ketanserin has been researched along with Seizures in 14 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Seizures: Clinical or subclinical disturbances of cortical function due to a sudden, abnormal, excessive, and disorganized discharge of brain cells. Clinical manifestations include abnormal motor, sensory and psychic phenomena. Recurrent seizures are usually referred to as EPILEPSY or seizure disorder.
| Excerpt | Relevance | Reference |
|---|---|---|
| " In order to clarify the role of 5-HT2 receptors in epilepsy, the present study examined the effects of a 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane(DOI) and a 5-HT2 receptor antagonist ketanserin on HIP-kindled seizures." | 7.68 | [Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin]. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1993) |
| "Kainic acid induces seizures and neurotoxicity in rats, produces changes in brain serotonin (5-HT), dopamine and noradrenaline metabolites among other changes in neurotransmitters." | 3.72 | Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats. ( Mancera-Flores, M; Osorio-Rico, L; Ríos, C, 2003) |
| " In order to clarify the role of 5-HT2 receptors in epilepsy, the present study examined the effects of a 5-HT2 receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-amino-propane(DOI) and a 5-HT2 receptor antagonist ketanserin on HIP-kindled seizures." | 3.68 | [Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin]. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1993) |
| "This study assessed the effects of a serotonin (5-HT)1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), a 5-HT2 agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and a 5-HT2 antagonist ketanserin on fully kindled seizures from the hippocampus." | 3.68 | Role of serotonin receptor subtype in seizures kindled from the feline hippocampus. ( Hasegawa, H; Nakamura, M; Wada, Y; Yamaguchi, N, 1992) |
| "Insulin produces seizures in healthy and diabetic animals." | 1.32 | Investigation of central mechanism of insulin induced hypoglycemic convulsions in mice. ( Anuradha, K; Hota, D; Pandhi, P, 2004) |
| "Convulsions were followed by significant increase in the tail-flick latencies (TFL), at least for 30 min of the post-ictal period." | 1.31 | Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms. ( Castro-Souza, C; Coimbra, NC; Garcia-Cairasco, N; Herrero, CF; Nora, JE; Segato, EN; Tedeschi-Filho, W, 2001) |
| " In contrast, chronic administration of imipramine, mianserin, and tranylcypromine, treatments that decreased ligand binding, did not decrease levels of 5-HT2 receptor mRNA." | 1.29 | Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex. ( Butler, MO; Duman, RS; Morinobu, S, 1993) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 7 (50.00) | 18.2507 |
| 2000's | 5 (35.71) | 29.6817 |
| 2010's | 2 (14.29) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Gunia-Krzyżak, A | 1 |
| Żelaszczyk, D | 1 |
| Rapacz, A | 1 |
| Żesławska, E | 1 |
| Waszkielewicz, AM | 1 |
| Pańczyk, K | 1 |
| Słoczyńska, K | 1 |
| Pękala, E | 1 |
| Nitek, W | 1 |
| Filipek, B | 1 |
| Marona, H | 1 |
| Hidaka, N | 1 |
| Suemaru, K | 1 |
| Araki, H | 1 |
| Osorio-Rico, L | 1 |
| Mancera-Flores, M | 1 |
| Ríos, C | 1 |
| Anuradha, K | 1 |
| Hota, D | 1 |
| Pandhi, P | 1 |
| Pericić, D | 2 |
| Lazić, J | 1 |
| Jazvinsćak Jembrek, M | 1 |
| Svob Strac, D | 1 |
| Strac, DS | 1 |
| Vlainić, J | 1 |
| Bodjarian, N | 1 |
| Carpentier, P | 1 |
| Baubichon, D | 1 |
| Blanchet, G | 1 |
| Lallement, G | 1 |
| Genkova-Papazova, M | 1 |
| Lazarova-Bakarova, M | 1 |
| Petkov, VD | 1 |
| Grant, KA | 1 |
| Hellevuo, K | 1 |
| Tabakoff, B | 1 |
| Nakamura, M | 2 |
| Wada, Y | 2 |
| Hasegawa, H | 2 |
| Yamaguchi, N | 2 |
| Butler, MO | 1 |
| Morinobu, S | 1 |
| Duman, RS | 1 |
| Coimbra, NC | 1 |
| Castro-Souza, C | 1 |
| Segato, EN | 1 |
| Nora, JE | 1 |
| Herrero, CF | 1 |
| Tedeschi-Filho, W | 1 |
| Garcia-Cairasco, N | 1 |
| Moreau, JL | 1 |
| Griebel, G | 1 |
| Jenck, F | 1 |
| Martin, JR | 1 |
| Widmer, U | 1 |
| Haefely, WE | 1 |
14 other studies available for ketanserin and Seizures
| Article | Year |
|---|---|
Structure-anticonvulsant activity studies in the group of (E)-N-cinnamoyl aminoalkanols derivatives monosubstituted in phenyl ring with 4-Cl, 4-CH
Topics: Amino Alcohols; Animals; Anticonvulsants; Crystallography, X-Ray; Disease Models, Animal; Dose-Respo | 2017 |
Serotonin-dopamine antagonism ameliorates impairments of spontaneous alternation and locomotor hyperactivity induced by repeated electroconvulsive seizures in rats.
Topics: Analysis of Variance; Animals; Behavior, Animal; Dopamine Antagonists; Electroshock; Haloperidol; Hy | 2010 |
Changes in brain serotonin turnover, body and head shakes in kainic acid-treated rats.
Topics: Amygdala; Animals; Behavior, Animal; Brain; Cerebral Cortex; Corpus Striatum; Excitatory Amino Acid | 2003 |
Investigation of central mechanism of insulin induced hypoglycemic convulsions in mice.
Topics: 5-Hydroxytryptophan; Animals; Anticonvulsants; Antihypertensive Agents; Blood Glucose; Dopamine; Dop | 2004 |
Stimulation of 5-HT 1A receptors increases the seizure threshold for picrotoxin in mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Drug Administration Schedule; Drug Th | 2005 |
Zimelidine decreases seizure susceptibility in stressed mice.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Anticonvulsants; Behavior, Animal; Convulsants; Ket | 2006 |
Involvement of non-muscarinic receptors in phosphoinositide signalling during soman-induced seizures.
Topics: Animals; Chlorpheniramine; Dimethyl Sulfoxide; Electroencephalography; Inositol 1,4,5-Trisphosphate; | 1995 |
The 5-HT2 receptor antagonist ketanserine prevents electroconvulsive shock- and clonidine-induced amnesia.
Topics: Amnesia; Animals; Avoidance Learning; Clonidine; Electroshock; Injections, Intraperitoneal; Ketanser | 1994 |
The 5-HT3 antagonist MDL-72222 exacerbates ethanol withdrawal seizures in mice.
Topics: Alcohol Withdrawal Delirium; Animals; Dose-Response Relationship, Drug; Electroencephalography; Evok | 1994 |
[Serotonergic mechanisms of hippocampal kindled seizures in cats--effects of 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane and ketanserin].
Topics: Amphetamines; Animals; Cats; Epilepsy; Hippocampus; Ketanserin; Kindling, Neurologic; Receptors, Ser | 1993 |
Chronic electroconvulsive seizures increase the expression of serotonin2 receptor mRNA in rat frontal cortex.
Topics: Animals; Antidepressive Agents; Blotting, Northern; Chronic Disease; Electroshock; Frontal Lobe; Ket | 1993 |
Post-ictal analgesia: involvement of opioid, serotoninergic and cholinergic mechanisms.
Topics: Analgesia; Animals; Atropine; Convulsants; Disease Models, Animal; Injections, Intraperitoneal; Keta | 2001 |
Role of serotonin receptor subtype in seizures kindled from the feline hippocampus.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Anticonvulsants; Cats; Electric Stimu | 1992 |
Behavioral profile of the 5HT1A receptor antagonist (S)-UH-301 in rodents and monkeys.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acoustic Stimulation; Animals; Brain; Cerebral Ventricles; C | 1992 |