ketanserin has been researched along with Muscle Contraction in 152 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Muscle Contraction: A process leading to shortening and/or development of tension in muscle tissue. Muscle contraction occurs by a sliding filament mechanism whereby actin filaments slide inward among the myosin filaments.
| Excerpt | Relevance | Reference |
|---|---|---|
| "1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin." | 7.68 | Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy. ( Dyer, DC; Zhang, L, 1993) |
| "Ketanserin is a selective S2-serotoninergic antagonist with additional alpha 1-adrenergic blocking properties." | 6.37 | Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin. ( Amery, A; Birkenhäger, W; Breckenridge, A; Bühler, F; Distler, A; Dormandy, J; Doyle, A; Frohlich, E; Hansson, L; Vanhoutte, P, 1988) |
| " The aim of the present study was to examine the modulatory effects of 5-HT receptors on the neurokinin A (NKA)-induced release of endogenous 5-HT and airway smooth muscle contraction in the isolated Fisher 344 rat trachea." | 3.70 | Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro. ( Germonpré, PR; Joos, GF; Pauwels, RA, 1998) |
| "1 nM) on isolated ovine uterine artery of late pregnancy, which were competitively antagonized by ketanserin." | 3.68 | Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy. ( Dyer, DC; Zhang, L, 1993) |
| " 3 The additional smooth muscle contraction stimulated by 5-HT was increased in the presence of the competitive substrate inhibitor for nitric oxide synthase, NG-nitro-L-arginine methyl ester (L-NAME, 100 microM)." | 3.68 | Endothelium-dependent contractile responses to 5-hydroxytryptamine in the rabbit basilar artery. ( Clark, AH; Garland, CJ; Seager, JM, 1992) |
| " The 5-HT2 receptor-antagonistic properties of AHR-16303B were demonstrated by inhibition of (a) [3H]ketanserin binding to rat cerebral cortical membranes (IC50 = 165 nM); (b) 5-hydroxytryptamine (5-HT)-induced foot edema in rats (minimum effective dose, (MED) = 0." | 3.68 | AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels. ( Appell, KC; Barrett, RJ; Kilpatrick, BF; Nolan, JC; Proakis, AG; Walsh, DA, 1991) |
| " Intrathecal injection of 5-methoxy-N,N'-dimethyltryptamine (5-MeODMT), (+/-)-1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane hydrochloride (DOI) or 2,5-dimethoxy-alpha,4-dimethylbenzene ethamine hydrochloride (DOM) produced dose-related back muscle contractions (BMC) and wet dog shakes (WDS) which were both markedly attenuated by intraperitoneal pretreatment with either ritanserin (1 mg kg-1), ketanserin (0." | 3.68 | Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats. ( Fone, KC; Marsden, CA; Robinson, AJ, 1991) |
| "Ketanserin is a selective S2-serotoninergic antagonist with additional alpha 1-adrenergic blocking properties." | 2.37 | Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin. ( Amery, A; Birkenhäger, W; Breckenridge, A; Bühler, F; Distler, A; Dormandy, J; Doyle, A; Frohlich, E; Hansson, L; Vanhoutte, P, 1988) |
| "We investigated the effects of partial bladder outlet obstruction (BOO) on the function and gene expression of 5-hydroxytryptamine (5-HT) receptor subtypes in rat bladder." | 1.39 | 5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats. ( Ikegaki, I; Kasahara, K; Kuriyama, H; Sakai, T; Tomita, K, 2013) |
| "Pretreatment with ketanserin (10 microM), a 5-HT2 antagonist, tropisetron (1 microM), a 5-HT3/4 antagonist, SDZ 216-525 (1 to 10 microM) and pindobind (10 microM), both selective 5-HT1A antagonists, or capsaicin (10 microM), which depletes sensory nerves from neuropeptides, had no effect on the inhibition of the cholinergic contraction by 8-OH-DPAT (10 to 30 microM)." | 1.30 | The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro. ( De Leyn, P; Demedts, MG; Deneffe, G; Dupont, LJ; Pype, JL; Verleden, GM, 1998) |
| "Fluoxetine treatment did not modify the binding parameters of [3H]-prazosin to vas deferens." | 1.30 | Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility. ( Borda, E; Busch, L; Wald, M, 1999) |
| " In both tissues, variations in perfusate [Ca2+] had similar effects: threshold contractile concentrations of 5-HT were unaffected, and the upper ends of the 5-HT dose-response curves were augmented or decreased by increased or decreased [Ca2+], respectively." | 1.29 | Interaction between Ca2+, verapamil, and ketanserin in rat tail artery and aorta. ( Marwood, JF; Okoro, EO; Stokes, GS, 1995) |
| " Pretreatment with either prazosin (5 x 10(-9) - 10(-8) M) or ketanserin (5 x 10(-9) - 10(-8) M) leads to decreased slopes and Emax in the 2C-B dose-response curves." | 1.28 | The action of the psychoactive drug 2C-B on isolated rat thoracic aorta. ( Borges, Y; Cassels, BK; Gonzalez, E; Lobos, M, 1992) |
| " Indices of amplification were leftward shifts of methoxamine dose-response (DR) curves produced by 5-HT (0." | 1.28 | Evidence for a 5-HT1-like receptor mediating the amplifying action of 5-HT in the rabbit ear artery. ( de la Lande, IS, 1992) |
| "5." | 1.28 | Analysis of the 5-HT receptors mediating contractions in the rabbit isolated renal artery. ( Feniuk, W; Saxena, PR; Tadipatri, S; van Heuven-Nolsen, D, 1991) |
| "Ketanserin did not inhibit contractions of any vessels." | 1.28 | Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries. ( Kazda, S, 1991) |
| "pretreatment with methysergide." | 1.28 | Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat. ( Danzebrink, RM; Gebhart, GF, 1991) |
| "3." | 1.27 | Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors. ( Kaumann, AJ, 1983) |
| "Ketanserin was a competitive antagonist of the effects of 5HT in both arteries." | 1.27 | Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf. ( Frenken, M; Kaumann, AJ, 1984) |
| "Histamine was a potent dilator agent in rat BA through a combination of both H1 and H2 receptors." | 1.27 | Differential vasomotor action of noradrenaline, serotonin, and histamine in isolated basilar artery from rat and guinea-pig. ( Chang, JY; Hardebo, JE; Owman, C, 1988) |
| " In addition, lack of Ca2+ caused a shift to the right in the dose-response curve for phenylephrine-induced IP formation whereas serotonin-induced IP formation was not affected by changes in Ca2+e." | 1.27 | Influence of Ca2+e on 5-HT2- and alpha 1-induced arterial contraction and phosphoinositide metabolism. ( Berta, P; Chevillard, C; Haiech, J; Mathieu, MN; Seguin, J; Vidal, N, 1986) |
| "Irindalone was more potent in inhibiting the serotonin-induced contractions and ketanserin was." | 1.27 | Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta. ( Boeck, V; Jensen, KT; Mikkelsen, EO; Nyborg, NC, 1988) |
| " Long-term administration of lithium decreased the number of not only 5-HT2 receptors in the frontal cortex but also 5-HT1 and 5-HT2 receptors in the hippocampus in rats." | 1.27 | Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain. ( Hotta, I; Segawa, T; Yamawaki, S, 1986) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 55 (36.18) | 18.7374 |
| 1990's | 75 (49.34) | 18.2507 |
| 2000's | 15 (9.87) | 29.6817 |
| 2010's | 7 (4.61) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Wainscott, DB | 1 |
| Cohen, ML | 3 |
| Schenck, KW | 2 |
| Audia, JE | 1 |
| Nissen, JS | 1 |
| Baez, M | 1 |
| Kursar, JD | 1 |
| Lucaites, VL | 1 |
| Nelson, DL | 2 |
| Leopoldo, M | 1 |
| Lacivita, E | 1 |
| Contino, M | 1 |
| Colabufo, NA | 1 |
| Berardi, F | 1 |
| Perrone, R | 1 |
| Lim, I | 1 |
| Chess-Williams, R | 1 |
| Sellers, D | 1 |
| Takanashi, A | 1 |
| Sakai-Saito, A | 1 |
| Hattori, T | 1 |
| Kanno-Saito, S | 1 |
| Katano, Y | 1 |
| Okada, T | 1 |
| Dawson, P | 1 |
| Opacka-Juffry, J | 1 |
| Moffatt, JD | 2 |
| Daniju, Y | 1 |
| Dutta, N | 1 |
| Ramsey, J | 1 |
| Davidson, C | 1 |
| Sung, DJ | 1 |
| Noh, HJ | 1 |
| Kim, JG | 1 |
| Park, SW | 1 |
| Kim, B | 1 |
| Cho, H | 1 |
| Bae, YM | 1 |
| Weigand, LA | 1 |
| Myers, AC | 1 |
| Meeker, S | 1 |
| Undem, BJ | 1 |
| Felixsson, E | 1 |
| Persson, IA | 1 |
| Eriksson, AC | 1 |
| Persson, K | 1 |
| Papamatheakis, DG | 1 |
| Vemulakonda, S | 1 |
| Blood, Q | 1 |
| Goyal, R | 1 |
| Rubalcava, M | 1 |
| Vrancken, K | 1 |
| Bennett, A | 1 |
| Dawson, A | 1 |
| Osman, NJ | 1 |
| Blood, AB | 1 |
| Pearce, WJ | 2 |
| Longo, LD | 1 |
| Wilson, SM | 1 |
| Sakai, T | 2 |
| Kasahara, K | 1 |
| Tomita, K | 1 |
| Ikegaki, I | 1 |
| Kuriyama, H | 1 |
| Lograno, MD | 1 |
| Romano, MR | 1 |
| Cocks, TM | 1 |
| Page, CP | 1 |
| Jähnichen, S | 1 |
| Radtke, OA | 1 |
| Pertz, HH | 1 |
| Mitsui, R | 1 |
| Ono, S | 1 |
| Karaki, S | 1 |
| Kuwahara, A | 1 |
| Kitazawa, T | 1 |
| Ukai, H | 1 |
| Komori, S | 1 |
| Taneike, T | 1 |
| Zhao, A | 1 |
| Urban, JF | 1 |
| Morimoto, M | 1 |
| Elfrey, JE | 1 |
| Madden, KB | 1 |
| Finkelman, FD | 1 |
| Shea-Donohue, T | 1 |
| Yamaguchi, M | 1 |
| Shibata, O | 1 |
| Nishioka, K | 1 |
| Makita, T | 1 |
| Sumikawa, K | 1 |
| Ishimura, M | 1 |
| Kataoka, S | 1 |
| Suda, M | 1 |
| Maeda, T | 1 |
| Hiyama, Y | 1 |
| Komada, T | 1 |
| Yano, S | 1 |
| Millar, JA | 1 |
| Facoory, BD | 1 |
| Laverty, R | 1 |
| Kaumann, AJ | 6 |
| Lidberg, P | 2 |
| Dahlström, A | 3 |
| Ahlman, H | 3 |
| Feniuk, W | 4 |
| McGoon, MD | 1 |
| Vanhoutte, PM | 8 |
| Frenken, M | 3 |
| Cohen, RA | 1 |
| Shepherd, JT | 2 |
| Müller-Schweinitzer, E | 1 |
| Engel, G | 1 |
| Moulds, RF | 1 |
| Iwanov, V | 1 |
| Medcalf, RL | 1 |
| Ogunbiyi, PO | 1 |
| Eyre, P | 1 |
| De Clerck, F | 1 |
| Van Nueten, JM | 4 |
| Janssen, PA | 1 |
| De Ridder, A | 1 |
| Kuemmerle, JF | 2 |
| Murthy, KS | 2 |
| Grider, JR | 2 |
| Martin, DC | 2 |
| Makhlouf, GM | 2 |
| Watts, SW | 1 |
| Gilbert, L | 1 |
| Webb, RC | 1 |
| Sikorski, BW | 1 |
| James, GM | 1 |
| Glance, SD | 1 |
| Hodgson, WC | 1 |
| King, RG | 1 |
| MacLean, MR | 2 |
| Clayton, RA | 1 |
| Hillis, SW | 1 |
| McIntyre, PD | 1 |
| Peacock, AJ | 1 |
| Templeton, AG | 1 |
| Martín, MT | 1 |
| Fernández, E | 1 |
| Fernández, AG | 1 |
| Goñalons, E | 1 |
| Park, SJ | 1 |
| Boulanger, CM | 1 |
| Kirchengast, M | 1 |
| Messori, E | 1 |
| Rizzi, CA | 1 |
| Candura, SM | 1 |
| Lucchelli, A | 1 |
| Balestra, B | 1 |
| Tonini, M | 1 |
| Okoro, EO | 2 |
| Marwood, JF | 2 |
| Stokes, GS | 1 |
| Krause, DN | 2 |
| Barrios, VE | 1 |
| Duckles, SP | 2 |
| Bingham, S | 1 |
| King, BF | 1 |
| Rushant, B | 1 |
| Smith, MI | 1 |
| Gaster, L | 1 |
| Sanger, GJ | 1 |
| Tavakoli, R | 1 |
| Frossard, N | 1 |
| Mizuno, R | 1 |
| Ohhashi, T | 2 |
| Bax, WA | 1 |
| Renzenbrink, GJ | 1 |
| Van Heuven-Nolsen, D | 2 |
| Thijssen, EJ | 1 |
| Bos, E | 1 |
| Saxena, PR | 4 |
| Matera, MG | 2 |
| De Santis, D | 1 |
| D'Agostino, B | 1 |
| Pallotta, M | 1 |
| Vacca, C | 1 |
| Cazzola, M | 2 |
| Rossi, F | 2 |
| Miyamoto, A | 2 |
| Sakota, T | 1 |
| Nishio, A | 2 |
| Taylor, EM | 1 |
| Pertz, H | 1 |
| Loza, MI | 1 |
| Ferreiro, TG | 1 |
| Sanz, F | 1 |
| Lozoya, E | 1 |
| Rodriguez, J | 1 |
| Manaut, F | 1 |
| Verde, I | 1 |
| Castro, E | 1 |
| Fontenla, JA | 1 |
| Cadavid, I | 1 |
| Zhang, L | 2 |
| Dyer, DC | 2 |
| Van Diest, MJ | 1 |
| Verbeuren, TJ | 2 |
| Herman, AG | 2 |
| Gidener, S | 1 |
| Kirkali, Z | 1 |
| Güven, H | 1 |
| Ishizawa, M | 1 |
| Obi, T | 1 |
| Dringenberg, HC | 1 |
| Vanderwolf, CH | 1 |
| Hamilton, JT | 1 |
| Nagakura, Y | 1 |
| Kamato, T | 1 |
| Nishida, A | 1 |
| Ito, H | 1 |
| Yamano, M | 1 |
| Miyata, K | 1 |
| Verheggen, R | 1 |
| Freudenthaler, S | 1 |
| Meyer-Dulheuer, F | 1 |
| Lachnit, WG | 1 |
| Ford, AP | 1 |
| Clarke, DE | 1 |
| Nishimura, Y | 1 |
| Sevcík, J | 1 |
| Ruzicka, V | 1 |
| Slánsky, J | 1 |
| Masek, K | 1 |
| Hu, XQ | 1 |
| Wang, JX | 1 |
| Ikomi, F | 1 |
| Geary, GG | 1 |
| Nakajima, M | 1 |
| Shiihara, Y | 1 |
| Shiba, Y | 1 |
| Sano, I | 1 |
| Mizumoto, A | 1 |
| Itoh, Z | 1 |
| Briejer, MR | 1 |
| Mathis, C | 1 |
| Schuurkes, JA | 1 |
| Bailey, SR | 1 |
| Elliott, J | 1 |
| Germonpré, PR | 1 |
| Joos, GF | 1 |
| Pauwels, RA | 1 |
| Teng, GQ | 1 |
| Williams, J | 1 |
| Purdy, R | 1 |
| Dupont, LJ | 1 |
| Pype, JL | 1 |
| Demedts, MG | 1 |
| De Leyn, P | 1 |
| Deneffe, G | 1 |
| Verleden, GM | 1 |
| O'Dowd, A | 1 |
| Miller, DJ | 1 |
| Karlsson, C | 1 |
| Bodelsson, G | 1 |
| Bodelsson, M | 1 |
| Stjernquist, M | 1 |
| Busch, L | 1 |
| Wald, M | 1 |
| Borda, E | 1 |
| Morecroft, I | 1 |
| Heeley, RP | 1 |
| Prentice, HM | 1 |
| Kirk, A | 1 |
| Roon, KI | 1 |
| Maassen Van Den Brink, A | 1 |
| Ferrari, MD | 1 |
| Gong, H | 1 |
| Nakamura, T | 1 |
| Hattori, K | 1 |
| Ohnuki, T | 1 |
| Rashid, M | 1 |
| Nakazawa, M | 1 |
| Watanabe, K | 1 |
| Nagatomo, T | 1 |
| Tuladhar, BR | 1 |
| Womack, MD | 1 |
| Naylor, RJ | 2 |
| Ikawati, Z | 1 |
| Nose, M | 1 |
| Maeyama, K | 1 |
| Hauser, DS | 1 |
| Mevissen, M | 1 |
| Weiss, R | 1 |
| Portier, CJ | 1 |
| Scholtysik, G | 1 |
| Studer, UE | 1 |
| Danuser, H | 1 |
| Kellum, JM | 1 |
| Innocent, O | 1 |
| Olufemi, A | 1 |
| Lobos, M | 1 |
| Borges, Y | 1 |
| Gonzalez, E | 1 |
| Cassels, BK | 1 |
| Vásquez, JV | 1 |
| Pinardi, G | 1 |
| Costantino, M | 1 |
| Lampa, E | 1 |
| de la Lande, IS | 1 |
| MacLennan, SJ | 1 |
| Martin, GR | 1 |
| Rinaldi-Carmona, M | 1 |
| Congy, C | 1 |
| Santucci, V | 1 |
| Simiand, J | 1 |
| Gautret, B | 1 |
| Neliat, G | 1 |
| Labeeuw, B | 1 |
| Le Fur, G | 1 |
| Soubrie, P | 1 |
| Breliere, JC | 1 |
| Seager, JM | 1 |
| Clark, AH | 1 |
| Garland, CJ | 1 |
| Cushing, DJ | 1 |
| Tadipatri, S | 1 |
| Pillai, G | 1 |
| Sutter, MC | 1 |
| Corson, MA | 1 |
| Sellers, JR | 1 |
| Adelstein, RS | 1 |
| Schoenberg, M | 1 |
| Reviriego, J | 3 |
| Fernandez-Alfonso, MS | 2 |
| Guerra, P | 1 |
| Marín, J | 3 |
| Barrett, RJ | 1 |
| Appell, KC | 1 |
| Kilpatrick, BF | 1 |
| Proakis, AG | 1 |
| Nolan, JC | 1 |
| Walsh, DA | 1 |
| Uma, S | 2 |
| Sahin-Erdemli, I | 1 |
| Gürdal, H | 1 |
| Tulunay, FC | 1 |
| Fone, KC | 1 |
| Robinson, AJ | 1 |
| Marsden, CA | 1 |
| Kazda, S | 1 |
| Ng, WW | 1 |
| Jing, J | 1 |
| Hyman, PE | 1 |
| Snape, WJ | 1 |
| Lai, FM | 1 |
| Tanikella, T | 1 |
| Cervoni, P | 1 |
| Danzebrink, RM | 1 |
| Gebhart, GF | 1 |
| Nyborg, NC | 2 |
| López de Pablo, AL | 1 |
| Marco, EJ | 1 |
| Benito, JM | 1 |
| Fraile, ML | 1 |
| Sanz, ML | 1 |
| Moreno, MJ | 1 |
| Conde, MV | 1 |
| Conti, A | 2 |
| Monopoli, A | 2 |
| Forlani, A | 2 |
| Ongini, E | 2 |
| Antona, C | 2 |
| Biglioli, P | 2 |
| Tøttrup, A | 1 |
| Forman, A | 1 |
| Funch-Jensen, P | 1 |
| Raundahl, U | 1 |
| Andersson, KE | 2 |
| Killam, AL | 1 |
| Nikam, SS | 1 |
| Lambert, GM | 1 |
| Martin, AR | 1 |
| Boeckxstaens, GE | 1 |
| Pelckmans, PA | 1 |
| Rampart, M | 1 |
| Bogers, JJ | 1 |
| Van Maercke, YM | 1 |
| Vällfors, B | 1 |
| Boström, S | 1 |
| Lüscher, TF | 1 |
| Kurz, KD | 1 |
| Awano, K | 1 |
| Yokoyama, M | 1 |
| Fukuzaki, H | 1 |
| Connor, HE | 1 |
| Humphrey, PP | 2 |
| Kalkman, HO | 1 |
| Neumann, V | 1 |
| Brauner, V | 1 |
| Demolle, D | 1 |
| Van Coevorden, A | 1 |
| Boeynaems, JM | 1 |
| Aono, J | 1 |
| Nabata, H | 1 |
| Ishizuka, N | 1 |
| Sakai, K | 1 |
| Moritoki, H | 2 |
| Fukuda, H | 2 |
| Kanaya, J | 2 |
| Ishida, Y | 2 |
| Costall, B | 1 |
| Gunning, SJ | 1 |
| Tattersall, FD | 1 |
| Chang, JY | 2 |
| Hardebo, JE | 2 |
| Owman, C | 3 |
| Janssens, WJ | 1 |
| Perren, MJ | 1 |
| Watts, AD | 1 |
| Clineschmidt, BV | 1 |
| Reiss, DR | 1 |
| Pettibone, DJ | 1 |
| Robinson, JL | 1 |
| Howlett, SE | 1 |
| Triggle, CR | 1 |
| Hoekman, TB | 1 |
| Nordström, O | 1 |
| Delbro, D | 1 |
| Ram, JL | 1 |
| Kreiman, MA | 1 |
| Gole, D | 1 |
| Bottaro, D | 1 |
| Shepro, D | 1 |
| Peterson, S | 1 |
| Hechtman, HB | 1 |
| Berta, P | 1 |
| Seguin, J | 1 |
| Vidal, N | 1 |
| Haiech, J | 1 |
| Mathieu, MN | 1 |
| Chevillard, C | 1 |
| Hedlund, H | 1 |
| Larsson, B | 1 |
| Mattiasson, A | 1 |
| Sjögren, C | 1 |
| Yamamoto, Y | 1 |
| Tomoike, H | 1 |
| Egashira, K | 1 |
| Nakamura, M | 1 |
| Arneklo-Nobin, B | 1 |
| Houston, DS | 1 |
| Bieger, D | 1 |
| Triggle, C | 1 |
| Heiligers, J | 1 |
| Mylecharane, EJ | 1 |
| Tio, R | 1 |
| Tuncer, M | 2 |
| Doğan, N | 1 |
| Ilhan, M | 1 |
| Kayaalp, SO | 2 |
| Kilbinger, H | 1 |
| Pfeuffer-Friederich, I | 1 |
| Vandeputte-Van Messon, G | 1 |
| Burvenich, C | 1 |
| Peeters, G | 1 |
| Vanhoutte, P | 1 |
| Amery, A | 1 |
| Birkenhäger, W | 1 |
| Breckenridge, A | 1 |
| Bühler, F | 1 |
| Distler, A | 1 |
| Dormandy, J | 1 |
| Doyle, A | 1 |
| Frohlich, E | 1 |
| Hansson, L | 1 |
| Mikkelsen, EO | 1 |
| Jensen, KT | 1 |
| Boeck, V | 1 |
| Sahlin, C | 1 |
| Svendgaard, NA | 1 |
| Hotta, I | 1 |
| Yamawaki, S | 1 |
| Segawa, T | 1 |
| Ashton, JH | 1 |
| Ogletree, ML | 1 |
| Michel, IM | 1 |
| Golino, P | 1 |
| McNatt, JM | 1 |
| Taylor, AL | 1 |
| Raheja, S | 1 |
| Schmitz, J | 1 |
| Buja, LM | 1 |
| Campbell, WB | 1 |
| Doggrell, SA | 1 |
| Klarskov, P | 1 |
| Hørby-Petersen, J | 1 |
| Iwamoto, T | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Investigating Serotonin Signalling in IBD Patients[NCT01650311] | 60 participants (Anticipated) | Observational | 2012-07-31 | Recruiting | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
3 reviews available for ketanserin and Muscle Contraction
| Article | Year |
|---|---|
An analysis of 5-hydroxytryptamine receptors mediating contraction of isolated smooth muscle.
Topics: Animals; Binding, Competitive; Cats; Cyproheptadine; Dogs; In Vitro Techniques; Ketanserin; Methoxam | 1984 |
Serotonin and vascular reactivity.
Topics: Animals; Blood Platelets; Calcium; Cold Temperature; Electric Stimulation; Hypoxia; Ketanserin; Lido | 1985 |
Serotoninergic mechanisms in hypertension. Focus on the effects of ketanserin.
Topics: Humans; Hypertension; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; Platelet Aggregation | 1988 |
149 other studies available for ketanserin and Muscle Contraction
| Article | Year |
|---|---|
Pharmacological characteristics of the newly cloned rat 5-hydroxytryptamine2F receptor.
Topics: Animals; Binding Sites; Cell Line; Cloning, Molecular; Gastric Fundus; Inositol 1,4,5-Trisphosphate; | 1993 |
Structure-activity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides, a class of 5-HT7 receptor agents. 2.
Topics: Amides; Animals; Cell Line; Guinea Pigs; Humans; Ileum; Male; Muscle Contraction; Muscle, Smooth; Pi | 2007 |
5-HT2A receptor is the predominant receptor mediating contraction of the isolated porcine distal ureter to 5-HT in young and old animals.
Topics: Aging; Animals; Dose-Response Relationship, Drug; Ketanserin; Muscle Contraction; Receptor, Serotoni | 2018 |
Differences between young and aged rats in voiding frequency and detrusor muscle serotonergic contraction.
Topics: Adrenergic alpha-Antagonists; Animals; Atropine; Ketanserin; Male; Muscle Contraction; Naphthalenes; | 2019 |
The effects of benzofury (5-APB) on the dopamine transporter and 5-HT2-dependent vasoconstriction in the rat.
Topics: Animals; Aorta; Benzofurans; Brain; Cocaine; Dopamine; Dopamine Plasma Membrane Transport Proteins; | 2014 |
Serotonin contracts the rat mesenteric artery by inhibiting 4-aminopyridine-sensitive Kv channels via the 5-HT2A receptor and Src tyrosine kinase.
Topics: 4-Aminopyridine; Action Potentials; Animals; Calcium Channel Blockers; Calcium Channels; Cells, Cult | 2013 |
Mast cell-cholinergic nerve interaction in mouse airways.
Topics: Animals; Atropine; Bronchoconstriction; Cholinergic Fibers; Electrophysiological Phenomena; Histamin | 2009 |
Horse chestnut extract contracts bovine vessels and affects human platelet aggregation through 5-HT(2A) receptors: an in vitro study.
Topics: Adenosine Diphosphate; Adrenergic alpha-1 Receptor Antagonists; Aesculus; Angiotensin II Type 1 Rece | 2010 |
Preservation of serotonin-mediated contractility in adult sheep pulmonary arteries following long-term high-altitude hypoxia.
Topics: Altitude Sickness; Animals; Benzamides; Calcium; Calcium Channel Blockers; Calcium Channels, L-Type; | 2011 |
5-Hydroxytryptamine-induced bladder hyperactivity via the 5-HT2A receptor in partial bladder outlet obstruction in rats.
Topics: Animals; Female; Ketanserin; Muscle Contraction; Rats; Receptor, Serotonin, 5-HT2A; Receptors, Serot | 2013 |
Pharmacological characterization of the 5-HT1A, 5-HT2 and 5-HT3 receptors in the bovine ciliary muscle.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Binding, Competitive; Cattle; Cell Membrane; Ciliar | 2003 |
Role of the epithelium and acetylcholine in mediating the contraction to 5-hydroxytryptamine in the mouse isolated trachea.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Atropine; Boron Compounds; Botulinum | 2004 |
Involvement of 5-HT1B receptors in triptan-induced contractile responses in guinea-pig isolated iliac artery.
Topics: Animals; Benzamides; Brain; Carbazoles; Dinoprost; Dose-Response Relationship, Drug; Drug Evaluation | 2004 |
Propionate modulates spontaneous contractions via enteric nerves and prostaglandin release in the rat distal colon.
Topics: Acetates; Animals; Atropine; Cholinergic Fibers; Colon, Descending; Cyclooxygenase Inhibitors; Enter | 2005 |
Pharmacological characterization of 5-hydroxytryptamine-induced contraction in the chicken gastrointestinal tract.
Topics: Anesthetics, Local; Animals; Atropine; Chickens; Dose-Response Relationship, Drug; Electric Stimulat | 2006 |
Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility.
Topics: Animals; Disease Models, Animal; Female; Gene Expression; Ketanserin; Mice; Mice, Inbred BALB C; Mus | 2006 |
Propofol attenuates ovalbumin-induced smooth muscle contraction of the sensitized rat trachea: inhibition of serotonergic and cholinergic signaling.
Topics: Adjuvants, Anesthesia; Anesthetics, Intravenous; Animals; Ketanserin; Male; Muscle Contraction; Musc | 2006 |
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Acetates; Acetylcholine; Albuter | 2006 |
Pharmacological characterization of 5-Hydroxytryptamine-receptor subtypes in circular muscle from the rat stomach.
Topics: Animals; Atropine; Dose-Response Relationship, Drug; Drug Synergism; Gastric Emptying; Gastric Fundu | 2007 |
Mechanism of action of ketanserin.
Topics: Animals; Antihypertensive Agents; Humans; Ketanserin; Muscle Contraction; Muscle, Smooth, Vascular; | 1982 |
Yohimbine and rauwolscine inhibit 5-hydroxytryptamine-induced contraction of large coronary arteries of calf through blockade of 5 HT2 receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Arteries; Cattle; Coronary Vessels | 1983 |
Is 5-HT a mediator in the motor control of the feline pylorus?
Topics: Animals; Cats; Dose-Response Relationship, Drug; Electric Stimulation; Female; Fluorescent Antibody | 1984 |
Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine.
Topics: Animals; Blood Platelets; Dogs; Epinephrine; In Vitro Techniques; Ketanserin; Muscle Contraction; No | 1984 |
Interaction of ketanserin and its metabolite ketanserinol with 5HT2 receptors in pulmonary and coronary arteries of calf.
Topics: Animals; Cattle; Coronary Vessels; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smoo | 1984 |
5-Hydroxytryptamine can mediate endothelium-dependent relaxation of coronary arteries.
Topics: Animals; Blood Platelets; Coronary Vessels; Dogs; In Vitro Techniques; Isometric Contraction; Ketans | 1983 |
Evidence for mediation by 5-HT2 receptors of 5-hydroxytryptamine-induced contraction of canine basilar artery.
Topics: Animals; Basilar Artery; Cerebral Cortex; Dogs; Female; In Vitro Techniques; Iodine Radioisotopes; K | 1983 |
The effects of platelet-derived contractile agents on human digital arteries.
Topics: Arteries; Blood Platelets; Humans; Imidazoles; In Vitro Techniques; Indomethacin; Ketanserin; Muscle | 1984 |
Effects of tryptamine antagonists on the anaphylactic contractions of the bovine pulmonary smooth muscles.
Topics: Anaphylaxis; Animals; Cattle; Horses; In Vitro Techniques; Ketanserin; Lung; Methysergide; Muscle Co | 1984 |
Platelet-mediated vascular contractions: inhibition of the serotonergic component by ketanserin.
Topics: Adenosine Diphosphate; Adenosine Triphosphate; Animals; Arachidonic Acid; Arachidonic Acids; Blood P | 1982 |
Interaction between 5-hydroxytryptamine and other vasoconstrictor substances in the isolated femoral artery of the rabbit; effect of ketanserin (R 41 468).
Topics: Animals; Drug Interactions; Evoked Potentials; Femoral Artery; In Vitro Techniques; Ketanserin; Musc | 1982 |
Selectivity of calcium antagonism and serotonin antagonism with respect to venous and arterial tissues.
Topics: Animals; Arteries; Calcium; Cinnarizine; Dogs; Flunarizine; Ketanserin; Muscle Contraction; Muscle, | 1981 |
Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells.
Topics: 4-Aminobenzoic Acid; Cyclic AMP; Humans; Inositol 1,4,5-Trisphosphate; Intestinal Mucosa; Ketanserin | 1995 |
5-Hydroxytryptamine2B receptor mediates contraction in the mesenteric artery of mineralocorticoid hypertensive rats.
Topics: Algorithms; Animals; Antihypertensive Agents; Blood Pressure; Data Interpretation, Statistical; Deso | 1995 |
Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta.
Topics: Amphetamines; Animals; Aorta; Arginine; Body Weight; Diabetes Mellitus, Experimental; Endothelium; I | 1993 |
5-HT1-receptor-mediated vasoconstriction in bovine isolated pulmonary arteries: influences of vascular endothelium and tone.
Topics: Amino Acid Oxidoreductases; Animals; Arginine; Cattle; Drug Interactions; Endothelium, Vascular; In | 1994 |
Mechanisms mediating the effects of cholecystokinin on avian small intestine longitudinal smooth muscle.
Topics: Acetylcholine; Amino Acid Sequence; Analysis of Variance; Animals; Chickens; Cholecystokinin; Dose-R | 1994 |
Effects of the combined 5-hydroxytryptamine2 receptor and Ca2+ channel antagonist LU49938 on the responsiveness of isolated porcine coronary arteries with and without endothelium.
Topics: Analysis of Variance; Animals; Calcium-Binding Proteins; Coronary Vessels; Dinoprost; Dose-Response | 1994 |
5-Hydroxytryptamine receptors that facilitate excitatory neuromuscular transmission in the guinea-pig isolated detrusor muscle.
Topics: Acetylcholine; Adenosine Triphosphate; Amphetamines; Animals; Dose-Response Relationship, Drug; Elec | 1995 |
Interaction between Ca2+, verapamil, and ketanserin in rat tail artery and aorta.
Topics: Animals; Aorta, Thoracic; Arteries; Calcium; In Vitro Techniques; Ketanserin; Male; Muscle Contracti | 1995 |
Melatonin receptors mediate potentiation of contractile responses to adrenergic nerve stimulation in rat caudal artery.
Topics: Animals; Arteries; Electric Stimulation; In Vitro Techniques; Isometric Contraction; Ketanserin; Mal | 1995 |
Antagonism by SB 204070 of 5-HT-evoked contractions in the dog stomach: an in-vivo model of 5-HT4 receptor function.
Topics: 4-Aminobenzoic Acid; Animals; Atropine; Dioxanes; Dogs; Dose-Response Relationship, Drug; Drug Inter | 1995 |
5-HT2-mediated bronchial responses after syngeneic lung transplantation in the rat.
Topics: Animals; Atropine; Bronchi; Dose-Response Relationship, Drug; Ketanserin; Lung Transplantation; Male | 1995 |
5-Hydroxytryptamine-induced NO-dependent relaxation in isolated strips of monkey popliteal lymph nodes.
Topics: Animals; Arginine; Aspirin; Dose-Response Relationship, Drug; Female; In Vitro Techniques; Ketanseri | 1995 |
5-HT receptors mediating contractions of the isolated human coronary artery.
Topics: Adolescent; Adult; Arteries; Blood Platelets; Child; Child, Preschool; Coronary Vessels; Dose-Respon | 1993 |
Role of 5-hydroxytryptamine in mediating adenosine-induced airway contraction.
Topics: Analysis of Variance; Animals; Atropine; Diphenhydramine; Dose-Response Relationship, Drug; Epitheli | 1995 |
Characterization of 5-hydroxytryptamine receptors on the isolated pig basilar artery by functional and radioligand binding studies.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Basilar Artery; Binding, Competitive; Dose-Response | 1994 |
Potentiation of responses to sympathetic nerve stimulation and vasoconstrictor agents by SK&F 103829 in the feline mesenteric circulation.
Topics: Animals; Benzazepines; Blood Pressure; Cats; Cattle; Female; In Vitro Techniques; Intestines; Ketans | 1994 |
5-Hydroxytryptamine (5-HT) contracts the guinea-pig isolated iliac artery via 5-HT1-like and 5-HT2 receptors.
Topics: Animals; Dinoprost; Female; Guinea Pigs; Iliac Artery; In Vitro Techniques; Ketanserin; Male; Muscle | 1993 |
Antiserotoninergic activity of 2-aminoethylbenzocyclanones in rat aorta: structure-activity relationships.
Topics: Animals; Aorta, Thoracic; Butyrophenones; In Vitro Techniques; Ketanserin; Ketones; Molecular Confor | 1993 |
Lysergic acid diethylamide is a partial agonist at 5-HT2 receptors in ovine uterine artery of late pregnancy.
Topics: Animals; Arteries; Female; In Vitro Techniques; Ketanserin; Lysergic Acid Diethylamide; Muscle Contr | 1993 |
Vascular interaction between 5-hydroxytryptamine and 15-lipoxygenase metabolites of arachidonic acid.
Topics: Animals; Arachidonate 15-Lipoxygenase; Arachidonic Acids; Body Weight; Dogs; Female; Hydroxyeicosate | 1993 |
Influence of serotonin on the human ureter: an in vitro pharmacological study.
Topics: Adult; Aged; Atropine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Indole | 1995 |
Inhibitory action of 5-hydroxytryptamine on propulsive activity of the guinea-pig isolated colon.
Topics: 5-Methoxytryptamine; Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniq | 1996 |
The vasomotor effects of 5-hydroxytryptamine on equine basilar arteries in vitro.
Topics: Animals; Basilar Artery; Dose-Response Relationship, Drug; Horses; Ketanserin; Methiothepin; Muscle | 1996 |
Urethane reduces contraction to 5-hydroxytryptamine (5-HT) and enhances the action of the 5-HT antagonist ketanserin on the rat thoracic aortic ring.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Calcium Chloride; In Vitro Techniques; Ketanser | 1995 |
Characterization of 5-hydroxytryptamine (5-HT) receptor subtypes influencing colonic motility in conscious dogs.
Topics: 4-Aminobenzoic Acid; Animals; Benzamides; Benzimidazoles; Biguanides; Bridged Bicyclo Compounds, Het | 1996 |
Participation of 5-HT1-like and 5-HT2A receptors in the contraction of human temporal artery by 5-hydroxytryptamine and related drugs.
Topics: Adult; Aged; Benzazepines; Collagenases; Endothelium, Vascular; Female; Headache; Humans; In Vitro T | 1996 |
SDZ NVI 085, an alpha 1A-adrenoceptor agonist with 5-HT2A receptor antagonist properties.
Topics: Adrenergic alpha-1 Receptor Agonists; Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Anima | 1996 |
Characterization of 5-hydroxytryptamine receptors mediating contractions in basilar arteries from stroke-prone spontaneously hypertensive rats.
Topics: Animals; Basilar Artery; Dose-Response Relationship, Drug; In Vitro Techniques; Ketanserin; Male; Me | 1996 |
Which type of 5-hydroxytryptamine receptor mediates relaxation of the longitudinal muscle of guinea pig proximal colon in vitro?
Topics: Animals; Colon; Dose-Response Relationship, Drug; Guinea Pigs; In Vitro Techniques; Indoles; Ketanse | 1996 |
Effects of 5HT2 receptor antagonists on responses to potassium depolarization in rat isolated aorta.
Topics: Animals; Aorta, Thoracic; Cinnarizine; Cyproheptadine; Diltiazem; Drug Synergism; Felodipine; Female | 1997 |
5-Hydroxytryptamine stimulates phosphoinositide hydrolysis and contraction in the ovine umbilical artery.
Topics: Animals; Female; In Vitro Techniques; Inositol Phosphates; Ketanserin; Muscle Contraction; Muscle, S | 1997 |
5-Hydroxytryptamine-induced endothelium-dependent and -independent relaxations in isolated dog anterior spinal small arteries.
Topics: Animals; Arteries; Aspirin; Dogs; Endothelium, Vascular; Epoprostenol; Female; Fibrinolytic Agents; | 1997 |
Melatonin directly constricts rat cerebral arteries through modulation of potassium channels.
Topics: Animals; Apamin; Benzimidazoles; Cerebral Arteries; Charybdotoxin; GTP-Binding Proteins; Ketanserin; | 1997 |
Effect of 5-hydroxytryptamine on gastrointestinal motility in conscious guinea-pigs.
Topics: Animals; Atropine; Consciousness; Duodenum; Eating; Fasting; Female; Gastrointestinal Motility; Guin | 1997 |
5-HT receptor types in the rat ileum longitudinal muscle: focus on 5-HT2 receptors mediating contraction.
Topics: 5-Methoxytryptamine; Animals; Female; Gastrointestinal Motility; Ileum; In Vitro Techniques; Ketanse | 1997 |
Plasma 5-hydroxytryptamine constricts equine digital blood vessels in vitro: implications for pathogenesis of acute laminitis.
Topics: Animals; Arteries; Chromatography, High Pressure Liquid; Coronary Vessels; Dose-Response Relationshi | 1998 |
Modulation by 5-HT1A receptors of the 5-HT2 receptor-mediated tachykinin-induced contraction of the rat trachea in vitro.
Topics: Animals; Electric Stimulation; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Neurokinin | 1998 |
Effects of maturation, artery size, and chronic hypoxia on 5-HT receptor type in ovine cranial arteries.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Aging; Animals; Carotid Artery, Common; Cerebral Arteries; F | 1998 |
The effects of 8-hydroxy-2-(di-n-propylamino)tetralin on the cholinergic contraction in guinea pig and human airways in vitro.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Bronchi; Bronchoconstriction; Capsai | 1998 |
Analysis of an H1 receptor-mediated, zinc-potentiated vasoconstrictor action of the histidyl dipeptide carnosine in rabbit saphenous vein.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carnosine; Cimetidine; Drug Interactions; Histamin | 1998 |
Characterization of 5-hydroxytryptamine receptors mediating circular smooth muscle contraction in the human umbilical artery.
Topics: Adolescent; Adult; Female; Humans; Ketanserin; Methiothepin; Muscle Contraction; Muscle, Smooth; Pre | 1999 |
Long-term treatment with fluoxetine associates with peripheral effects on rat vas deferens contractility.
Topics: Adrenergic Agents; Animals; Antidepressive Agents, Second-Generation; Binding Sites; Calcium; Cycloo | 1999 |
5-hydroxytryptamine receptors mediating contraction in human small muscular pulmonary arteries: importance of the 5-HT1B receptor.
Topics: Base Sequence; Benzamides; Biphenyl Compounds; DNA Primers; Humans; Ketanserin; Muscle Contraction; | 1999 |
Bovine isolated middle cerebral artery contractions to antimigraine drugs.
Topics: Animals; Cattle; In Vitro Techniques; Ketanserin; Middle Cerebral Artery; Muscle Contraction; Muscle | 1999 |
A novel 5-HT(2) antagonist, sarpogrelate hydrochloride, shows inhibitory effects on both contraction and relaxation mediated by 5-HT receptor subtypes in porcine coronary arteries.
Topics: Animals; Coronary Vessels; Ergonovine; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle R | 2000 |
Pharmacological characterization of the 5-HT receptor-mediated contraction in the mouse isolated ileum.
Topics: Animals; Atropine; Dioxanes; Dose-Response Relationship, Drug; Female; Granisetron; Ileum; In Vitro | 2000 |
Do mucosal mast cells contribute to the immediate asthma response?
Topics: Animals; Asthma; Connective Tissue; Female; Histamine Release; Histocytochemistry; Immunoglobulin E; | 2001 |
Effects of ketanserin and DOI on spontaneous and 5-HT-evoked peristalsis of the pig ureter in vivo.
Topics: Animals; Female; Indophenol; Ketanserin; Male; Methysergide; Muscle Contraction; Muscle, Smooth; Rec | 2002 |
Coexistence of contractile and relaxant 5-hydroxytryptamine receptors coupled to distinct signaling pathways in intestinal muscle cells: convergence of the pathways on Ca2+ mobilization.
Topics: 5-Hydroxytryptophan; Animals; Calcium; Cells, Cultured; Cyclic AMP; Guinea Pigs; Intestinal Mucosa; | 1992 |
Receptors mediating the actions of 5-hydroxytryptamine on the isolated retractor muscle of the penis preparations from Archachatina marginata (Swainson).
Topics: Animals; Ergolines; Indoles; Ketanserin; Lysergic Acid Diethylamide; Muscle Contraction; Muscles; Re | 1992 |
The action of the psychoactive drug 2C-B on isolated rat thoracic aorta.
Topics: Adrenergic alpha-Agonists; Animals; Aorta, Thoracic; Dimethoxyphenylethylamine; Endothelium, Vascula | 1992 |
Vasomotor responses in the isolated perfused external and internal carotid vascular beds of the rat.
Topics: Animals; Blood Pressure; Carotid Arteries; Carotid Artery, External; Carotid Artery, Internal; Femal | 1992 |
Role of 5-HT2 receptor subtypes in mediating adenosine-induced airway contraction.
Topics: Acetylcholine; Adenosine; Animals; Guinea Pigs; Histamine; In Vitro Techniques; Isometric Contractio | 1992 |
Evidence for a 5-HT1-like receptor mediating the amplifying action of 5-HT in the rabbit ear artery.
Topics: Acetylcholine; Animals; Arteries; Ear, External; In Vitro Techniques; Ketanserin; Methoxamine; Muscl | 1992 |
Effect of the thromboxane A2-mimetic U46619 on 5-HT1-like and 5-HT2 receptor-mediated contraction of the rabbit isolated femoral artery.
Topics: Animals; Biphenyl Compounds; Femoral Artery; Heptanoic Acids; In Vitro Techniques; Ketanserin; Male; | 1992 |
Biochemical and pharmacological properties of SR 46349B, a new potent and selective 5-hydroxytryptamine2 receptor antagonist.
Topics: Animals; Brain; Electroencephalography; Escape Reaction; Female; Fluorobenzenes; Guinea Pigs; In Vit | 1992 |
Endothelium-dependent contractile responses to 5-hydroxytryptamine in the rabbit basilar artery.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Animals; Arginine; Basilar Artery; Endothelium, Vascular; Fe | 1992 |
Comparison of the serotonin receptors that mediate smooth muscle contraction in canine and porcine coronary artery.
Topics: Animals; Coronary Vessels; Dogs; Ergolines; Jugular Veins; Ketanserin; Muscle Contraction; Muscle, S | 1992 |
Analysis of the 5-HT receptors mediating contractions in the rabbit isolated renal artery.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; 8-Hydroxy-2-(di-n-propylamino)te | 1991 |
Effect of human plasma proteins on spontaneous contractile activity of rat mesenteric portal vein.
Topics: Alpha-Globulins; Animals; Atropine; Beta-Globulins; Blood Proteins; Chlorpheniramine; gamma-Globulin | 1990 |
Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase.
Topics: Animals; Atropine; Calcium; Cattle; Enzyme Activation; Glycopeptides; In Vitro Techniques; Indometha | 1990 |
Effects of Ca2+ antagonists nifedipine and diltiazem on isolated human chorionic arteries and veins.
Topics: Arteries; Calcium; Calcium Radioisotopes; Diltiazem; Female; Humans; In Vitro Techniques; Ketanserin | 1990 |
AHR-16303B, a novel antagonist of 5-HT2 receptors and voltage-sensitive calcium channels.
Topics: Animals; Atrial Function; Blood Pressure; Calcium; Calcium Channel Blockers; Calcium Channels; Calci | 1991 |
Receptors mediating the contractile effect of serotonin (5-HT) in the isolated common bile duct of guinea-pig.
Topics: Animals; Atropine; Common Bile Duct; Dose-Response Relationship, Drug; Female; Guinea Pigs; Ketanser | 1991 |
Heterogeneous inhibitory effect of nitrendipine on 5-HT-responses in rabbit vascular tissues.
Topics: Animals; Aorta, Thoracic; Carotid Arteries; In Vitro Techniques; Ketanserin; Kinetics; Muscle Contra | 1991 |
Characterization of the 5-HT receptor subtypes involved in the motor behaviours produced by intrathecal administration of 5-HT agonists in rats.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Amphetamines; Animals; Clorgyline; Fluoxetine; Injections, S | 1991 |
Inhibitory effects of nisoldipine on serotonin and potassium induced contractions of porcine coronary and femoral arteries.
Topics: Animals; Coronary Vessels; Femoral Artery; In Vitro Techniques; Ketanserin; Muscle Contraction; Musc | 1991 |
Ability of ketanserin to block different receptors in human placental vessels.
Topics: Female; Histamine; Histamine Antagonists; Humans; In Vitro Techniques; Ketanserin; Muscle Contractio | 1990 |
Effect of 5-hydroxytryptamine and its antagonists on colonic smooth muscle of the rabbit.
Topics: Animals; Atropine; Colon; Dose-Response Relationship, Drug; Electric Stimulation; In Vitro Technique | 1991 |
Characterization of serotonin receptors in isolated rat intramyocardial coronary artery.
Topics: Animals; Coronary Vessels; Dinoprost; Endothelium; Ketanserin; Kinetics; Male; Muscle Contraction; M | 1991 |
Evidence that spinal 5-HT1, 5-HT2 and 5-HT3 receptor subtypes modulate responses to noxious colorectal distension in the rat.
Topics: Amidines; Animals; Blood Pressure; Colon; Indoles; Ketanserin; Male; Methysergide; Muscle Contractio | 1991 |
Ageing is associated with increased 5-HT2-receptor affinity and decreased receptor reserve in rat isolated coronary arteries.
Topics: Aging; Animals; Coronary Vessels; In Vitro Techniques; Ketanserin; Kinetics; Male; Muscle Contractio | 1991 |
Response of isolated cat middle cerebral artery to platelets: effect of endothelium removal.
Topics: Animals; Blood Platelets; Cats; Cerebral Arteries; Cyproheptadine; Endothelium, Vascular; Female; In | 1991 |
Role of 5-HT2 receptors in serotonin-induced contraction in the human mammary artery.
Topics: Female; Humans; Imidazoles; In Vitro Techniques; Ketanserin; Mammary Arteries; Muscle Contraction; M | 1990 |
5-Hydroxytryptamine induces contraction in isolated human mammary artery: effect of ketanserin.
Topics: Female; Humans; In Vitro Techniques; Ketanserin; Mammary Arteries; Muscle Contraction; Muscle, Smoot | 1990 |
Effects of transmural field stimulation in isolated muscle strips from human esophagus.
Topics: Atropine; Carbachol; Electric Stimulation; Esophagus; Humans; In Vitro Techniques; Ketanserin; Muscl | 1990 |
Comparison of two different arterial tissues suggests possible 5-hydroxytryptamine2 receptor heterogeneity.
Topics: Animals; Aorta, Thoracic; Binding Sites; Femoral Artery; Ketanserin; Male; Muscle Contraction; Muscl | 1990 |
Pharmacological characterization of 5-hydroxytryptamine receptors in the canine terminal ileum and ileocolonic junction.
Topics: Animals; Colon; Culture Techniques; Dogs; Female; Ileum; Indoles; Intestinal Mucosa; Ketanserin; Mal | 1990 |
On the nature of the contractile motor responses of the rat stomach elicited by serotonin or substance P in vitro.
Topics: Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Ketanserin; Male; Mu | 1985 |
Influence of ketanserin on 5-hydroxytryptamine-induced cerebrovascular spasm in the cat.
Topics: Animals; Cats; Cerebrovascular Circulation; Ischemic Attack, Transient; Ketanserin; Muscle Contracti | 1985 |
Are there interactions between S2-serotonergic and alpha 1-adrenergic receptors in isolated canine arteries?
Topics: Animals; Coronary Vessels; Dogs; Female; Femoral Artery; In Vitro Techniques; Ketanserin; Male; Musc | 1988 |
5-HT2-receptor antagonists: alpha 1- vs. 5-HT2-receptor blocking properties in blood vessels.
Topics: Adrenergic alpha-Antagonists; Animals; Blood Pressure; Ergolines; Ketanserin; Male; Muscle Contracti | 1988 |
A two-state model for the 5-HT2 receptor: effects of alpha-adrenoceptor ligands.
Topics: Animals; Binding, Competitive; Cattle; Coronary Vessels; Ketanserin; Methysergide; Muscle Contractio | 1988 |
Role of serotonin, histamine, and thromboxane A2 in platelet-induced contractions of coronary arteries and aortae from rabbits.
Topics: Animals; Aorta, Thoracic; Aspirin; Blood Platelets; Coronary Vessels; Diphenhydramine; Endothelium, | 1989 |
5-Hydroxytryptamine contracts human coronary arteries predominantly via 5-HT2 receptor activation.
Topics: 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; Adult; Child; Coronary Vessels; | 1989 |
Evidence for two populations of 5-hydroxytryptamine receptors in dog basilar artery.
Topics: Animals; Basilar Artery; Cocaine; Dogs; In Vitro Techniques; Indomethacin; Ketanserin; Muscle Contra | 1989 |
Supersensitivity of atherosclerotic rabbit aorta to ergometrine is mediated by 5-HT2 receptors.
Topics: Animals; Aorta, Thoracic; Arteriosclerosis; Body Weight; Cyproheptadine; Ergonovine; In Vitro Techni | 1989 |
Stimulation of aortic smooth muscle prostacyclin by serotonin: role of distinct receptors in contractile and synthetic states.
Topics: Animals; Aorta, Thoracic; Cattle; Cells, Cultured; Epoprostenol; Ketanserin; Methiothepin; Muscle Co | 1989 |
Effects of 5-hydroxytryptamine on human isolated placental chorionic arteries and veins.
Topics: Arteries; Calcium; Calcium Radioisotopes; Female; Humans; In Vitro Techniques; Ketanserin; Methyserg | 1989 |
Mechanism of the hypotensive effect of a novel phenylpiperazine derivative, SGB-1534: antagonism at alpha 1-adrenergic and 5-HT2 receptors.
Topics: Adrenergic alpha-Antagonists; Anesthesia; Animals; Antihypertensive Agents; Decerebrate State; Gastr | 1985 |
Ketanserin potentiates the prejunctional inhibitory effect of 5-hydroxytryptamine on rat vas deferens.
Topics: Animals; Drug Synergism; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; | 1986 |
Modification of electrical field stimulation-induced contractions in the guinea-pig ileum by metoclopramide and ICS 205-930 depends on the integrity of the mucosa.
Topics: Animals; Drug Interactions; Electric Stimulation; Guinea Pigs; Ileum; In Vitro Techniques; Indoles; | 1986 |
Differential vasomotor action of noradrenaline, serotonin, and histamine in isolated basilar artery from rat and guinea-pig.
Topics: Adrenergic alpha-Antagonists; Animals; Basilar Artery; Endothelium, Vascular; Histamine; Histamine A | 1988 |
A comparison of 5-hydroxytryptamine receptors mediating contraction in rabbit aorta and dog saphenous vein: evidence for different receptor types obtained by use of selective agonists and antagonists.
Topics: Animals; Aorta; Dogs; In Vitro Techniques; Ketanserin; Methoxamine; Muscle Contraction; Muscle, Smoo | 1985 |
Characterization of 5-hydroxytryptamine receptors in rat stomach fundus.
Topics: Animals; Binding, Competitive; Brain Chemistry; Gastric Fundus; In Vitro Techniques; Ketanserin; Mal | 1985 |
Effects of noradrenaline, serotonin, and selected antagonists on the vascular smooth muscle of normal and dystrophic chickens.
Topics: Animals; Chickens; Dose-Response Relationship, Drug; Ketanserin; Male; Muscle Contraction; Muscle, S | 1986 |
Adenosine-induced contractions of the isolated rat trachea are mediated by 5-hydroxytryptamine.
Topics: Adenosine; Animals; Ketanserin; Male; Muscle Contraction; Muscle, Smooth; Piperidines; Rats; Rats, I | 1986 |
LY165163 and 8-OH-DPAT have agonist effects on a serotonin responsive muscle of Aplysia.
Topics: 8-Hydroxy-2-(di-n-propylamino)tetralin; Acetylcholine; Animals; Aplysia; In Vitro Techniques; Ketans | 1987 |
Serotonin, histamine, and norepinephrine mediation of endothelial and vascular smooth muscle cell movement.
Topics: Animals; Aorta; Cattle; Cell Movement; Cells, Cultured; Depression, Chemical; Diphenhydramine; Endot | 1985 |
Influence of Ca2+e on 5-HT2- and alpha 1-induced arterial contraction and phosphoinositide metabolism.
Topics: Animals; Arteries; Calcium; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Muscle, Smoot | 1986 |
Ketanserin interaction with urethral alpha-adrenoceptors.
Topics: Adult; Animals; Female; Humans; In Vitro Techniques; Ketanserin; Muscle Contraction; Muscle, Smooth; | 1987 |
Attenuation of endothelium-related relaxation and enhanced responsiveness of vascular smooth muscle to histamine in spastic coronary arterial segments from miniature pigs.
Topics: Animals; Calcimycin; Coronary Vasospasm; Dinoprost; Disease Models, Animal; Endothelium, Vascular; H | 1987 |
Effects of tryptamine mediated through 2 states of the 5-HT2 receptor in calf coronary artery.
Topics: Animals; Cattle; Coronary Vessels; Endothelium, Vascular; In Vitro Techniques; Ketanserin; Methyserg | 1988 |
Adrenergic and serotoninergic mechanisms in human hand arteries and veins studied by fluorescence histochemistry and in vitro pharmacology.
Topics: Arteries; Binding, Competitive; Biogenic Amines; Epinephrine; Female; Hand; Humans; Isoproterenol; K | 1985 |
Adenine nucleotides, serotonin, and endothelium-dependent relaxations to platelets.
Topics: Adenine Nucleotides; Animals; Apyrase; Blood Platelets; Coronary Vessels; Dogs; Endothelium; Female; | 1985 |
Pharmacological properties of mechanical responses of the rat oesophageal muscularis mucosae to vagal and field stimulation.
Topics: Animals; Dioxolanes; Electric Stimulation; Esophagus; Hexamethonium Compounds; In Vitro Techniques; | 1985 |
Excitatory 5-hydroxytryptamine receptors in the cat urinary bladder are of the M- and 5-HT2-type.
Topics: Animals; Atropine; Cats; Cyproheptadine; Dimethylphenylpiperazinium Iodide; Drug Interactions; Femal | 1985 |
Serotonin-induced contraction of canine saphenous vein: mediation by 5-HT1 receptors.
Topics: Animals; Clonidine; Dogs; Drug Interactions; Emetics; In Vitro Techniques; Ketanserin; Mianserin; Mu | 1985 |
Two types of receptors for 5-hydroxytryptamine on the cholinergic nerves of the guinea-pig myenteric plexus.
Topics: Acetylcholine; Animals; Binding, Competitive; Cocaine; Electric Stimulation; Female; Guinea Pigs; Ke | 1985 |
Effect of serotonin on the motility of smooth muscles in teats of lactating cows.
Topics: Animals; Cattle; Female; Ketanserin; Lactation; Mammary Glands, Animal; Methysergide; Mianserin; Mil | 1985 |
Comparison of the effect of irindalone, a novel serotonin 5-HT2 antagonist and ketanserin on mechanical responses of rat thoracic aorta.
Topics: Animals; Aorta, Thoracic; Imidazoles; In Vitro Techniques; Ketanserin; Male; Muscle Contraction; Mus | 1988 |
Nerves containing serotonin, its interaction with noradrenaline, and characterization of serotonin receptors in cerebral arteries of monkey.
Topics: Animals; Cerebral Arteries; Chlorocebus aethiops; Electric Stimulation; Female; Immunohistochemistry | 1987 |
Long-term lithium treatment causes serotonin receptor down-regulation via serotonergic presynapses in rat brain.
Topics: 5-Hydroxytryptophan; Animals; Brain; Frontal Lobe; Head; Hippocampus; In Vitro Techniques; Ketanseri | 1986 |
Cooperative mediation by serotonin S2 and thromboxane A2/prostaglandin H2 receptor activation of cyclic flow variations in dogs with severe coronary artery stenoses.
Topics: Animals; Coronary Circulation; Coronary Disease; Dogs; Drug Antagonism; Epinephrine; Hemodynamics; I | 1987 |
Differential antagonism of the initial fast and secondary slow contractile responses of the rat isolated aorta to 5-hydroxytryptamine by mianserin and ketanserin.
Topics: Animals; Drug Interactions; In Vitro Techniques; Ketanserin; Male; Mianserin; Muscle Contraction; Mu | 1987 |
The subtype of serotonin (5-HT) receptors in the rat pulmonary artery.
Topics: Animals; Female; In Vitro Techniques; Ketanserin; Male; Methysergide; Mianserin; Muscle Contraction; | 1987 |
Influence of serotonin on lower urinary tract smooth muscle in vitro.
Topics: Animals; Cyproheptadine; Dose-Response Relationship, Drug; Female; Humans; In Vitro Techniques; Keta | 1986 |
Age-related change in serotonin-mediated prejunctional inhibition of rat vas deferens.
Topics: Adenosine Triphosphate; Aging; Animals; Drug Synergism; Electric Stimulation; In Vitro Techniques; K | 1986 |