ketanserin has been researched along with Myocardial Ischemia in 8 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Myocardial Ischemia: A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).
| Excerpt | Relevance | Reference |
|---|---|---|
| "To test the hypothesis that ketanserin augments coronary collateral blood flow and decreases myocardial ischemia during balloon angioplasty." | 9.09 | Intracoronary ketanserin augments coronary collateral blood flow and decreases myocardial ischemia during balloon angioplasty. ( Antoniadis, A; Kremastinos, DT; Kyriakides, ZS; Nikolaou, N; Sbarouni, E, 1999) |
| "To test the hypothesis that ketanserin augments coronary collateral blood flow and decreases myocardial ischemia during balloon angioplasty." | 5.09 | Intracoronary ketanserin augments coronary collateral blood flow and decreases myocardial ischemia during balloon angioplasty. ( Antoniadis, A; Kremastinos, DT; Kyriakides, ZS; Nikolaou, N; Sbarouni, E, 1999) |
| "Myocardial ischemia was induced by a treadmill exercise test associated with limitation of left anterior descending coronary blood flow." | 1.32 | Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists. ( Dubreuil, B; Guilbert, F; Herbert, JM; Janiak, P; Lainée, P; McCort, G; O'Connor, SE, 2004) |
| " Animals in groups 4 and 8 were given both lidoflazine and ketanserin according to the dosing schedules above." | 1.27 | Preservation of the ischemic canine myocardium: a comparison of hypothermia, lidoflazine, and ketanserin. ( Clark, NJ; McJames, SW; Pace, NL; Port, JD; Stanley, TH; Stockham, RJ, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (12.50) | 18.7374 |
| 1990's | 6 (75.00) | 18.2507 |
| 2000's | 1 (12.50) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Guilbert, F | 1 |
| Lainée, P | 1 |
| Dubreuil, B | 1 |
| McCort, G | 1 |
| O'Connor, SE | 1 |
| Janiak, P | 1 |
| Herbert, JM | 1 |
| Clark, NJ | 1 |
| Port, JD | 1 |
| McJames, SW | 1 |
| Stockham, RJ | 1 |
| Stanley, TH | 1 |
| Pace, NL | 1 |
| Grover, GJ | 1 |
| Sargent, CA | 1 |
| Dzwonczyk, S | 1 |
| Normandin, DE | 1 |
| Antonaccio, MJ | 1 |
| Mitsuoka, W | 1 |
| Egashira, S | 1 |
| Tagawa, H | 1 |
| Kuga, T | 1 |
| Hayashi, Y | 1 |
| Yamada, A | 1 |
| Tomoike, H | 1 |
| Nakamura, M | 1 |
| Takeshita, A | 1 |
| Kaumann, AJ | 1 |
| Frenken, M | 1 |
| Posival, H | 1 |
| Brown, AM | 1 |
| Buus, NH | 1 |
| Terp, K | 1 |
| Baandrup, U | 1 |
| Mulvany, MJ | 1 |
| Nyborg, NC | 1 |
| Kyriakides, ZS | 1 |
| Sbarouni, E | 1 |
| Nikolaou, N | 1 |
| Antoniadis, A | 1 |
| Kremastinos, DT | 1 |
| Schad, H | 1 |
| Heimisch, W | 1 |
| Barankay, A | 1 |
| Hesse, S | 1 |
| Mendler, N | 1 |
1 trial available for ketanserin and Myocardial Ischemia
| Article | Year |
|---|---|
Intracoronary ketanserin augments coronary collateral blood flow and decreases myocardial ischemia during balloon angioplasty.
Topics: Angioplasty, Balloon; Antihypertensive Agents; Collateral Circulation; Coronary Circulation; Coronar | 1999 |
7 other studies available for ketanserin and Myocardial Ischemia
| Article | Year |
|---|---|
Serotonin aggravates exercise-induced cardiac ischemia in the dog: effect of serotonin receptor antagonists.
Topics: Animals; Dogs; Endothelium, Vascular; Female; Hemodynamics; Hypercholesterolemia; Infusions, Intrave | 2004 |
Preservation of the ischemic canine myocardium: a comparison of hypothermia, lidoflazine, and ketanserin.
Topics: Animals; Antihypertensive Agents; Blood Pressure; Calcium Channel Blockers; Cardiac Output; Cardiopu | 1988 |
Protective effect of serotonin (5-HT2) receptor antagonists in ischemic rat hearts.
Topics: Animals; Cinanserin; Disease Models, Animal; Ergolines; Heart; Hemodynamics; Ketanserin; L-Lactate D | 1993 |
Augmentation of coronary responsiveness to serotonin at the site of X-ray-induced intimal thickening in miniature pigs.
Topics: Animals; Coronary Vasospasm; Coronary Vessels; Endothelium, Vascular; Histamine; Ketanserin; Male; M | 1995 |
Variable participation of 5-HT1-like receptors and 5-HT2 receptors in serotonin-induced contraction of human isolated coronary arteries. 5-HT1-like receptors resemble cloned 5-HT1D beta receptors.
Topics: Adult; Arteriosclerosis; Binding, Competitive; Cardiomyopathy, Dilated; Cloning, Molecular; Coronary | 1994 |
Pharmacological characterization of coronary small arteries from pigs with chronic ischaemic myocardial remodelling.
Topics: Acetylcholine; Animals; Bradykinin; Cardiomegaly; Cardiotonic Agents; Chronic Disease; Coronary Vess | 1998 |
Effects of the serotonin-antagonist ketanserin on the function of ischaemic and normally perfused myocardium and modification by beta-1-blockade in anaesthetized normotensive dogs.
Topics: Adrenergic beta-Antagonists; Animals; Blood Pressure; Coronary Circulation; Dogs; Female; Heart; Hea | 1992 |