ketanserin has been researched along with Muscle Rigidity in 2 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Muscle Rigidity: Continuous involuntary sustained muscle contraction which is often a manifestation of BASAL GANGLIA DISEASES. When an affected muscle is passively stretched, the degree of resistance remains constant regardless of the rate at which the muscle is stretched. This feature helps to distinguish rigidity from MUSCLE SPASTICITY. (From Adams et al., Principles of Neurology, 6th ed, p73)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil." | 7.67 | Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. ( Cline, EJ; Koob, GF; Smith, NT; Weinger, MB, 1987) |
| "Systemic pretreatment with ketanserin, a relatively specific type-2 serotonin receptor antagonist, significantly attenuated the muscle rigidity produced in rats by the potent short-acting opiate agonist alfentanil." | 3.67 | Ketanserin pretreatment reverses alfentanil-induced muscle rigidity. ( Cline, EJ; Koob, GF; Smith, NT; Weinger, MB, 1987) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (50.00) | 18.7374 |
| 1990's | 1 (50.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Weinger, MB | 2 |
| Chen, DY | 1 |
| Lin, T | 1 |
| Lau, C | 1 |
| Koob, GF | 2 |
| Smith, NT | 2 |
| Cline, EJ | 1 |
2 other studies available for ketanserin and Muscle Rigidity
| Article | Year |
|---|---|
A role for CNS alpha-2 adrenergic receptors in opiate-induced muscle rigidity in the rat.
Topics: Adrenergic alpha-Agonists; Alfentanil; Animals; Electromyography; Hindlimb; Imidazoles; Ketanserin; | 1995 |
Ketanserin pretreatment reverses alfentanil-induced muscle rigidity.
Topics: Adjuvants, Anesthesia; Alfentanil; Animals; Fentanyl; Ketanserin; Male; Muscle Rigidity; Preanesthet | 1987 |