ketanserin has been researched along with Postoperative Complications in 24 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Postoperative Complications: Pathologic processes that affect patients after a surgical procedure. They may or may not be related to the disease for which the surgery was done, and they may or may not be direct results of the surgery.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Twenty patients requiring management of postoperative arterial hypertension following coronary artery bypass grafting (CABG) were randomly treated with either ketanserin (n = 10) or sodium nitroprusside (SNP) (n = 10)." | 9.06 | [Ketanserin versus sodium nitroprusside in the treatment of hypertension following coronary surgery. Effect on intrapulmonary right and left shunt and arterial oxygenation]. ( Lauwers, P; Möllhoff, T; Mulier, JP; Müller, E; Van Aken, H, 1989) |
| "Forty adult patients, who developed postoperative hypertension (greater than 160/90 mm Hg) following major abdominal surgery were given double-blind, randomized either ketanserin 10 mg i." | 9.06 | The influence of ketanserin, droperidol and hydergine on postoperative hypertension during early recovery following major abdominal surgery. ( Anger, C; Hoch, D; Lawin, P; Van Aken, H, 1987) |
| "In patients developing hypertension following coronary artery bypass surgery (CABG) the possible role of 5-hydroxytryptamine (5-HT; serotonin) was investigated by injecting ketanserin, a specific 5-HT2-receptor antagonist." | 7.66 | The use of ketanserin, a 5-hydroxytryptamine receptor antagonist, for treatment of postoperative hypertension following coronary artery bypass surgery. ( Kolling, JB; Reneman, RS; Scheijgrond, HW; van der Starre, PJ, 1983) |
| "The possible role of 5-hydroxytryptamine (serotonin) in patients developing hypertension following coronary artery bypass surgery was investigated by intravenous administration of ketanserin, a specific 5-hydroxytryptamine-receptor antagonist." | 7.66 | Ketanserin in the treatment of hypertension following coronary artery bypass surgery. A preliminary study. ( De Wet, JI; Diedericks, BJ; Roelofse, JA, 1983) |
| "Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation." | 5.40 | Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. ( Chen, G; Chen, L; Fan, W; Guo, Y; Liu, L; Qian, Y; Shi, B; Xiao, L, 2014) |
| "When hypertension (defined as mean arterial pressure > 85 mmHg) developed within the first 2 hours after arrival in the intensive care unit, patients received urapidil (n = 62) or ketanserin (n = 60) to reach a mean arterial pressure between 65 and 75 mmHg." | 5.08 | A randomized multicenter double-blind comparison of urapidil and ketanserin in hypertensive patients after coronary artery surgery. ( Kal, JE; Kooyman, J; Korsten, HH; Langemeijer, JJ; Porsius, M; van den Ende, R; van der Starre, PJ; van der Stroom, JG; van Wezel, HB; van Zwieten, PA, 1997) |
| "Thirty patients who developed arterial hypertension following coronary artery bypass grafting, despite sedation, were treated randomly with sodium nitroprusside (SNP), ketanserin or urapidil." | 5.06 | Effects of urapidil, ketanserin and sodium nitroprusside on venous admixture and arterial oxygenation following coronary artery bypass grafting. ( Lauwers, P; Möllhoff, T; Mulier, JP; Müller, E; Van Aken, H, 1990) |
| "Twenty patients requiring management of postoperative arterial hypertension following coronary artery bypass grafting (CABG) were randomly treated with either ketanserin (n = 10) or sodium nitroprusside (SNP) (n = 10)." | 5.06 | [Ketanserin versus sodium nitroprusside in the treatment of hypertension following coronary surgery. Effect on intrapulmonary right and left shunt and arterial oxygenation]. ( Lauwers, P; Möllhoff, T; Mulier, JP; Müller, E; Van Aken, H, 1989) |
| "Forty adult patients, who developed postoperative hypertension (greater than 160/90 mm Hg) following major abdominal surgery were given double-blind, randomized either ketanserin 10 mg i." | 5.06 | The influence of ketanserin, droperidol and hydergine on postoperative hypertension during early recovery following major abdominal surgery. ( Anger, C; Hoch, D; Lawin, P; Van Aken, H, 1987) |
| "In patients developing hypertension following coronary artery bypass surgery (CABG) the possible role of 5-hydroxytryptamine (5-HT; serotonin) was investigated by injecting ketanserin, a specific 5-HT2-receptor antagonist." | 3.66 | The use of ketanserin, a 5-hydroxytryptamine receptor antagonist, for treatment of postoperative hypertension following coronary artery bypass surgery. ( Kolling, JB; Reneman, RS; Scheijgrond, HW; van der Starre, PJ, 1983) |
| "The possible role of 5-hydroxytryptamine (serotonin) in patients developing hypertension following coronary artery bypass surgery was investigated by intravenous administration of ketanserin, a specific 5-hydroxytryptamine-receptor antagonist." | 3.66 | Ketanserin in the treatment of hypertension following coronary artery bypass surgery. A preliminary study. ( De Wet, JI; Diedericks, BJ; Roelofse, JA, 1983) |
| "Ketanserin may be a useful treatment for hypertension following coronary artery surgery as it reduced arterial pressure without reflex tachycardia." | 2.66 | Effect of ketanserin on sodium nitroprusside requirements, arterial pressure control and heart rate following coronary artery bypass surgery. ( Colvin, JR; Hodsman, NB; Kenny, GN, 1989) |
| "Ketanserin is a serotonin antagonist with alpha-blocking effect." | 2.38 | [Use of ketanserin in anesthesia. A selective S2 serotonin receptor antagonist]. ( Knudsen, F; Nielsen, LH; Olesen, AS, 1990) |
| "Biliary fibrosis is a major complication after donation after cardiac death (DCD) liver transplantation." | 1.40 | Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats. ( Chen, G; Chen, L; Fan, W; Guo, Y; Liu, L; Qian, Y; Shi, B; Xiao, L, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 12 (50.00) | 18.7374 |
| 1990's | 9 (37.50) | 18.2507 |
| 2000's | 2 (8.33) | 29.6817 |
| 2010's | 1 (4.17) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Chen, L | 1 |
| Chen, G | 1 |
| Guo, Y | 1 |
| Liu, L | 1 |
| Xiao, L | 1 |
| Fan, W | 1 |
| Shi, B | 1 |
| Qian, Y | 1 |
| Reuben, SS | 1 |
| Tagari, PC | 1 |
| Kaye, AH | 1 |
| Teddy, PJ | 1 |
| Schachter, M | 1 |
| Adams, CB | 1 |
| Boullin, DJ | 1 |
| van der Starre, PJ | 4 |
| Scheijgrond, HW | 2 |
| Reneman, RS | 3 |
| Kolling, JB | 1 |
| Diedericks, BJ | 1 |
| Roelofse, JA | 1 |
| De Wet, JI | 1 |
| van den Broeke, JJ | 1 |
| Karliczek, GF | 1 |
| Brenken, U | 1 |
| Schokkenbroek, R | 1 |
| Homan van der Heide, JN | 1 |
| Miranda, DR | 1 |
| Stoutenbeek, CP | 1 |
| Zandstra, D | 1 |
| Alexander, JP | 1 |
| Felding, M | 1 |
| Cold, GE | 1 |
| Jacobsen, CJ | 1 |
| Stjernholm, P | 1 |
| Voss, K | 1 |
| Borawski, J | 1 |
| Mazerska, M | 1 |
| Rydzewski, A | 1 |
| Pawlak, K | 1 |
| Rowinski, M | 1 |
| Mysliwiec, M | 1 |
| van der Stroom, JG | 1 |
| van Wezel, HB | 1 |
| Langemeijer, JJ | 1 |
| Korsten, HH | 1 |
| Kooyman, J | 1 |
| Kal, JE | 1 |
| Porsius, M | 1 |
| van den Ende, R | 1 |
| van Zwieten, PA | 1 |
| Kranke, P | 1 |
| Eberhart, LH | 1 |
| Roewer, N | 1 |
| Tramèr, MR | 1 |
| Bogle, RG | 1 |
| Mikulic, E | 1 |
| Rull, D | 1 |
| Puntoni, L | 1 |
| Shu, CC | 1 |
| Chan, KH | 1 |
| Lee, TY | 1 |
| Lui, PW | 1 |
| Daiy, YP | 1 |
| Ma, JY | 1 |
| Chow, LH | 1 |
| Nielsen, LH | 1 |
| Knudsen, F | 1 |
| Olesen, AS | 1 |
| Dehring, DJ | 1 |
| Möllhoff, T | 2 |
| Van Aken, H | 3 |
| Mulier, JP | 2 |
| Müller, E | 2 |
| Lauwers, P | 2 |
| Hodsman, NB | 1 |
| Colvin, JR | 1 |
| Kenny, GN | 1 |
| Harinck-de Weerd, JE | 1 |
| Ansari, A | 1 |
| Anger, C | 2 |
| Carter, JA | 1 |
| Prys-Roberts, C | 1 |
| Hoch, D | 1 |
| Lawin, P | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Prevention of Complex Regional Pain Syndrome Using Liposomal Encapsulated Vitamin C in Programmed Knee Surgery; A Prospective Randomized Trial[NCT04204200] | 66 participants (Actual) | Interventional | 2014-01-06 | Completed | |||
| Traitement Des Frissons Lors de la césarienne Sous anesthésie péridurale Durant le Travail - un Essai Clinique randomisé Comparant la dexmédétomidine et la mépéridine[NCT03115047] | Phase 3 | 80 participants (Actual) | Interventional | 2017-05-07 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
Radiographs of the knee in Schuss with an external decoaptation which must be close to 0 cm and a pan gono gram standing from the front (NCT04204200)
Timeframe: After one-year follow-up
| Intervention | participants (Number) |
|---|---|
| Allocated to Conventional Vitamin C (n= 22) | 0 |
| Allocated to Liposomal Vitamin C (n= 22) | 0 |
| Allocated to Placebo (n= 22) | 0 |
Radiographs of the knee in monopodial support at 30° flexion (schuss) were taken. Measurement analysis of the translation of the tibia relative to the femur which must be close to 0 cm for the patient to be positive for the outcome. (NCT04204200)
Timeframe: After one-year follow-up
| Intervention | participants (Number) |
|---|---|
| Allocated to Conventional Vitamin C (n= 22) | 1 |
| Allocated to Liposomal Vitamin C (n= 22) | 0 |
| Allocated to Placebo (n= 22) | 0 |
X-rays of the knee and Schuss profile with an internal and external decoaptation which must be close to 0 cm with pan gonogram standing from the front (x-rays of the long axes of the pelvis of the ankles with measurement of the HKA axes on the prosthesis side and on the non-side operated which must be close to 180°) to have eccentric arthritis. (NCT04204200)
Timeframe: After one-year follow-up
| Intervention | participants (Number) |
|---|---|
| Allocated to Conventional Vitamin C (n= 22) | 1 |
| Allocated to Liposomal Vitamin C (n= 22) | 0 |
| Allocated to Placebo (n= 22) | 2 |
We take an x-ray of the knee then we calculate of the Index of Caton and Deschamps AT / AP which must be close to 1 cm (from the upper edge to the lower edge of the patella which must be equal to the distance between the tip of the patella and anterior tibial tuberosity) to be interpreted as a transposed tuberosity. (NCT04204200)
Timeframe: After one-year of follow-up
| Intervention | participants (Number) |
|---|---|
| Allocated to Conventional Vitamin C (n= 22) | 1 |
| Allocated to Liposomal Vitamin C (n= 22) | 0 |
| Allocated to Placebo (n= 22) | 2 |
4 reviews available for ketanserin and Postoperative Complications
| Article | Year |
|---|---|
Preventing the development of complex regional pain syndrome after surgery.
Topics: Analgesics; Anesthesia, Conduction; Anesthesia, Epidural; Calcitonin; Complex Regional Pain Syndrome | 2004 |
Pharmacological treatment of postoperative shivering: a quantitative systematic review of randomized controlled trials.
Topics: Adrenergic alpha-Agonists; Analgesics, Opioid; Clonidine; Humans; Ketanserin; Lidocaine; Meperidine; | 2002 |
[Use of ketanserin in anesthesia. A selective S2 serotonin receptor antagonist].
Topics: Anesthesia, Intravenous; Humans; Hypertension; Ketanserin; Postoperative Complications; Receptors, S | 1990 |
Antihypertensive mechanism of ketanserin in postoperative hypertension after cardiopulmonary bypass.
Topics: Aged; Blood Pressure; Cardiopulmonary Bypass; Dose-Response Relationship, Drug; Epinephrine; Humans; | 1988 |
6 trials available for ketanserin and Postoperative Complications
| Article | Year |
|---|---|
Ketanserin: a new perspective in posttransplant erythrocytosis?
Topics: Adult; Erythropoietin; Humans; Ketanserin; Kidney Transplantation; Male; Middle Aged; Polycythemia; | 1996 |
A randomized multicenter double-blind comparison of urapidil and ketanserin in hypertensive patients after coronary artery surgery.
Topics: Aged; Antihypertensive Agents; Coronary Vessels; Double-Blind Method; Hemodynamics; Humans; Hyperten | 1997 |
Effects of urapidil, ketanserin and sodium nitroprusside on venous admixture and arterial oxygenation following coronary artery bypass grafting.
Topics: Antihypertensive Agents; Coronary Artery Bypass; Heart Rate; Hemodynamics; Humans; Hypertension; Ket | 1990 |
[Ketanserin versus sodium nitroprusside in the treatment of hypertension following coronary surgery. Effect on intrapulmonary right and left shunt and arterial oxygenation].
Topics: Blood Pressure; Cardiac Output; Coronary Artery Bypass; Coronary Disease; Ferricyanides; Heart Rate; | 1989 |
Effect of ketanserin on sodium nitroprusside requirements, arterial pressure control and heart rate following coronary artery bypass surgery.
Topics: Adult; Aged; Blood Pressure; Coronary Artery Bypass; Double-Blind Method; Female; Ferricyanides; Hea | 1989 |
The influence of ketanserin, droperidol and hydergine on postoperative hypertension during early recovery following major abdominal surgery.
Topics: Abdomen; Adult; Aged; Antihypertensive Agents; Dihydroergotoxine; Double-Blind Method; Droperidol; F | 1987 |
14 other studies available for ketanserin and Postoperative Complications
| Article | Year |
|---|---|
Ketanserin, a serotonin 2A receptor antagonist, alleviates ischemia-related biliary fibrosis following donation after cardiac death liver transplantation in rats.
Topics: Animals; Biliary Tract Diseases; Cells, Cultured; Drug Evaluation, Preclinical; Fibroblasts; Fibrosi | 2014 |
The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.
Topics: Adult; Aged; Animals; Female; Humans; Hydroxyindoleacetic Acid; Intracranial Aneurysm; Intraoperativ | 1983 |
The use of ketanserin, a 5-hydroxytryptamine receptor antagonist, for treatment of postoperative hypertension following coronary artery bypass surgery.
Topics: Coronary Artery Bypass; Female; Heart Rate; Hemodynamics; Humans; Hypertension; Infusions, Parentera | 1983 |
Ketanserin in the treatment of hypertension following coronary artery bypass surgery. A preliminary study.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Coronary Artery Bypass; Humans; Hypertension; | 1983 |
Is prevention of hypertension after open heart surgery possible by blocking 5HT2-receptors with ketanserin?
Topics: Adult; Aged; Anesthesia; Aortic Valve; Coronary Artery Bypass; Heart Valve Prosthesis; Hemodynamics; | 1982 |
The effects of serotonin-receptor blockade after cardiopulmonary by-pass. A pilot study.
Topics: Aged; Cardiopulmonary Bypass; Female; Hemodynamics; Humans; Ketanserin; Male; Middle Aged; Pilot Pro | 1982 |
The effect of ketanserin upon postoperative blood pressure, cerebral blood flow and oxygen metabolism in patients subjected to craniotomy for cerebral tumours.
Topics: Adult; Aged; Antihypertensive Agents; Blood Pressure; Body Temperature; Brain; Brain Neoplasms; Cere | 1995 |
Ketanserin for hypertension after upper gastrointestinal surgery.
Topics: Adrenergic alpha-Antagonists; Digestive System Surgical Procedures; Humans; Hypertension; Ketanserin | 1991 |
Ketanserin for hypertension after upper gastrointestinal surgery.
Topics: Adult; Humans; Hypertension; Ketanserin; Male; Postoperative Complications; Stomach Neoplasms | 1991 |
The use of ketanserin for postoperative hypertension after abdominal surgery.
Topics: Abdomen; Adult; Aged; Female; Humans; Hypertension; Ketanserin; Male; Middle Aged; Postoperative Com | 1990 |
Ketanserin in the treatment of pulmonary hypertension after valvular surgery: comparison with sodium nitroprusside.
Topics: Heart Valve Diseases; Humans; Hypertension, Pulmonary; Ketanserin; Nitroprusside; Postoperative Comp | 1990 |
Ketanserin in the treatment of systemic hypertension during and following coronary artery bypass surgery.
Topics: Blood Pressure; Cardiac Output; Coronary Artery Bypass; Fentanyl; Heart Rate; Humans; Hypertension; | 1989 |
Nitroprusside and ketanserin in the treatment of postoperative hypertension following coronary artery bypass grafting: a haemodynamic and ventilatory comparison.
Topics: Blood Pressure; Coronary Artery Bypass; Female; Ferricyanides; Heart Rate; Humans; Hypertension; Ket | 1986 |
Acute and chronic pulmonary thromboembolism: current perspectives. Part VII: Current trends and newer developments.
Topics: Angiography; Heparin; Humans; Ketanserin; Magnetic Resonance Spectroscopy; Postoperative Complicatio | 1987 |