ketanserin has been researched along with Nelson Syndrome in 2 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Nelson Syndrome: A syndrome characterized by HYPERPIGMENTATION, enlarging pituitary mass, visual defects secondary to compression of the OPTIC CHIASM, and elevated serum ACTH. It is caused by the expansion of an underlying ACTH-SECRETING PITUITARY ADENOMA that grows in the absence of feedback inhibition by adrenal CORTICOSTEROIDS, usually after ADRENALECTOMY.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketanserin was given to 2 patients with Nelson's syndrome, with only transient ACTH decrease in one, and no changes in ACTH response to CRH after 1 month treatment in both cases." | 2.69 | Effect of the serotonin antagonists ritanserin and ketanserin in Cushing's disease. ( Belluardo, P; Boscaro, M; Fallo, F; Fava, GA; Franceschetto, A; Sonino, N, 2000) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Prescott, RW | 1 |
| Ratcliffe, WA | 1 |
| Taylor, PK | 1 |
| Sonino, N | 1 |
| Fava, GA | 1 |
| Fallo, F | 1 |
| Franceschetto, A | 1 |
| Belluardo, P | 1 |
| Boscaro, M | 1 |
2 trials available for ketanserin and Nelson Syndrome
| Article | Year |
|---|---|
Effect of an oral serotonin antagonist, ketanserin, on plasma ACTH concentrations in Nelson's syndrome.
Topics: Adrenocorticotropic Hormone; Adult; Aged; Clinical Trials as Topic; Double-Blind Method; Female; Hum | 1984 |
Effect of the serotonin antagonists ritanserin and ketanserin in Cushing's disease.
Topics: Adolescent; Adrenocorticotropic Hormone; Adult; Cushing Syndrome; Female; Hormones; Humans; Hydrocor | 2000 |