ketanserin has been researched along with Spinal Cord Injuries in 7 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Spinal Cord Injuries: Penetrating and non-penetrating injuries to the spinal cord resulting from traumatic external forces (e.g., WOUNDS, GUNSHOT; WHIPLASH INJURIES; etc.).
| Excerpt | Relevance | Reference |
|---|---|---|
| "Testing for autonomic dysreflexia was conducted by measuring mean arterial pressure (MAP) at rest and after colon distension-induced hypertension." | 1.36 | Development of autonomic dysreflexia after spinal cord injury is associated with a lack of serotonergic axons in the intermediolateral cell column. ( Cormier, CM; Marsh, DR; Mukhida, K; Walker, G, 2010) |
| " dosage again displayed significant efficacy when administered at 15 min delaying treatment to 30 min resulted in only marginal therapeutic actions." | 1.29 | Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment. ( Agresta, CA; Azim, S; Chavin, J; Kelly, G; Puniak, MA; Salzman, SK; Wang, L, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (28.57) | 18.2507 |
| 2000's | 3 (42.86) | 29.6817 |
| 2010's | 2 (28.57) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gerasimenko, IuP | 1 |
| Moshonkina, TR | 1 |
| Pavlova, NV | 1 |
| Tomilovskaia, ES | 1 |
| Kozlovskaia, IB | 1 |
| Cormier, CM | 1 |
| Mukhida, K | 1 |
| Walker, G | 1 |
| Marsh, DR | 1 |
| Basura, GJ | 2 |
| Nantwi, KD | 1 |
| Goshgarian, HG | 2 |
| Golder, FJ | 1 |
| Mitchell, GS | 1 |
| Salzman, SK | 2 |
| Kelly, G | 1 |
| Chavin, J | 1 |
| Wang, L | 1 |
| Puniak, MA | 2 |
| Agresta, CA | 2 |
| Azim, S | 1 |
| Zhou, SY | 1 |
| Liu, ZJ | 1 |
| Maitland-Heriot, RP | 1 |
| Freeman, GM | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Neurovascular Mechanisms of Intermittent Hypoxia Induced Neural Plasticity[NCT05183113] | 43 participants (Actual) | Interventional | 2019-05-20 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
7 other studies available for ketanserin and Spinal Cord Injuries
| Article | Year |
|---|---|
[Serotoninergic system morphofunctional aspects in control of postural and locomotion function].
Topics: Animals; Exercise Test; Gait; Hindlimb; Injections, Intraperitoneal; Ketanserin; Locomotion; Male; P | 2012 |
Development of autonomic dysreflexia after spinal cord injury is associated with a lack of serotonergic axons in the intermediolateral cell column.
Topics: Analysis of Variance; Animals; Autonomic Dysreflexia; Axons; Blood Pressure; Choline O-Acetyltransfe | 2010 |
Theophylline-induced respiratory recovery following cervical spinal cord hemisection is augmented by serotonin 2 receptor stimulation.
Topics: Action Potentials; Amphetamines; Animals; Cervical Vertebrae; Diaphragm; Drug Synergism; Female; Imm | 2002 |
Spinal synaptic enhancement with acute intermittent hypoxia improves respiratory function after chronic cervical spinal cord injury.
Topics: Animals; Arteries; Blood Gas Analysis; Cell Count; Chronic Disease; Diagnostic Imaging; Hydrogen-Ion | 2005 |
Characterization of mianserin neuroprotection in experimental spinal trauma: dose/route response and late treatment.
Topics: Animals; Dose-Response Relationship, Drug; Drug Administration Routes; Edema; Ketanserin; Male; Mian | 1994 |
Serotonin(2) receptors mediate respiratory recovery after cervical spinal cord hemisection in adult rats.
Topics: Amphetamines; Animals; Asphyxia; Cervical Vertebrae; Female; Ketanserin; Phrenic Nerve; Pyrazines; R | 2001 |
The serotonin antagonist mianserin improves functional recovery following experimental spinal trauma.
Topics: Analysis of Variance; Animals; Cyproheptadine; Dose-Response Relationship, Drug; Ketanserin; Male; M | 1991 |