ketanserin has been researched along with Thrombosis in 15 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Thrombosis: Formation and development of a thrombus or blood clot in the blood vessel.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The potential antithrombotic effect of aspirin and metoclopramide were studied in a model of arterial thrombosis in rats." | 3.68 | Enhancement of antithrombotic effect of aspirin by metoclopramide in rats. ( al-Humayyd, MS; Mobarok Ali, AT, 1991) |
| "Two highly sensitive models of arterial and venous thrombosis forming with the test of endothelial stability a complementary system with a maximum stress on the role of vascular lesion were used to test a series of four antithrombotic drugs (heparin, acetylsalicylic acid, dipyridamole, sulfinpyrazone) and four drugs with other indications but with an antithrombotic activity in experiment (prenylamine, troxerutin, ketanserin and pizotifen)." | 3.67 | Antithrombotics in view of thrombosis models. ( Hladovec, J, 1986) |
| "The relative importance of ADP, arachidonic acid metabolites and serotonin as thrombogenic factors was evaluated in rats by comparing, after oral administration, the effects of two inhibitors of ADP-induced platelet aggregation (ticlopidine and PCR 4099), three cyclo-oxygenase inhibitors (aspirin, triflusal and indobufen) and a selective serotonin 5HT2 receptor antagonist (ketanserin) on platelet aggregation, in four platelet-dependent thrombosis models and on bleeding time." | 3.67 | ADP plays a key role in thrombogenesis in rats. ( Bernat, A; Cazenave, JP; Defreyn, G; Delebassée, D; Gordon, JL; Maffrand, JP, 1988) |
| "Fibrinogen concentration was lower than in the untreated group." | 2.69 | Long-term effects of erythropoietin on platelet serotonin storage and platelet aggregation in hemodialysis patients with reference to ketanserin treatment. ( Azzadin, A; Borawski, J; Buczko, W; Mysliwiec, M; Pawlak, K; Rydzewski, A, 1998) |
| "Pre-treatment with ketanserin (1." | 1.27 | Restoration of post-thrombotic peripheral collateral circulation in the cat by ketanserin, a selective 5-HT2-receptor antagonist. ( De Clerck, F; De Gryse, A; Loots, W; Nevelsteen, A, 1984) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 5 (33.33) | 18.7374 |
| 1990's | 10 (66.67) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Malyszko, J | 1 |
| Pawlak, K | 3 |
| Borawski, J | 2 |
| Malyszko, JS | 1 |
| Mysliwiec, M | 3 |
| Nevelsteen, A | 1 |
| De Clerck, F | 3 |
| Loots, W | 1 |
| De Gryse, A | 1 |
| Hirata, Y | 1 |
| Umemura, K | 1 |
| Uematsu, T | 1 |
| Nakashima, M | 1 |
| Herbert, JM | 1 |
| Bernat, A | 2 |
| Barthelemy, G | 1 |
| Dol, F | 1 |
| Rinaldi, M | 1 |
| Beaughard, M | 1 |
| Brasset, M | 1 |
| John, G | 1 |
| Massingham, R | 1 |
| Rydzewski, A | 1 |
| Azzadin, A | 1 |
| Buczko, W | 2 |
| Pawlak, D | 1 |
| Chabielska, E | 1 |
| Małyszko, J | 1 |
| Takada, A | 1 |
| Mobarok Ali, AT | 1 |
| al-Humayyd, MS | 1 |
| Hollenberg, NK | 1 |
| Hladovec, J | 1 |
| Schumacher, WA | 1 |
| Goldenberg, HJ | 1 |
| Harris, DN | 1 |
| Ogletree, ML | 1 |
| Maffrand, JP | 1 |
| Delebassée, D | 1 |
| Defreyn, G | 1 |
| Cazenave, JP | 1 |
| Gordon, JL | 1 |
| Prosdocimi, M | 1 |
| Zatta, A | 1 |
| Finesso, M | 1 |
3 reviews available for ketanserin and Thrombosis
| Article | Year |
|---|---|
Effects of serotonin on platelets and blood vessels.
Topics: Animals; Blood Platelets; Ketanserin; Muscle, Smooth, Vascular; Serotonin; Thrombosis; Vasoconstrict | 1991 |
Implications of thrombosis and vasospasm in peripheral vascular disease.
Topics: Animals; Endothelium, Vascular; Humans; Ketanserin; Peripheral Vascular Diseases; Serotonin; Thrombo | 1991 |
The role of serotonin in thrombogenesis.
Topics: Animals; Blood Platelets; Calcium; Coronary Disease; Dogs; Fibrinolysis; Ketanserin; Phosphatidylino | 1990 |
1 trial available for ketanserin and Thrombosis
| Article | Year |
|---|---|
Long-term effects of erythropoietin on platelet serotonin storage and platelet aggregation in hemodialysis patients with reference to ketanserin treatment.
Topics: Adolescent; Adult; Bleeding Time; Blood Platelets; Child; Erythropoietin; Female; Fibrinogen; Hemost | 1998 |
11 other studies available for ketanserin and Thrombosis
| Article | Year |
|---|---|
Effect of ketanserin on platelet function and bleeding time in uremic patients treated with erythropoietin.
Topics: Adult; Anemia; Blood Coagulation; Blood Coagulation Tests; Case-Control Studies; Drug Monitoring; Er | 1995 |
Restoration of post-thrombotic peripheral collateral circulation in the cat by ketanserin, a selective 5-HT2-receptor antagonist.
Topics: Animals; Blood Platelets; Blood Pressure; Cats; Collateral Circulation; Ketanserin; Piperidines; Pro | 1984 |
An experimental myocardial infarction model in the rat and its properties.
Topics: Animals; Biphenyl Compounds; Clopidogrel; Coronary Vessels; Disease Models, Animal; Electrocardiogra | 1995 |
Antithrombotic activity of SR 46349, a novel, potent and selective 5-HT2 receptor antagonist.
Topics: Animals; Bleeding Time; Coronary Circulation; Depression, Chemical; Disease Models, Animal; Dogs; Fi | 1993 |
Failure of calcium channel blockade to reduce platelet-mediated cyclic flow variations in dogs with coronary stenosis and endothelial injury.
Topics: Animals; Aspirin; Calcium Channel Blockers; Coronary Circulation; Coronary Disease; Diltiazem; Disea | 1995 |
A potent 5-hydroxytryptamine receptor (5-HT2A) antagonist, DV-7028, delays arterial thrombosis development in rats.
Topics: Animals; Aorta, Abdominal; Bleeding Time; Ketanserin; Male; Piperidines; Platelet Aggregation; Rats; | 1998 |
Enhancement of antithrombotic effect of aspirin by metoclopramide in rats.
Topics: 5-Hydroxytryptophan; Administration, Oral; Animals; Aspirin; Benzamides; Body Temperature; Bridged B | 1991 |
Antithrombotics in view of thrombosis models.
Topics: Animals; Anticoagulants; Arteries; Aspirin; Dipyridamole; Female; Hydroxyethylrutoside; Ketanserin; | 1986 |
Effect of thromboxane receptor antagonists on renal artery thrombosis in the cynomolgus monkey.
Topics: Animals; Dose-Response Relationship, Drug; Ketanserin; Macaca fascicularis; Platelet Aggregation; Re | 1987 |
ADP plays a key role in thrombogenesis in rats.
Topics: Adenosine Diphosphate; Animals; Clopidogrel; Cyclooxygenase Inhibitors; Disease Models, Animal; Fema | 1988 |
Stenosis and vascular damage as a cause of thrombosis in the dog femoral artery.
Topics: Angiography; Animals; Blood Pressure; Blood Vessels; Dogs; Femoral Artery; Heart Rate; Imidazoles; I | 1988 |