ketanserin has been researched along with Ischemic Attack, Transient in 10 studies
Ketanserin: A selective serotonin receptor antagonist with weak adrenergic receptor blocking properties. The drug is effective in lowering blood pressure in essential hypertension. It also inhibits platelet aggregation. It is well tolerated and is particularly effective in older patients.
ketanserin : A member of the class of quinazolines that is quinazoline-2,4(1H,3H)-dione which is substituted at position 3 by a 2-[4-(p-fluorobenzoyl)piperidin-1-yl]ethyl group.
Ischemic Attack, Transient: Brief reversible episodes of focal, nonconvulsive ischemic dysfunction of the brain having a duration of less than 24 hours, and usually less than one hour, caused by transient thrombotic or embolic blood vessel occlusion or stenosis. Events may be classified by arterial distribution, temporal pattern, or etiology (e.g., embolic vs. thrombotic). (From Adams et al., Principles of Neurology, 6th ed, pp814-6)
| Excerpt | Relevance | Reference |
|---|---|---|
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 5.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| "After subarachnoid hemorrhage, a pronounced network of serotonin-immunoreactive nerve fibers was demonstrated in the vessel wall." | 1.28 | Uptake and release of serotonin in rat cerebrovascular nerves after subarachnoid hemorrhage. ( Emilsson, K; Hardebo, JE; Nystedt, S; Owman, C; Szabò, C, 1992) |
| "(S)-Emopamil has a less potent calcium antagonistic effect (EC50 = 270 nmol/l) on the aorta than verapamil and gallopamil (EC50 = 35 and 14 nmol/l, respectively)." | 1.28 | (S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile. ( Hofmann, HP; Raschack, M; Unger, L, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 5 (50.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Klisch, J | 2 |
| Bode-Greuel, KM | 2 |
| Horvath, E | 1 |
| Klisch, C | 1 |
| Els, T | 1 |
| Tagari, PC | 1 |
| Kaye, AH | 1 |
| Teddy, PJ | 1 |
| Schachter, M | 1 |
| Adams, CB | 1 |
| Boullin, DJ | 1 |
| Fujikura, H | 1 |
| Kato, H | 1 |
| Araki, T | 1 |
| Ban, H | 1 |
| Hasegawa, Y | 1 |
| Kogure, K | 1 |
| Piera, MJ | 1 |
| Beaughard, M | 1 |
| Michelin, MT | 1 |
| Winslow, E | 1 |
| Massingham, R | 1 |
| Tsuji, T | 1 |
| Cook, DA | 1 |
| Szabò, C | 1 |
| Emilsson, K | 1 |
| Hardebo, JE | 1 |
| Nystedt, S | 1 |
| Owman, C | 1 |
| Vällfors, B | 1 |
| Dahlström, A | 1 |
| Boström, S | 1 |
| Ahlman, H | 1 |
| Hofmann, HP | 1 |
| Raschack, M | 1 |
| Unger, L | 1 |
| Wroblewska, B | 1 |
| Kumami, K | 1 |
| Cvejic, V | 1 |
| Mrsulja, BB | 1 |
| Spatz, M | 1 |
10 other studies available for ketanserin and Ischemic Attack, Transient
| Article | Year |
|---|---|
Additive neuroprotective effect of Ketanserin and Ipsapirone on the hippocampal damage after transient forebrain ischemia in the Mongolian gerbil.
Topics: Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Drug Therapy, Combination; Female | 2003 |
The 5-hydroxytryptamine antagonist ketanserin inhibits the vasoconstrictor activity of per-operative CSF, from subarachnoid haemorrhage patients, on isolated tissues.
Topics: Adult; Aged; Animals; Female; Humans; Hydroxyindoleacetic Acid; Intracranial Aneurysm; Intraoperativ | 1983 |
Effects of naftidrofuryl oxalate, a 5-HT2 antagonist, on neuronal damage and local cerebral blood flow following transient cerebral ischemia in gerbils.
Topics: Animals; Autoradiography; Brain; Cerebrovascular Circulation; Gerbillinae; Hippocampus; Histamine H2 | 1994 |
Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.
Topics: Animals; Behavior, Animal; Body Temperature; Brain; Gerbillinae; Ischemic Attack, Transient; Ketanse | 1995 |
Effect of ketanserin on 5-hydroxytryptamine-induced constriction in isolated, perfused canine basilar arteries exposed to blood.
Topics: Animals; Basilar Artery; Dogs; Ischemic Attack, Transient; Ketanserin; Perfusion; Potassium Chloride | 1996 |
Ketanserin reduces neuronal calcium accumulation and cell death in the hippocampus of the Mongolian gerbil after transient forebrain ischemia.
Topics: Animals; Biological Transport; Body Temperature; Cell Death; Cell Survival; Female; Gerbillinae; Hip | 1992 |
Uptake and release of serotonin in rat cerebrovascular nerves after subarachnoid hemorrhage.
Topics: Animals; Basilar Artery; Electric Stimulation; Ischemic Attack, Transient; Ketanserin; Male; Oxidopa | 1992 |
Influence of ketanserin on 5-hydroxytryptamine-induced cerebrovascular spasm in the cat.
Topics: Animals; Cats; Cerebrovascular Circulation; Ischemic Attack, Transient; Ketanserin; Muscle Contracti | 1985 |
(S)-emopamil, a novel calcium and serotonin antagonist for the treatment of cerebrovascular disorders. 1st communication: pharmacological profile.
Topics: Animals; Binding, Competitive; Calcium Channel Blockers; Cerebrovascular Disorders; Female; Guinea P | 1989 |
Cerebrocortical modulation of S2-receptors and turnover rate of 5-hydroxytryptamine in ischemia.
Topics: Animals; Brain Edema; Cerebral Cortex; Gerbillinae; Ischemic Attack, Transient; Ketanserin; Kinetics | 1987 |