ketanserin has been researched along with Malignant Carcinoid Syndrome in 12 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Malignant Carcinoid Syndrome: A symptom complex associated with CARCINOID TUMOR and characterized by attacks of severe flushing of the skin, diarrheal watery stools, bronchoconstriction, sudden drops in blood pressure, edema, and ascites. The carcinoid tumors are usually located in the gastrointestinal tract and metastasize to the liver. Symptoms are caused by tumor secretion of serotonin, prostaglandins, and other biologically active substances. Cardiac manifestations constitute CARCINOID HEART DISEASE. (Dorland, 27th ed; Stedman, 25th ed)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Ketanserin is a 5HT-2 antagonist with no mixed receptor agonist-antagonist activity." | 1.29 | [Symptomatic relief of carcinoid syndrome by ketanserin. A case]. ( Cella, G; Luzzatto, G; Pozza, M, 1995) |
| "Ketanserin has been shown to have both 5-HT2-serotonergic and alpha 1-adrenergic antagonist activity." | 1.27 | Is there alpha-adrenergic blockade and/or serotonergic blockade during chronic ketanserin treatment? ( Ball, SG; Robertson, JI, 1985) |
| "Calcium infusion induced carcinoid symptoms in only two of six patients, which were associated with elevated 5-HT levels (whereas elevated SP levels were seen in only one patient)." | 1.27 | The pentagastrin test in the diagnosis of the carcinoid syndrome. ( Ahlman, H; Dahlström, A; Grönstad, K; Jaffe, BM; Nilsson, O; Oberg, K, 1985) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 8 (66.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Fischler, M | 1 |
| Dentan, M | 1 |
| Westerman, MN | 1 |
| Vourc'h, G | 1 |
| Freitag, B | 1 |
| Luzzatto, G | 1 |
| Pozza, M | 1 |
| Cella, G | 1 |
| Egermayer, P | 1 |
| Town, GI | 1 |
| Peacock, AJ | 1 |
| Janssen, M | 1 |
| Salm, EF | 1 |
| Breburda, CS | 1 |
| van Woerkens, LJ | 1 |
| de Herder, WW | 1 |
| v/d Zwaan, C | 1 |
| Roelandt, JR | 1 |
| Robertson, JI | 2 |
| Ball, SG | 1 |
| Ahlman, H | 3 |
| Dahlström, A | 3 |
| Grönstad, K | 2 |
| Jaffe, BM | 2 |
| Nilsson, O | 1 |
| Oberg, K | 2 |
| Ahlund, L | 1 |
| Martner, J | 1 |
| Stenqvist, O | 1 |
| Tylén, U | 1 |
| Tisell, LE | 1 |
| Zinner, MJ | 1 |
| Houghton, K | 1 |
| Carter, JA | 1 |
| Padfield, NL | 1 |
| Sullivan, PA | 1 |
| O'Donovan, M | 1 |
2 reviews available for ketanserin and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Role of serotonin in the pathogenesis of acute and chronic pulmonary hypertension.
Topics: Blood Platelet Disorders; Collagen Diseases; Humans; Hypertension, Portal; Hypertension, Pulmonary; | 1999 |
Carcinoid syndrome and serotonin: therapeutic effects of ketanserin.
Topics: Animals; Humans; Ketanserin; Malignant Carcinoid Syndrome; Serotonin | 1990 |
10 other studies available for ketanserin and Malignant Carcinoid Syndrome
| Article | Year |
|---|---|
Prophylactic use of ketanserin in a patient with carcinoid syndrome.
Topics: Female; Humans; Hypertension; Intraoperative Complications; Ketanserin; Malignant Carcinoid Syndrome | 1983 |
[Symptomatic relief of carcinoid syndrome by ketanserin. A case].
Topics: Aged; Fatal Outcome; Humans; Ketanserin; Male; Malignant Carcinoid Syndrome | 1995 |
Carcinoid crisis during transesophageal echocardiography.
Topics: Antineoplastic Agents, Hormonal; Echocardiography, Transesophageal; Humans; Ketanserin; Male; Malign | 2000 |
Is there alpha-adrenergic blockade and/or serotonergic blockade during chronic ketanserin treatment?
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Blood Pressure; Humans; Ketanserin | 1985 |
The pentagastrin test in the diagnosis of the carcinoid syndrome.
Topics: Carcinoid Tumor; Female; Gastrointestinal Neoplasms; Humans; Hydroxyindoleacetic Acid; Ketanserin; M | 1985 |
SMS 201-995 and provocation tests in preparation of patients with carcinoids for surgery or hepatic arterial embolization.
Topics: Aged; Embolization, Therapeutic; Female; Hemodynamics; Hepatic Artery; Humans; Hydroxyindoleacetic A | 1988 |
The pentagastrin test in the diagnosis of the carcinoid syndrome. Blockade of gastrointestinal symptoms by ketanserin.
Topics: Aged; Calcium; Digestive System; Female; Humans; Ketanserin; Liver Neoplasms; Male; Malignant Carcin | 1985 |
Peri-operative management of carcinoid syndrome using ketanserin.
Topics: Aged; Antihypertensive Agents; Embolization, Therapeutic; Female; Hepatic Artery; Humans; Hypertensi | 1986 |
Carcinoid syndrome: comparison of pretreatment regimes in the same patient.
Topics: Blood Pressure; Cyproheptadine; Embolization, Therapeutic; Fenclonine; Hepatic Artery; Humans; Ketan | 1987 |
Ketanserin, a 5-HT antagonist, in symptomatic treatment of carcinoid syndrome.
Topics: Humans; Ketanserin; Male; Malignant Carcinoid Syndrome; Middle Aged | 1986 |