ketanserin has been researched along with Schizophrenia in 27 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Schizophrenia: A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia." | 9.08 | Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. ( Bäbler, A; Hell, D; Vogel, H; Vollenweider, FX; Vollenweider-Scherpenhuyzen, MF, 1998) |
| "Here, we measured serotonin2A receptor occupancy with [(18)F]altanserin PET in 15 first-episode antipsychotic-naïve schizophrenia patients before and after 6 months of quetiapine treatment." | 5.15 | Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine. ( Aggernaes, B; Baaré, WF; Ebdrup, BH; Erritzoe, D; Glenthoj, B; Kalbitzer, J; Knudsen, GM; Lublin, H; Oranje, B; Pinborg, LH; Rasmussen, H; Svarer, C, 2011) |
| "Psilocybin, an indoleamine hallucinogen, produces a psychosis-like syndrome in humans that resembles first episodes of schizophrenia." | 5.08 | Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action. ( Bäbler, A; Hell, D; Vogel, H; Vollenweider, FX; Vollenweider-Scherpenhuyzen, MF, 1998) |
| "The binding of [3H]paroxetine and [3H]ketanserin to particulate membranes from frontal cortex of subjects who had or did not have schizophrenia was measured as was [3H]paroxetine binding to particulate membranes from the hippocampus and caudate nucleus." | 3.69 | Serotonin2 receptors and the serotonin transporter in the schizophrenic brain. ( Copolov, DL; Dean, B; Hayes, W; Hill, C; Keks, N; Naylor, L; Opeskin, K; Pavey, G, 1996) |
| " The role of the reported increase in dopamine receptors (measured as 3H-spiperone binding sites) in post-mortem brain tissue from patients with schizophrenia in the aetiology of the disease is, however, unclear." | 3.66 | Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action. ( Iversen, LL; Reynolds, GP; Rossor, MN, 1983) |
| " Instead, selective serotonin 2A receptor (5HT(2A)R) antagonists ketanserin and MDL-11939 replicate the effect of SGAs, repressing the activity in WT mice at a dosage that fails to suppress the activity of Egr3(-/-) mice." | 1.38 | Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine. ( Elizalde, DI; Gallitano, AL; González-Maeso, J; Ingram, WM; Janowski, SA; Kamel, CM; Kozlenkov, A; Levine, S; Lish, JR; Resnik, J; Shoker, J; Williams, AA, 2012) |
| " Parallel analyses of rat brain tissue showed no changes in 5-HT1A or 5-HT2A receptor mRNAs or binding site densities after chronic administration of haloperidol." | 1.29 | 5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia. ( Burnet, PW; Eastwood, SL; Harrison, PJ, 1996) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (7.41) | 18.7374 |
| 1990's | 6 (22.22) | 18.2507 |
| 2000's | 11 (40.74) | 29.6817 |
| 2010's | 8 (29.63) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Rowley, M | 1 |
| Bristow, LJ | 1 |
| Hutson, PH | 1 |
| Bali, A | 1 |
| Malhotra, S | 1 |
| Dhir, H | 1 |
| Kumar, A | 1 |
| Sharma, A | 1 |
| Cao, X | 1 |
| Zhang, Y | 1 |
| Chen, Y | 1 |
| Qiu, Y | 1 |
| Yu, M | 1 |
| Xu, X | 1 |
| Liu, X | 1 |
| Liu, BF | 1 |
| Zhang, L | 1 |
| Zhang, G | 1 |
| Rasmussen, H | 5 |
| Ebdrup, BH | 3 |
| Oranje, B | 4 |
| Pinborg, LH | 4 |
| Knudsen, GM | 5 |
| Glenthøj, B | 2 |
| Malkova, NV | 1 |
| Gallagher, JJ | 1 |
| Yu, CZ | 1 |
| Jacobs, RE | 1 |
| Patterson, PH | 1 |
| Frokjaer, VG | 2 |
| Hilker, RW | 1 |
| Madsen, J | 3 |
| Anhøj, S | 1 |
| Dean, B | 6 |
| Crossland, N | 1 |
| Boer, S | 1 |
| Scarr, E | 3 |
| Erritzoe, D | 3 |
| Andersen, R | 1 |
| Aggernaes, B | 2 |
| Kalbitzer, J | 2 |
| Baaré, W | 2 |
| Svarer, C | 3 |
| Lublin, H | 3 |
| Glenthoj, B | 2 |
| Baaré, WF | 1 |
| Williams, AA | 1 |
| Ingram, WM | 1 |
| Levine, S | 1 |
| Resnik, J | 1 |
| Kamel, CM | 1 |
| Lish, JR | 1 |
| Elizalde, DI | 1 |
| Janowski, SA | 1 |
| Shoker, J | 1 |
| Kozlenkov, A | 1 |
| González-Maeso, J | 2 |
| Gallitano, AL | 1 |
| Muguruza, C | 1 |
| Moreno, JL | 1 |
| Umali, A | 1 |
| Callado, LF | 1 |
| Meana, JJ | 1 |
| Arranz, B | 1 |
| Rosel, P | 1 |
| Sarró, S | 1 |
| Ramirez, N | 1 |
| Dueñas, R | 1 |
| Cano, R | 1 |
| María Sanchez, J | 1 |
| San, L | 1 |
| Pavey, G | 3 |
| Copolov, D | 1 |
| Matsumoto, I | 1 |
| Inoue, Y | 1 |
| Iwazaki, T | 1 |
| Hurlemann, R | 2 |
| Boy, C | 1 |
| Meyer, PT | 1 |
| Scherk, H | 1 |
| Wagner, M | 2 |
| Herzog, H | 1 |
| Coenen, HH | 1 |
| Vogeley, K | 1 |
| Falkai, P | 1 |
| Zilles, K | 2 |
| Maier, W | 2 |
| Bauer, A | 2 |
| Matusch, A | 1 |
| Kuhn, KU | 1 |
| Berning, J | 1 |
| Elmenhorst, D | 1 |
| Winz, O | 1 |
| Kolsch, H | 1 |
| Kristiansen, KT | 1 |
| Haugbol, S | 1 |
| Pinborg, L | 1 |
| Glenthoj, BY | 1 |
| Reynolds, GP | 1 |
| Rossor, MN | 1 |
| Iversen, LL | 1 |
| Laruelle, M | 1 |
| Abi-Dargham, A | 1 |
| Casanova, MF | 1 |
| Toti, R | 1 |
| Weinberger, DR | 1 |
| Kleinman, JE | 1 |
| Hayes, W | 3 |
| Opeskin, K | 2 |
| Naylor, L | 1 |
| Hill, C | 2 |
| Keks, N | 1 |
| Copolov, DL | 2 |
| Burnet, PW | 2 |
| Eastwood, SL | 2 |
| Harrison, PJ | 2 |
| Vollenweider, FX | 1 |
| Vollenweider-Scherpenhuyzen, MF | 1 |
| Bäbler, A | 1 |
| Vogel, H | 1 |
| Hell, D | 1 |
| Hussain, T | 1 |
| Kitsoulis, S | 1 |
| Govitrapong, P | 1 |
| Chagkutip, J | 1 |
| Turakitwanakan, W | 1 |
| Srikiatkhachorn, A | 1 |
| Gittins, R | 1 |
| Baker, K | 1 |
| Mita, T | 1 |
| Hanada, S | 1 |
| Nishino, N | 1 |
| Kuno, T | 1 |
| Nakai, H | 1 |
| Yamadori, T | 1 |
| Mizoi, Y | 1 |
| Tanaka, C | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| 5-HT2A-receptor Binding: Implications for the Pathophysiology of Schizophrenia and Effects of Treatment With Antipsychotic Drugs[NCT00207064] | 46 participants (Actual) | Interventional | 2004-04-30 | Completed | |||
| Proposal To Develop A Rapid And Cost-Effective Diagnostic Test For Schizophrenia[NCT03781115] | Phase 1 | 24 participants (Anticipated) | Interventional | 2017-11-20 | Recruiting | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
1 review available for ketanserin and Schizophrenia
| Article | Year |
|---|---|
Current and novel approaches to the drug treatment of schizophrenia.
Topics: Animals; Antipsychotic Agents; Cholinergic Agonists; Disease Models, Animal; Dopamine Antagonists; E | 2001 |
2 trials available for ketanserin and Schizophrenia
| Article | Year |
|---|---|
Serotonin2A receptor blockade and clinical effect in first-episode schizophrenia patients treated with quetiapine.
Topics: Adult; Antipsychotic Agents; Dibenzothiazepines; Dose-Response Relationship, Drug; Female; Follow-Up | 2011 |
Psilocybin induces schizophrenia-like psychosis in humans via a serotonin-2 agonist action.
Topics: Adult; Analysis of Variance; Dose-Response Relationship, Drug; Female; Hallucinogens; Humans; Ketans | 1998 |
24 other studies available for ketanserin and Schizophrenia
| Article | Year |
|---|---|
Synthesis and evaluation of 1-(quinoliloxypropyl)-4-aryl piperazines for atypical antipsychotic effect.
Topics: Animals; Antipsychotic Agents; Mice; Oxyquinoline; Schizophrenia; Stereotyped Behavior | 2009 |
Synthesis and Biological Evaluation of Fused Tricyclic Heterocycle Piperazine (Piperidine) Derivatives As Potential Multireceptor Atypical Antipsychotics.
Topics: Animals; Antipsychotic Agents; Body Weight; Chemistry Techniques, Synthetic; Drug Design; Ether-A-Go | 2018 |
Neocortical serotonin2A receptor binding predicts quetiapine associated weight gain in antipsychotic-naive first-episode schizophrenia patients.
Topics: Adult; Antipsychotic Agents; Body Mass Index; Dibenzothiazepines; Female; Follow-Up Studies; Humans; | 2014 |
Manganese-enhanced magnetic resonance imaging reveals increased DOI-induced brain activity in a mouse model of schizophrenia.
Topics: Amphetamines; Animals; Behavior, Animal; Brain Mapping; Brain-Derived Neurotrophic Factor; Contrast | 2014 |
Low frontal serotonin 2A receptor binding is a state marker for schizophrenia?
Topics: Adolescent; Adult; Antipsychotic Agents; Female; Fluorine Radioisotopes; Frontal Lobe; Humans; Ketan | 2016 |
Evidence for altered post-receptor modulation of the serotonin 2a receptor in schizophrenia.
Topics: Adolescent; Adult; Aged; Antipsychotic Agents; Binding Sites; Cerebral Cortex; Female; Humans; Ketan | 2008 |
Decreased frontal serotonin2A receptor binding in antipsychotic-naive patients with first-episode schizophrenia.
Topics: Adult; Antipsychotic Agents; Brain; Case-Control Studies; Female; Fluorine Radioisotopes; Frontal Lo | 2010 |
Reduced levels of serotonin 2A receptors underlie resistance of Egr3-deficient mice to locomotor suppression by clozapine.
Topics: Animals; Clozapine; Disease Models, Animal; Early Growth Response Protein 3; Humans; Hypnotics and S | 2012 |
Dysregulated 5-HT(2A) receptor binding in postmortem frontal cortex of schizophrenic subjects.
Topics: Amphetamines; Animals; Antipsychotic Agents; Diagnostic and Statistical Manual of Mental Disorders; | 2013 |
Altered platelet serotonin 5-HT2A receptor density but not second messenger inositol trisphosphate levels in drug-free schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Blood Platelets; Case-Control Studies; Female; Humans; Inositol 1,4,5-T | 2003 |
Hippocampal 5-hydroxytryptamine receptors: abnormalities in postmortem brain from schizophrenic subjects.
Topics: Adult; Aged; Autoradiography; Binding Sites; Female; Hippocampus; Humans; Ketanserin; Male; Middle A | 2004 |
5-HT2A and muscarinic receptors in schizophrenia: a postmortem study.
Topics: Aged; Aged, 80 and over; Autoradiography; Brain; Case-Control Studies; Female; Humans; Ketanserin; M | 2005 |
Decreased prefrontal 5-HT2A receptor binding in subjects at enhanced risk for schizophrenia.
Topics: Adult; Brain Mapping; Case-Control Studies; Female; Fluorine Radioisotopes; Humans; Image Processing | 2005 |
5-HT2A receptor density is decreased in the at-risk mental state.
Topics: Adult; Brain; Brain Mapping; Cerebral Cortex; Dominance, Cerebral; Early Diagnosis; Female; Fluorine | 2008 |
Cortical and subcortical 5-HT2A receptor binding in neuroleptic-naive first-episode schizophrenic patients.
Topics: Adult; Antipsychotic Agents; Binding, Competitive; Brain; Brain Chemistry; Brain Mapping; Caudate Nu | 2008 |
Preliminary studies of human cortical 5-HT2 receptors and their involvement in schizophrenia and neuroleptic drug action.
Topics: Antipsychotic Agents; Cerebral Cortex; Humans; Ketanserin; Piperidines; Receptors, Serotonin; Schizo | 1983 |
Selective abnormalities of prefrontal serotonergic receptors in schizophrenia. A postmortem study.
Topics: Adult; Diagnosis, Differential; Down-Regulation; Female; Frontal Lobe; Humans; Ketanserin; Male; Mid | 1993 |
Serotonin2 receptors and the serotonin transporter in the schizophrenic brain.
Topics: Adolescent; Adult; Aged; Brain Chemistry; Carrier Proteins; Caudate Nucleus; Female; Hippocampus; Hu | 1996 |
Decreased frontal cortical serotonin2A receptors in schizophrenia.
Topics: Adult; Aged; Antipsychotic Agents; Autopsy; Female; Frontal Lobe; Humans; Ketanserin; Male; Middle A | 1996 |
5-HT1A and 5-HT2A receptor mRNAs and binding site densities are differentially altered in schizophrenia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Adult; Aged; Animals; Antipsychotic Agents; Autoradiography; | 1996 |
Changes in serotonin2A and GABA(A) receptors in schizophrenia: studies on the human dorsolateral prefrontal cortex.
Topics: Adult; Aged; Aged, 80 and over; Binding, Competitive; Female; Humans; Ketanserin; Male; Middle Aged; | 1999 |
Platelet 5-HT(2A) receptors in schizophrenic patients with and without neuroleptic treatment.
Topics: Adult; Antipsychotic Agents; Blood Platelets; Case-Control Studies; Dopamine Antagonists; Dose-Respo | 2000 |
Expression of serotonin 5-HT(2A) receptors in the human cerebellum and alterations in schizophrenia.
Topics: Adult; Aged; Aged, 80 and over; Astrocytes; Binding Sites; Blotting, Western; Cell Compartmentation; | 2001 |
Decreased serotonin S2 and increased dopamine D2 receptors in chronic schizophrenics.
Topics: Adult; Aged; Caudate Nucleus; Chronic Disease; Female; Frontal Lobe; Humans; Ketanserin; Male; Middl | 1986 |