ketanserin has been researched along with Neuroblastoma in 3 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Neuroblastoma: A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)
| Excerpt | Relevance | Reference |
|---|---|---|
| "We have assessed the ability of the serotonergic antagonist mianserin to modulate the number and functional activity of human 5-hydroxytryptamine2A (5-HT2A) and 5-HT2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y." | 7.69 | Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. ( Elliott, JM; Newton, RA, 1997) |
| " In the current study, we examined the inhibitory effects of 5HT(2A)R antagonists, ketanserin and ritanserin, both on JCV infection and on propagation by using human neuroblastoma cells IMR-32 and JCI, which continuously produce JCV." | 3.75 | Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells. ( Nakamichi, K; Nukuzuma, C; Nukuzuma, S; Takegami, T, 2009) |
| "We have assessed the ability of the serotonergic antagonist mianserin to modulate the number and functional activity of human 5-hydroxytryptamine2A (5-HT2A) and 5-HT2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y." | 3.69 | Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y. ( Elliott, JM; Newton, RA, 1997) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 2 (66.67) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Nukuzuma, S | 1 |
| Nakamichi, K | 1 |
| Nukuzuma, C | 1 |
| Takegami, T | 1 |
| Newton, RA | 2 |
| Phipps, SL | 1 |
| Flanigan, TP | 1 |
| Newberry, NR | 1 |
| Carey, JE | 1 |
| Kumar, C | 1 |
| McDonald, B | 1 |
| Chen, C | 1 |
| Elliott, JM | 2 |
3 other studies available for ketanserin and Neuroblastoma
| Article | Year |
|---|---|
Inhibitory effect of serotonin antagonists on JC virus propagation in a carrier culture of human neuroblastoma cells.
Topics: Cell Line, Tumor; Down-Regulation; Humans; JC Virus; Ketanserin; Neuroblastoma; Receptor, Serotonin, | 2009 |
Characterisation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors expressed in the human neuroblastoma cell line SH-SY5Y: comparative stimulation by hallucinogenic drugs.
Topics: Adrenergic alpha-Agonists; Amphetamines; Antiparkinson Agents; Calcium; Choroid Plexus; Electrophysi | 1996 |
Mianserin-induced down-regulation of human 5-hydroxytryptamine2A and 5-hydroxytryptamine2C receptors stably expressed in the human neuroblastoma cell line SH-SY5Y.
Topics: Cell Membrane; DNA, Complementary; Down-Regulation; Ergolines; Humans; Ketanserin; Kinetics; Mianser | 1997 |