disease patients in two large United States nationwide databases: application of a novel, graphical methodology.
    Pituitary, 2015, Volume: 18, Issue:4

    Topics: ACTH-Secreting Pituitary Adenoma; Adenoma; Adrenalectomy; Adult; Antineoplastic Agents, Hormonal; Co

2015
Assessment of the outcomes of the treatment of Cushing's disease in the hospitals of Castilla-La Mancha.
    Endocrinologia y nutricion : organo de la Sociedad Espanola de Endocrinologia y Nutricion, 2015, Volume: 62, Issue:5

    Topics: ACTH-Secreting Pituitary Adenoma; Adult; Combined Modality Therapy; Comorbidity; Craniotomy; Diabete

2015
Successful outcome of pregnancy in a patient with Cushing's disease under treatment with ketoconazole during the first trimester of gestation.
    Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology, 2011, Volume: 27, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; ACTH-Secreting Pituitary Adenoma; Adult; Cushing Syndrome; Female;

2011