ketanserin has been researched along with Serotonin Syndrome in 4 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Serotonin Syndrome: An adverse drug interaction characterized by altered mental status, autonomic dysfunction, and neuromuscular abnormalities. It is most frequently caused by use of both serotonin reuptake inhibitors and monoamine oxidase inhibitors, leading to excess serotonin availability in the CNS at the serotonin 1A receptor.
| Excerpt | Relevance | Reference |
|---|---|---|
| " blood pressure, heart rate, body temperature) can be reduced, possibly due to a pharmacodynamic interaction at the serotonin reuptake transporter (SERT)." | 2.48 | Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions. ( Hondebrink, L; Meulenbelt, J; Rietjens, SJ; Westerink, RH, 2012) |
| " However, the neural mechanism by which extracellular 5-HT is elevated to a toxic level for the syndrome remains to be determined." | 1.35 | Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome. ( Huang, X; Krishnamoorthy, S; Ma, Z; Tao, R; Vukovich, NP; Zhang, G, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 2 (50.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zhang, G | 2 |
| Krishnamoorthy, S | 2 |
| Ma, Z | 2 |
| Vukovich, NP | 1 |
| Huang, X | 1 |
| Tao, R | 2 |
| Wei, J | 1 |
| Auerbach, SB | 1 |
| Rietjens, SJ | 1 |
| Hondebrink, L | 1 |
| Westerink, RH | 1 |
| Meulenbelt, J | 1 |
| Morley, KC | 1 |
| Arnold, JC | 1 |
| McGregor, IS | 1 |
1 review available for ketanserin and Serotonin Syndrome
| Article | Year |
|---|---|
Pharmacokinetics and pharmacodynamics of 3,4-methylenedioxymethamphetamine (MDMA): interindividual differences due to polymorphisms and drug-drug interactions.
Topics: Animals; Blood Pressure; Body Temperature; Brain; Carbazoles; Carvedilol; Cytochrome P-450 CYP2D6; D | 2012 |
3 other studies available for ketanserin and Serotonin Syndrome
| Article | Year |
|---|---|
Assessment of 5-hydroxytryptamine efflux in rat brain during a mild, moderate and severe serotonin-toxicity syndrome.
Topics: 5-Hydroxytryptophan; Animals; Antidepressive Agents; Body Temperature; Clorgyline; Cyproheptadine; D | 2009 |
Involvement of 5-HT2A receptors in the serotonin (5-HT) syndrome caused by excessive 5-HT efflux in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Body Temperature; Brain; Clorgyline; Hypothermia, Induced; Ketanserin; | 2010 |
Serotonin (1A) receptor involvement in acute 3,4-methylenedioxymethamphetamine (MDMA) facilitation of social interaction in the rat.
Topics: Animals; Hallucinogens; Indoles; Interpersonal Relations; Ketanserin; Male; N-Methyl-3,4-methylenedi | 2005 |